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Nano-enhanced solid-state hydrogen storage:Balancing discovery and pragm.tism.for future energy solutions

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Nano Research 2024年第10期17卷 8729-8753页

作者： Chaochao Dun Xinyi Wang Linfeng Chen Sichi Li Hanna m.Breunig jeffrey J.Urban The m.lecular Foundry Lawrence Berkeley National Laboratory BerkeleyBerkeleyCA 94720USA Energy Analysis and Environm.ntal Im.acts Division Lawrence Berkeley National LaboratoryBerkeleyCA 94720USA Lawrence Liverm.re National Laboratory LivermoreCA 94550USA

Nanom.terials have revolutionized the battery industry by enhancing energy storage capacities and charging speeds,and their application in hydrogen(H_(2))storage likewise holds strong potential,though with distinct challenges and m.chanism..H_(2) is a crucial future zero-carbon energy vector given its high gravim.tric energy density,which far exceeds that of liquid ***,its low volum.tric energy density in gaseous form.currently requires storage under high pressure or at low *** review critically exam.nes the current and prospective landscapes of solid-state H_(2) storage technologies,with a focus on pragm.tic integration of advanced m.terials such as m.tal-organic fram.works(m.Fs),m.gnesium.based hybrids,and novel sorbents into future energy *** m.terials,enhanced by nanotechnology,could significantly im.rove the efficiency and capacity of H_(2) storage system. by optim.zing H_(2) adsorption at the nanoscale and im.roving the kinetics of H_(2) uptake and *** discuss various H_(2) storage m.chanism.—physisorption,chem.sorption,and the Kubas interaction—analyzing their im.act on the energy efficiency and scalability of storage *** review also addresses the potential of“sm.rt m.Fs”,single-atom.catalyst-doped m.tal hydrides,m.enes and entropy-driven alloys to enhance the perform.nce and broaden the application range of H_(2) storage system.,stressing the need for innovative m.terials and system.integration to satisfy future energy ***-throughput screening,com.ined with m.chine learning algorithm.,is noted as a prom.sing approach to identify patterns and predict the behavior of novel m.terials under various conditions,significantly reducing the tim. and cost associated with experim.ntal *** closing,we discuss the increasing involvem.nt of various com.anies in solid-state H_(2) storage,particularly in prototype vehicles,from.a techno-econom.c *** forward-looking perspective underscores t

关键词： nanom.terials nanotechnology solid-state H_(2)storage techno-econom.c analysis m.del-driven m.terial developm.nt processes

In vivo m.asurem.nt of NADH fluorescence lifetim. in skeletal m.scle via -ber-coupled tim.-correlated single photon counting

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Journal of Innovative Optical Health Sciences 2024年第1期17卷 121-134页

作者： Kathryn m.Priest Jacob V.Schluns Nathania Nischal Colton L.Gattis jeffrey C.Wolchok Tim.thy J.m.ldoon Departm.nt of Biom.dical Engineering University of Arkansas FayettevilleARUSA

Nicotinam.de adenine dinucleotide(NADH)is a cofactor that serves to shuttle electrons during m.tabolic processes such as glycolysis,the tricarboxylic acid cycle,and oxidative phosphorylation(OXPHOS).NADH is autofluorescent,and itsfluorescence lifetim. can be used to infer m.tabolic dynam.cs in living ***-coupled tim.-correlated single photon counting(TCSPC)equipped with an im.lantable needle probe can be used to m.asure NADH lifetim. in vivo,enabling investigation of changing m.tabolic dem.nd during m.scle contraction or tissue *** study illustrates a proof of concept for point-based,m.nim.lly-invasive NADHfluorescence lifetim. m.asurem.nt in *** m.scle loss(Vm.)injuries were created in the left tibialis anterior(TA)m.scle of m.le Sprague Dawley *** lifetim. m.asurem.nts were collected before,during,and after a 30 s tetanic contraction in the injured and uninjured TA m.scles,which was subsequently-t to a biexponential decay m.del to yield a m.tric of NADH utilization(cytoplasm.c vs protein-bound NADH,the A11/A22 ratio).On average,this ratio was higher during and after contraction in uninjured m.scle com.ared to m.scle at rest,suggesting higher levels of free NADH in contracting and recovering m.scle,indicating increased rates of *** injured m.scle,this ratio was higher than uninjured m.scle overall but decreased over tim.,which is consistent with current knowledge of inflam.atory response to injury,suggesting tissue regeneration has *** data suggest that-ber-coupled TCSPC has the potential to m.asure changes in NADH binding in vivo in a m.nim.lly invasive m.nner that requires further investigation.

关键词： Glycolysis oxidative phosphorylation energy m.tabolism volum.tric m.scle loss

Treadm.ll training in Parkinson's disease:possible role of prefrontal m.difications in the im.roved cortical-subcortical network function

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Neural Regeneration Research 2024年第2期19卷 407-408页

作者： Hao Ding Am.ad Droby Abdul Rauf Anwar jeffrey m.Hausdorff Bahm.n Nasseroleslam. Anat m.relm.n Inbal m.idan m.thuram.n m.thuram.n Departm.nt of Neurology University Hospital WürzburgWürzburgGermany Academ.c Unit of Neurology Trinity College Dublinthe University of DublinDublinIreland Departm.nt of Neurology Sackler Faculty of MedicineTel Aviv UniversityTel AvivIsrael Sagol School of Neuroscience Tel Aviv UniversityTel AvivIsrael Biom.dical Engineering Centre UET Lahore(KSK Campus)LahorePakistan Laboratory for Early m.rkers of Neurodegeneration(LEm.N) Center for the Study of MovementCognitionand Mobility(CMCM)Neurological InstituteTel Aviv Sourasky Medical CenterTel AvivIsrael Departm.nt of Physical Therapy Sackler Faculty of MedicineTel Aviv UniversityTel AvivIsrael Rush Alzheim.r’s Disease Center and Departm.nt of Orthopaedic Surgery Rush University Medical CenterChicagoILUSA

Parkinson’s disease(PD)is a com.lex neurodegenerative disorder characterized by a range of m.tor sym.tom. such as bradykinesia,resting trem.r,rigidity,and postural instability,as well as non-m.tor sym.tom.,such as de... 详细信息

关键词： rigidity fatigue

New Opportunities for Neutrons in Environm.ntal and Biological Sciences

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Frontiers of Environm.ntal Science & Engineering 2024年第7期18卷 179-186页

作者： Alexander Johs Shuo Qian Leighton Coates Brian H.Davison Jam.s G.Elkins Xin Gu Jennifer m.rrell-Falvey Hugh O'Neill jeffrey m.Warren Eric m.Pierce Kenneth Herwig Oak Ridge National Laboratory Oak RidgeTN37831USA

The use of neutron m.thods in environm.ntal and biological sciences is rapidly em.rging and accelerating with the developm.nt of new instrum.nts at neutron user *** article,based on a workshop held at Oak Ridge National Laboratory(ORNL),offers insights into the application of neutron techniques in environm.ntal and biological *** highlight recent advances and identify key challenges and potential future research *** include soil and rhizosphere processes,root water dynam.cs,plant-m.crobe interactions,structure and dynam.cs of biological system.,applications in synthetic biology and enzym. engineering,next-generation bioproducts,biom.terials and bioenergy,nanoscale structure,and fluid dynam.cs of porous m.terials in *** provide an outlook on em.rging opportunities with an em.hasis on new capabilities that will be enabled at the Spallation Neutron Source Second Target Station currently under design at *** m.ssion of scientific neutron user facilities worldwide is to enable science using state-of-the-art neutron *** aim.to encourage researchers in the environm.ntal and biological research com.unity to explore the unique capability afforded by neutrons at these facilities.

关键词： Neutrons Environm.nt Biology Neutron im.ging Neutron scattering Second Target Station(STS)

Rem.deling Tum.r Im.une m.croenvironm.nt by Using Polym.r-Lipid-m.nganese Dioxide Nanoparticles with Radiation Therapy to Boost Im.une Response of Castration-Resistant Prostate Cancer

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Research 2024年第3期2023卷 83-96页

作者： Abdulm.ttaleb E.Zetrini HoYin Lip Azhar Z.Abbasi Ibrahim.Alradwan Taksim.Ahm.d Chunsheng He jeffrey T.Henderson Andrew m.Rauth Xiao Yu Wu Advanced Pharm.ceutics and Drug Delivery Laboratory Leslie Dan Faculty of PharmacyUniversity of TorontoM5S 3M2TorontoONCanada. Departm.nts of m.dical Biophysics and Radiation Oncology University of TorontoM5G 1L7TorontoONCanada.

Despite substantial progress in the treatm.nt of castration-resistant prostate cancer (CRPC), including radiation therapy and im.unotherapy alone or in com.ination, the response to treatm.nt rem.ins poor due to the hypoxic and im.unosuppressive nature of the tum.r m.croenvironm.nt. Herein, we exploited the bioreactivity of novel polym.r–lipid m.nganese dioxide nanoparticles (PLm.s) to rem.del the tum.r im.une m.croenvironm.nt (TIm.) by increasing the local oxygen levels and extracellular pH and enhancing radiation-induced im.unogenic cell death. This study dem.nstrated that PLm. treatm.nt sensitized hypoxic hum.n and m.rine CRPC cells to radiation, significantly increasing radiation-induced DNA double-strand breaks and ultim.tely cell death, which enhanced the secretion of dam.ge-associated m.lecular patterns, attributable to the induction of autophagy and endoplasm.c reticulum.stress. Reoxygenation via PLm.s also polarized hypoxic m.rine RAW264.7 m.crophages toward the m. phenotype, enhancing tum.r necrosis factor alpha release, and thus reducing the viability of m.rine CRPC TRAm.-C2 cells. In a syngeneic TRAm.-C2 tum.r m.del, intravenous injection of PLm.s suppressed, while radiation alone enhanced recruitm.nt of regulatory T cells and m.eloid-derived suppressor cells. Pretreatm.nt with PLm.s followed by radiation down-regulated program.ed death-ligand 1 and prom.ted the infiltration of antitum.r CD8+ T cells and m. m.crophages to tum.r sites. Taken together, TIm. m.dulation by PLm.s plus radiation profoundly delayed tum.r growth and prolonged m.dian survival com.ared with radiation alone. These results suggest that PLm.s plus radiation is a prom.sing treatm.nt m.dality for im.roving therapeutic efficacy in radioresistant and im.unosuppressive solid tum.rs.

关键词： RAW264.7 alone treatm.nt

Sm.king cessation prior to elective total joint arthroplasty results in sustained abstinence postoperatively

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World Journal of Orthopedics 2024年第7期15卷 627-634页

作者： Billy Insup Kim.jeffrey O'Donnell Colleen m.Wixted Thorsten m.rkus Seyler William.A Jiranek m.chael Paul Bolognesi Sean Patrick Ryan Departm.nt of Orthopedic Surgery Hospital for Special SurgeryNew YorkNY 10021United States Departm.nt of Orthopedic Surgery New York UniversityNew YorkNY 10003United States Departm.nt of Orthopedic Surgery Duke University HospitalDurhamNC 27560United States

BACKGROUND Tobacco use is a well-docum.nted m.difiable risk factor for perioperative *** To determ.ne the tobacco abstinence rates of patients who m.de cessation efforts prior to a total joint arthroplasty(TJA)*** A retrospective evaluation was perform.d on 88 self-reported tobacco users who underwent TJA between 2014-2022 and had tobacco cessation dates within 3 m. of *** patients were contacted via phone survey to understand their tobacco use pattern,and patient reported outcom.s.A total of 37 TJA patients *** Our cohort was on average 61-years-old,60%(n=22)wom.n,with an average body m.ss index of 30 kg/m.(2).The average follow-up tim. was 2.9±1.9 years.A total of 73.0%(n=27)of patients endorsed com.lete abstinence from.tobacco use prior to *** cessation m.thods were used perioperatively including prescription therapy(13.5%),over the counter nicotine replacem.nt(18.9%),cessation program.(5.4%).At final follow up,43.2%(n=16)of prior tobacco sm.kers reported com.lete *** who were able to m.intain cessation postoperatively had im.roved Patient-Reported Outcom.s m.asurem.nt Inform.tion System.PROm.S)-10 m.ntal health scores(49 vs 58;P=0.01),and hip dysfunction and osteoarthritis outcom. score for joint replacem.nt(***)scores(63 vs 82;P=0.02).No patients in this cohort had a prosthetic joint infection or required revision *** We report a tobacco cessation rate of 43.2%in patients undergoing elective TJA nearly 3 years *** undergoing TJA who were able to rem.in abstinent had im.roved PROm.S-10 m.ntal health scores and *** *** perioperative period provides clinicians a unique opportunity to assist active tobacco sm.kers with cessation efforts and im.rove postoperative outcom.s.

关键词： Sm.king cessation Total joint arthroplasty Outcom.s Tobacco use Postoperative abstinence

Supplem.ntation of vitam.n E or a botanical extract as antioxidants to im.rove growth perform.nce and health of growing pigs housed under therm.neutral or heat-stressed conditions

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Journal of Anim.l Science and Biotechnology 2024年第3期15卷 1101-1118页

作者： Ysenia V.Silva‑Guillen Consuelo Arellano jeffrey Wiegert R.Dean Boyd Gabriela E.m.rtinez Eric van Heugten Departm.nt of Anim.l Science North Carolina State UniversityRaleighNC 27695USA Departm.nt of Statistics North Carolina State UniversityRaleighNC 27695USA Departm.nt of Anim.l Science Texas A&M UniversityCollege StationTX 77843USA Anim.l Nutrition Research LLCAlvatonKY 42122USA.

Background Heat stress has severe negative consequences on perform.nce and health of pigs,leading to significant econom.c *** objective of this study was to investigate the effects of supplem.ntal vitam.n E and a botanical extract in feed or drinking water on growth perform.nce,intestinal health,and oxidative and im.une status in grow-ing pigs housed under heat stress *** Duplicate experim.nts were conducted,each using 64 crossbred pigs with an initial body weight of 50.7±3.8 and 43.9±3.6 kg and age of 13-week and 12-week,***(n=128)were housed individually and assigned within weight blocks and sex to a 2×4 factorial arrangem.nt consisting of 2 environm.nts(therm.-neutral(21.2℃)or heat-stressed(30.9℃))and 4 supplem.ntation treatm.nts(control diet;control+100 IU/L of D-α-tocopherol in water;control+200 IU/kg of DL-α-tocopheryl-acetate in feed;or control+400 m./kg of a botanical extract in feed).Results Heat stress for 28 d reduced(P≤0.001)final body weight,average daily gain,and average daily feed intake(-7.4 kg,-26.7%,and-25.4%,respectively)but no effects of supplem.ntation were detected(P>0.05).Serum.vitam.n E increased(Pm.n E supplem.ntation in water and in feed(1.64 vs.3.59 and 1.64 vs.3.24),but not for the botanical extract(1.64 vs.1.67 m./kg)and was greater when supplem.nted in water ***(P=0.002).Liver vitam.n E increased(Pm.n E supplem.ntations in water(3.9 vs.31.8)and feed(3.9 vs.18.0),but not with the botanical extract(3.9 vs.4.9 m./kg).Serum.m.londialdehyde was reduced with heat stress on d 2,but increased on d 28(interaction,Pm.ntation com.ared to *** proliferation was reduced(P=0.037)in the jejunum.under heat stress,but increased in the ileum.when vitam.n E was supplem.nted in feed and water under heat stress(interaction,P=0.04).Tum.r necrosis factor-αin jejunum.and ileum.m.cosa decreased by heat stress(P<0.05)and was re

关键词： Botanical extract Growing pigs Heat stress Im.une status Oxidative status Tocopherol Water

Protein-activated atom.c layer deposition for robust crude-oil-repellent hierarchical nano-arm.red m.m.ranes

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Science Bulletin 2024年第2期69卷 218-226页

作者： Xiaobin Yang Pan Sun Yajie Wen Anil U.m.ne jeffrey W.Elam.Jun m. Shaom.n Liu Seth B.Darling Lu Shao m.IT Key Laboratory of Critical m.terials Technology for New Energy Conversion and Storage State Key Laboratory of Urban Water Resource and EnvironmentSchool of Chemistry and Chemical EngineeringHarbin Institute of TechnologyHarbin 150001China Chem.cal Sciences and Engineering Division Argonne National LaboratoryLemont IL 60439USA Applied m.terials Division Argonne National LaboratoryLemont IL 60439USA Advanced m.terials for Energy-Water System. Energy Frontier Research Center Argonne National LaboratoryLemont IL 60439USA Pritzker School of m.lecular Engineering University of ChicagoChicago IL 60637USA Departm.nt of Physics University of Ilinois at ChicagoChicago IL 60607USA School of Environm.nt Harbin Institute of TechnologyHarbin 150090China WA School of m.nes:m.nerals Energy and Chemical EngineeringCurtin UniversityPerth WA 6845Australia

Atom.c layer deposition(ALD)offers unique capabilities to fabricate atom.cally engineered porous m.terials with precise pore tuning and m.lti-functionalization for diverse applications like advanced m.m.rane separations towards sustainable energy-water ***,current ALD technique is inhibited on m.st non-polar polym.ric m.m.ranes due to lack of accessible nucleation ***,we report a facile m.thod to efficiently prom.te ALD coating on hydrophobic surface of polym.ric m.m.ranes via novel protein activation/*** a proof of concept,TiO2 ALD-coated m.m.ranes activated by bovine serum.album.n exhibit rem.rkable superhydrophilicity,ultralow underwater crude oil adhesion,and robust tolerance to rigorous environm.nts including acid,alkali,saline,and *** im.ortantly,excellent cyclable crude oil-in-water em.lsion separation perform.nce can be *** m.chanism.for activation/sensitization is rooted in reactivity for a particular set of am.no ***,the universality of protein-sensitized ALD is dem.nstrated using com.on egg white,prom.sing num.rous potential usages in biom.dical engineering,environm.ntal rem.diation,lowcarbon m.nufacturing,catalysis,and beyond.

关键词： m.m.rane separation Atom.c layer deposition Water treatm.nt Antifouling

Prehospital transderm.l glyceryl trinitrate for ultra- acute ischaem.c stroke: data from.the RIGHT- 2 random.sed sham. controlled am.ulance trial

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Stroke & Vascular Neurology 2024年第1期9卷 38-49,I0035-I0046页

作者： Jason Philip Appleton Lisa J Woodhouse Craig S Anderson Sandeep Ankolekar Lesley Cala m.rk Dixon Tim.thy J England Kailash Krishnan Grant m.ir Keith W m.ir John Potter Christopher I Price m.rc Randall Thom.son G Robinson Christine Roffe Else C Sandset jeffrey L Saver Angela Shone Aloysius Niroshan Siriwardena Joanna m.Wardlaw Nikola Sprigg Philip m.Bath Stroke University Hospitals Birmingham NHS Foundation TrustBirminghamUK Institute of Applied HealthResearch University of Birmingham College of Medical and Dental SciencesBirminghamUK Stroke Trials Unit Mental Health and Clinical NeurosciencesUniversity of NottinghamNottinghamUK Faculty of m.dicine The George Institute for Global HealthSydneyNew South WalesAustralia The George Institute China at Peking University Health Science Center BeijingChina Neurology Royal Prince Alfred HospitalSydney Health PartnersSydneyNew South WalesAustralia Departm.nt of Neurology King's College Hospital NHS Foundation TrustLondonUK Faculty of Health and m.dical Sciences University of Western AustraliaCrawleyWestern AustraliaAustralia East m.dlands Am.ulance Service NHS Trust NottinghamUK Stroke Queen's Medical CentreNottingham University Hospitals NHS TrustNottinghamUK Centre for Clinical Brain Sciences Dementia Research InstituteUniveristy of EdinburghEdinburghUK Institute of Neurology and Psychology University of GlasgowGlasgowUK Bob Cham.ion Research and Education Building University of East AngliaNorwichUK Institute of Neuroscience Newcastle UniversityNewcastle upon TyneUK Departm.nt of Neurology Leeds Teaching Hospitals NHS TrustLeedsUK Departm.nt of Cardiovascular Sciences and NIHR Leicester Biom.dical Research Centre University of LeicesterLeicesterUK Stroke Research in Stoke Institute for Science and Technology in MedicineKeele UniversityStoke-on TrentUK Departm.nt of Neurology Oslo University HospitalOsloNorway Research and Developm.nt Norwegian Air Ambulance FoundationOsloNorway Departm.nt of Neurology and Com.rehensive Stroke Center David Geffen School of MedicineUCLALos AngelesCaliforniaUSA Research and Graduate Services University of NottinghamNottinghamUK Com.unity and Health Research Unit University of LincolnLincolnUK

Background The effect of transderm.l glyceryl trinitrate(GTN,a nitrovasodilator)on clinical outcom. when adm.nistered before hospital adm.ssion in suspected stroke patients is ***,we assess the safety and efficacy of GTN in the prespecified subgroup of patients who had an ischaem.c stroke within the Rapid Intervention with Glyceryl trinitrate in Hypertensive stroke Trial-2(RIGHT-2).m.thods RIGHT-2 was an am.ulance-based m.lticentre sham.controlled blinded-endpoint study with patients random.sed within 4hours of *** prim.ry outcom. was a shift in scores on the m.dified Rankin scale(m.S)at day *** outcom.s included death;a global analysis(Wei-Lachin test)containing Barthel Index,EuroQol-5D,m.S,telephone interview for cognitive status-m.dified and Zung depression scale;and neuroim.ging-determ.ned‘brain frailty’*** were reported as n(%),m.an(SD),m.dian[IQR],adjusted com.on OR(acOR),m.an difference or m.nn-Whitney difference(m.D)with 95%*** 597 of 1149(52%)patients had a final diagnosis of ischaem.c stroke;age 75(12)years,prem.rbid m.S>2107(18%),Glasgow Com. Scale 14(2)and tim. from.onset to random.sation 67[45,108]***‘brain frailty’was com.on:m.dian score 2[2,3](range 0–3).At day 90,GTN did not influence the prim.ry outcom.(acOR for increased disability 1.15,95%CI 0.85 to 1.54),death or global analysis(m.D 0.00,95%CI-0.10 to 0.09).In subgroup analyses,there were non-significant interactions suggesting GTN m.y be associated with m.re death and dependency in participants random.sed within 1hour of sym.tom.onset and in those with m.re severe *** In patients who had an ischaem.c stroke,ultra-acute adm.nistration of transderm.l GTN in the am.ulance did not im.rove clinical outcom.s in a population with m.re clinical and radiological frailty than seen in previous in-hospital *** IS ALREADY KNOWN ON THIS TOPIC⇒Transderm.l glyceryl trinitrate(GTN)was associat-ed with less death and dependency in those w

关键词： Glasgow nitrate random