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Arabidopsis thaliana histone deacetylase1(AtHD1)is localized in euchromatic regions and demonstrates histone deacetylase activity in vitro

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Cell Research 2006年第5期16卷 479-488页

作者： Paulus m Fong Z jeffrey Chen Department of Soil and Crop Sciences Texas A&M UniversityCollege StationTX 77843USA molecular Cell and Developmental Biology University of Texas at AustinAustinTX78712USA

Arabidopsis thaliana histone deacetylase 1 (AtHD1 or AtHDA19),a homolog of yeast RPD3,is a global regulator ofmany physiological and developmental processes in *** spite of the genetic evidence for a role of AtHD1 in plantgene regulation and development,the biochemical and cellular properties of AtHD1 are poorly *** we reportcellular localization patterns of AtHD1 in vivo and histone deacetylase activity in *** transient and stable expres-sion of a green fluorescent protein (GFP)-tagged AtHD1 in onion cells and in roots,seeds and leaves of the transgenicArabidopsis,respectively,revealed that AtHD1 is localized in the nucleus presumably in the euchromatic regions andexcluded from the *** localization patterns of AtHD1 are different from those of AtHD2 and AtHDA6 thatare involved in nucleolus formation and silencing of transgenes and repeated DNA elements,*** addition,a histone deacetylase activity assay showed that the recombinant AtHD1 produced in bacteria demonstrated a specifichistone deacetylase activity in *** data suggest that AtHD1 is a nuclear protein and possesses histone deacetylaseactivities responsible for global transcriptional regulation important to plant growth and development.

关键词： Arabidopsis histone deacetylase RPD3 subcellular localization gene silencing chromatin

Effects of ambient DIN:DIP ratio on the nitrogen uptake of harmful dinoflagellate Prorocentrum minimum and Prorocentrum donghaiense in turbidistat

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Chinese Journal of Oceanology and Limnology 2011年第4期29卷 746-761页

作者：李纪 Patricia m. GLIBERT jeffrey A. ALEXANDER University of maryland Center for Environmental Science Horn Point Laboratory PO Box 775 Cambridge MD 21613 USA

The effects of varying nitrogen （N）： phosphorus （P） ratios on the growth and N-uptake and assimilation of the harmful dinoflagellates Prorocentrum minimum and Prorocentrum donghaiense were examined in turbidistat culture experiments. Algal cultures were supplied with media containing PO4^3- in various concentrations to obtain a wide range of N：P ratios. Experiments to determine rates of N uptake and assimilation of different N sources （NO^3-, NH4^＋, urea and glycine by P. minimum and NO3^-, NH4^＋ by P. donghaiense） were conducted using ^15-N tracer techniques at each N：P ratio. The growth rates suggested nutrient limitation at both high and low N：P ratios relative to the Redfield ratio. On a diel basis, the growth of both species was regulated by the light-dark cycle, which may be a result of regulation of both lightdependent growth and light-independent nutrient uptake. maximum growth rates of both species always occurred at the beginning of light phase. In P-rich medium （low N：P ratio）, both species had higher N assimilation rates, suggesting N limitation. Low assimilation coefficients at high N：P ratios suggested P limitation of N uptake and assimilation. NO3 ^-and NH4^＋ contributed more than 90% of the total N uptake of P. minimum. Reduced N sources were more quickly assimilated than NO3^-. Highest average daily growth rates were recorded near an N：P ratio of 12 for both species. The N uptake rates of cultures at N：P ratios near Redfield ratio were more balanced with growth rates. The linkage between growth rates and N uptake/assimilation rates were conceptually described by the variation of cell N quota. The N：P ratios affect the N uptake and growth of Prorocentrum spp., and may regulate their bloom progression in eutrophic ecosystems.

关键词： harmful dinoflagellate N:P ratio nitrogen uptake continuous culture Prorocentrum spp

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Pain management strategies in penile implantation

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Asian Journal of Andrology 2020年第1期22卷 34-38页

作者： jeffrey L Ellis Andrew m Higgins Jay Simhan Department of Urology Einstein Healthcare NetworkDivision of Urologic OncologyDepartment of Surgical OncologyFox Chase Cancer CenterPhiladelphiaPA 19141 USA

The opioid epidemic continues to be a serious public health *** have pointed to prescription drug misuse as a nidus for patients to become addicted to opioids and as such,urologists and other surgical subspecialists must critically define optimal pain management for the various procedures performed within their respective *** pain following penile prosthesis implantation remains a unique challenge for urologists,given the increased pain patients commonly experience in the postoperative *** most of the existing urological literature focuses on interventions performed in the operating room,there are many studies that examine the role of preoperative adjunctive pain medicine in diminishing postoperative narcotic *** are relatively few studies looking at postoperative strategies for managing pain in prosthetic surgery with follow-up past the immediate *** review assess the various strategies employed for managing pain following penile implantation through the lens of the current state of the opioid crisis,thus examining how urologists can responsibly treat pain without contributing to the growing threat of opioid addiction.

关键词： analgesia epidemic opioid pain prosthetic

Salinization:the ultimate threat to temperate lakes,with particular reference to Southeastern Wisconsin(USA)

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Chinese Journal of Oceanology and Limnology 2015年第6期33卷 1461-1475页

作者： jeffrey A.THORNTON Thomas m.SLAWSKI Hebin LIN International Environmental management Services Ltd. Watershed Services Coordinator The Meadows Center for Water and the EnvironmentTexas State University601 University DriveSan MarcosTX 78666United States of America Graduate School of Human Development and Environment Kobe University3-11 TsurukabutoNada-kuKobeHyogo 657 8501Japan Southeastern Wisconsin Regional Planning Commission W239 N1812 Rockwood DriveP.O.Box 1607WaukeshaWI 53187-1607United States of America

many lakes in Southeastern Wisconsin(the metropolitan-milwaukee area) are gradually becoming increasingly "salty".While these waterbodies would not be considered presently to be saline lakes,there has been a rapid increase in the chloride concentrations in most of these lakes over the last 30 years,with the lakes increasing from a mean chloride concentration of about 19 mg/L to over 100 mg/L in some *** ecological impacts can be expected when chloride values exceed 250 mg/L,the rate of increase presents a basis for concern,especially since the underlying geology of the region is based on limestone/dolomite which is deficient in ***,the origin of the chlorides is anthropogenic:human and industrial wastewaters(treatment of which has effected improvements in trophic status but has not affected other water-borne contaminants) and winter de-icing practices based upon large quantities of sodium chloride are major contributors to the increasing concentrations of chloride in the region's *** taking remedial measures,the rate of salinization is expected to continue to increase,resulting,ultimately,in the alteration of the freshwater systems in the region.

关键词： salinization temperate lakes chloride concentrations salt management

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Stability of Two Conservative,High-Order Fluid-Fluid Coupling methods

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Advances in Applied mathematics and mechanics 2019年第6期11卷 1287-1338页

作者： jeffrey m.Connors Robert D.Dolan University of Connecticut Department of MathematicsStorrsCT 06269USA

This paper investigates two methods of coupling fluids across an interface,motivated by air-sea interaction in application *** method is for sequential configurations,where the air code module in invoked over some time interval prior to the sea *** other method is for concurrent setups,in which the air and sea modules run in *** focus is the temporal representation of air-sea *** methods we study conserve moments of the fluxes,with an arbitrary order of accuracy possible in *** step sizes are allowed for the two fluid *** a posteriori stability indicator is defined,which can be computed efficiently on-the-fly over each coupling *** a model of two coupled fluids with natural heat convection,using finite elements in space,we prove the sufficiency of our stability *** certain conditions,we also prove that stability can be enforced by iteration when the coupling interval is small *** particular,for solutions in a certain class,we show that the step size scaling is no worse than O(h)in three dimensions of space,where Oh is a mesh *** is a sharper result than what has been shown previously for related algorithms with finite element *** examples illustrate the behavior of the algorithms under a wide variety of configurations.

关键词： Air-sea atmosphere-ocean fluid-fluid partitioned time stepping conservative coupling

Pancreatic paraganglioma diagnosed by endoscopic ultrasoundguided fine needle aspiration: A case report and review of literature

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World Journal of Gastroenterology 2021年第37期27卷 6322-6331页

作者： Gandhi Lanke John m Stewart jeffrey H Lee Department of Gastroenterology Hepatology and NutritionMD Anderson Cancer CenterLubbockTX 79407United States Pathology-lab medicine Division MD Anderson Cancer CenterHoustonTX 77030United States Department of Gastroenterology Hepatology and NutritionMD Anderson Cancer CenterHoustonTX 77030United States

BACKGROUND Pancreatic paragangliomas(PPGL)are rare benign neuroendocrine neoplasms but malignancy can *** are often misdiagnosed as pancreatic neuroendocrine tumor or pancreatic *** SUmmARY We reviewed 47 case reports of PPGL published in Pubmed to *** patients(15/47)with PPGL underwent endoscopic ultrasound-guided fine needle aspiration(EUS-FNA).Only six(6/15)were correctly diagnosed as *** patients with PPGL underwent surgical resection except three(one patient surgery was aborted because of hypertensive crisis,two patients had metastasis or involvement of major vessels).Our patient remained on close surveillance as she was *** Accurate preoperative diagnosis of PPGL can be safely achieved by EUS-FNA with *** team approach should be considered to bring the optimal results in the management of PPGL.

关键词： Pancreatic paraganglioma Endoscopic ultrasound-guided fine needle aspiration meta-iodobenzylguanidine scan metanephrines GATA-3 Immunohistochemistry Case report

蛋白活化原子层沉积用于超强原油排斥的层级纳米装甲膜（英文）

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Science Bulletin 2024年第2期 218-226页

作者：杨晓彬孙盼温雅洁 Anil U.mane jeffrey W.Elam 马军刘少敏 Seth B.Darling 邵路 mIIT Key Laboratory of Critical materials Technology for New Energy Conversion and Storage State Key Laboratory of Urban Water Resource and Environment School of Chemistry and Chemical Engineering Harbin Institute of Technology Chemical Sciences and Engineering Division Argonne National Laboratory Advanced materials for Energy-Water Systems Energy Frontier Research Center Argonne National Laboratory School of Environment Harbin Institute of Technology Pritzker School of molecular Engineering University of Chicago Department of Physics University of Illinois at Chicago Applied materials Division Argonne National Laboratory WA School of mines: minerals Energy and Chemical Engineering Curtin University

Atomic layer deposition(ALD) offers unique capabilities to fabricate atomically engineered porous materials with precise pore tuning and multi-functionalization for diverse applications like advanced membrane separations towards sustainable energy-water systems. However, current ALD technique is inhibited on most non-polar polymeric membranes due to lack of accessible nucleation sites. Here, we report a facile method to efficiently promote ALD coating on hydrophobic surface of polymeric membranes via novel protein activation/sensitization. As a proof of concept, TiO2ALD-coated membranes activated by bovine serum albumin exhibit remarkable superhydrophilicity, ultralow underwater crude oil adhesion, and robust tolerance to rigorous environments including acid, alkali, saline, and *** importantly, excellent cyclable crude oil-in-water emulsion separation performance can be achieved. The mechanism for activation/sensitization is rooted in reactivity for a particular set of amino acids. Furthermore, the universality of protein-sensitized ALD is demonstrated using common egg white,promising numerous potential usages in biomedical engineering, environmental remediation, lowcarbon manufacturing, catalysis, and beyond.

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Chemically activated carbon nanofibers for adsorptive removal of bisphenol-A:Batch adsorption and breakthrough curve study

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Chinese Journal of Chemical Engineering 2023年第9期61卷 248-259页

作者： Wenming Hao Basma I.Waisi Timothy m.Vadas jeffrey R.mcCutcheon College of Chemical Engineering and Technology Taiyuan University of TechnologyTaiyuan 030024China Department of Chemical&Biomolecular Engineering University of ConnecticutStorrsCT 06269United States Department of Chemical Engineering University of BaghdadBaghdad 10071Iraq Department of Civil and Environmental Engineering University of ConnecticutStorrsCT 06269United States

Activated carbon nanofibers(ACNFs)with small diameter can significantly increase the accessibility of intra pores and accelerate adsorption of molecules from *** this study,ACNFs were made by blending K_(2)CO_(3)or ZnCl_(2)as the activating agent into the polyacrylonitrile(PAN)in dimethylformamide solution for electrospinning prior to ***-A(BPA),an endocrine disruption pollutant,is widely applied in the production of polycarbonate plastics and epoxy ***,BPA is often used as a model contaminant commonly removed via *** adsorption studies were used to evaluate the kinetics and adsorption capacity of the ***-Peterson(R-P)and Langmuir models were found to fit the isotherm of BPA adsorption better than Freundlich model,showing the homogeneous nature of the PAN originated *** adsorption kinetics was better described by the pseudo second-order model than that by the pseudo first-order *** fitting by intraparticle diffusion model indicates the adsorption of BPA onto ACNFs is mainly controlled by pore *** pH value and ionic strength reduced BPA adsorption from aqueous *** breakthrough curves studied in two different fixed bed systems(cross flow bed system and packed flow bed system)confirmed the scalability of BPA removal by ACNFs in dynamic adsorption *** modified dose-response model predicted well the fixed-bed outlet concentration profiles.

关键词： Activated carbon nanofibers(ACNFs) Chemical activation Bisphenol-A(BPA) Fixed bed Adsorption

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Post-endoscopic retrograde cholangiopancreatography pancreatitis

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Gastroenterology Report 2015年第1期3卷 32-40页

作者： Adarsh m.Thaker jeffrey D.mosko Tyler m.Berzin Center for Advanced Endoscopy Division of GastroenterologyBeth Israel Deaconess Medical CenterHarvard Medical SchoolBostonMAUSA

Acute pancreatitis remains the most common complication of endoscopic retrograde cholangiopancreatography(ERCP).It is reported to occur in 2–10%of unselected patient samples and up to 40%of high-risk *** purpose of this article is to review the evidence behind the known risk factors for post-ERCP pancreatitis,as well as the technical and medical approaches developed to prevent *** have been many advances in identifying the causes of this *** on this knowledge,a variety of preventive strategies have been developed and *** approach to prevention begins with careful patient selection and performing ERCP for specific indications,while considering alternative diagnostic modalities when *** should also be classified by high-risk factors such as young age,female sex,suspected sphincter of Oddi dysfunction,a history of post-ERCP pancreatitis,and normal serum bilirubin,all of which have been identified in numerous research *** pathways of injury that are believed to cause post-ERCP pancreatitis eventually lead to the common endpoint of inflammation,and these individual steps can be targeted for preventive therapies through procedural techniques and medical *** includes the use of a guide wire for cannulation,minimizing the number of cannulation attempts,avoiding contrast injections or trauma to the pancreatic duct,and placement of a temporary pancreatic duct stent in high-risk *** of rectal non-steroidal anti-inflammatory agents(NSAIDs)in high-risk patients is the proven pharmacological measure for prevention of post-ERCP *** evidence for or against numerous other attempted therapies is still unclear,and ongoing investigation is required.

关键词： endoscopic retrograde cholangiopancreatography pancreatitis prevention complications