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Infectious Diseases of Poverty 2021年第3期10卷 121-121页

作者： Ning Feng jeffrey karl edwards Philip Odhiambo Owiti Guo-Min Zhang Zulma Vanessa Rueda Vallejo Katrina Hann Shui-Sen Zhou Myo Minn Oo Elizabeth Marie Geoffroy Chao Ma Tao Li Jun Feng Yi Zhang Xiao-Ping Dong Center for Global Public Health Chinese Center for Disease Control and PreventionBeijingChina 不详

Background:Chinese Center for Disease Control and Prevention(China CDC)introduced the Structured Operational Research Training Initiative(SORT IT)into China to build a special capacity and equip public health professionals with an effective tool to support developing countries in strengthening their operational *** paper aims to investigate and analyze the implementation,outcomes and challenges of the first cycle of SORT IT in China.

关键词： Operational research Capacity building Disease control program

Missed opportunities for hepatitis C treatment at a tertiary care hospital in South Australia

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World Journal of Hepatology 2022年第8期14卷 1576-1583页

作者： Sreecanth Sibhi Raja Suzanne edwards jeffrey Stewart Dep Huynh Department of Gastroenterology The Queen Elizabeth HospitalWoodville 5011South AustraliaAustralia Department of Statistician School of Public HealthUniversity of AdelaideAdelaide 5000South AustraliaAustralia

BACKGROUND Hepatitis C is a global epidemic and an estimated 230000 Australians were living with chronic hepatitis C in *** effective public health policy and state commitment,Australia has utilised the advent of direct acting antiviral(DAA)therapy to transform the therapeutic landscape for hepatitis C virus(HCV).However,treatment rates are falling and novel public health approaches are required to maintain momentum for HCV *** discourse in cascades of care have focused on expanding testing capabilities but less attention has been given to linking previously diagnosed patients back to *** simple and focused study rests on the premise that hospital admissions are an excellent opportunity to identify and refer previously diagnosed patients for HCV *** To assess whether inpatients with HCV are appropriately referred on for *** We conducted a retrospective single centre cohort study that examined all patients with HCV presenting to The Queen Elizabeth Hospital(QEH)inpatient service between January 1 and December 31,*** is a tertiary care hospital in South *** main inclusion criteria were patients with active HCV infection who were eligible for DAA *** study cohort was identified using a comprehensive list of diagnosis based on international classification of diseases-10 AM codes for chronic viral *** were excluded from the analysis if they had previously received DAA therapy or spontaneously cleared *** presenting with decompensated liver cirrhosis or other systemic medical conditions conferring poor short-term prognosis were also excluded from the *** primary outcome of our study was referral of patients for HCV *** outcomes included assessment of factors predicting treatment *** There were 309 inpatients identified with hepatitis C as a principal or additional diagnosis between January 1 and December 31,*** these patients,

关键词： Hepatitis C Viral hepatitis Treatment cascade Hepatology Public health Missed opportunities

Does playing a sports active video game improve object control skills of children with autism spectrum disorder?

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Journal of Sport and Health Science 2017年第1期6卷 17-24,127页

作者： Jacqueline edwards Sarah jeffrey Tamara May Nicole J.Rinehart Lisa M.Barnett School of Health and Social Development Faculty of HealthDeakin UniversityGeelongVIC 3125Australia Department of Paediatrics Faculty of MedicineDentistry and Health SciencesUniversity of MelbourneParkvilleVIC 3052Australia School of Psychology Faculty of HealthDeakin UniversityGeelongVIC 3125Australia Murdoch Childrens Research Institute ParkvilleVIC 3052Australia

Background: Active video games(AVGs) encourage whole body movements to interact or control the gaming system, allowing the opportunity for skill development. Children with autism spectrum disorder(ASD) show decreased fundamental movement skills in comparison with their typically developing(TD) peers and might benefit from this approach. This pilot study investigates whether playing sports AVGs can increase the actual and perceived object control(OC) skills of 11 children with ASD aged 6–10 years in comparison to 19 TD children of a similar *** was a secondary ***: Actual(Test of Gross Motor Development) and perceived OC skills(Pictorial Scale of Perceived Movement Skill Competence for Young Children) were assessed before and after the intervention(6 × 45 min).Results: Actual skill scores were not improved in either group. The ASD group improved in perceived skill. All children completed the required dose and parents reported the intervention was ***: The use of AVGs as a play-based intervention may not provide enough opportunity for children to perform the correct movement patterns to influence skill. However, play of such games may influence perceptions of skill ability in children with ASD, which could improve motivation to participate in physical activities.

关键词： Autism spectrum disorder Child Exergaming Fundamental movement skills Physical self-perception Xbox

Targeting multiple signaling pathways:the new approach to acute myeloid leukemia therapy

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Signal Transduction and Targeted Therapy 2021年第1期6卷 41-69页

作者： Jenna LCarter Katie Hege Jay Yang Hasini AKalpage Yongwei Su Holly edwards Maik Hüttemann jeffrey WTaub Yubin Ge Cancer Biology Graduate Program Wayne State University School of MedicineDetroitMIUSA MD/PhD Program Wayne State University School of MedicineDetroitMIUSA Department of Oncology Wayne State University School of MedicineDetroitMIUSA Molecular Therapeutics Program Barbara Ann Karmanos Cancer InstituteWayne State University School of MedicineDetroitMIUSA Center for Molecular Medicine and Genetics Wayne State University School of MedicineDetroitMIUSA National Engineering Laboratory for AIDS Vaccine Key Laboratory for Molecular Enzymology and EngineeringThe Ministry of EducationSchool of Life SciencesJilin UniversityChangchunChina Division of Pediatric Hematology/Oncology Children’s Hospital of MichiganDetroitMIUSA Department of Pediatrics Wayne State University School of MedicineDetroitMIUSA

Acute myeloid leukemia(AML)is the most common form of acute leukemia in adults and the second most common form of acute leukemia in *** this,very little improvement in survival rates has been achieved over the past few *** is partially due to the heterogeneity of AML and the need for more targeted therapeutics than the traditional cytotoxic chemotherapies that have been a mainstay in therapy for the past 50 *** the past 20 years,research has been diversifying the approach to treating AML by investigating molecular pathways uniquely relevant to AML cell proliferation and *** we review the development of novel therapeutics in targeting apoptosis,receptor tyrosine kinase(RTK)signaling,hedgehog(HH)pathway,mitochondrial function,DNA repair,and c-Myc *** has been an impressive effort into better understanding the diversity of AML cell characteristics and here we highlight important preclinical studies that have supported therapeutic development and continue to promote new ways to target AML *** addition,we describe clinical investigations that have led to FDA approval of new targeted AML therapies and ongoing clinical trials of novel therapies targeting AML survival *** also describe the complexity of targeting leukemia stem cells(LSCs)as an approach to addressing relapse and remission in AML and targetable pathways that are unique to LSC *** comprehensive review details what we currently understand about the signaling pathways that support AML cell survival and the exceptional ways in which we disrupt them.

关键词： myeloid approach approval

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Inhibition of Mcl-1 enhances cell death induced by the Bcl-2-selective inhibitor ABT-199 in acute myeloid leukemia cells

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Signal Transduction and Targeted Therapy 2017年第1期2卷 242-250页

作者： Daniel A Luedtke Xiaojia Niu Yihang Pan Jianyun Zhao Shuang Liu Holly edwards Kang Chen Hai Lin jeffrey W Taub Yubin Ge Cancer Biology Graduate Program Wayne State University School of MedicineDetroitMichiganUSA National Engineering Laboratory for AIDS Vaccine School of Life SciencesJilin UniversityChangchunChina Department of Pathology and Laboratory Medicine Weill Cornell MedicineNew YorkNew YorkUSA Department of Pediatrics Wayne State University School of MedicineDetroitMichiganUSA Department of Oncology Wayne State University School of MedicineDetroitMichiganUSA Molecular Therapeutics Program Karmanos Cancer InstituteWayne State University School of MedicineDetroitMichiganUSA Department of Obstetrics and Gynecology Wayne State University School of MedicineDetroitMichiganUSA Mucosal Immunology Studies Team National Institute of Allergy and Infectious DiseasesNational Institutes of HealthBethesdaMarylandUSA Department of Hematology and Oncology The First Hospital of Jilin UniversityChangchunChina Division of Pediatric Hematology and Oncology Children’s Hospital of MichiganDetroitMichiganUSA.

Acute myeloid leukemia(AML)is a serious *** 5-year survival rates remain frustratingly low(65%for children and 26%for adults).Resistance to frontline chemotherapy(usually cytarabine)often develops;therefore a new treatment modality is ***-2 family proteins play an important role in balancing cell survival and *** antiapoptotic Bcl-2 family proteins have been found to be dysregulated in ***-199,a BH3 mimetic,was developed to target antiapoptotic protein *** ABT-199 has demonstrated promising results,resistance *** studies in AML show that ABT-199 alone decreases the association of proapoptotic protein Bim with Bcl-2,but this is compensated by increased association of Bim with prosurvival protein Mcl-1,stabilizing Mcl-1,resulting in resistance to *** this study,we investigated the antileukemic activity of the Mcl-1-selective inhibitor A-1210477 in combination with ABT-199 in AML *** found that A-1210477 synergistically induced apoptosis with ABT-199 in AML cell lines and primary patient *** synergistic induction of apoptosis was decreased upon Bak,Bax and Bim *** A-1210477 treatment alone also increased Mcl-1 protein levels,combination with ABT-199 reduced binding of Bim to *** results demonstrate that sequestration of Bim by Mcl-1,a mechanism of ABT-199 resistance,can be abrogated by combined treatment with the Mcl-1 inhibitor A-1201477.

关键词： chemotherapy alone treatment

Simultaneous cotargeting of ATR and RNA Polymerase I transcription demonstrates synergistic antileukemic effects on acute myeloid leukemia

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Signal Transduction and Targeted Therapy 2019年第1期4卷 240-242页

作者： Tingting Wang Margaret Shatara Fangbing Liu Tristan Knight Holly edwards Guan Wang Hai Lin Yue Wang jeffrey W.Taub Yubin Ge National Engineering Laboratory for AIDS Vaccine Key Laboratory for Molecular Enzymology and Engineeringthe Ministry of EducationSchool of Life SciencesJilin University130021 ChangchunPeople’s Republic of China Division of Pediatric Hematology/Oncology Department of PediatricsChildren’s Hospital of MichiganDetroitMI 48201USA Department of Pediatrics Wayne State University School of MedicineDetroitMI 48201USA Department of Oncology Wayne State University School of MedicineDetroitMI 48201USA Molecular Therapeutics Program Barbara Ann Karmanos Cancer InstituteWayne State University School of MedicineDetroitMI 48201USA Department of Hematology and Oncology The First Hospital of Jilin University130021 ChangchunPeople’s Republic of China Department of Pediatric Hematology and Oncology The First Hospital of Jilin University130021 ChangchunPeople’s Republic of China

Dear Editor,Continued development of novel therapeutic agents is critical to improve the survival of patients with acute myeloid leukemia(AML).RNA Polymerase I(Pol I)-mediated transcription and ribosomal biogenesis become dysregulated,thereby allowing synthesis of necessary substrates to support uncontrolled cancer cell proliferation *** Pol I transcription rate is higher in AML cells than nonleukemic myeloid precursors 2,suggesting Pol I transcrip-tion as a therapeutic target for ***-5461 is a potent Pol I transcription inhibitor and stabilizer of the DNA G-quadruplex structure,which causes G2/M-phase arrest via the ATR(ataxia telangiectasia and Rad3-related protein)-mediated DNA damage response(DDR)3–5.

关键词： myeloid acute leukemic

Inhibition of CDK9 by voruciclib synergistically enhances cell death induced by the Bcl-2 selective inhibitor venetoclax in preclinical models of acute myeloid leukemia

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Signal Transduction and Targeted Therapy 2020年第1期5卷 2332-2342页

作者： Daniel A.Luedtke Yongwei Su Jun Ma Xinyu Li Steven ABuck Holly edwards Lisa Polin Juiwanna Kushner Sijana HDzinic Kathryn White Hai Lin jeffrey WTaub Yubin Ge Cancer Biology Graduate Program Wayne State University School of MedicineDetroitMI 48201USA School of Life Sciences Jilin University130021 ChangchunChina Division of Pediatric Hematology and Oncology Children’s Hospital of MichiganDetroitMIUSA48201 Department of Pediatrics Wayne State University School of MedicineDetroitMI 48201USA Department of Oncology Wayne State University School of MedicineDetroitMI 48201USA Molecular Therapeutics Program Karmanos Cancer InstituteWayne State University School of MedicineDetroitMI 48201USA Department of Hematology and Oncology The First Hospital of Jilin University130021 ChangchunChina

Venetoclax,an FDA-approved Bcl-2 selective inhibitor for the treatment of chronic lymphocytic leukemia and acute myeloid leukemia(AML),is tolerated well in elderly patients with AML and has good overall response rates;however,resistance remains a *** this study,we show that targeting CDK9 with voruciclib in combination with venetoclax results in synergistic antileukemic activity against AML cell lines and primary patient ***9 inhibition enhances venetoclax activity through downregulation of Mcl-1 and ***,downregulation of Mcl-1 is transient,which necessitates an intermittent treatment schedule to allow for repeated downregulation of ***,an every other day schedule of the CDK9 inhibitor is effective in vitro and in vivo in enhancing the efficacy of *** preclinical data provide a rationale for an intermittent drug administration schedule for the clinical evaluation of the combination treatment for AML.

关键词： venetoclax clinical CDK9

The Utility of Voided Urine Samples as a Proxy for the Vaginal Microbiome and for the Prediction of Bacterial Vaginosis

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Infectious Microbes & Diseases 2022年第4期4卷 149-156页

作者： Bin Zhu Christopher Diachok Laahirie Edupuganti David J.edwards jeffrey R.Donowitz Katherine Tossas Andrey Matveyev Katherine M.Spaine Vladimir Lee Myrna G.Serrano Gregory A.Buck Department of Microbiology and Immunology School of MedicineVirginia Commonwealth UniversityRichmondVirginiaUSA Center for Microbiome Engineering and Data Analysis Virginia Commonwealth UniversityRichmondVirginiaUSA Department of Statistical Sciences and Operations Research College of Humanities and SciencesVirginia Commonwealth UniversityRichmondVirginiaUSA Department of Pediatric Infectious Diseases Children's Hospital of Richmond at Virginia Commonwealth UniversityRichmondVirginiaUSA Department of Infectious Diseases and International Health University of VirginiaCharlottesvilleVirginiaUSA Department of Health Behavior and Policy School of MedicineVirginia Commonwealth UniversityRichmondVirginiaUSA Department of Family Medicine and Population Health School of MedicineVirginia Commonwealth UniversityRichmondVirginiaUSA Computer Science Department College of EngineeringVirginia Commonwealth UniversityRichmondVirginiaUSA Genomics Core Virginia Commonwealth UniversityRichmondVirginiaUSA

Recent work has shown that the vaginal microbiome exerts a strong impact on women's gynecological ***,collection of vaginal specimens is invasive and requires previous clinical training or the involvement of a trained *** contrast,urine sample collection is routine and noninvasive and does not require involvement of a *** sought to compare the vaginal and urogenital microbiomes to assess the utility of voided urine samples as a proxy for the vaginal *** urogenital and vaginal samples were collected from pregnant women and characterized by 16S rRNA taxonomic *** examined diversities and compositions of paired urogenital and vaginal microbiomes using five discrete strategies to explore the similarity between the vaginal and urogenital microbiomes.A strategy comparing the paired urogenital and vaginal microbiomes in which taxa were assigned using the STIRRUPS database and urine-specific taxa were removed showed no significant difference in diversity and composition between the paired urogenital and vaginal ***,the relative abundances of common vaginal taxa were linearly correlated with those in the paired *** similarities suggest that voided urine samples could represent a noninvasive protocol for accurate profiling of the vaginalmicrobiome with likely clinical ***,a machine learning model was established in which the voided urine microbiome was compared favorably to the vaginal microbiome in predicting bacterial vaginosis.

关键词： 16S rRNA vaginal microbiome urine microbiome bacterial vaginosis reproductive and gynecologic health

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药物不良反应：定义、诊断与管理

药物不良反应杂志 2001年第2期3卷 93-99页

作者： I Ralph edwards jeffrey K Aronson WHO国际药物监测合作中心

我们将药物不良反应定义为"药物用于防治疾病而引起可以觉察到的有害的或不利的反应,这预示着继续给药会有危险,需要预防或特定治疗措施,或减少剂量,乃至停药",这样一些反应现今以世界卫生组织不良反应术语(WHO-ART)进行报告,后者终将... 详细信息

我们将药物不良反应定义为"药物用于防治疾病而引起可以觉察到的有害的或不利的反应,这预示着继续给药会有危险,需要预防或特定治疗措施,或减少剂量,乃至停药",这样一些反应现今以世界卫生组织不良反应术语(WHO-ART)进行报告,后者终将成为国际疾病分类(ICD)的一个组成部分.

关键词：药物副作用定义诊断管理

Health system and patient-level factors serving as facilitators and barriers to rheumatic heart disease care in Sudan

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Global Health Research and Policy 2021年第1期6卷 110-121页

作者： jeffrey G.edwards Michele Barry Dary Essam Mohammed Elsayed Mohamed Abdulkarim Basamat M.A.Elhossein Zahia H.A.Mohammed Abdelmunim Elnogomi Amna S.E.Elfaki Ahmed Elsayed Andrew Y.Chang Stanford University School of Medicine StanfordCAUSA Present Address:Boston Medical Center Department of PediatricsBoston University School of MedicineResidency Program Coordinatorc/o Jeffrey Edwards801 AlbanySt BostonMA 02119-2598USA Boston Children’s Hospital Harvard Medical SchoolBostonMAUSA Department of Medicine Stanford UniversityStanfordCAUSA Center for Innovation in Global Health Stanford UniversityStanfordCAUSA Alazhari Health Research Center Alzaeim Alazhari Uni-versityKhartoumSudan Faculty of Medicine Alzaeim Alazhari UniversityKhartoumSudan Medical Technical College Alzaeim Alazhari UniversityKhartoumSudan Department of Psychiatry Alzaeim Alazhari University KhartoumKhartoumSudan Al-Shaab Teaching Hospital KhartoumSudan Cardiovascular Institute Stanford UniversityStanfordCAUSA

Background:Rheumatic heart disease(RHD)remains a leading cause of morbidity and mortality in Sub-Saharan Africa despite widely available preventive therapies such as prophylactic benzathine penicillin G(BPG).In this study,we sought to characterize facilitators and barriers to optimal RHD treatment with BPG in ***:We conducted a mixed-methods study,collecting survey data from 397 patients who were enrolled in a national RHD registry between July and November *** cross-sectional surveys included information on demographics,healthcare access,and patient perspectives on treatment barriers and *** associated with increased likelihood of RHD treatment adherence to prophylactic BPG were assessed by using adjusted logistic *** data were enhanced by focus group discussions with 20 participants,to further explore health system factors impacting RHD ***:Our quantitative analysis revealed that only 32%of the study cohort reported optimal prophylaxis *** age,reduced primary RHD healthcare facility wait time,perception of adequate health facility staffing,increased treatment costs,and high patient knowledge about RHD were significantly associated with increased odds of treatment *** data revealed significant barriers to RHD treatment arising from health services factors at the health system level,including lack of access due to inadequate healthcare staffing,lack of faith in local healthcare systems,poor ancillary services,and patient lack of understanding of *** of RHD treatment included strong interpersonal ***:Multiple patient and system-level barriers to RHD prophylaxis adherence were identified in Khartoum,*** included patient self-efficacy and participant perception of healthcare facility *** local health system infrastructure,while enhancing RHD patient education,may help to improve treatment adherence in this vulnerable populatio

关键词： Rheumatic heart disease Health services research Global health Risk factors Barriers and facilitators to care