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Endoscopy is of low yield in the identification of gastrointestinal neoplasia in patients with dermatomyositis: A cross-sectional study

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world Journal of Gastroenterology 2017年第26期23卷 4788-4795页

作者： Trilokesh D Kidambi Gabriela Schmajuk Andrew J Gross James w Ostroff Jonathan P Terdiman jeffrey K Lee Division of Gastroenterology University of California Division of Rheumatology University of California Division of Rheumatology San Francisco Veterans Affairs Medical Center

To determine the prevalence of gastrointestinal neoplasia among dermatomyositis patients who underwent an esophagogastroduodenoscopy and/or colonoscopy. METHODSA cross-sectional study examining the results of upper endoscopy and colonoscopy in adults with dermatomyositis at an urban, university hospital over a ten year period was performed. Chart review was performed to confirm the diagnosis of dermatomyositis. Findings on endoscopy were collected and statistical analyses stratified by age and presence of symptoms were performed. RESULTSAmong 373 adult patients identified through a code based search strategy, only 163 patients had dermatomyositis confirmed by chart review. Of the 47 patients who underwent upper endoscopy, two cases of Barrett’s esophagus without dysplasia were identified and there were no cases of malignancy. Of the 67 patients who underwent colonoscopy, no cases of malignancy were identified and an adenoma was identified in 15% of cases. No significant differences were identified in the yield of endoscopy when stratified by age or presence of symptoms. CONCLUSIONThe yield of endoscopy is low in patients with dermatomyositis and is likely similar to the general population; we identified no cases of malignancy. A code based search strategy is inaccurate for the diagnosis of dermatomyositis, calling into question the results of prior population-based studies. Larger studies with rigorously validated search strategies are necessary to understand the risk of gastrointestinal malignancy in patients with dermatomyositis.

关键词： Endoscopy Dermatomyositis Colon cancer Screening

Combined kinematic and static analysis of an articulated lower limb traction device for a rehabilitation robotic system

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Science China(Technological Sciences) 2021年第6期64卷 1189-1202页

作者： LI Yuan ZI Bin YANG ZhengMeng GE jeffrey School of Mechanical Engineering Hefei University of TechnologyHefei 230009China Intelligent Interconnected Systems Laboratory of Anhui Province(Hefei University of Technology) Hefei 230009China Department of Mechanical Engineering Stony Brook UniversityStony Brook NY 11794-2300USA

This paper presents a design of an articulated lower limb traction device(ALLTD) with joint torque generators for a cable-driven parallel rehabilitation robotic system(CDPRRS). An earlier version of the ALLTD uses a rigid link to model the lower limbs of a patient. This paper extends this scenario to include articulations in the lower limbs and analyzes the resulting two-link mechanism. Due to the force-displacement coupled structure, the inverse and forward kinematics of the ALLTD model are analyzed in combination with the requirement for static force balance. Examples using the limb parameters of Chinese adults are provided to show the efficacy of our model. The workspaces and cable tensions of the model indicate that the ALLTD could satisfy the rehabilitation training needs of patients with various lengths of lower limbs.

关键词： rehabilitation robotic system cable-link mechanism combined kinematics and statics symmetric structure

Effects of inorganic or organic selenium on immunoglobulins in swine

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Journal of Animal Science and Biotechnology 2014年第2期5卷 236-244页

作者： Ashley Gelderman jeffrey Clapper Department of Animal Science South Dakota State University

A study was conducted to determine if Se source fed during gestation and lactation affects passive transfer of immunoglobulins. Sixty days prior to breeding （d -60）, gilts were randomly assigned to one of three treatments prior to breeding and throughout gestation： control （Control, no supplemental Se; n = 8）, inorganic Se （Inorganic Se, 0.3 ppm; n = 4） and organic Se （Organic Se, 0.3 ppm; n = 4）. Blood was collected on d -60, 57 and 113 of gestation and on d 21 of lactation and milk was collected at d 0, 1, 7, 14, and 21 of lactation. Blood was collected from piglets at d 0, 1, 7, 14, and 21 of age. Gilts fed organic Se had greater （P 〈 0.05） circulating concentrations of Se than Inorganic and Control gilts. Regardless of treatment, circulating concentrations of Se were greatest （P 〈 0.05） at d -60 compared to all other days. Serum concentrations of IgG were greatest （P 〈 0.05） in gilts at d 57 of gestation compared to d 113. Serum concentrations of IgA were greatest （P 〈 0.05） on d 113 of gestation and d 21 of lactation compared to d -60 and 57. Serum concentrations of IgM were greater （P 〈 0.05） at d 57 compared to d -60. Inorganic gilts had greater （P 〈 0.05） colostral and milk concentrations of IgG and IgM than Organic or Control gilts. Circulating concentrations of Se in piglets were greatest （P 〈 0.05） at d 14 and 21 of age compared to all other days. Piglets from gilts supplemented with organic Se had greater （P 〈 0.05） circulating concentrations of Se on d 1 versus piglets from gilts supplemented with no additional Se. The immunoglobulin concentrations of IgG, IgA, and IgM were lowest （P 〈 0.05） on d 0 and then different sources of Se did not affect the immunoglobulin ncreased when compared to d 1. The addition of concentrations in the gilt or piglet.

关键词： Immunoglobulin Pig Selenium

The therapeutic implications of immunosuppressive tumor aerobic glycolysis

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Cellular & Molecular Immunology 2022年第1期19卷 46-58页

作者： Bradley I.Reinfeld wKimryn Rathmell Tae Kon Kim jeffrey C.Rathmell Department of Medicine Division of Hematology and OncologyVanderbilt University Medical CenterNashvilleTNUSA

In 2011,Hanahan and weinberg added“Deregulating Cellular Energetics”and“Avoiding Immune Destruction”to the six previous hallmarks of *** this seminal paper,there has been a growing consensus that these new hallmarks are not mutually exclusive but rather *** following review summarizes how founding genetic events for tumorigenesis ultimately increase tumor cell glycolysis,which not only supports the metabolic demands of malignancy but also provides an immunoprotective niche,promoting malignant cell proliferation,maintenance and *** mechanisms by which altered metabolism contributes to immune impairment are multifactorial:(1)the metabolic demands of proliferating tumor cells and activated immune cells are similar,thus creating a situation where immune cells may be in competition for key nutrients;(2)the metabolic byproducts of aerobic glycolysis directly inhibit antitumor immunity while promoting a regulatory immune phenotype;and(3)the gene programs associated with the upregulation of glycolysis also result in the generation of immunosuppressive cytokines and *** this perspective,we shed light on important considerations for the development of new classes of agents targeting cancer *** types of therapies can impair tumor growth but also pose a significant risk of stifling antitumor immunity.

关键词： cancer metabolism immuno logy glycolysis

The CUL4A ubiquitin ligase is a potential therapeutic target in skin cancer and other malignancies

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Chinese Journal of Cancer 2013年第9期32卷 478-482页

作者： jeffrey Hannah Peng-Bo Zhou Department of Pathology and Laboratory Medicine Weill Cornell Medical College and Weill Cornell Graduate School of Medical Sciences Department of Pathology and Laboratory Medicine Weill Cornell Medical College

Cullin 4A(CUL4A)is an E3 ubiquitin ligase that directly affects DNA repair and cell cycle progression by targeting substrates including damage-specific DNA-binding protein 2(DDB2),xeroderma pigmentosum complementation group C(XPC),chromatin licensing and DNA replication factor 1(Cdt1),and *** work from our laboratory has shown that Cul4a-deficient mice have greatly reduced rates of ultraviolet-induced skin *** a cellular level,Cul4a-deficient cells have great capacity for DNA repair and demonstrate a slow rate of proliferation due primarily to increased expression of DDB2 and p21,*** suggests that CUL4A promotes tumorigenesis(as well as accumulation of skin damage and subsequent premature aging)by limiting DNA repair activity and expediting S phase *** addition,CUL4A has been found to be up-regulated via gene amplification or overexpression in breast cancers,hepatocellular carcinomas,squamous cell carcinomas,adrenocortical carcinomas,childhood medulloblastomas,and malignant pleural *** of its oncogenic activity in skin cancer and up-regulation in other malignancies,CUL4A has arisen as a potential candidate for targeted therapeutic *** this review,we outline the established functions of CUL4A and discuss the E3ligase’s emergence as a potential driver of tumorigenesis.

关键词：泛素连接酶恶性肿瘤皮肤癌治疗 DNA修复 DNA结合蛋白靶点细胞水平

Beyond dichotomies in species and speciation

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National Science Review 2022年第12期9卷 15-17页

作者： jeffrey L.Feder Patrik Nosil Department of Biological Sciences University of Notre Dame Centre d'Ecologie Fonctionnelle et Evolutive University MontpellierCNRS EPHE IRD

Speciation is not as mysterious as D arwin once described it [1].Nevertheless,important questions *** discussed by wu[2] and highlighted in a series of papers in National Science Review (NSR),these issues equate with imposing dichotomous perspectives on speciation,when the nature of species and the processes creating them can complicate discrete categorization.

关键词： DIVERGENCE EVOLUTION ADAPTATION INVERSIONS CONTINUUM RACE

Relationships between Gene Structure and Genome Instability in Flowering Plants

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Molecular Plant 2018年第3期11卷 407-413页

作者： jeffrey L. Bennetzen Xuewen wang State Key Laboratory of Tea Plant Biology and Utilization/Key Laboratory of Tea Biology and Processing Ministry of Agriculture Anhui Agricultural University HefeiAnhui 230036 People's Republic of China Department of Genetics University of Georgia Athens GA 30602 USA

Flowering plant （angiosperm） genomes are exceptional in their variability with respect to genome size, ploidy, chromosome number, gene content, and gene arrangement. Gene movement, although observed in some of the earliest plant genome comparisons, has been relatively underinvestigated. we present here- in a description of several interesting properties of plant gene and genome structure that are pertinent to the successful movement of a gene to a new location. These considerations lead us to propose a model that can explain the frequent success of plant gene mobility, namely that Small Insulated Genes Move Around （SlGMAR）. The SIGMAR model is then compared with known processes for gene mobilization, and predic- tions of the SIGMAR model are formulated to encourage future experimentation. The overall results indicate that the frequent gene movement in angiosperm genomes is partly an outcome of the unusual properties of angiosperm genes, especially their small size and insulation from epigenetic silencing.

关键词： epigenetic silencing gene insulators gene movement illegitimate recombination inaccurate DNA break repair transposon mobilization

Recent advances in flexible and stretchable electronics, sensors and power sources

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Science China Chemistry 2012年第5期55卷 718-725页

作者： TOK jeffrey B.-H. Department of Chemical Engineering Stanford University Stanford CA 94305 USA

There has been ongoing keen interest to mold electronic devices into desired shapes and be laid on desired configurable surfaces. In specific, the ability to design materials that can bend, twist, compress and stretch repeatedly, while still able to maintain its full capability as conductors or electrodes, has led to numerous efforts to develop flexible and stretchable (bio)devices that are both technologically challenging and environmentally friendly (e.g. biodegradable). In this review, we highlight several recent significant results that have made impacts toward the field of flexible and stretchable electronics, sensors and power sources.

关键词： organic transistors flexible electronics stretchable electronics electronic skin sensor

Graph theory approach to determine configurations of multidentate and high coverage adsorbates for heterogeneous catalysis

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npj Computational Materials 2020年第1期6卷 998-1003页

作者： Siddharth Deshpande Tristan Maxson jeffrey Greeley Davidson School of Chemical Engineering Purdue University480 W Stadium Mall DriveWest LafayetteIN 47907USA

Heterogeneous catalysts constitute a crucial component of many industrial processes,and to gain an understanding of the atomicscale features of such catalysts,ab initio density functional theory is widely ***,growing computational power has permitted the extension of such studies to complex reaction networks involving either high adsorbate coverages or multidentate adsorbates,which bind to the surface through multiple *** all possible adsorbate configurations for such systems,however,is often not possible based on chemical intuition *** systematically treat such complexities,we present a generalized Python-based graph theory approach to convert atomic scale models into undirected graph *** representations,when combined with workflows such as evolutionary algorithms,can systematically generate high coverage adsorbate models and classify unique minimum energy multidentate adsorbate configurations for surfaces of low symmetry,including multi-elemental alloy surfaces,steps,and kinks.

关键词： configuration theory catalysis