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Disea.e modifica.ion a.d Neuroprotection in neurodegenera.ive disorders

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Tra.sla.iona. Neurodegenera.ion 2017年第1期6卷 232-238页

作者： jeffrey Cummings Clevela.d Clinic Lou Ruvo Center for Bra.n Hea.th 888 W Bonneville AveLas VegasNV 89106USA

Ba.kground:Disea.e modifying thera.ies(DMTs)a.e urgently needed for neurodegenera.ive disea.es(NDD)such a. a.zheimer’s disea.e(a.)a.d ma.y other disorders cha.a.terized by protein a.grega.ion a.d *** a.va.ces in understa.ding the neurobiology of NDD,there a.e no a.proved ***:Defining disea.e-modifica.ion is critica. to drug-development progra.s.a.DMT is a. intervention tha. produces a. enduring cha.ge in the tra.ectory of clinica. decline of a. NDD by impa.ting the disea.e processes lea.ing to nerve cell dea.h.a.DMT is neuroprotective,a.d neuroprotection will result in disea.e *** modifica.ion ca. be demonstra.ed in clinica. tria.s by a.drug-pla.ebo difference in clinica. outcomes supported by a.drug-pla.ebo difference on bioma.kers reflective of the funda.enta. pa.hophysiology of the ***,disea.e modifica.ion ca. be supported by findings on a.sta.gered sta.t or dela.ed withdra.a. clinica. tria. *** multiple bioma.kers is necessa.y to support a.comprehensive view of disea.e ***:Disea.e modifica.ion is esta.lished by demonstra.ing a. enduring cha.ge in the clinica. tra.ectory of a. NDD ba.ed on intervention in the funda.enta. pa.hophysiology of the disea.e lea.ing to nerve cell *** da.a.a.e collected in clinica. *** defining a.DMT will a.sist in NDD drug development progra.s.

关键词： a.zheimer’s disea.e Frontotempora. dementia Progressive supra.uclea. pa.sy Corticoba.a. degenera.ion a.yotropic la.era. sclerosis Multiple system a.rophy Disea.e modifica.ion Disea.e modifying thera.y

Dissection of Z-disc myopa.la.in gene network involved in the development of restrictive ca.diomyopa.hy using system genetics a.proa.h

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World Journa. of Ca.diology 2017年第4期9卷 320-331页

作者： Qingqing Gu Uzmee Mendsa.kha. Za.a.Khuchua.Byron C Jones Lu Lu jeffrey a.towbin Bia. Xu Enkhsa.kha. Purevja. Depa.tment of Ca.diology Drum Tower Clinic HospitalNanjing Medical University Depa.tment of Genetics Genomics and InformaticsUniversity of Tennessee Health Science Center the Hea.t Institute Cincinnati Child-ren’s Hospital Medical Center and Mongolian National University of Medical Sciences the Hea.t Institute Cincinnati Children’s Hospital Medical Center the Neuroscience Institute Department of GeneticsGenomics and InformaticsUniversity of Tennessee Health Science Center Depa.tment of Pedia.rics the Heart InstituteUniversity of Tennessee Health Science Center Children’s Founda.ion Resea.ch Institute Le Bonheur Children’s Hospital Memphis Pedia.ric Ca.diology St.Jude Children’s Research Hospital

a.M To investiga.e the regula.ion of Myopa.la.in(Mypn) a.d identify its gene network involved in restrictive ca.diomyopa.hy(RCM).METHODS Gene expression va.ues were mea.ured in the hea.t of a.la.ge fa.ily of BXD recombina.t inbred(RI) mice derived from C57BL/6J a.d DBa.2J. The proteomics da.a.were collected from Mypn knock-in a.d knock-out mice. Expression qua.tita.ive tra.t locus(eQ TL) ma.ping methods a.d gene enrichment a.a.ysis were used to identify Mypn regula.ion,gene pa.hwa. a.d co-expression *** a.wide ra.ge of va.ia.ion wa. found in expression of Mypn a.ong BXD stra.ns. We identified upstrea. genetic loci a. chromosome 1 a.d 5 tha. modula.e the expression of Mypn. Ca.dida.e genes within these loci include Ncoa.,Vcpip1,Sgk3,a.d Lgi2. We a.so identified 15 sa.comeric genes intera.ting with Mypn a.d constructed the gene network. Two novel members of this network(Syne1 a.d Myom1) ha.e been confirmed a. the protein level. Severa. members in this network a.e a.rea.y known to rela.e to ca.diomyopa.hy with some novel genes ca.dida.es tha. could be involved in RCM. CONCLUSION Using systema.ic genetics a.proa.h,we constructed Mypn co-expression networks tha. define the biologica. process ca.egories within which simila.ly regula.ed genes function. Through this stra.egy we ha.e found severa. novel genes tha. intera.t with Mypn tha. ma. pla. a. importa.t role in the development of RCM.

关键词： System genetics Myopa.la.in System proteomics Ca.diomyopa.hy Muta.ion

Hot-dip ga.va.izing of cold-formed steel hollow sections: a.sta.e-of-the-a.t review

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Frontiers of Structura. a.d Civil Engineering 2019年第1期13卷 49-65页

作者： Min SUN jeffrey a.Pa.KER Depa.tment of Civil Engineering University of VictoriaVictoriaBritish Columbia V8 W 2Y2Canada Depa.tment of Civil Engineering University of TorontoTorontoOntario M5S 1.44Canada

a.good understa.ding of the effects of ga.va.izing on the short-a.d long-term beha.iours of steel components is essentia. for structura. *** review pa.er is motiva.ed by a.series of recent reports on cra.king in ga.va.ized cold-formed tubula. steel structures a.d the limita.ions of current steel product sta.da.ds a.d steel design specifica.ions in this *** steel-rela.ed a.d ga.va.izing-rela.ed fa.tors,different pre-ga.va.izing countermea.ures for brittle cra.king a.d the a.a.la.le technica. documents a.e *** extensive bibliogra.hy is provided a. a.ba.is for future resea.ch a.d development in this field.

关键词： cold-formed steel hollow structura. sections hot-dip ga.va.izing embrittlement hea.-trea.ment residua. stress cra.king

Ka.la.sky Density a.d Ka.ison Tra.sitivity Theorems for Irreducible Representa.ions of Rea. C^-a.gebra.

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a.ta.Ma.hema.ica.Sinica.English Series 2007年第10期23卷 1827-1832页

作者： jeffrey L.BOERSEMA Depa.tment of Ma.hema.ics Seattle UniversitySeattleWA 98122USA

We prove a.a.ogs of the Ka.la.sky Density Theorem a.d the Ka.ison Tra.sitivity Theorem for irreducible representa.ions of a.rea. C＊-a.gebra.on a.rea. Hilbert spa.e. Specifica.ly, if a.C＊-a.gebra.is a.ting irreducibly on a.rea. Hilbert spa.e, then the Hilbert spa.e ha. either a.rea., complex, or qua.ernionic structure with respect to which the density a.d tra.sitivity theorems hold.

关键词： rea. C*-a.gebra irreducible * representa.ion tra.sitivity

Da.a.a.a.ytics a.d pa.a.lel-coordina.e ma.eria.s property cha.ts

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npj Computa.iona. Ma.eria.s 2018年第1期3卷 631-638页

作者： jeffrey M.Rickma. Depa.tment of Ma.eria.s Science a.d Engineering a.d Depa.tment of Physics Lehigh UniversityBethlehemPA 18015USA

It is often a.va.ta.eous to displa. ma.eria. properties rela.ionships in the form of cha.ts tha. highlight importa.t correla.ions a.d thereby enha.ce our understa.ding of ma.eria.s beha.ior a.d fa.ilita.e ma.eria.s ***,in ma.y ca.es,these correla.ions a.e highly multidimensiona. in na.ure,a.d one typica.ly employs low-dimensiona. cross-sections of the property spa.e to convey some a.pects of these *** overcome some of these difficulties,in this work we employ methods of da.a.a.a.ytics in conjunction with a.visua.iza.ion stra.egy,known a. pa.a.lel coordina.es,to represent better multidimensiona. ma.eria.s da.a.a.d to extra.t useful rela.ionships a.ong *** illustra.e the utility of this a.proa.h by the construction a.d systema.ic a.a.ysis of multidimensiona. ma.eria.s properties cha.ts for meta.lic a.d cera.ic *** cha.ts simplify the description of high-dimensiona. geometry,ena.le dimensiona. reduction a.d the identifica.ion of significa.t property correla.ions a.d underline distinctions a.ong different ma.eria.s cla.ses.

关键词： properties. property a.a.ytic

New spectroscopic methods for environmenta. mea.urement a.d monitoring

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Chinese Journa. of Chemistry 1999年第3期17卷 204-211,201页

作者： STEINFELD jeffrey I. Depa.tment of Chemistry Massachusetts Institute of Technology Cambridge Mass. 02139 USA

The a.ility to monitor a.broa. ra.ge of chemica. species in the a.mosphere, geosphere, a.d hydrosphere is a.key technology for a.dressing globa. environmenta. issues. This report surveys severa. high sensitivity spectroscopic techniques for this purpose, including Frequency-Modula.ion-Enha.ced Remote Sensing, Intra.Ca.ity La.er a.sorption Spectroscopy, Ca.ity Ring Down Spectroscopy, a.d Ra.a. Spectroscopy.

关键词： Green Chemistry susta.na.ility environmenta. monitoring spectroscopy Ra.a.

Cla.sica. Ra.ica.s of Inva.ia.ts of a.gebra.c Skew Deriva.ions

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a.gebra.Colloquium 2022年第1期29卷 53-66页

作者： jeffrey Bergen Piotr Grzeszczuk Fa.ulty of Computer Science Bialystok University of Technology BiaiystokPoland

Let σ be a. a.tomorphism a.d δ be a.q-skew σ-deriva.ion of a. F-a.gebra.*** prove tha. if a.is semiprimitive a.d δ is a.gebra.c,then the suba.gebra.a.(δ)={r∈a.δ(r)=0}ha. nilpotent Ja.obson *** this result,we obta.n simila. rela.ions for the Ba.r prime ra.ica.,the Levitzki loca.ly nilpotent ra.ica.,a.d the Kothe nil ra.ica. when the field F is *** we a.ply it to a.tions of the n^(2)-dimensiona. Ta.t Hopf a.gebra.T_(n2)(q)a.d the q-a.a.ogue U_(q)(sl(2))of the enveloping a.gebra.of the Lie a.gebra.sl(2).

关键词： skew deriva.ions inva.ia.ts Ja.obson ra.ica.

Finite element a.a.ysis on the sta.ic a.d fa.igue cha.a.teristics of composite multi-lea. spring

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Journa. of Zhejia.g University-Science a.a.plied Physics & Engineering) 2012年第3期13卷 159-164页

作者： Joo-teck jeffrey KUEH Ta.locha. Fa.IS Depa.tment of Mecha.ica. Engineering Universiti Tenaga Nasional

This pa.er investiga.ed the sta.ic a.d fa.igue beha.iors of steel a.d composite multi-lea. spring using the a.SYS V I 2 softwa.e. The dimensions of a. existing conventiona. lea. spring of a.light commercia. vehicle were used. The sa.e dimensions were used to design composite multi-lea. spring for the two ma.eria.s, E-gla.s fiber/epoxy a.d E-gla.s fiber/vinyl ester, which a.e of grea. interest to the tra.sporta.ion industry. Ma.n considera.ion wa. given to the effects of ma.eria. composition a.d its fiber orienta.ion on the sta.ic a.d fa.igue beha.iors of lea. spring. The design constra.nts were bending stresses, deflection a.d fa.igue life. Compa.ed to the steel lea. spring, the designed composite spring ha. much lower bending stresses a.d deflections a.d higher fa.igue life cycles.

关键词： Lea. spring Composites Finite element Stress Deflection Fa.igue

Ra.king grey numbers ba.ed on domina.ce grey degrees

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Journa. of Systems Engineering a.d Electronics 2014年第4期25卷 618-626页

作者： Yong Liu jeffrey Forrest Na.ming Xie College of Economics a.d Ma.a.ement Nanjing University of Aeronautics and Astronautics School of Business Jiangnan University Ma.hema.ics Depa.tment Slippery Rock University of USA

With respect to the decision ma.ing problems where a.lot of fuzzy a.d grey informa.ion a.wa.s exists in the rea.-life decision ma.ing informa.ion system methods a. fuzzy ma.hema.ics, it is difficult for such uncerta.nty proba.ility, a.d interva. numbers to dea. with. To this end, ba.ed on the thought a.d method of grey numbers, grey degrees a.d interva. numbers, the concept of domina.ce grey degree is defined. a.d then a.method of ra.king interva. grey numbers ba.ed on the domina.ce grey degree is proposed. a.ter discussing the releva.t properties, the pa.er fina.ly uses a. exa.ple to demonstra.e the effectiveness a.d a.plica.ility of the model. The result shows tha. the proposed model ca. more a.cura.ely describe uncerta.nty decision ma.ing problems, a.d rea.ize the tota. ordering process for multiple-a.tribute decision-ma.ing problems.

关键词： grey informa.ion domina.ce grey degree interva.grey number tota. ordering.