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Ba.k to the dra.ing boa.d:Overview of the next genera.ion of combina.ion thera.y for infla.ma.ory bowel disea.e

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World Journa. of Ga.troenterology 2024年第25期30卷 3182-3184页

作者： jeffrey a.Lowell Micha.l J Fa.ber Keith Sulta. Depa.tment of Medicine Zucker School of Medicine at HofstraNorth Shore University Hospital-Long Island Jewish Medical CenterManhassetNY 11030United States Preclinica. Studies New York Institute of Technology College of Osteopathic MedicineGlen HeadNY 11545United States Division of Ga.troenterology Northwell HealthNorth Shore University Hospital and Long Island Jewish Medical CenterGreat NeckNY 10021United States

Infla.ma.ory bowel disea.e(IBD)is entering a.potentia.ly new era.of combined *** et a. provide a. insightful review of the current sta.e of combina.ion thera.y,with a.focus on the use of a.combined biologic a.d immunomodula.or,a. well a. emerging da.a.on the future potentia. of dua.-biologic thera.y(DBT).While current evidence for DBT is limited,encoura.ing sa.ety profiles a.d ongoing tria.s suggest a.brighter future for this *** importa.ce of controlled tria.s should be stressed in esta.lishing new trea.ment *** prospective ra.domized tria.s of DBT a.d perha.s future combina.ions of biologics a.d sma.l molecule thera.ies will hopefully guide the next genera.ion of IBD ca.e.

关键词： Infla.ma.ory bowel disea.e Biologics Immunomodula.ors Dua.-thera.y Combina.ion thera.y

New insights on the high-corrosion resista.ce of UHP Mg-Ge a.loys tested in a.simula.ed physiologica. environment

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Journa. of Ma.nesium a.d a.loys 2024年第3期12卷 1026-1044页

作者： Ting Liu Xingrui Chen jeffrey Venezuela.Yua. Wa.g Zhiming Shi Wenyi Chen Ma.thew Da.gusch Centre for a.va.ced Ma.eria.s Processing a.d Ma.ufa.turing(a.Pa.) School of Mechanical and Mining Engineeringthe University of QueenslandBrisbaneQLD 4072Australia CSIRO Minera. Resources 1 Technology CourtPullenvaleQLD 4069Australia

UHP Mg-Ge a.loys wa. recently found to provide excellent corrosion *** pa.er provides new insights on the mecha.ism of improved corrosion resista.ce of UHP Mg-Ge a.loys in Ha.ks’*** studied UHP Mg-0.5Ge a.d UHP Mg-1Ge a.loys showed superior corrosion resista.ce compa.ed to UHP Mg a.d WE43,with the Mg-1Ge exhibiting the best corrosion *** exceptiona. corrosion resista.ce of the UHP a.loy is a.tributed to(i)Mg_(2)Ge’s a.ility to suppress ca.hodic kinetics,(ii)Ge’s ca.a.ility to a.celera.e the forma.ion of a.highly pa.sive la.er,a.d the(iii)low a.ounts of corrosion-a.celera.ing impurities.

关键词： UHP Mg-Ge a.loy Ca.hodic kinetics suppression Biodegra.a.le meta.s In vitro corrosion Ma.nesium corrosion.

a.va.ces in ground hea. excha.gers for spa.e hea.ing a.d cooling:Review a.d perspectives

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Energy a.d Built Environment 2024年第2期5卷 255-269页

作者： Ping Cui Weibo Ya.g Wenke Zha.g Ke Zhu jeffrey D.Spitler Mingzhi Yu School of Therma. Engineering Shandong Jianzhu UniversityJinanShandong 250101China College of Electrica. Energy and Power EngineeringYangzhou UniversityYangzhouJiangsu 225127China Depa.tment of Mecha.ica. Engineering Oklahoma State UniversityStillwaterOKUSA

a. a.renewa.le energy source,geotherma. energy ha. been widely used to provide spa.e hea.ing a.d cooling for *** therma. performa.ce of ground hea. excha.ger(GHE)is significa.t for the opera.ing efficiency of the ground source hea. pump(GSHP)*** pa.er presents a.comprehensive review of developments a.d a.va.ces of three kinds of GHE,including vertica. borehole GHE(VBGHE),Pile GHE(PGHE),a.d deep borehole GHE(DBGHE)which a.e currently popula. in la.ger GSHP ***,a.a.ytica. models proposed to a.a.lyze hea. tra.sfer process of VBGHE with different geologica. conditions a.e summa.ized,such a. homogenous or heterogeneous ground,with or without groundwa.er *** a.d short-time step models a.d mea.ures to improve GHE therma. performa.ce a.e a.so ***,a.summa.y of resea.ch a.va.ces in PGHE is provided,which includes the hea. tra.sfer models of PGHE,the effects of geometric structure,oper-a.ion modes,pile spa.ing,use of pha.e cha.ge ma.eria.(PCM),therma. properties of PCM,thermo-mecha.ica. beha.ior a.d/or therma. performa.ce of *** effects of groundwa.er flow direction a.d velocity on PGHE a.e a.so summa.ized in ***,models of three kinds of DBGHEs,i.e.,deep coa.ia. GHE(DCGHE),deep U-bend GHE(DUGHE)a.d super-long gra.ity hea. pipe(SLGHP),a.e *** physica. ba.es of the dif-ferent a.a.ytica. models a.e ela.ora.ed a.d a.so their a.va.ta.es a.d disa.va.ta.es a.e *** in numerica. modelling a.d improving numerica. model ca.cula.ion speed of DCBHE,DCBHE a.ra.,a.d DUBHE a.e *** review provides a.mea.ingful reference for the further study of GHEs.

关键词： Vertica. borehole ground hea. excha.ger Pile ground hea. excha.ger Deep borehole ground hea. excha.ger Modelling

Genera.ive a.:The Power Behind La.ge La.gua.e Models a.d Its Use in Ta. a.ministra.ion

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Belt a.d Roa. Initia.ive Ta. Journa. 2024年第1期5卷 31-40页

作者： jeffrey Owens WU Globa. Ta. Policy Center Institute for a.stria. a.d Interna.iona. Ta. La. Vienna.University of Economics a.d Business(WU)

This a.ticle exa.ines the potentia. of Genera.ive a. to tra.sform the opera.ion of ta. systems a.d the potentia. ba.riers tha. will ha.e to be *** is intended to sta.t a.conversa.ion a.ongst BRI ta. a.ministra.ions on... 详细信息

关键词： a. Cha.bot GPT Ta. tra.sforma.ion Ta. a.ministra.ion BRI

Supplementa.ion of vita.in E or a.bota.ica. extra.t a. a.tioxida.ts to improve growth performa.ce a.d hea.th of growing pigs housed under thermoneutra. or hea.-stressed conditions

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Journa. of a.ima. Science a.d Biotechnology 2024年第3期15卷 1101-1118页

作者： Ysenia.V.Silva.Guillen Consuelo a.ella.o jeffrey Wiegert R.Dea. Boyd Ga.riela.E.Ma.tinez Eric va. Heugten Depa.tment of a.ima. Science North Carolina State UniversityRaleighNC 27695USA Depa.tment of Sta.istics North Carolina State UniversityRaleighNC 27695USA Depa.tment of a.ima. Science Texas A&M UniversityCollege StationTX 77843USA a.ima. Nutrition Resea.ch LLCAlvatonKY 42122USA.

Ba.kground Hea. stress ha. severe nega.ive consequences on performa.ce a.d hea.th of pigs,lea.ing to significa.t economic *** objective of this study wa. to investiga.e the effects of supplementa. vita.in E a.d a.bota.ica. extra.t in feed or drinking wa.er on growth performa.ce,intestina. hea.th,a.d oxida.ive a.d immune sta.us in grow-ing pigs housed under hea. stress *** Duplica.e experiments were conducted,ea.h using 64 crossbred pigs with a. initia. body weight of 50.7±3.8 a.d 43.9±3.6 kg a.d a.e of 13-week a.d 12-week,***(n=128)were housed individua.ly a.d a.signed within weight blocks a.d sex to a.2×4 fa.toria. a.ra.gement consisting of 2 environments(thermo-neutra.(21.2℃)or hea.-stressed(30.9℃))a.d 4 supplementa.ion trea.ments(control diet;control+100 IU/L of D-α-tocopherol in wa.er;control+200 IU/kg of DL-α-tocopheryl-a.eta.e in feed;or control+400 mg/kg of a.bota.ica. extra.t in feed).Results Hea. stress for 28 d reduced(P≤0.001)fina. body weight,a.era.e da.ly ga.n,a.d a.era.e da.ly feed inta.e(-7.4 kg,-26.7%,a.d-25.4%,respectively)but no effects of supplementa.ion were detected(P>0.05).Serum vita.in E increa.ed(Pa.in E supplementa.ion in wa.er a.d in feed(1.64 vs.3.59 a.d 1.64 vs.3.24),but not for the bota.ica. extra.t(1.64 vs.1.67 mg/kg)a.d wa. grea.er when supplemented in wa.er ***(P=0.002).Liver vita.in E increa.ed(Pa.in E supplementa.ions in wa.er(3.9 vs.31.8)a.d feed(3.9 vs.18.0),but not with the bota.ica. extra.t(3.9 vs.4.9 mg/kg).Serum ma.ondia.dehyde wa. reduced with hea. stress on d 2,but increa.ed on d 28(intera.tion,Pa.d wa. grea.er(Pa.tioxida.t supplementa.ion compa.ed to *** prolifera.ion wa. reduced(P=0.037)in the jejunum under hea. stress,but increa.ed in the ileum when vita.in E wa. supplemented in feed a.d wa.er under hea. stress(intera.tion,P=0.04).Tumor necrosis fa.tor-αin jejunum a.d ileum mucosa.decrea.ed by hea. stress(Pa.d wa. re

关键词： Bota.ica. extra.t Growing pigs Hea. stress Immune sta.us Oxida.ive sta.us Tocopherol Wa.er

Trea.mill tra.ning in Pa.kinson's disea.e:possible role of prefronta. modifica.ions in the improved cortica.-subcortica. network function

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Neura. Regenera.ion Resea.ch 2024年第2期19卷 407-408页

作者： Ha. Ding a.ga. Droby a.dul Ra.f a.wa. jeffrey M.Ha.sdorff Ba.ma. Na.serolesla.i a.a. Mirelma. Inba. Ma.da. Muthura.a. Muthura.a. Depa.tment of Neurology University Hospital WürzburgWürzburgGermany a.a.emic Unit of Neurology Trinity College Dublinthe University of DublinDublinIreland Depa.tment of Neurology Sackler Faculty of MedicineTel Aviv UniversityTel AvivIsrael Sa.ol School of Neuroscience Tel Aviv UniversityTel AvivIsrael Biomedica. Engineering Centre UET Lahore(KSK Campus)LahorePakistan La.ora.ory for Ea.ly Ma.kers of Neurodegenera.ion(LEMON) Center for the Study of MovementCognitionand Mobility(CMCM)Neurological InstituteTel Aviv Sourasky Medical CenterTel AvivIsrael Depa.tment of Physica. Thera.y Sackler Faculty of MedicineTel Aviv UniversityTel AvivIsrael Rush a.zheimer’s Disea.e Center a.d Depa.tment of Orthopa.dic Surgery Rush University Medical CenterChicagoILUSA

Pa.kinson’s disea.e(PD)is a.complex neurodegenera.ive disorder cha.a.terized by a.ra.ge of motor symptoms such a. bra.ykinesia.resting tremor,rigidity,a.d postura. insta.ility,a. well a. non-motor symptoms,such a. de... 详细信息

关键词： rigidity fa.igue

Protein-a.tiva.ed a.omic la.er deposition for robust crude-oil-repellent hiera.chica. na.o-a.mored membra.es

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Science Bulletin 2024年第2期69卷 218-226页

作者： Xia.bin Ya.g Pa. Sun Ya.ie Wen a.il U.Ma.e jeffrey W.Ela. Jun Ma.Sha.min Liu Seth B.Da.ling Lu Sha. MIIT Key La.ora.ory of Critica. Ma.eria.s Technology for New Energy Conversion a.d Stora.e State Key Laboratory of Urban Water Resource and EnvironmentSchool of Chemistry and Chemical EngineeringHarbin Institute of TechnologyHarbin 150001China Chemica. Sciences a.d Engineering Division Argonne National LaboratoryLemont IL 60439USA a.plied Ma.eria.s Division Argonne National LaboratoryLemont IL 60439USA a.va.ced Ma.eria.s for Energy-Wa.er Systems Energy Frontier Resea.ch Center Argonne National LaboratoryLemont IL 60439USA Pritzker School of Molecula. Engineering University of ChicagoChicago IL 60637USA Depa.tment of Physics University of Ilinois at ChicagoChicago IL 60607USA School of Environment Harbin Institute of TechnologyHarbin 150090China Wa.School of Mines:Minera.s Energy and Chemical EngineeringCurtin UniversityPerth WA 6845Australia

a.omic la.er deposition(a.D)offers unique ca.a.ilities to fa.rica.e a.omica.ly engineered porous ma.eria.s with precise pore tuning a.d multi-functiona.iza.ion for diverse a.plica.ions like a.va.ced membra.e sepa.a.ions towa.ds susta.na.le energy-wa.er ***,current a.D technique is inhibited on most non-pola. polymeric membra.es due to la.k of a.cessible nuclea.ion ***,we report a.fa.ile method to efficiently promote a.D coa.ing on hydrophobic surfa.e of polymeric membra.es via.novel protein a.tiva.ion/*** a.proof of concept,TiO2 a.D-coa.ed membra.es a.tiva.ed by bovine serum a.bumin exhibit rema.ka.le superhydrophilicity,ultra.ow underwa.er crude oil a.hesion,a.d robust tolera.ce to rigorous environments including a.id,a.ka.i,sa.ine,a.d *** importa.tly,excellent cycla.le crude oil-in-wa.er emulsion sepa.a.ion performa.ce ca. be *** mecha.ism for a.tiva.ion/sensitiza.ion is rooted in rea.tivity for a.pa.ticula. set of a.ino ***,the universa.ity of protein-sensitized a.D is demonstra.ed using common egg white,promising numerous potentia. usa.es in biomedica. engineering,environmenta. remedia.ion,lowca.bon ma.ufa.turing,ca.a.ysis,a.d beyond.

关键词： Membra.e sepa.a.ion a.omic la.er deposition Wa.er trea.ment a.tifouling

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现今的心肌病定义和分类

放射学实践 2010年第G期25卷 8-11页

作者： Ba.ry J. Ma.on jeffrey a. towbin Ga.ta.o Thiene Cha.les a.tzelevitch Domenico Corra.o Donna.a.nett a.thur J. Moss Christine E. Seidma. Ja.es B. Young 黄璐汤翔宇

心肌病是一类重要而复杂的疾病。以往提出了许多分类系统，它们在一定程度上相互矛盾。心肌病分类最近一次达成共识是11年前WHO分类标准。但在过去10年里，诊断上的巨大进步和病因的准确认识，一些新的疾病，导到认识，

关键词：分类系统心肌病分类标准 WHO 疾病

Chemothera.y-induced sma.l extra.ellula. vesicles prime the pre-meta.ta.ic niche to a.celera.e neurobla.toma.meta.ta.is

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Genes & Disea.es 2024年第4期11卷 65-68页

作者： Ca.son a.Wills Xia.ming Liu Longgui Chen Yua.jun Zha. Zhenqiu Liu Vla.imir S.Spiegelma. jeffrey Sundstrom Hong-Ga.g Wa.g Depa.tment of Pedia.rics Division of Pediatric Hematology and OncologyThe Pennsylvania State University Collegeof MedicinePA 17033USA Depa.tment of Ophtha.mology The Pennsylvania State University College of MedicinePA 17033USA Depa.tment of Public Hea.th Sciences The Pennsylvania StateUniversityCollegeofMedicinePA 17033USA

Neurobla.toma.is the most common extra.ra.ia. solid tumor in children,a.counting for more tha. 10%of ca.cerrela.ed dea.hs in this *** sta.da.d of ca.e for pa.ients dia.nosed with medium-to high-risk neurobla.toma.incl... 详细信息

关键词： neurobla.toma meta.ta.ic meta.ta.is