检索结果-南通市图书馆

Operations researchapplications and algorithms 4th ed.

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

2004年

作者： Winston Wayne l.Wayne l. Winston with cases by jeffrey B. Goldberg. Goldberg jeffrey B.

来源：畅想之星图书光盘版（南... 评论

在线全文

畅想之星图书光盘版（南通市图书馆镜像）

学校读者我要写书评

暂无评论

北京当代城市形态的“休克效应”

瞭望 2005年第33期 54-55页

作者：苏解放(jeffrey l.Soule)

美国规划协会全国政策主任、院士级注册规划师苏解放（jeffrey ***），是一位长期参与中国城市规划的美国学者，今年4月他重访自己所熟悉的北京，从市中心区沿着长安街步行至东五环路的城市边缘。他说这是他所难忘的经历，真实感受到了... 详细信息

美国规划协会全国政策主任、院士级注册规划师苏解放（jeffrey ***），是一位长期参与中国城市规划的美国学者，今年4月他重访自己所熟悉的北京，从市中心区沿着长安街步行至东五环路的城市边缘。他说这是他所难忘的经历，真实感受到了这个城市存在的问题。回到美国后，他写了一篇评论投给本刊，以期进一步地交流和探讨，经他允许，本刊将他的文章作了适度压缩，并配分段标题发表如下——

关键词：城市形态北京注册规划师效应休克当代美国学者城市规划城市边缘

应用组织型纤溶酶原激活物行静脉溶栓治疗急性缺血性卒中的时间窗延长——美国心脏协会/美国卒中协会的科学建议

在线全文

学校读者我要写书评

暂无评论

中国脑血管病杂志 2009年第8期6卷 446-448页

作者： del Zoppo G J saver J l Jauch E C Adams H P Jr. 代表美国心脏协会卒中委员会

美国心脏协会卒中委员会发布了关于急性缺血性卒中的现行治疗指南，其中包括应用重组组织型纤溶酶原激活物（rt—PA）行静脉溶栓的建议。尽管该药对改善神经功能预后有一定的疗效，但由于患者通常在发病3h后方能到达医院，往往已经超过... 详细信息

美国心脏协会卒中委员会发布了关于急性缺血性卒中的现行治疗指南，其中包括应用重组组织型纤溶酶原激活物（rt—PA）行静脉溶栓的建议。尽管该药对改善神经功能预后有一定的疗效，但由于患者通常在发病3h后方能到达医院，往往已经超过了用药的时间窗。因此，大部分缺血性卒中患者未能接受rt—PA治疗。目前研究认为，增加rt—PA治疗例数的最可能方法就是延长治疗时间窗。

关键词：卒中组织型纤溶酶原激活物脑出血指南 AHA科学声明

Rice Interploidy Crosses Disrupt Epigenetic Regulation, Gene Expression, and Seed Development

在线全文

学校读者我要写书评

暂无评论

Molecular Plant 2018年第2期11卷 300-314页

作者： limei Wang Jingya Yuan Yujie Ma Wu Jiao Wenxue Ye Dong-lei Yang Chuandeng Yi Z. jeffrey Chen State Key laboratory of Crop Genetics and Germplasm Enhancement Nanjing Agricultural University 1 Weigang Road Nanjing 210095 China Department of Molecular Biosciences Institute for Cellular and Molecular Biology Center for Computational Biology and Bioinformatics The University of Texasat Austin Austin TX 78712 USA Jiangsu Key laboratory of Crop Genetics and Physiology Yangzhou University Yangzhou 225009 China

Seed development in angiosperms requires a 2：1 maternal-to-paternal genome ratio （2m：lp） in the endo- sperm. When the ratio is disrupted, the seed development is impaired. Rice interploidy crosses result in endosperm failures, but the underlying molecular mechanisms remain unclear. Here, we report that the defective endosperm in rice interploidy crosses was associated with nonadditive expression of small RNAs and protein-coding genes. Interestingly, 24-nt small interfering RNAs were enriched in the 5＇ and 3＇ flanking sequences of nonadditively expressed genes in the interploidy crosses and were negatively associated with the expression of imprinted genes. Furthermore, some PRC2 family genes and DNA methylaUon-related genes including OsMETlb and OsCMT3a were upregulated in the 2x4 cross （polli- nating a diploid ＂mother＂ with a tetraploid ＂father＂） but repressed in the reciprocal cross. These different epigenetic effects could lead to precocious or delayed cellularization during endosperm development. Notably, many endosperm-preferred genes, including starch metabolic and storage protein genes during grain filling, were found to be associated with DNA methylation or H3K27me3, which are repressed in both 2×4 and 4 ×2 crosses. WUSCHEl homeobox2 （WOX2）-Iike （WOX2l）, an endosperm-preferred gene, was expressed specifically in the rice endosperm, in contrast to WOX2 expression in the Arabidopsis embryo. Disruption of WOX2l in transgenic rice by CRISPR/Cas9-mediated gene editing blocked starch and protein accumulation, resulting in seed abortion. In addition to gene repression, disrupting epigenetic process in the interploidy crosses also induced expression of stress-responsive genes. Thus, maintaining the 2m：lp genome ratio in the endosperm is essential for normal grain development in rice and other cereal crops.

关键词： seed polyploidy small RNA gene expression endosperm epigenetics

PROTECT:一项预防血栓复发的协调性卒中治疗计划

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

世界核心医学期刊文摘（神经病学分册） 2005年第3期1卷 50-51页

作者： Ovbiagele B. saver J.l. Fredieu A. 李一明 Stroke Center Department of Neurology Univ. of California at Los Angeles 710 Westwood Plaza Los Angeles CA 90095 United States Dr.

Objective: To assess the impact of the Preventing Recurrence of Thromboembolic Events through Coordinated Treatment (PROTECT) Program on achievement of its ei ght secondary prevention goals at the time of discharge. Methods: Achievement ra tes for the eight program goals at time of discharge were compared in all patien ts discharged from a university hospitalbased stroke service with a diagnosis of ischemic st roke or TIA during a 1 year period after implementation of the PROTECT Program vs rates obtained from a comparable group of patients admitted to the same servi ce during the preceding year. Results: Demographic and medical features were com parable in the baseline and intervention cohorts for all patients with cerebral ischemia presumed due to large vessel atherosclerosis or small vessel disease (baseline year n = 117, intervention n = 130). Implementation rates in patients without specific contraindications increased for all four medication goals: 97 t o 100%for antithrombotic agents, 68 to 97%for statins, 42 to 90%for angiotens in converting enzyme inhibitors/angiotensin receptor blockers, and 14 to 70%fo r diuretics. Although data were not collected on baseline lifestyle instruction rates, instruction in the programs four lifestyle interventions was achieved b y discharge in 100%of the intervention cohort. Conclusion: Implementation of th is single center, systems based, inhospital program to initiate secondary stro ke prevention therapies was associated with a substantial increase in treatment utilization at the time of hospital discharge.

关键词：卒中治疗 PROTECT 生活方式指导脑缺血干预组他汀类药物血管紧张素抗凝血药物大学医院受体阻断剂

Super-anti-freezing,tough and adhesive titanium carbide and l-ornithine-enhanced hydrogels

在线全文

学校读者我要写书评

暂无评论

生物质资源与工程(英文) 2023年第2期8卷 136-145页

作者： Zhangkang li Jamie leBlanc Hitendra Kumar Hongguang Zhang Weijun Yang Xiao He Qingye lu jeffrey Van Humbeck Keekyoung Kim Jinguang Hu Department of Biomedical Engineering University of CalgaryCalgaryUniversity Drive NWCalgaryAB T2N 1N4Canada Department of Chemistry University of CalgaryUniversity Drive NWCalgary T2N 1N4AlbertaCanada Department of Mechanical and Manufacturing Engineering University of CalgaryUniversity Drive NWCalgary T2N 1N4AlbertaCanada Pathology and laboratory Medicine Cumming School of EngineeringUniversity of CalgaryHospital Drive NWT2N 4N1AlbertaCanada Department of Chemical and Petroleum Engineering University of CalgaryUniversity Drive NWCalgary T2N 1N4AlbertaCanada Key laboratory of Synthetic and Biological Colloids Ministry of EducationSchool of Chemical and Material EngineeringJiangnan UniversityWuxiJiangsu214122China

Hydrogels are highly porous three-dimensional crosslinked polymer networks consisting of hy-drophilic polymers,employed most practically in medicine and industry,often as *** hydrogels suffer limitations in their mechanical properties,such as tensile and com-pression,and freeze at sub-zero temperatures,which compromise their ability as useful *** this study,the incorporation of l-ornithine-based zwitterionic monomer(OZM),titanium carbide(MXene),and glycerol within polyacrylamide hydrogels was used to prepare a novel polyacrylamide/polyl-ornithine-based zwitterion/MXene(PAM/Porn/MXene)hydrogel to im-prove the mechanical,adhesion,and anti-freezing properties of pure polyacrylamide *** study also analyzed the mechanical strength(tensile and compression),adhesion,and anti-freezing properties of a novel PAM/Porn/MXene hydrogel at 1%,4%,and 10%MXene concen-trations to establish to what extent the conductive MXene material enhanced these properties and concluded that the tensile and compressive properties improved linearly with the increase in the concentrations of MXene,adhesion decreased with the increased MXene concentrations,and syn-ergistic interaction between MXene and OZM significantly improved the anti-freezing properties up to-80°C.

关键词： Super-anti-freezing Tough Adhesive l-ornithine MXene

Measuring the antioxidative activities of Queso Fresco after post-packaging high-pressure processing

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Advances in Bioscience and Biotechnology 2012年第4期3卷 297-303页

作者： Moushumi Paul jeffrey D. Brewster Diane l. Van Hekken Peggy M. Tomasula Dairy and Functional Foods Research Unit USDA ARS NAA ERRC 600 East Mermaid Lane Wyndmoor PA USA Molecular Characterization of Foodborne Pathogens Research Unit USDA ARS NAA ERRC 600 East Mermaid Lane Wyndmoor PA USA

Some milk-associated proteins are known to be nutritionally valuable and form bioactive peptides that exhibit activity against hypertension and oxidative stress. Consumption of cheeses, such as the popular Hispanic-style cheese Queso Fresco (QF), may be a vehicle for delivery of these milk-associated peptides. This paper describes the effects of high-pressure processing (HPP) on the antioxidative activity (ORAC- Fl value) of water-soluble proteins extracted from QF samples. QFs were manufactured according to a commercial-make procedure using pasteurized, homogenized milk, without added starter cultures. The cheese was cut into 45 × 45 × 150 mm3 blocks, double packaged in vacuum bags, and received the following HPP treatments: 200, 400, or 600 MPa for either 0, 5, 10, or 20 min, with warming to an internal temperature of either 22℃ or 40℃ prior to HPP treatment. Results show that the core temperature of the cheese during HPP directly affects the ORAC-Fl value. The activities of the lower temperature cheeses are independent of time and pressure, and have a median ORAC-Fl value of 27 trolox equivalents (TE). The higher temperature cheeses have higher ORAC-Fl values ranging from 21.5 to 96.0 TE;the highest activity corresponded to the cheese held at 400 MPa for the longest time under pressure (20 min). The 600 MPa cheeses increase in activity with increasing time under pressure, but are less active than the control cheese. These results indicate that processing temperature and pressure are important factors in the antioxidative activity of these QF samples and further understanding of the roles of these variables may lead to the manufacture of healthier and more nutritious cheeses and dairy products.

关键词： ORAC-Fl Assay Queso Fresco Antioxidant High Pressure Processing

基于GM(1,1|τ,r)模型的城市道路短时交通流预测

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

交通运输系统工程与信息 2013年第6期13卷 60-66页

作者：郭欢肖新平 jeffrey Forrest 武汉理工大学理学院武汉430063 宾州州立SR大学数学系

充分考虑城市道路交通系统中交通流存在的延迟性和非线性,本文基于灰色GM(1,1|τ,r)模型对城市道路短时交通流进行建模预测.首先,通过建立城市交通路段上交通流量大于通行能力时的速度-流量关系,得到交通系统延迟时间τ的计算模型.再针... 详细信息

充分考虑城市道路交通系统中交通流存在的延迟性和非线性,本文基于灰色GM(1,1|τ,r)模型对城市道路短时交通流进行建模预测.首先,通过建立城市交通路段上交通流量大于通行能力时的速度-流量关系,得到交通系统延迟时间τ的计算模型.再针对交通流存在的非线性特征,以模型的预测效果最优为目标,建立关于非线性因子的优化模型并利用粒子群算法寻找最佳的非线性参数r.最后对武汉市友谊大道某一路段进行交通实验,将灰色GM(1,1|τ,r)模型的预测结果与灰色GM(1,1)模型和支持向量机进行比较.结果表明,GM(1,1|τ,r)模型的预测精度有明显的提高,能为智能交通系统的管理和控制提供及时可靠的信息资源.

关键词：城市交通 GM(1,1|τ,r)模型短时交通流预测速度-流量模型延迟时间非线性因子

Management of computed tomography scan detected hemothorax in blunt chest trauma:What computed tomography scan measurements say?

在线全文

学校读者我要写书评

暂无评论

World Journal of Radiology 2018年第12期10卷 184-189页

作者： Mahdi Malekpour Kenneth Widom James Dove Joseph Blansfield Mohsen Shabahang Denise Torres jeffrey l Wild Department of Surgery Section of Trauma and Acute Care SurgeryGeisinger Medical Center

AIM To investigate the hemothorax size for which tube thoracostomy is *** Over a 5-year period, we included all patients who were admitted with blunt chest trauma to our level 1 trauma center. Focus was placed on identifying the hemothorax size requiring tube *** A total number of 274 hemothoraces were studied. All patients with hemothoraces measuring above 3 cm received a chest tube. The 50% predicted probability of tube thoracostomy was 2 cm. Pneumothorax was associated with odds of receiving tube thoracostomy for hemothoraces below 2 cm(Odds Ratio:4.967, 95%CI: 2.225-11.097, P lUSION All patients with a hemothorax size greater than 3% underwent tube thoracostomy. Prospective studies are warranted to elucidate the clinical outcome of patients with smaller hemothoraces.

关键词： Chest trauma Blunt Hemothorax Chest tube Occult Computed tomography scan