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A computational method to help identify and measure metallines in high resolution QSO spectra

Research in Astronomy and Astrophysics 2011年第11期11卷 1279-1297页

作者： Xi-Heng Shi David Tytler Jin-Liang Hou David Kirkmant jeffery lee Benjamin Ou Key Laboratory for Research in Galaxies and Cosmology Shanghai Astronomical ObservatoryChinese Academy of Sciences Shanghai 200030 China Center for Astrophysics and Space Sciences University of California San Diego La Jolla CA92093-0424 USA

A computational code is developed to help identify metal absorption lines in high resolution QSO spectra, especially in the Lyα forest. The input to the code includes a list of line central wavelengths, column densities and Doppler widths. The code then searches for candidate metal absorption systems and assesses the probability that each system could be real. The framework of the strategy we employ is described in detail and we discuss how to estimate the errors in line profile fitting that are essential to identification. A series of artificial spectra is constructed to calibrate the performance of the code. Due to the effects of blending and noise on Voigt profile fitting, the completeness of the identification depends on the column density of absorbers. For intermediate and strong artificial metal absorbers, more than 90% could be confirmed by the code. The results of applying the code to the real spectra of QSOs HS0757＋5218 and Q0100＋1300 are also presented.

关键词： methods data analysis-quasars absorption lines-quasars individual(HS0757+5218, Q0100+1300)

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Appraisal of needle-based confocal laser endomicroscopy inthe diagnosis of pancreatic cysts

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World Journal of Gastroenterology 2016年第4期22卷 1701-1710页

作者： Somashekar G Krishna jeffery H lee Department of Gastroenterology Hepatologyand NutritionThe Ohio State University Medical CenterColumbusOH 43210United States Department of Gastroenterology Hepatologyand NutritionThe University of Texas MD Anderson Cancer CenterHoustonTX 77030United States

Nearly 2.5% of cross-sectional imaging studies will report a finding of a cystic pancreatic lesion. Eventhough most of these are incidental findings, it remains very concerning for both patients and treating clinicians. Differentiating and predicting malignant transformation in pancreatic cystic lesions is clinically challenging. Current evaluation of suspicious cystic lesions includes a combination of radiologic imaging, endoscopic ultrasound(EUS) and cyst fluid analyses. Despite these attempts, precise diagnostic stratification among nonmucinous, mucinous, and malignant cystic lesions is often not possible until surgical resection. EUS-guided needle based confocal laser endomicroscopy(n CLE) for evaluation of pancreatic cysts is emerging as a powerful technique with remarkable potential. Though limited imaging data from 3 large clinical trials(INSPECT, DETECT and CONTACT) are currently the reference standard for n CLE imaging, nonetheless these have not been validated in large studies. The aim of this review article is to review the evolving role of EUS-guided n CLE in management of pancreatic cystic lesions in terms of its significance, adverse events, limitations, and implications.

关键词： Pancreatic cyst Needle-based confocal laserendomicroscopy Endoscopic ultrasound Intraductalpapillary mucinous neoplasm Mucinous cystadenoma Serous cystadenoma Pancreatic cancer

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Emerging trend for LED wafer level packaging

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Frontiers of Optoelectronics 2012年第2期5卷 119-126页

作者： S.W.Ricky lee Rong ZHANG K.CHEN jeffery C.C.LO Center for Advanced Microsystems Packaging The Hong Kong University of Science&Technology(HKUST)Hong KongChina HKUST LED-FPD Technology R&D Center at Foshan Guangdong 528200 China

Currently most light emitting diode （LED） components are made with individual chip packaging technology. The main manufacturing processes follow conventional chip-based IC packaging. In the past several years, there has been an uprising trend in the IC industry to migrate from chip-based packaging to wafer level packaging （WLP）. Therefore, there is a need for LEDs to catch up. This paper introduces advanced LED WLP technologies. The contents cover key enabling processes such as preparation of silicon sub-mount wafer, implementation of interconnection, deposition of phosphor, wafer level encapsulation, and their integration. The emphasis is placed on how to achieve high throughput, low cost manufacturing through WLE

关键词： light emitting diode (LED) wafer levelpackaging (WLP)

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Design and Development of Anti-Icing Aluminum Surface

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Materials Sciences and Applications 2013年第6期4卷 347-356页

作者： Yongxin Wang Daniel Orol jeffery Owens Katherine Simpson Hoon Joo lee Air Force Research Laboratory Tyndall Air Force Base Tyndall USA Cary Academy Cary USA Textile Engineering Chemistry and Science North Carolina State University Raleigh USA

An anti-icing surface has been designed and prepared with an aluminum panel by creating an artificial lotus leaf which is highly hydrophobic. The hydrophobicity of a solid surface can be generated by decreasing its surface tension and increasing the roughness of the surface. On a highly hydrophobic surface, water has a high contact angle and it can easily rolls off, carrying surface dirt and debris with it. Super-cooled water or freezing rain can also run off this highly hydrophobic surface instead of forming ice on the surface, due to the reduction of the liquid-solid adhesion. This property can also help a surface to get rid of the ice after the water becomes frozen. In this study, a Cassie-Baxter rough surface was modeled, and an aluminum panel was physically and chemically modified based on the modeled structure. Good agreement was found between predicted values and experimental results for the contact and roll-off angles of water. Most importantly, by creating this highly hydrophobic aluminum rough surface, the anti-icing and de-icing properties of the modified surface were drastically improved compared to the control aluminum surface, and the cost will be reduced.

关键词： Anti-Icing De-Icing Wetting Hydrophobic Aluminum

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Nanotrap-enabled quantification of KRAS-induced peptide hydroxylation in blood for cancer early detection

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Nano Research 2019年第6期12卷 1445-1452页

作者： Zaian Deng Zhen Zhao Bo Ning jeffery Basilio Karen Mann Jie Fu Yajun Gu Yuanqing Ye Xifeng Wu Jia Fan Paul Chiao Tony Hu College of Health Science and Environmental Engineering Shenzhen Technology UniversityShenzhen 518118 China School of Biological and Health Systems Engineering Virginia G. Piper Biodesign Center for Personalized DiagnosticsThe Biodesign InstituteArizona State UniversityTempeArizona 85287USA Department of Nanomedicine Houston Methodist Research InstituteHoustonTexas 77030USA Pathology and Laboratory Medicine Weill Cornell Medical CollegeNew York New York 10065USA Center for Molecular Design and Biomimetics The Biodesign InstituteArizona State UniversityTempeArizona 85287USA Department of Laboratory Medicine Clinical CenterNational Institutes of HealthBethesdaMaryland 20892USA Department of Molecular Oncology H. Lee Moffitt Cancer CenterTampaFlorida 33612USA Department of Molecular and Cellular Oncology The University of Texas MD Anderson Cancer CenterHoustonTexas 77030USA School of Medical Laboratory Tianjin Medical UniversityTianjin 300203China Department of Epidemiology The University of Texas MD Anderson Cancer CenterHoustonTexas 77030USA

Circulating peptide is a potential source of biomarkers for cancer ***,the existence of large molecular weight proteins in plasma have a disastrous effect on circulating peptides isolating and ***,nanotrap fractionation following by mass spectrometry have been applied to quantify the levels of bradykinin (BK) and hydroxylated bradykinin (Hyp-BK) as a relative measure of KRAS-regulated prolyl-4-hydroxylase alpha-1 (P4HA1) which may serve as early diagnosis marker for pancreatic ductal adenocarcinoma (PDAC).We found that P4HA1 can be upregulated by KRASG12v,which is a PDAC driver mutation,using HPNE/KRAS and HPNE *** we revealed that P4HA1 is overexpressed in PDAC tumors,compared to normal and inflamed pancreatic *** interference revealed that P4HA1 activity was primarily responsible for Hyp-BK *** spectrometry analysis revealed that plasma Hyp-BK/BK ratio was higher in PDAC than pancreatitis patients and healthy controls,while the area under the receiver operating characteristic (ROC) curve (AUC) is 0.8209 (95%Cl,0.7269-0.9149).The Hyp-BK/BK association with PDAC was reproduced in another cohort,where this ratio was found to increase with advancing tumor *** novel findings paved the way for wider applications of Nanotrap coupled mass spectrometry as a powerful tool for revealing biosignatures from plasma.

关键词： nanotrap hydroxylation level bradykinin pancreatic ductal adenocarcinoma

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建立卒中医疗体系的建议美国卒中协会特别工作组关于建立卒中体系的建议

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国际脑血管病杂志 2005年第12期13卷 883-894页

作者： lee H. Schwamm Arthur Pancioli Joe E. Acker Ⅲ Larry B. Goldstein Richard D. Zorowitz Timothy J. Shephard Peter Moyer Mark Gorman S. Claiborne Johnston Pamela W. Duncan Phil Gorelick jeffery Frank Steven K. Stranne Renee Smith William Federspiel Katie B. Horton Ellen Magnis Robert J. Adams 林豪杰董继宏金丽蓉彭伟锋汪昕复旦大学附属中山医院神经内科

在美国,卒中一直是残疾和死亡的重要原因.每年约有70万例美国人新发或复发卒中,在与其他心血管病分开评价时,卒中在美国仍是第三位死亡原因.在美国卒中还是严重和长期残疾的第一位原因[1].

关键词：初级卒中中心二级预防患者医务人员医务工作者急性卒中防治体系医疗体系美国卒中协会医疗亚急性期工作组

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The Genomic Variation of 3,000 diverse Rice (Oryza sativa L.)Accessions:Discoveries And Applications In Rice Improvement

The Genomic Variation of 3,000 diverse Rice (Oryza sativa L....

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2018中国作物学会学术年会

作者：黎志康 Fan Zhang Whensheng Wang Ramil Mauleon Zhiqiang Hu Dmytro Chebotarov Shuaishuai Tai Zhichao Min Li Tianqing Zheng Roven Rommel Fuentes Locedie Mansueto Dario Copetti Millicent Sanciangco Kevin Christian Palis Jianlong Xu Chen Sun Hongliang Zhang Binying Fu Yongming Gao Xiuqin Zhao Fei Shen Xiao Cui Hong Yu Zichao Li Miaolin Chen jeffery Detras Yongli Zhou Xinyuan Zhang Yue Zhao Dave Kudrna Chunchao Wang Rui Li Ben Jia Jinyuan Lu Xianchang He Zhaotong Dong Jiabao Xu Yanhong Li Miao Wang Jianxin Shi Jing Li Dabing Zhang Seunhee lee Wushu Hu Alexander Poliakov Inna Dubchak Victor Jun Ulat Frances Nikki Borja John Robert Mendoza Jauhar Ali Ming Yang Yongchao Niu Zhen Yue Ma.Elizabeth B.Naredo Jayson Talag Xueqiang Wang Jinjie Li Xiaodong Fang Ye Yin Jean-Christophe Glaszmann Jianwei Zhang Jiayang Li Ruaraidh Sackville Hamilton Rod A.Wing Chaochun Wei Jue Ruan Gengyun Zhang Kenneth L.Mcnally Nickolai Alexandrov Hei Leung Hei Institute of Crop Sciences Chinese Academy of Agricultural Sciences Shenzhen Institute for Innovative Breeding Chinese Academy of Agricultural Sciences International Rice Research Institute School of Life Sciences and Biotechnology Shanghai Jiao Tong University Shanghai Center for Bioinformation Technology BGI Genomics BGI-Shenzhen Agricultural Genomics Institute at Shenzhen Chinese Academy of Agricultural Sciences Anhui Agricultural University Arizona Genomics Institute School of Plant SciencesUniversity of Arizona China Agricultural University Institute of Genetics and Developmental Biology Chinese Academy of Sciences Lawrence Berkeley National Laboratory

Asian cultivated rice(Oryza sativa L.) is the staple food for the half world population with rich within species *** analyses of the genome resequencing data of a core collection of 3,010 rice accessions revealed four important aspects of the genomic diversity within ***,over 42 million SNPs and >3 million small InDels were discovered against five reference ***,we discovered more than 90,000 structural(>100 bps) variations(SVs) when compared with the Geng reference genome,consisting primarily of small-sized deletions and translocations,plus many duplications and *** SVs accounted for significant portion of the rice genome and involved most(～80%) rice ***,we discovered >12,000 full-length novel protein-coding genes plus 9000+ novel genes of partial sequences that are absent in the Nipponbare reference *** rice pan genome consists of ～62%core genes/gene families that are present in all rice lines,and ～38%distributed genes that are present only some of rice ***,using large-effect SNPs and InDels of all loci in the PG,a rice functional haplotype database was *** SNP,PG and SV variation clearly resolve the 3,010 rice accessions into two major subspecies,Xian(indica) and Geng(japonica),plus Aus and Aro groups and multiple subpopulations within Xian and *** reduced diversity was found in genomic regions where over 1,000 agronomically important and domestication-related genes *** efforts have been taken to identify and mine genes/QTLs/alleles associated with a wide range of important traits in rice using the 3 k materials and SNP *** demonstrate how the results of the 3 k RGP could be used in rice improvement,genomic constitutions of 476 BC F introgression lines(ILs) from our breeding program were constructed using high-quality reference genomes of their 9 parents and the 3 k RGP *** compared with their recurrent parent,Huang-hua-

关键词： Rice genome diversity population structure pan genomes genomics-based breeding by design

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