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N-acetyl proline-glycine-proline: implications for neurological disorders

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Neural Regeneration Research 2016年第6期11卷 898-899页

作者： jeff w.Hill Edwin M.Nemoto Department of Neurosurgery University of New Mexico Health Sciences Center

N-acetyl proline-glycine-proline（ac-PGP）is a matrix-derived chemoattractant,or matrikine,produced by the degradation of ***-PGP was first identified in studies of alkali eye injury in rabbits（Pfister et al.,1995）.

关键词： proline glycine acetyl neurological neuronal collagen neutrophil alkali potent chemokine

Assembly of zinc metallacrowns with an a-amino hydroxamic acid ligand

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Chinese Chemical Letters 2015年第4期26卷 444-448页

作者： Joseph Jankolovits jeff w.Kampf Vincent L.Pecoraro Chemistry Department University of Michigan

In the assembly of metallacrowns for molecular recognition, luminescence, and molecular magnetism applications, substituting the ring ion can have profound effects on the structure, stability, and physical properties of the inorganic macrocycle. The assembly of Zn（ll） metallacrowns with an ,^-amino hydroxamic acid ligand （pheHA） was investigated studied metallacrowns containing Cu（lI） and Ni（I1）. to compare the assembly behavior with the well Electrospray ionization mass spectrometry reveals that the benchmark species Zns（pheHA）42＋ and LnZns（pheHA）s3. assemble in pyridine, which is consistent with the behavior of Cu（II） and Ni（ll）. A LnZn4（pheHA）43. species is also observed in a 1：1 DMF-pyridine mixture. An unprecedented La（III）[16-MCznul）.pn^HA,HpheHA-6]s＋ complex was crystallo- graphically characterized that possesses unusual C2 symmetry. These results provide insights into the design of functional metallacrowns through ring ion substitution.

关键词： MetallacrownSelf-assemblySupramolecular chemistryLanthanide5Zinc

Debugging Concurrent Software： Advances and Challenges

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Journal of Computer Science & Technology 2016年第5期31卷 861-868页

作者： jeff Huang Charles Zhang Department of Computer Science and Engineering Texas A&M University College Station TX 77843 U.S.A. Department of Computer Science and Engineering Hong Kong University of Science and Technology Hong Kong China

Concurrency debugging is an extremely important yet challenging problem that has been hampering developer productivity and software reliability in the multicore era. we have worked on this problem in the past eight years and have developed several effective methods and automated tools for helping developers debugging shared memory concurrent programs. This article discusses challenges in concurrency debugging and summarizes our research contributions in four important directions： concurrency bug reproduction, detection, understanding, and fixing. It also discusses other recent advances in tackling these challenges.

关键词： debugging concurrency record and replay

Game theory, learning, and control systems

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National Science Review 2020年第7期7卷 1118-1119页

作者： jeff S.Shamma Computer Electrical and Mathematical Science and Engineering Division King Abdullah University of Science and Technology

Game theory is the study of interacting decision makers, whereas control systems involve the design of intelligent decision-making *** many control systems are interconnected, the result can be viewed through the lens of game theory. This article discusses both long standing connections between these fields as well as new connections stemming from emerging applications.

关键词： Game theory

Towards Physarum Robots: Computing and Manipulating on water Surface

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Journal of Bionic Engineering 2008年第4期5卷 348-357页

作者： Andrew Adamatzky jeff Jones Department of Computer Science University of the West of England

Plasmodium of Physarum polycephalum is an ideal biological substrate for implementing concurrent anu parauel computation, including combinatorial geometry and optimization on graphs. The scoping experiments on Physarum computing in conditions of minimal friction, on the water surface were performed. The laboratory and computer experimental results show that plasmodium of Physarum is capable of computing a basic spanning tree and manipulating of light-weight objects. we speculate that our results pave the pathways towards the design and implementation of amorphous biological robots.

关键词： biological computing amorphous robots unconventional computation amoeba

Spatial distribution of δ2H and δ18O values in the hydrologic cycle of the Nile Basin

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Journal of Arid Land 2015年第2期7卷 133-145页

作者： jeff B LANGMAN School of Science and Engineering American University in Cairo Department of Geological Sciences University of Idaho

Existing δ2H and δ18O values for precipitation and surface water in the Nile Basin were used to analyze precipitation inputs and the influence of evaporation on the isotopic signal of the Nile River and its tributaries. The goal of the data analysis was to better understand basin processes that influence seasonal streamflow for the source waters of the Nile River, because climate and hydrologic models have continued to produce high uncertainty in the prediction of precipitation and streamflow in the Nile Basin. An evaluation of differences in precipitation δ2H and δ18O values through linear regression and distribution analysis indicate variation by region and season in the isotopic signal of precipitation across the Nile Basin. The white Nile Basin receives precipitation with a more depleted isotopic signal compared to the Blue Nile Basin. The hot temperatures of the Sahelian spring produce a greater evaporation signal in the precipitation isotope distribution compared to precipitation in the Sahara/Mediterranean region, which can be influenced by storms moving in from the Mediterranean Sea. The larger evaporative effect is reversed for the two regions in summer because of the cooling of the Sahel from inflow of Indian Ocean monsoon moisture that predominantly influences the climate of the Blue Nile Basin. The regional precipitation isotopic signals convey to each region＇s streamflow, which is further modified by additional evaporation according to the local climate. Isotope ratios for white Nile streamflow are significantly altered by evaporation in the Sudd, but this isotopic signal is minimized for streamflow in the Nile River during the winter, spring and summer seasons because of the flow dominance of the Blue Nile. During fall, the contribution from the white Nile may exceed that of the Blue Nile, and the heavier isotopic signal of the white Nile becomes apparent. The variation in climatic conditions of the Nile River Basin provides a means of identifying mech

关键词： Nile River arid environment deuterium excess regional climate model uncertainty evaporation isotope effects

Orthopaedic education in the era of surgical simulation: Still at the crawling stage

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world Journal of Orthopedics 2017年第4期8卷 290-294页

作者： Kivanc Atesok Peter mac Donald jeff Leiter James Dubberley Richard Satava Ann Van Heest Shepard Hurwitz J Lawrence Marsh Department of Surgery Section of Orthopaedic SurgeryUniversity of Manitoba Department of Surgery University of Wash-ington Department of Orthopaedic Surgery University of Minnesota Department of Orthopaedic Surgery University of North Carolina Department of Orthopedics and Rehabilitation University of Iowa

Surgical skills education is in the process of a crucial transformation from a master-apprenticeship model to simulation-based training. Orthopaedic surgery is one of the surgical specialties where simulation-based skills training needs to be integrated into the curriculum efficiently and urgently. The reason for this strong and pressing need is that orthopaedic surgery covers broad human anatomy and pathologies and requires learning enormously diverse surgical procedures including basic and advanced skills. Although the need for a simulationbased curriculum in orthopaedic surgery is clear, several obstacles need to be overcome for a smooth transformation. The main issues to be addressed can be summarized as defining the skills and procedures so that simulation-based training will be most effective; choosing the right time period during the course of orthopaedic training for exposure to simulators; the right amount of such exposure; using objective, valid and reliable metrics to measure the impact of simulation-based training on the development and progress of surgical skills; and standardization of the simulation-based curriculum nationwide and internationally. In the new era of surgical education, successful integration of simulation-based surgical skills training into the orthopaedic curriculum will depend on efficacious solutions to these obstacles in moving forward.

关键词： Surgical simulation Orthopaedic surgery Education Skills training

Seasonal changes in Hermit Thrush (Catharus guttatus) song syntax

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Avian Research 2024年第2期15卷 172-179页

作者： Sean P.Roach Luke C.McLean jeff w.mac.eod Leslie S.Phillmore Psychology Department University of New Brunswick Saint John100 Tucker Park RoadSaint JohnNBCanada Department of Psychology and Neuroscience Dalhousie University1355 Oxford StHalifaxNSB3H 4J1Canada

In many songbird species,birdsong features phonological syntax,meaning that the units within their vocal se-quences are ordered in a non-random way that adheres to a *** such syntactical patterns have been richly described in many species,comparatively little is known about how those patterns contribute to song achieving its important *** each of song’s main functions,territorial defense and mate attraction,evidence of a role for syntax is *** species for which syntax has been thoroughly described is the Hermit Thrush(Catharus guttatus),which presents song types from their repertoires in a semi-predictable order and,in doing so,rapidly cycle up and down the frequency *** objective of the present study was to explore the importance of song syntax in the Hermit Thrush through a within-subject examination of how measures of syntax,such as the predictability of song type order within song sequences,shift over the breeding *** hypothesized that,if such syntactical characteristics are important to breeding behaviour,they would be most prominent at the start of the breeding season when activity associated with territory establishment and mate attraction is most *** revealed that,as predicted,the rigidness of song type ordering within se-quences was highest at the start of the season and declined *** song type sequences were most predictable at the vitally important early part of the breeding season fit our hypothesis that this aspect of song syntax is important to song’s functions related to territory establishment and/or mate *** work will clarify whether that role relates to one of song’s two main functions or serves song transmission in some broader way.

关键词： Birdsong Hermit Thrush Seasonal change Stereotypy Syntax

Correlation between MEG and BOLD fMRI signals induced by visual flicker stimuli

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仪器仪表学报 2007年第4期28卷 577-582页

作者： Chu Renxin Holroyd Tom Duyn jeff Department of Radiology Harvard Medical School Boston Massachusetts USA MEG Core Facility National Institute of Mental Health National Institutes of Health Bethesda Maryland USA Advanced MRI Section LFMI National Institute of Neurological Disorders and Stroke National Institutes of Health Bethesda Maryland USA

The goal of this work was to investigate how the MEG signal amplitude correlates with that of BOLD fMRI. To investigate the correlation between fMRI and macroscopic electrical activity, BOLD fMRI and MEG was performed on the same subjects (n=5). A visual flicker stimulus of varying temporal frequency was used to elicit neural responses in early visual areas. A strong similarity was observed in frequency tuning curves between both modalities. Although, averaged over subjects, the BOLD tuning curve was somewhat broader than MEG, both BOLD and MEG had maxima at a flicker frequency of 10 Hz. Also, we measured the first and second harmonic components as the stimuli frequency by MEG. In the low stimuli frequency (less than 6 Hz), the second harmonic has comparable amplitude with the first harmonic, which implies that neural frequency response is nonlinear and has more nonlinear components in low frequency than in high frequency.

关键词：视频 fMRI MEG 信号