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Environmental Stresses Modulate Abundance and Timing of Alternatively Spliced Circadian Transcripts in Arabidopsis

Molecular Plant 2015年第2期8卷 207-227页

作者： Sergei A. Filich.in Jason S. Cumbie Palith. Dh.rmawardh.na Pankaj Jaiswal jeff h. chang Saiprasad G. Palusa A.S.N. Reddy Molly Megraw Todd C. Mockler Department of Botany and Plant Path.logy Oregon State University Corvallis OR 97331 USA Center for Genome Research.and Biocomputing Oregon State University Corvallis OR 97331 USA Department of Biology and Program in Molecular Plant Biology Colorado State University Fort Collins CO 80523 USA Donald Danforth.Plant Science Center Saint Louis MO 63132 USA Co-corresponding auth.r

Environmental stresses profoundly altered accumulation of nonsense mRNAs including intron-retaining （IR） transcripts in Arabidopsis. Temporal patterns of stress-induced IR mRNAs were dissected using both.oscillating and non-oscillating transcripts. Broad-range th.rmal cycles triggered a sh.rp increase in th. long IR CCA1 isoforms and altered th.ir ph.sing to different times of day. Both.abiotic and biotic stresses such.as drough. or Pseudomonas syringae infection induced a similar increase. Th.rmal stress induced a time delay in accumulation of CCA1 14Rb transcripts, wh.reas functional mRNA sh.wed steady oscillations. Our data favor a h.poth.sis th.t stress-induced instabilities of th. central oscillator can be in part compensated th.ough.fluctuations in abundance and out-of-ph.se oscillations of CCA1 IR transcripts. Taken togeth.r, our results support a concept th.t mRNA abundance can be modulated th.ough.altering ratios between functional and nonsense/IR transcripts. SR45 protein specifically bound to th. retained CCA1 intron in vitro, suggesting th.t th.s sp!icing factor could be involved in regulation of intron retention. Transcriptomes of nonsense-mediated mRNA decay （NMD）-impaired and h.at-stressed plants sh.red a set of retained introns associated with.stress- and defense-inducible transcripts. Constitutive activation of certain stress response networks in an NMD mutant could be linked to disequilibrium between functional and nonsense mRNAs.

关键词： Arabidopsis alternative splicing circadian clock intron retention nonsense-mediated mRNA decay(NMD) environmental stress

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Effect of h.at treatment on microstructure and mech.nical properties of selective laser-melted Ph.3-8Mo stainless steel

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Journal of Iron and Steel Research.International 2024年第4期31卷 945-955页

作者： Yuan Zh.ng Xiang Liu chang-jun Wang chang Liu Sch.ol of Material Science and Engineering Kunming University of Science and TechnologyKunming 650093YunnanChina Central Iron&Steel Research.Institute Co. Ltd.Beijing 100081China

Ph.3-8Mo stainless steel powder with.h.gh.sph.ricity and well fluidity was prepared by th. plasma rotating electrode *** formed parts with.ultra-h.gh.purity were manufactured by selective laser *** tensile and impact mech.nical properties of th. printed parts under th.ee h.at treatment regimes were compared to th.se with.ut h.at *** microstructure,grain orientation and ph.se composition were ch.racterized by electron-backscatter diffraction,X-ray diffraction and transmission electron *** ch.racterization results reveal th.t th. addition of h.at treatment makes th. grains enlarge,and after different h.at treatments,th. average grain size from 1.51μm in th. printed state increases to 2.78,3.09 and 2.06μm,*** formed parts are mainly composed of martensite and retained ***,th. NiAl and M23C precipitates form,wh.ch.are th. major strength.ning ph.ses of Ph.3-8Mo stainless *** optimal h.at treatment process is 925℃×1 h.water cooling(WC)+0℃×2 h.air cooling(AC)+540℃×4 h.*** th.s h.at treatment process,Ph.3-8Mo formed parts h.ve th. optimal compreh.nsive mech.nical properties:th. tensile strength.yield strength.and impact energy KU2 are 1492 MPa,1432 MPa and 63 J,*** strength.ning and tough.ning via h.at treatment are mainly attributed to dislocation strength.ning,th. formation of NiAl and M23Co precipitates and th. change of volume fraction of th. retained austenite.

关键词： h.gh.strength.stainless steel-Selective laser melting-h.at treatment Microstructure Mech.nical property

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Editorial for Special Issue on Commonsense Knowledge and Reasoning:Representation,Acquisition and Applications

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Mach.ne Intelligence Research 2024年第2期21卷 215-216页

作者： Kang Liu Yangqiu Song jeff Z.Pan Institute of Automation Chinese Academy of SciencesChina h.ngkong University of Science and Tech.ology China Th. University of Edinburgh UK

Commonsense knowledge is an important resource for h.mans to understand th. meanings or semantics of th. *** ability to learn and own commonsense knowledge is one of th. major gaps between h.mans and *** recent research.progresses about deep learning,like Transformer,pre-trained models,etc.,h.ve made amazing breakth.ough. in many fields,including computer version,natural language learning,etc.,letting th. mach.nes h.ve rich.commonsense knowledge and possess th. reasoning ability is still difficult and under-resolved.

关键词： own let breakth.ough

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Effect of tubastatin A on NLRP3 inflammasome activation in macroph.ges under h.poxia/ reoxygenation conditions

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World Journal of Emergency Medicine 2024年第4期15卷 289-296页

作者： h.o Li chang Liu Ying Cui Panpan chang Wei Ch.ng Department of Emergency Medicine the First Hospital of China Medical UniversityShenyang 110001China Trauma Medicine Center Peking University People's HospitalBeijing 100871China Key Laboratory of Trauma and Neural Regeneration Peking UniversityBeijing 100871China National Center for Trauma Medicine of Ch.na Beijing 100871China

BACKGROUND:Th.re are currently no effective drugs to mitigate th. isch.mia/reperfusion injury caused by fluid resuscitation after h.morrh.gic sh.ck(h.).Th. aim of th.s study was to explore th. potential of th. h.stone deacetylase 6(h.AC6)-specific inh.bitor tubastatin A(TubA)to suppress nucleotide-binding oligomerization domain-like receptor protein 3(NLRP3)inflammasome activation in macroph.ges under h.poxia/reoxygenation(h.R)***:Th. viability of RAW264.7 cells subjected to h.R after treatment with.different concentrations of TubA was assessed using a cell-counting kit-8(CCK8)***,2.5μmol/L TubA was used with.RAW264.7 cells under h.R ***264.7 cells were divided into th.ee groups,namely th. control,h.R,and TubA *** levels of reactive oxygen species(ROS)in th. cells were detected using fluorescence *** protein expression of h.AC6,h.at sh.ck protein 90(h.p90),inducible nitric oxide synth.se(iNOS),NLRP3,gasdermin-D(GSDMD),Caspase-1,GSDMD-N,and Caspase-1 p20 was detected by western *** levels of interleukin-1β(IL-1β)and IL-18 in th. supernatants were detected using enzyme-linked immunosorbent assay(ELISA).RESULTS:h.AC6,h.p90,and iNOS expression levels were significantly h.gh.r(Ph. h.R group th.n in th. control group,but lower in th. TubA group th.n in th. h.R group(Ph.n comparing th. h.R group to th. control group,ROS levels were significantly h.gh.r(Ph. TubA group(Ph. h.R group h.d h.gh.r NLRP3,GSDMD,Caspase-1,GSDMD-N,and Caspase-1 p20 expression levels th.n th. control group(Ph.wever,th. TubA group h.d significantly lower expression levels th.n th. h.R group(Ph. supernatants were significantly h.gh.r in th. h.R group compared to th. control group(Ph. TubA group compared to th. h.R group(Ph.bited th. expression of h.AC6,h.p90,and iNOS in macroph.ges

关键词： h.morrh.gic sh.ck h.poxia/reoxygenation Macroph.ge NLRP3 Tubastatin A

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Event-triggered h.(∞) consensus control for input-constrained multi-agent systems via reinforcement learning

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Control Th.ory and Tech.ology 2024年第1期22卷 25-38页

作者： Jinxuan Zh.ng chang-E Ren College of Information Engineering Capital Normal UniversityBeijing100089China

Th.s article presents an event-triggered h.(∞) consensus control sch.me using reinforcement learning (RL) for nonlinear second-order multi-agent systems (MASs) with.control constraints. First, considering control constraints, th. constrained h.(∞) consensus problem is transformed into a multi-player zero-sum game with.non-quadratic performance functions. Th.n, an event-triggered control meth.d is presented to conserve communication resources and a new triggering condition is developed for each.agent to make th. triggering th.esh.ld independent of th. disturbance attenuation level. To derive th. optimal controller th.t can minimize th. cost function in th. case of worst disturbance, a constrained h.milton–Jacobi–Bellman (h.B) equation is defined. Since it is difficult to solve analytically due to its strongly non-linearity, reinforcement learning (RL) is implemented to obtain th. optimal controller. In specific, th. optimal performance function and th. worst-case disturbance are approximated by a time-triggered critic network;meanwh.le, th. optimal controller is approximated by event-triggered actor network. After th.t, Lyapunov analysis is utilized to prove th. uniformly ultimately bounded (UUB) stability of th. system and th.t th. network weigh. errors are UUB. Finally, a simulation example is utilized to demonstrate th. effectiveness of th. control strategy provided.

关键词： h.(∞)optimal control Input constrains Multi-agent systems(MASs) Reinforcement learning(RL)

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Numerical analysis of a projecting wall type oscillating water column(PW-OWC)wave energy converter in regular waves

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Journal of h.drodynamics 2024年第3期36卷 479-491页

作者： Lei Tan Ruiyuan chang Tomoki Ikoma Department of Oceanic Arch.tecture and Engineering College of Science and TechnologyNihon UniversityChibaJapan

Oscillating water column(OWC)based wave energy absorption devices are classic wh.ch.h.ve been widely used for h.rnessing ocean wave *** paper presents a numerical study on a projecting wall(PW)type OWC wave energy converter in regular *** computational fluid dynamics(CFD)modelling of a stationary floating PW-OWC model in a th.ee-dimensional wave flume is ach.eved by th. software *** analyses are carried out based on CFD simulations and th. linear potential flow solutions with.modifications to account for turbine-induced *** present numerical solutions are validated against our previous experimental *** is found th.t both.th. CFD and modified linear potential flow predictions are in reasonably good agreements with.th. experimental data in th. first order results of OWC and air pressure *** th. nonlinear responses are included in th. result,th. modified linear potential flow solution is found to sligh.ly under-estimate th. wave energy conversion performance at long *** th. airflows above and below th. ch.mber orifice,th. CFD results suggest th.t th.y are almost unidirectional,oscillating in not only th. base frequency but also subh.rmonic and ultrah.rmonic *** evolution of th. OWC responses during an entire period and th. ph.se analysis based on CFD simulations are *** ph.se results provide th. crucial evidence to th. reasonability of th. ph.sics-based modification of th. potential flow model in modelling of *** present results and analysis are expected to be beneficial to th. understanding on th. ph.sical mech.nism of OWCs and th. design of ph.se control strategies.

关键词： Computational fluid dynamics(CFD)simulation h.drodynamic analysis oscillating water column(OWC)damping orifice airflow ph.se difference

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An Experimental Study on Response and Control of a Flapping-Wing Aerial Robot Under Wind Gusts

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Journal of Bionic Engineering 2024年第1期21卷 209-223页

作者： Kazuki Sh.mura h.karu Aono chang-kwon Kang Graduate Sch.ol of Science and Tech.ology Shinshu University3-15-1 TokidaUedaNagano 3868567Japan Department of Mech.nical Engineering and Robotics 3-15-1 TokidaUedaNagano 3868567Japan Department of Mech.nical and Aerospace Engineering University of Alabama in HuntsvilleTechnology Hall N266HuntsvilleAL35899USA

Bioinspired flapping-wing micro-air-veh.cles(FWMAVs)h.ve th. potential to be useful aerial tools for gath.ring information in various *** recent advancements in manufacturing tech.ologies and better understanding of aerodynamic mech.nisms beh.nd of th. flapping fligh.,outdoor fligh.s h.ve become a ***,to fully realize th. potential of FWMAVs,furth.r improvements are necessary,particularly in terms of stability and robustness under gusty *** th.s study,th. response and control of a tailless two-winged FWMAV under th. wind gusts are *** experiments are conducted with.a one-degree-of-freedom gimbal to focus on effects of wind gusts on th. rotational motion of th. ***-derivative and sliding-mode controls are adopted for th. attitude *** present th.t th. body angles changed in time and reach.d approximately 50°at th. maximum due to th. wing *** sliding-mode controller can more effectively control th. rotational angle in th. presence of disturbances and both.th. wing speed and changes in wind speed h.ve an impact on th. effectiveness of attitude *** results contribute to th. development of of tailless two-winged,single-motor driven FWMAVs in terms of th. design of attitude controller and testing apparatus.

关键词： Flapping-wing micro-air veh.cles Sliding-mode control Pitch.and roll angle-Wind gus

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Population genomic data reveal low genetic diversity,divergence and local adaptation among th.eatened Reeves's Ph.asant(Syrmaticus reevesii)

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Avian Research 2024年第1期15卷 1-11页

作者： Qi Lu Pengch.ng Wang Jiang chang De Ch.n Sh.ngh.n Gao Jacob h.glund Zh.ngwang Zh.ng Ministry of Education Key Laboratory for Biodiversity Science and Ecological Engineering College of Life SciencesBeijing Normal UniversityBeijing100875China Jiangsu Key Laboratory for Biodiversity and Biotech.ology College of Life SciencesNanjing Normal UniversityNanjing210023China State Key Laboratory of Environmental Criteria and Risk Assessment Chinese Research Academy of Environmental SciencesBeijing100012China State Key Laboratory of Microbial Resources Institute of MicrobiologyChinese Academy of SciencesBeijing100101China Department of Ecology and Genetics Animal EcologyUppsala UniversityUppsalaSweden

Population genomic data could provide valuable information for conservation efforts;h.wever,limited studies h.ve been conducted to investigate th. genetic status of th.eatened ***’s Ph.asant(Syrmaticus reevesii)is facing population decline,attributed to increases in h.bitat *** is a knowledge gap in understanding th. genomic status and genetic basis underlying th. local adaptation of th.s th.eatened ***,we used population genomic data to assess population structure,genetic diversity,inbreeding patterns,and genetic ***,we identified candidate genes linked with.adaptation across th. current distribution of Reeves’s *** present study assembled th. first de novo genome sequence of Reeves’s Ph.asant and annotated 19,458 *** also sequenced 30 individuals from th.ee populations(Dabie Mountain,Sh.nnongjia,Qinling Mountain)and found th.t th.re was clear population structure among th.se *** comparing with.oth.r th.eatened species,we found th.t Reeves’s Ph.asants h.ve low genetic *** of h.mozygosity suggest th.t th. Sh.nnongjia population h.s experienced serious *** demograph.c h.story results indicated th.t th.ee populations experienced several declines during th. glacial *** adaptative analysis among th. populations identified 241 candidate genes under directional *** are involved in a large variety of processes,including th. immune response and *** results suggest th.t th. th.ee populations sh.uld be considered as th.ee different conservation *** current study provides genetic evidence for conserving th. th.eatened Reeves’s Ph.asant and provides genomic resources for global biodiversity management.

关键词： Conservation genetics Local adaptation Ph.asant Wh.le-genome sequencing

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Pt nanodendrites with.a PtIr alloy surface structure exh.bit excellent stability toward acidic h.drogen evolution reaction

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Nano Research 2024年第6期17卷 4844-4849页

作者： chang Liu Zongnan Wei Minna Cao Rong Cao State Key Laboratory of Structural Ch.mistry Fujian Institute of Research on the Structure of MatterChinese Academy of SciencesFuzhou 350002China University of Ch.nese Academy of Sciences Beijing 100049China Fujian Science and Tech.ology Innovation Laboratory for Optoelectronic Information of Ch.na Fuzhou 350108China

Th. development of effective and stable electrocatalysts for th. h.drogen evolution reaction(h.R)in acidic electrolytes is a significant *** th.s work,h.mogeneous Pt nanodendrites(Pt NDs)with.a PtIr sh.ll were successfully synth.sized by a two-step wet ch.mical *** open th.ee-dimensional(3D)dendritic structure exh.bited exceptional electrocatalytic ch.racteristics,exposing as many active sites as ***,by alloying Ir with.Pt on th. surface,catalytic activity was greatly enh.nced wh.le ensuring extremely h.gh.*** surface-enrich.d platinum nanodendritic catalysts(Pt@PtIr NDs)outperformed th. control samples and th. commercial *** acidic h.R test,Pt@PtIr NDs h.d a lower overpotential(22 mV)th.n Pt NDs(26 mV)and commercial Pt/C(31 mV)at 10 mA/cm^(2),and th. activity of Pt@PtIr NDs remained consistent even after undergoing a continuous durability test for at least 168 h.wh.ch.was much.superior to th. performance of commercial Pt/C(10 h.under identical test *** study revealed th.t th. application of 3D Pt dendritic metal alloys may offer a ch.nce for th. development of enh.nced electrocatalysts in acidic h.R.

关键词： Pt nanodendrites iridium h.gh.stability h.drogen evolution reaction alloy

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A meth.dology for laser tool setters calibration and its precise math.matical model

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Ch.nese Journal of Aeronautics 2024年第7期37卷 564-581页

作者： Tao FANG Zixi FANG Ze Zh.ng Ch.N Zh.yong chang Sch.ol of Mech.nical Engineering Northwestern Polytechnical UniversityXi’an 710072China Gina Cody Sch.ol of Engineering and Computer Science Concordia UniversityMontrealQuebec H3G 1M8Canada changsh. Optimum CNC Corporation Changsha 410221China Institute for Aero-engine Smart Assembly of Sh.anxi Province Xi’an 710072China

On-mach.ne tool setting is a pivotal approach.in ach.eving intelligent manufacturing,and laser tool setters h.ve become a crucial component of smart mach.ne *** tool setters play a crucial role in precisely measuring th. dimensions of cutting tools during th. part mach.ning process,focusing on tool length.and *** a measuring instrument,th. positions of th. laser axis of th. laser tool setter need to be accurately calibrated before ***,in actual calibration scenarios,traditional calibration meth.ds face ch.llenges due to installation errors in th. tool setter and geometric errors in th. measuring *** address th.s issue,th.s study proposes a novel calibration ***,th. calibration mech.nism of th. laser beam axis is *** on th. accurate math.matical model of th. laser beam and th. measuring rod,and using th. polygon clipping algorith.,th. math.matical mech.nism of th. laser tool setter’s work is ***,a novel meth.d is introduced to calculate th. compensation distance between th. laser beam reference point and th. rod bottom center point at each.moment during ***,by utilizing th. kinematic ch.in of th. tool setter calibration system,a new calibration meth.d is developed to accurately calibrate th. position of th. laser beam axis in th. mach.ne tool coordinate ***,th. accuracy of th. calibration meth.d is verified th.ough.simulation experiments and calibration *** meth.d improves th. calibration accuracy of th. tool setter,and th. math.matical model of th. laser tool setter can be extended to th. measurement of tools,th.reby improving th. precision of tool *** research.significantly improves th. efficient production performance of smart mach.ne tools.

关键词： On-mach.ne tool setting Smart mach.ne tools Math.matical model Calibration meth.d Laser tool sette

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