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胸腔镜前路矫形内固定治疗特发性胸椎脊柱侧凸手术技术

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中华骨科杂志 2010年第3期30卷 I0041-I0054页

作者： Peter O. Newton, md Vidyadhar V. Upasani, md Juliano Lhamby, md Valerie L. Ugrinow, BA jeff B. Pawelek, BS Tracey P. Bastrom, MA 邱勇(译) Investigation performed at Rady Children's Hospital and Health Center San Diego California 南京鼓楼医院脊柱科 210008

背景：胸腔镜前路矫形内固定植骨融合术的患者随访2年的疗效已经有相关的研究报道，本研究的目的是评价其随访5年的结果。方法l本研究包括41例接受胸腔镜前路矫形内固定植骨融合术治疗的特发性胸椎脊柱侧凸患者，这些患者均在规定时间... 详细信息

背景：胸腔镜前路矫形内固定植骨融合术的患者随访2年的疗效已经有相关的研究报道，本研究的目的是评价其随访5年的结果。方法l本研究包括41例接受胸腔镜前路矫形内固定植骨融合术治疗的特发性胸椎脊柱侧凸患者，这些患者均在规定时间间隔随访。前瞻性收集并记录的数据包括：患者的一般资料、影像学测量、临床畸形测量、肺功能、椎体间融合评价、SRS-24评分及术前、术后的并发症。对术前、术后2年、5年的病例资料进行对比。另外，对特定的研究对象和失随访的患者术后2年的影像学测量、肺功能、SRS-24评分进行比较。

关键词：前路矫形脊柱侧凸固定治疗胸腔镜特发性手术技术胸椎影像学测量

Convolution Integrals and a Mirror Theorem from Toric Fiber Geometry

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Advances in Pure Mathematics 2019年第9期9卷 637-684页

作者： jeff Brown Baltimore MD USA

Let E be a toric fibration arising from symplectic reduction of a direct sum of complex line bundles over (almost) Kähler base B. Then each torus-fixed point of the toric manifold fiber defines a section of the fibration. Let La be convex line bundles over B, Aa smooth divisors of B arising as the zero loci of generic sections of La , and a particular fixed-point section of E. Further assume the {Aa} to be mutually disjoint. The manifold is a new manifold with tautological line bundles over new projective spaces in the geometry, where previously there was a simpler vector bundle in the given local geometry (Section 1.5). Thus, we compute genus-0 Gromov-Witten invariants of in terms of genus-0 Gromov-Witten invariants of B and of {Aa}, the matrix used for the symplectic reduction description of the fiber of the toric fibration E→B, and the restriction maps . The proofs utilize the fixed-point localization technique describing the geometry of and its genus-0 Gromov-Witten theory, as well as the Quantum Lefschetz theorem relating the genus-0 Gromov-Witten theory of A with that of B.

关键词： Gromov-Witten Invariant Quantum Cohomology Fixed-Point Localization Birational Geometry

Detection of a possible superluminous supernova in the Epoch of Reionization

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Science Bulletin 2017年第10期62卷 675-678页

作者： Jeremy Mould Tim Abbott jeff Cooke Chris Curtin Antonios Katsianis Anton Koekemoer Edoardo Tescari Syed Uddin Lifan Wang Stuart Wyithe Centre for Astrophysical & Supercomputing Swinburne University Hawthorn 3122 Australia Cerro Tololo lnteramerican Observatory NOAO La Serena Chile Space Telescope Science Institute Baltimore MD 21218 USA Purple Mountain Observatory Chinese Academy of Sciences Nanjing 210008 China Texas A&M University College Station 7X 77843 USA University of Melbourne School of Physics Melbourne 3010 Australia Departamento de Astronornia Universidad de Chile Los Condes Santiago. Chile

The Epoch of Reionization(EoR)poses a number of puzzles,including the sufficiency of ionizing radiation,the rapid production of supermassive black holes and the early appearance of abundant metals in larger *** the first of these,solutions focus on the main sequence evolution of massive stars,but the second and third puzzles involve the terminal phase of stellar evolution,

关键词：超新星再电离大质量恒星检测光度恒星演化电离辐射 EOR

Profiling Chromatin Accessibility at Single-cell Resolution

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Genomics, Proteomics & Bioinformatics 2021年第2期19卷 172-190页

作者： Sarthak Sinha Ansuman T.Satpathy Weiqiang Zhou Hongkai Ji Jo A.Stratton Arzina Jaffer Nizar Bahlis Sorana Morrissy jeff A.Biernaskie Department of Comparative Biology&Experimental Medicine Faculty of Veterinary MedicineUniversity of CalgaryCalgaryAB T2N 4N1Canada Department of Pathology Stanford University School of MedicineStanfordCA 94305USA Department of Biostatistics Bloomberg School of Public HealthJohns Hopkins UniversityBaltimoreMD 21205USA Alberta Children’s Hospital Research Institute University of CalgaryCalgaryAB T2N 4N1Canada Hotchkiss Brain Institute University of CalgaryCalgaryAB T2N 4N1Canada Arnie Charbonneau Cancer Institute University of CalgaryCalgaryAB T2N 4Z6Canada Department of Biochemistry and Molecular Biology Cumming School of MedicineUniversity of CalgaryCalgaryAB T2N 4N1Canada

How distinct transcriptional programs are enacted to generate cellular heterogeneity and plasticity,and enable complex fate decisions are important open *** key regulator is the cell’s epigenome state that drives distinct transcriptional programs by regulating chromatin ***-wide chromatin accessibility measurements can impart insights into regulatory sequences(in)accessible to DNA-binding proteins at a single-cell *** review outlines molecular methods and bioinformatic tools for capturing cell-to-cell chromatin variation using single-cell assay for transposase-accessible chromatin using sequencing(scATAC-seq)in a scalable *** also covers joint profiling of chromatin with transcriptome/proteome measurements,computational strategies to integrate multi-omic measurements,and predictive bioinformatic tools to infer chromatin accessibility from single-cell transcriptomic *** refinements that increase power for cell discovery through robust chromatin coverage and integrate measurements from multiple modalities will further expand our understanding of gene regulation during homeostasis and disease.

关键词： Single-cell ATAC-seq Gene regulation Epigenetics Single-cell multi-omics Cis-regulatory elements

Oxysterols as promising small molecules for bone tissue engineering: Systematic review

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World Journal of Orthopedics 2020年第7期11卷 328-344页

作者： Ethan Cottrill Julianna Lazzari Zach Pennington jeff Ehresman Andrew Schilling Naomi Dirckx Nicholas Theodore Daniel Sciubba Timothy Witham Department of Neurosurgery The Johns Hopkins University School of MedicineBaltimoreMD 21287United States

BACKGROUND Bone tissue engineering is an area of continued interest within orthopaedic surgery,as it promises to create implantable bone substitute materials that obviate the need for autologous bone ***,oxysterols–oxygenated derivatives of cholesterol-have been proposed as a novel class of osteoinductive small molecules for bone tissue ***,we present the first systematic review of the in vivo evidence describing the potential therapeutic utility of oxysterols for bone tissue *** To systematically review the available literature examining the effect of oxysterols on in vivo bone *** We conducted a systematic review of the literature following PRISMA *** the PubMed/MEDLINE,Embase,and Web of Science databases,we queried all publications in the English-language literature investigating the effect of oxysterols on in vivo bone *** were screened for eligibility using PICOS criteria and assessed for potential bias using an expanded version of the SYRCLE Risk of Bias assessment *** full-text articles examining the effect of oxysterols on in vivo bone formation were *** data included:Animal species,surgical/defect model,description of therapeutic and control treatments,and method for assessing bone *** outcome was fusion rate for spinal fusion models and percent bone regeneration for critical-sized defect *** were tabulated and described by both surgical/defect model and oxysterol ***,data from all included studies were aggregated to posit the mechanism by which oxysterols may mediate in vivo bone *** Our search identified 267 unique articles,of which 27 underwent full-text *** studies(all preclinical)met our inclusion/exclusion *** the 13 included studies,5 employed spinal fusion models,2 employed critical-sized alveolar defect models,and 6 employed critical-sized calvarial defect *** upon SYRCLE c

关键词： Oxysterol Bone tissue engineering Critical-sized defect Biomaterial Orthopaedic surgery Systematic review

Film properties as a function of alternating versus direct current.

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Film properties as a function of alternating versus direct c...

心脏手术患者使用大剂量氨甲环酸与非缺血性癫痫发作的相关性研究

第八届中国辐射固化年会

作者： Sonny J nsson jeff Okamitsu David Harbourne Fusion UV Systems Inc.910 Clopper RoadGaithersburgMD 20878-1357 USA Fusion UV Systems Inc.910 Clopper RoadGaithersburgMD 20878-1357 USA Fusion UV Systems Inc.910 Clopper RoadGaithersburgMD 20878-1357 USA

＜正＞This paper is dealing with the mechanical film or coating properties in general and more specifically to some essential and very important features, such as the degree of conversion. Degree of conversion means the consumption of C=C double bonds in an acrylate mixture as a function of "rippled versus non-rippled light" from an UV emitting light source. The states of the art as well as descriptions and experimental details over this subject are all well documented in the patent application US 6,908,586 B2 （1）.

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麻醉与镇痛 2013年第3期9卷 45-48页

作者： John M. Murkin Florian Falter jeff Granton Bryan Young Chris tiana Burt Michael Chu, md, FRCSC Department of Anesthesiology and Perioperative Medicine University Hospital-LHSCUniversity of Western Ontario London Ontario Canada department of Anaesthesiaand Intensive Care Papworth Hospital Cambridge United Kingdom Clinical Neurological Sciences Surgery University Hospital-LHSC University of Western Ontario London Ontario Canada

背景我们在两个实验中心同时观察到心脏手术患者术后癫痫发作的发生率明显升高，从1．3％增长至3.8％。恰巧此时临床停止使用抑肽酶，转而应用大剂量氨甲环酸（tranexamicacid，TXA）。本篇综述的目的在于采用回顾性分析研究氨甲环酸的... 详细信息

背景我们在两个实验中心同时观察到心脏手术患者术后癫痫发作的发生率明显升高，从1．3％增长至3.8％。恰巧此时临床停止使用抑肽酶，转而应用大剂量氨甲环酸（tranexamicacid，TXA）。本篇综述的目的在于采用回顾性分析研究氨甲环酸的应用与术后患者癫痫发作的相关性。方法应用图表回顾了围术期癫痫发作的24例患者的详细情况。所有患者都有神经系统评估和脑影像学检查，但只有11例进行了脑电监测。结果24例患者中有21例未发现有新近发生的脑缺血损伤，其余3例发生了缺血损伤，可能引发了癫痫发作。所有患者在木中均接受了大剂量氨甲环酸的治疗，用药剂量在61～259mg/kg之间，但癫痫发作后均未出现永久性神经系统异常。患者平均年龄为69．9岁，其中21例患者进行的是心脏切开手术，3例患者行冠脉搭桥术。只有1例未进行体外循环。目前尚未有证据显示脑缺血、脑代谢异常及高热等原因诱发了此24例患者癫痫发作。结论行体外循环或是心脏切开手术的老年患者给予大剂量氨甲环酸可诱发癫痫发作。

关键词：术后患者癫痫发作氨甲环酸心脏手术大剂量相关性非缺血性神经系统异常

荒山造林生态恢复项目环境效益非市场价值评估研究——长江上游四川平原案例

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林业经济 2014年第10期36卷 71-77页

作者：赵金成袁梅谢晨王雪红 jeff Bennett 王亚明彭伟国家林业局经济发展研究中心北京100714 亚太森林恢复与可持续管理网络中心北京100102 澳大利亚国立大学克劳福德学院

中国政府在长江上游实施的生态恢复项目提供了一系列环境商品和服务,例如减少水蚀、空气净化、生物多样性保护。文章采用选择模型(Choice Modeling)技术评估了四川省生态恢复项目在成都和上海两地产生的环境效益非市场价值,环境属性的... 详细信息

中国政府在长江上游实施的生态恢复项目提供了一系列环境商品和服务,例如减少水蚀、空气净化、生物多样性保护。文章采用选择模型(Choice Modeling)技术评估了四川省生态恢复项目在成都和上海两地产生的环境效益非市场价值,环境属性的隐含价格则采用MNL以及RPL模型进行了估算。结果表明,两城市样本对于来自生态恢复项目的环境服务均有支付意愿,环境效益在两地隐含价格之间没有显著差异。基于RPL模型,对于此项目的环境改善,成都每个受访者的平均支付意愿是人民币1062.55元,上海是人民币962.72元。两地城市居民的支付意愿之间没有显著差异。

关键词：生态恢复支付意愿环境价值选择模型

NOTUM inhibition increases endocortical bone formation and bone strength

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Bone Research 2019年第1期7卷 54-65页

作者： Robert Brommage jeff Liu Peter Voge Faika Mseeh Andrea Y.Thompson David G.Potter Melanie K.Shadoan Gwenn M.Hansen Sabrina Jeter-Jones Jie Cui Dawn Bright Jennifer P.Bardenhagen Deon D.Doree Sofia Moverare-Skrtic Karin H.Nilsson Petra Henning Ulf H.Lerner Claes Ohlsson Arthur T.Sands James E.Tarver David R.Powell Brian Zambrowicz Qingyun Liu Lexicon Pharmaceuticals The WoodlandsTXUSA Wntrix HoustonTXUSA PRA Health Sciences RaleighNCUSA University of Pennsylvania PhiladelphiaPAUSA Regeneron Pharmaceuticals TarrytownNYUSA University of Texas HoustonTXUSA Centre for Bone and Arthritis Research Institute of MedicineThe Sahlgrenska Academy at University of GothenburgGothenburgSweden Centre for Bone and Arthritis Research University of GothenburgGothenburgSweden Biogen CambridgeMAUSA St.Jude Children’s Research Hospital MemphisTNUSA md Anderson Cancer Center HoustonTXUSA Bethyl Laboratories MontgomeryTXUSA Merck RahwayNJUSA Nurix San FranciscoCAUSA

The disability,mortality and costs caused by non-vertebral osteoporotic fractures are *** osteoporosis therapies are highly effective at reducing vertebral but not non-vertebral *** bone is a major determinant of non-vertebral bone *** identify novel osteoporosis drug targets,we phenotyped cortical bone of 3 366 viable mouse strains with global knockouts of druggable *** bone thickness was substantially elevated in Notum?/?*** is a secreted WNT lipase and we observed high NOTUM expression in cortical bone and osteoblasts but not *** orally active small molecules and a neutralizing antibody inhibiting NOTUM lipase activity were *** increased cortical bone thickness and strength at multiple skeletal sites in both gonadal intact and ovariectomized rodents by stimulating endocortical bone ***,inhibition of NOTUM activity is a potential novel anabolic therapy for strengthening cortical bone and preventing non-vertebral fractures.

关键词： disability osteoporosis fractures