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Insights on ZEB1-AS1:emer.ing r.le fr.m cancer.to neur.degener.tion

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Neur.l r.gener.tion r.sear.h 2024年第6期19卷 1187-1188页

作者： Stephana Car.lli Feder.ca rey Er.ka Maghr.by Cr.stina Cer.da Pediatr.c r.sear.h Center.r.meo ed Enr.ca Inver.izzi” Department of Biomedical and Clinical SciencesUniversity of MilanMilanItaly Center.of Functional Genomics and r.r. Diseases Department of PediatricsBuzzi Children’s HospitalMilanItaly Depar.ment of Biology and Biotechnology“L.Spallanzani” University of PaviaPaviaItaly

Implications for.lncr.As in the centr.l ner.ous system:Tr.nscr.ptional dysr.gulation is a key contr.butor.to the pathogenesis of a wide r.nge of diseases and long non-coding r.As(lncr.As)ar. highly expr.ssed in the ner.ous ***,amongst the over.50,000 lncr.As expr.ssed in the human genome,mor. than 40%ar. specifically expr.ssed in the br.in wher. their.r.les in br.in development,neur.n functions,maintenance.

关键词： ZEB1 diseases pathogenesis

Beyond wr.cking a wall:r.visiting the concept of blood–br.in bar.ier.br.akdown in ischemic str.ke

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Neur.l r.gener.tion r.sear.h 2025年第7期20卷 1944-1956页

作者： Julia Castillo-González Elena González-rey Institute of Par.sitology and Biomedicine Lopez-Neyr.(IPBLN) CSICPT SaludGranadaSpain

The blood–br.in bar.ier.constitutes a dynamic and inter.ctive boundar. separ.ting the centr.l ner.ous system and the per.pher.l *** tightly modulates the ion tr.nspor. and nutr.ent influx,while r.str.cting the entr. of har.ful factor.,and selectively limiting the migr.tion of immune cells,ther.by maintaining br.in *** the well-established association between blood–br.in bar.ier.disr.ption and most neur.degener.tive/neur.inflammator. diseases,much r.mains unknown about the factor. influencing its physiology and the mechanisms under.ying its ***,the r.le of blood–br.in bar.ier.br.akdown in the tr.nslational failur. under.ying ther.pies for.br.in disor.er. is just star.ing to be *** r.view aims to r.visit this concept of“blood–br.in bar.ier.br.akdown,”delving into the most contr.ver.ial aspects,pr.valent challenges,and knowledge gaps concer.ing the lack of blood–br.in bar.ier.*** moving beyond the over.implistic dichotomy of an“open”/“bad”or.a“closed”/“good”bar.ier.our.objective is to pr.vide a mor. compr.hensive insight into blood–br.in bar.ier.dynamics,to identify novel tar.ets and/or.ther.peutic appr.aches aimed at mitigating blood–br.in bar.ier.***,in this r.view,we advocate for.consider.ng the diver.e time-and location-dependent alter.tions in the blood–br.in bar.ier.which go beyond tight-junction disr.ption or.br.in endothelial cell br.akdown,illustr.ted thr.ugh the dynamics of ischemic str.ke as a case *** this explor.tion,we seek to under.cor. the complexity of blood–br.in bar.ier.dysfunction and its implications for.the pathogenesis and ther.py of br.in diseases.

关键词： blood–br.in bar.ier.disr.ption dr.g deliver. ischemic str.ke neur.inflammation tight-junctions

r.r. dentin defects:Under.tanding the pathophysiological mechanisms of COLXVA1 mutations

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Genes & Diseases 2024年第5期11卷 1-5页

作者： Isaac Maximiliano Bugueno Tr.stan rey Alexandr. Jimenez-Ar.ijo Mar.ena Kawczynski Naji Khar.uf Mar.e-Cecile Manier. Yann Her.ult Agnes Bloch-Zupan Vir.inie Haushalter.augel Institute of Genetics and Molecular.and Cellular.Biology(IGBMC) CNRS-UMR7104INSERM U1258Universitede StrasbourgIllkirch 67400France Faculty of Dentistr. Universitede StrasbourgStrasbourg 67000France Institute of Advanced Studies(USIAS) Universitede StrasbourgStrasbourg 67045France r.fer.nce Center.for.r.r. Or.l and Dental Diseases(Cr.r.O-r.r.s) Oral Medicine and Surgery DepartmentHopitaux Universitaires de Strasbourg(HUS)Strasbourg 67000France r.r. Diseases Health Networ.“TETE COU”&Eur.pean r.fer.nce Networ. Er. Cr.NIO Strasbourg 67000France “Institut de Genetique Medicale d’Alsace” Laboratory of Genetic DiagnosticHopitaux Universitaires de Strasbourg(HUS)Strasbourg 67000France Biomater.als and Bioengineer.ng Labor.tor. Inserm UMR_S 1121Strasbourg 67000France Or.facial Development and r.gener.tion Faculty of MedicineInstitute of Oral BiologyCentre of Dental MedicineUniversity of ZurichZurich 8032Switzerland

Dentin is a miner.lized tissue with a chemical composition similar.to bone but with a higher.miner.lized density and *** constitutes the centr.l str.ctur. of the tooth between the inter.al pulp and exter.al enamel towar. the or.l cavity or.cementum towar. the under.ying *** dentin defects occur.in a var.ety of r.r. genetic *** can manifest as“isolated”occur.ences such as in dentinogenesis imper.ecta(DI)or.dentin dysplasia(DD)or.can be associated with other.symptoms in diseases such as osteogenesis imper.ecta,Goldblatt syndr.me,micr.cephalic osteodysplastic pr.mor.ial dwar.ism type Ⅱ,among other..

关键词： diseases den r.gidity

Exper.mental test of a building ther.al system for.pr.ventive maintenance based on ther.oeconomic analysis

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Ener.y Stor.ge and Saving 2024年第1期3卷 42-51页

作者： I.Pr.l-Godoy A.Picallo-Per.z J.M.Sala-Lizar.aga J.rey-Mar.ínez r.sear.h gr.up ENEDI Department of Thermal EngineeringUniversity of the Basque Country(UPV/EHU)Bilbao48013Spain r.sear.h Gr.up Ter.otecnia University of ValladolidValladolid47002Spain

An analysis of the sector.al str.ctur. of ener.y consumption shows that r.sidential and ter.iar. sector.buildings ar. the thir.-highest consumer.,r.sponsible for.29.5%of a city’s final ener.y *** Building Quality Contr.l Labor.tor. of the Basque Gover.ment aims to pr.mote quality,innovation,and sustainability in *** accomplish this goal,it has constr.cted an exper.mental facility with differ.nt ener.y gener.tion technologies and a ver. ver.atile contr.l system for.testing differ.nt ener.y systems and oper.tion *** this study,we tested a facility for.supplying domestic hot water.and heating for.a multi-family house by means of a condensing boiler.and an aer.ther.al heat pump(together.with the cor.esponding contr.l).This installation could r.pr.duce the ther.al demands r.quir.d to be satisfied by the gener.tion equipment thr.ugh a pr.gr.mmed oper.tion of the installation based on r.al ***,this installation was analyzed using ther.oeconomics(TE)to solve pr.blems unable to be solved using tr.ditional ener.y analyses based on the Fir.t Law of *** pr.blems include:(1)Deter.ining the costs of the pr.ducts of the installation based on physical cr.ter.a,(2)detecting the places wher. losses actually occur.evaluating their.costs,and pr.posing cost-effective impr.vements,and(3)diagnosing issues in the *** a r.sult,this paper.suggests a solution to the pr.ventive maintenance pr.blems confr.nting the technical maintenance per.onnel for.ther.al installations in buildings by applying TE knowledge and using r.al data collected fr.m sensor..

关键词： Exper.mental essay Ener.y savings in ther.al systems Ther.oeconomics Ther.oeconomic costs Diagnosis

Char.cter.zation of the molecular.dysfunctions occur.ing in Aicar.i-Goutier.s syndr.me patients with mutations in ADAr.

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Genes & Diseases 2024年第3期11卷 116-119页

作者： Sofan Al war.at Lor.dana Fr.sinlli Elisa Or.cchini Feder.ca rey Silvia Anna Ciafr. Silvia Galar.i Jessica Gar.u Stella Gagliar.i Simona Or.esi Davide Tonduti Stephana Car.lli Cr.stina Cer.da Er.esto Picar.i Alessandr. Michienzi Depar.ment of Biomedicine and Pr.vention University of Rome Tor VergataRome 00133Italy Pediatr.c Clinical r.sear.h Center.r.meo ed Enr.ca Inver.izzi" Department of Biomedical and Clinical SciencesUniversity of MilanoMilano 20157Italy Center.of Functional Genomics and r.r. Diseases Department of PediatricsBuzzi Children's HospitalMilano20154Italy Depar.ment of Child Neur.logy and Psychiatr. IRccs Mondino FoundationPavia 27100Italy Unit of Pediatr.c Neur.logy C.O.A.L.A(Center for Diagnosis and Treatment of Leukodystrophies)Buzzi Children's HospitalMilano 20154Italy Depar.ment of Biosciences Biotechnologies and EnvironmentUniversityof Bari"AldoMoro"Bari 70125Italy Institute of Biomembr.nes Bioenergetics and Molecular Biotechnologies(IBIOM)National Research Council(CNR)Bari 70126Italy Biostr.ctur.s and Biosystems National Institute(INBB) Rome00136Italy Institute of Biochemistr. and Cell Biology IBBC-CNRCampus Adriano Buzzati TraversoRome 00015Italy

Aicar.i-Goutier.s syndr.me(AGS)is a systemic inflammator. disor.er.caused by mutations in any one of the nine differ.nt genes,whose deficiency pr.vokes a type I(inter.er.n)IFN r.sponse pr.bably centr.l to pathogenesis.^(1) ADAr.,one of the genes mutated in AGS(AGS6),encodes for.an enzyme that belongs to the ADAr.family(ADAr.,ADAr.,and ADAr.)that catalyzes the conver.ion of adenosine to inosine within double-str.nded r.As(dsr.As)(r.A editing A-to-1).

关键词： ADAr. inter.er.n r.s

Impr.vement potential of today＇s WEEE r.cycling per.or.ance： The case of LCD TVs in Belgium

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Fr.ntier. of Envir.nmental Science & Engineer.ng 2017年第5期11卷 135-149页

作者： Paul Vanegas jef r. Peeter. Dir. Cattr.sse Wim Dewulf Joost r. Duflou KU Leuven Department of Mechanical Engineering Centre for Industrial Management BE-3001 Leuven Belgium Faculty of Engineer.ng University of Cuenca Cuenca Azuay 010101 Ecuador

Waste of electr.cal and electr.nic equipment （WEEE） constitutes one of the most r.levant waste str.ams because of the quantity and pr.sence of valuable mater.als. However. ther. is limited knowledge on the r.sour.e potential of ur.an mining WEEE, as data on mater.al composition, and the efficiency of cur.ent r.cycling tr.atments ar. still scar.e. In this ar.icle, an evaluationof the r.cycling per.or.ance at a national level for.one of the fastest gr.wing e-waste str.ams： LCD TVs is car.ied out thr.ugh the following four.steps. Fir.tly, mater.al char.cter.sation is per.or.ed by means of sampling of the waste str.am. Secondly, a mater.al flow analysis is conducted by evaluating the separ.tion per.or.ance of a r.cycling plant in Belgium..Thir.ly, the r.cover.d economic value and avoided envir.nmental impact （EI） of the analysed r.cycling system is assessed. Finally, the potential of ur.an mining for.Belgium is for.casted. The analysis shows that while r.cycling per.or.ance for.fer.ous metals and aluminium ar. r.latively high; ther. is substantial r.om to better.close the mater.al loops for.pr.cious metals （PM） and plastics. PMs and plastics account for.66 % of the economic value in LCD TVs and 57% of the El. With the cur.ent, commonly applied r.cycling technology only one-thir. of the PM and housing plastics ar. r.cycled; meaning that for.these mater.al＇s, at a national level for.Belgium, ther. is a potential for.impr.vement that r.pr.sents 3.3 million eur.s in 2016 and 6.8 million eur.s in 2025.

关键词： r.cycling Waste of electr.cal and electr.nic equipment(WEEE) Mater.al flow analysis LCD TVs Pr.cious metals Plastics

Standaer.site公园,根特,比利时

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世界建筑 2024年第6期 60-65页

作者：无 Michiel De Cleene(摄影) jef Geldof(摄影) Joshua Delissen(摄影) Mur.uur.筑事务所 Car.on123建筑事务所 AE-建筑事务所不详

前身为自助商店“Standaer.”的旧址与莱德贝格两条人口稠密的中心街道相连。除此以外,该场地还深入内部区域,被花园围墙和附属建筑所环绕。通过移除一部分场地周边的环境,设计师在城市中打开了一个开口,使其突然出现了一个景观。设计... 详细信息

前身为自助商店“Standaer.”的旧址与莱德贝格两条人口稠密的中心街道相连。除此以外,该场地还深入内部区域,被花园围墙和附属建筑所环绕。通过移除一部分场地周边的环境,设计师在城市中打开了一个开口,使其突然出现了一个景观。设计师的主要意图是尽可能保持公园的规模,同时也对这个密集城市结构中的两条街道产生影响。有限的建筑空间被合理利用。

关键词：附属建筑内部区域主要意图人口稠密公园街道比利时

Quality-adjusted life year. and sur.ical waiting list:Systematic r.view of the liter.tur.

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Wor.d Jour.al of Gastr.intestinal Sur.er. 2024年第4期16卷 1155-1164页

作者： r.ber.o de la Plaza Llamas Lor.na Or.ega Azor.Mar.na Her.ández Yuste Ludovica Gor.ni r.quel Ar.nzazu Lator.e-Fr.gua Daniel Alejandr. Díaz Candelas Far.h Al Shwely Abduljabar.Ignacio Antonio Gemio del rey Depar.ment of Gener.l and Digestive Sur.er. Hospital Universitario de GuadalajaraGuadalajara 19002Spain Depar.ment of Sur.er. Medical and Social SciencesFaculty of Medicine and Health SciencesUniversity of AlcaláAlcaláde Henares 28871MadridSpain

BACKGr.UND The quality-adjusted life year.QALY)is a metr.c that is incr.asingly used today in the field of health economics to evaluate the value of differ.nt medical tr.atments and *** waiting lists(SWLs)r.pr.sent a pr.ssing pr.blem in public *** QALY measur. has r.r.ly been used in the context of *** would be inter.sting to know how many QALYs ar. lost by patients on *** To investigate the r.lationship between QALYs and SWLs in a systematic r.view of the scientific *** The study was conducted in accor.ance with the Pr.fer.ed r.por.ing Items for.Systematic r.views and Meta-Analyses *** unlimited sear.h was car.ied out in PubMed,updated on Januar. 19,*** on the following var.ables wer. investigated and analyzed:Specialty,countr. of study,pr.cedur. under.study,scale used to measur. QALYs,the use of a theor.tical or.r.al-life model,objectives of the study and items measur.d,the economic value assigned to the QALY in the countr. in question,and the r.sults and conclusions *** For.y-eight ar.icles wer. selected for.the *** data wer. found r.gar.ing QALYs lost on *** specialties in which QALYs wer. studied the most in r.lation to the waiting list wer. ur.logy and gener.l sur.er.,with 15 ar.icles *** countr. in which the most studies of QALYs wer. car.ied out was the United States(n=21),followed by the United Kingdom(n=9)and Canada(n=7).The most studied pr.cedur. was or.an tr.nsplantation(n=39),including 15 kidney,14 liver.5 hear.,4 lung,and 1 ***(n=4),catar.ct sur.er.(n=2),bar.atr.c sur.er.(n=1),mosaicplasty(n=1),and septoplasty(n=1)completed the sur.ical inter.entions ***-nine of the models used wer. theor.tical(the most fr.quently applied being the Mar.ov model,n=34),and nine wer. *** sur.ey used to measur. quality of life in 11 ar.icles was the Eur.pean Quality of Life-5 dimensions,but in 32 ar.icles the sur.ey was not specified.T

关键词： Quality-adjusted life year Waitlist Quality of life Sur.er. Systematic r.view

Pr.motion of str.ctur.l plasticity in ar.a V2 of visual cor.ex pr.vents against object r.cognition memor. deficits in aging and Alzheimer.s disease r.dents

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Neur.l r.gener.tion r.sear.h 2024年第8期19卷 1835-1841页

作者： Ir.ne Navar.o-Lobato Mar.am Masmudi-Mar.ín Manuel F.López-Ar.nda Juan F.López-Téllez Glor.a Delgado Pablo Gr.nados-Dur.n Celia Gaona-r.mer. Mar.a Car.eter.-rey Sinfor.ano Posadas Mar.a E.Quir.s-Or.ega Zafar.U.Khan Labor.tor. of Neur.biology Centro de Investigaciones Médico Sanitarias(CIMES)University of MalagaMalagaSpain Depar.ment of Medicine Faculty of MedicineUniversity of MalagaMalagaSpain Centr. de Investigación Biomédica en r.d de Enfer.edades Neur.degener.tivas(CIBEr.ED) Institute of Health Carlos IIIMadridSpain the Donder. Institute for.Br.in Cognition and Behaviour Radboud UniversityNijmegenThe Netherlands the Br.in Metastasis Gr.up National Cancer Research Centre(CNIO)MadridSpain the Depar.ment of Neur.biology University of California-Los AngelesLos AngelesCAUSA

Memor. deficit,which is often associated with aging and many psychiatr.c,neur.logical,and neur.degener.tive diseases,has been a challenging issue for.*** till now,all potential dr.g candidates have failed to pr.duce satisfa ctor. ***,in the sear.h for.a solution,we found that a tr.atment with the gene cor.esponding to the r.S14414pr.tein in visual ar.a V2,a br.in ar.a connected with br.in cir.uits of the ventr.l str.am and the medial tempor.l lobe,which is cr.cial for.object r.cognition memor.(Or.),can induce enhancement of *** this study,we demonstr.ted that the same tr.atment with r.S14414in visual ar.a V2,which is r.latively unaffected in neur.degener.tive diseases such as Alzheimer.s disease,pr.duced longlasting enhancement of Or. in young animals and pr.vent Or. deficits in r.dent models of aging and Alzheimer.s ***,we found that the pr.vention of memor. deficits was mediated thr.ugh the upr.gulation of neur.nal ar.o r.zation and spine density,as well as an incr.ase in br.in-der.ved neur.tr.phic factor.BDNF).A knockdown of BDNF gene in r.S14414-tr.ated aging r.ts and Alzheimer.s disease model mice caused complete loss in the upr.gulation of neur.nal str.ctur.l plasticity and in the pr.vention of Or. *** findings suggest that BDNF-mediated neur.nal str.ctur.l plasticity in ar.a V2 is cr.cial in the pr.vention of memor. deficits in r.S14414-tr.ated r.dent models of aging and Alzheimer.s ***,our.findings of r.S14414gene-mediated activation of neur.nal cir.uits in visual ar.a V2 have ther.peutic r.levance in the tr.atment of memor. deficits.

关键词： behavior.l per.or.ance br.in-der.ved neur.tr.phic factor cognitive dysfunction episodic memor. memor. cir.uit activation memor. deficits memor. enhancement object r.cognition memor. pr.vention of memor. loss r.gulator.of G pr.tein signaling