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Quality-adjusted life years and surgical waiting list:Systematic review of the literature

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World Journal of Gastrointestinal Surgery 2024年第4期16卷 1155-1164页

作者： Roberto de la Plaza Llamas Lorena Ortega Azor Marina Hernández Yuste Ludovica Gorini Raquel Aránzazu Latorre-Fragua daniel Alejandro díaz Candelas Farah Al Shwely Abduljabar Ignacio Antonio Gemio del rey department of General and digestive Surgery Hospital Universitario de GuadalajaraGuadalajara 19002Spain department of Surgery Medical and Social SciencesFaculty of Medicine and Health SciencesUniversity of AlcaláAlcaláde Henares 28871MadridSpain

BACKGROUNd The quality-adjusted life year(QALY)is a metric that is increasingly used today in the field of health economics to evaluate the value of different medical treatments and *** waiting lists(SWLs)represent a pressing problem in public *** QALY measure has rarely been used in the context of *** would be interesting to know how many QALYs are lost by patients on *** To investigate the relationship between QALYs and SWLs in a systematic review of the scientific *** The study was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses *** unlimited search was carried out in PubMed,updated on January 19,*** on the following variables were investigated and analyzed:Specialty,country of study,procedure under study,scale used to measure QALYs,the use of a theoretical or real-life model,objectives of the study and items measured,the economic value assigned to the QALY in the country in question,and the results and conclusions *** Forty-eight articles were selected for the *** data were found regarding QALYs lost on *** specialties in which QALYs were studied the most in relation to the waiting list were urology and general surgery,with 15 articles *** country in which the most studies of QALYs were carried out was the United States(n=21),followed by the United Kingdom(n=9)and Canada(n=7).The most studied procedure was organ transplantation(n=39),including 15 kidney,14 liver,5 heart,4 lung,and 1 ***(n=4),cataract surgery(n=2),bariatric surgery(n=1),mosaicplasty(n=1),and septoplasty(n=1)completed the surgical interventions ***-nine of the models used were theoretical(the most frequently applied being the Markov model,n=34),and nine were *** survey used to measure quality of life in 11 articles was the European Quality of Life-5 dimensions,but in 32 articles the survey was not specified.T

关键词： Quality-adjusted life year Waitlist Quality of life Surgery Systematic review

Two New Taccalonolides from Tropic Plant Tacca subflaellata

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Chinese Chemical Letters 2003年第1期14卷 68-71页

作者： Yue HUANG A.muehlbauer 等 KunmingInstituteofBotany ChineseAcademyofSciencesKuming650204 BayerAG PharmaResearchCenterWuppertalLifeScienceCenterNaturalProductsP.O.Box101709D-42096WuppertalGermany

Two new steroidal bitter principles, taccolanolide O, P have been isolated from Tacca subflaellata and their structures were established by spectroscopic methods.

关键词： Tacca subflaellatea taccalonolides.

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Reimagining large river management using the Resist–Accept–direct(RAd) framework in the Upper Mississippi River

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Ecological Processes 2023年第4期12卷 3-22页

作者： Nicole K.Ward Abigail J.Lynch Erik A.Beever Joshua Booker Kristen L.Bouska Holly Embke jef.rey N.Houser John F.Kocik Joshua Kocik david J.Lawrence Mary Grace Lemon doug Limpinsel Madeline R.Magee Bryan M.Maitland Owen Mc Kenna Andrew Meier John M.Morton jef.rey d.muehlbauer Robert Newman devon C.Oliver Heidi M.Rantala Greg G.Sass Aaron Shultz Laura M.Thompson Jennifer L.Wilkening National Park Service Climate Change Response Program Habitat Conservation division NOAA Wisconsin department of Natural Resources Aquatic Sciences Center Center for Limnology U.S. Geological Survey Northern Prairie Wildlife Research Center and Midwest Climate Adaptation Science Center U.S. Army Corps of Engineers Alaska Wildlife Alliance U.S. Geological Survey Alaska Cooperative Fish and Wildlife Research Unit University of Alaska Fairbanks University of North dakota Great Lakes Indian Fish and Wildlife Commission (GLIFWC) Minnesota department of Natural Resources U.S. Geological Survey National Climate Adaptation Science Center and School of Natural Resources University of Tennessee U.S. Geological Survey National Climate Adaptation Science Center U.S. Geological Survey Northern Rocky Mountain Science Center department of Ecology Montana State University U.S. Fish and Wildlife Service National Wildlife Refuge System U.S. Geological Survey Upper Midwest Environmental Sciences Center U.S. Geological Survey Midwest Climate Adaptation Science Center NOAA NEFSC Orono University of Nebraska-Lincoln

Background Large-river decision-makers are charged with maintaining diverse ecosystem services through unprecedented social-ecological transformations as climate change and other global stressors intensify. The interconnected, dendritic habitats of rivers, which often demarcate jurisdictional boundaries, generate complex management challenges. Here, we explore how the Resist–Accept–direct(RAd) framework may enhance large-river management by promoting coordinated and deliberate responses to social-ecological trajectories of change. The RAd framework identifies the full decision space of potential management approaches, wherein managers may resist change to maintain historical conditions, accept change toward different conditions, or direct change to a specified future with novel conditions. In the Upper Mississippi River System, managers are facing social-ecological transformations from more frequent and extreme high-water events. We illustrate how RAd-informed basin-, reach-, and site-scale decisions could:(1) provide cross-spatial scale framing;(2) open the entire decision space of potential management approaches; and(3) enhance coordinated inter-jurisdictional management in response to the trajectory of the Upper Mississippi River *** The RAd framework helps identify plausible long-term trajectories in different reaches(or subbasins) of the river and how the associated social-ecological transformations could be managed by altering site-scale conditions. Strategic reach-scale objectives may reprioritize how, where, and when site conditions could be altered to contribute to the basin goal, given the basin's plausible trajectories of change(e.g., by coordinating action across sites to alter habitat connectivity, diversity, and redundancy in the river mosaic).Conclusions When faced with long-term systemic transformations(e.g., > 50 years), the RAd framework helps explicitly consider whether or when the basin vision or goals may no longer be achievable,

关键词： Ecosystem Management Transformation Social-ecological system Anthropocene Climate change Basin planning Cross-scale interactions

Initialisation of a hybrid AC/dC power system for harmonic stability analysis using a power flow formulation

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High Voltage 2020年第5期5卷 534-542页

作者： Aleksandra Lekić Hakan Ergun jef Beerten department of Electrical Engineering(ESAT-ELECTA) KU LeuvenLeuvenBelgium

This study presents the initialisation of a hybrid alternating current/direct current(AC/dC)power system to determine the operation point around which the system is linearised as a starting point for an electromagnetic or harmonic stability *** this end,each AC or dC power system component is modelled in the Fourier transform domain and further adjusted to a simplified representation compatible with a power flow *** study also presents how voltage source converter(VSC)high-voltage dC-based systems can be analysed when the different VSC controls are *** result of the power flow solution is then used for the power converters’initialisation.

关键词： AC/dC system formulation

Role of bioengineering structures made of willow cuttings in marly sediment trapping: assessment of three real-size experiments in the Southern French Alps

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Journal of Mountain Science 2018年第2期15卷 225-236页

作者： Freddy rey Univ.Grenoble Alpes Irstea Grenoble

Improving knowledge on the ability of bioengineering structures made of willow cuttings to enhance efficient and sustainable sediment trapping in marly gullies in the Southern French Alps under a mountainous Mediterranean climate, to decreasesediment trapped per experiment, the mean annual values reached 0.25, 0.14 and 0.08 m3 yr-1 in experiments C, A and B, respectively. Maximum values for one structure reached 1.94 m3 per year in experiment C. The significance of the volumes ofsediment yield at their outlets, is a key issue today for the international scientific community working in geosciences and ecology. This study therefore aims to assess three real-size experiments(A, B and C) carried out between 2003 and 2013 in this environment. A total of 157 bioengineering structures using purple and white willow(Salix purpurea and Salix incana)cuttings – which have been shown to resprout and survive more than 2 years after their installation,corresponding to brush layers with brush mats on wooden sills(BLM), 1.2 m wide and 2 m long,installed on the floors of 33 experimental marly gullies, were monitored. The results showed that sediment trapping occurred upstream of the vegetation barriers from the 1 st year *** the depth of sediment trapped per experiment, the mean annual values reached 11.2 cm yr-1 after 3 years in experiment A, 7.7 cm yr-1 after 2–4 years in experiment C and 5.1 cm yr-1 after 5 years in experiment B. Occasionally, BLMs showed that they could trap up to 16 and 15 cm yr-1 in experiments A and C, respectively. Considering the volumes oftrapped sediment and the sustainability of sediment trapping are discussed, and rules for bioengineering strategies are proposed.

关键词： Erosion Marly gully Vegetation barriers Ecological engineering Salix

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Simulation of Spherulite Growth Using a Comprehensive Approach to Modeling the First-Order Isotropic/Smectic-A Mesophase Transition

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Communications in Computational Physics 2010年第2期7卷 301-316页

作者： Nasser Mohieddin Abukhdeir Alejandro d.rey department of Chemical Engineering McGill UniversityMontrealQuebec H3A 2B2Canada

A comprehensive modeling and simulation study of the first-orderisotropic/smectic-A transition is presented and applied to phase diagram computationand two-dimensional spherulite growth. An approach based on nonlinear optimiza-tion, that incorporates experimental data (from 12CB, dodecyl-cyanobiphenyl), is usedto determine physically realistic model parameters. These parameters are then used inconjunction with an optimized phase diagram computation method. Additionally, atime-dependent formulation is presented and applied to the study of two-dimensionalsmectic-A spherulite growth. These results show the growth kinetics and defect dy-namics of nanoscale smectic-A spherulite growth in an isotropic phase with an initiallyradial layer configuration.

关键词： Liquid crystals simulation phase transitions

Whole genome synthesis： from poliovirus to synthetic yeast

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Frontiers of Electrical and Electronic Engineering in China 2017年第1期5卷 105-109页

作者： Junbiao dai Yizhi Cai Yinjing Yuan Huanming Yang jef d. Boeke Center for Synthetic Biology Engineering Research Shenzhen Institutes of Advanced Technology Chinese Academy of Sciences Shenzhen 518055 China School of Biological Sciences The King's Buildings University of Edinburgh EH9 3BF United Kingdom Key Laboratory of Systems Bioengineering (Ministry of Education) SynBio Research Platform Collaborative Innovation Center of Chemical Science and Engineering (Tianjin) School of Chemical Engineering and Technology Tianjin University Tianjin 300072 China BGI-Shenzhen Shenzhen 518083 China Institute for Systems Genetics and department of Biochemistry and Molecular Pharmacology New York University Langone Medical Center New York NY 10011 USA

About thirty years ago when the human genome project （HGP） was first proposed, there was widespread disagreement on whether it was worth spending $3 billion to sequence a genome with only 3% coding sequences, which ... 详细信息

关键词： Genome synthesis Human Genome Project Genomics Poliovirus Outcomes of Education Economy Life sciences

Reimagining large river management using the Resist–Accept–direct(RAd) framework in the Upper Mississippi River

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Ecological Processes 2023年 645-664页

作者： Nicole K.Ward Abigail J.Lynch Erik A.Beever Joshua Booker Kristen L.Bouska Holly Embke jef.rey N.Houser John F.Kocik Joshua Kocik david J.Lawrence Mary Grace Lemon doug Limpinsel Madeline R.Magee Bryan M.Maitland Owen McKenna Andrew Meier John M.Morton jef.rey d.muehlbauer Robert Newman devon C.Oliver Heidi M.Rantala Greg G.Sass Aaron Shultz Laura M.Thompson Jennifer L.Wilkening Minnesota department of Natural Resources U.S.Geological Survey National Climate Adaptation Science Center U.S.Geological Survey Northern Rocky Mountain Science Center department of Ecology Montana State University U.S.Fish and Wildlife Service National Wildlife Refuge System U.S.Geological Survey Upper Midwest Environmental Sciences Center U.S.Geological Survey Midwest Climate Adaptation Science Center NOAA NEFSC Orono University of Nebraska-Lincoln National Park Service Climate Change Response Program Habitat Conservation division NOAA Wisconsin department of Natural Resources Aquatic Sciences Center Center for Limnology U.S.Geological Survey Northern Prairie Wildlife Research Center and Midwest Climate Adaptation Science Center U.S.Army Corps of Engineers Alaska Wildlife Alliance U.S.Geological Survey Alaska Cooperative Fish and Wildlife Research Unit University of Alaska Fairbanks University of North dakota Great Lakes Indian Fish and Wildlife Commission (GLIFWC) U.S.Geological Survey National Climate Adaptation Science Center and School of Natural Resources University of Tennessee

Background Large-river decision-makers are charged with maintaining diverse ecosystem services through unprecedented social-ecological transformations as climate change and other global stressors intensify. The interconnected,dendritic habitats of rivers, which often demarcate jurisdictional boundaries, generate complex management challenges. Here, we explore how the Resist–Accept–direct(RAd) framework may enhance large-river management by promoting coordinated and deliberate responses to social-ecological trajectories of change. The RAd framework identifies the full decision space of potential management approaches, wherein managers may resist change to maintain historical conditions, accept change toward different conditions, or direct change to a specified future with novel conditions. In the Upper Mississippi River System, managers are facing social-ecological transformations from more frequent and extreme high-water events. We illustrate how RAd-informed basin-, reach-, and site-scale decisions could:(1) provide cross-spatial scale framing;(2) open the entire decision space of potential management approaches; and(3) enhance coordinated inter-jurisdictional management in response to the trajectory of the Upper Mississippi River *** The RAd framework helps identify plausible long-term trajectories in different reaches(or subbasins)of the river and how the associated social-ecological transformations could be managed by altering site-scale conditions. Strategic reach-scale objectives may reprioritize how, where, and when site conditions could be altered to contribute to the basin goal, given the basin's plausible trajectories of change(e.g., by coordinating action across sites to alter habitat connectivity, diversity, and redundancy in the river mosaic).Conclusions When faced with long-term systemic transformations(e.g., > 50 years), the RAd framework helps explicitly consider whether or when the basin vision or goals may no longer be achievable, an

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Protein-Repairing Methionine Sulfoxide Reductases in Photosynthetic Organisms： Gene Organization, Reduction Mechanisms, and Physiological Roles

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Molecular Plant 2009年第2期2卷 202-217页

作者： Lionel Tarrago Edith Laugier Pascal rey CEA DSV IBEB Laboratoire d'Ecophysiologie Moleculaire des Plantes B~timent 161 SBVME CEA-Cadarache 13108 Saint-Paul-lez-Durance Cedex France

Methionine oxidation to methionine sulfoxide （MetSO） is reversed by two types of methionine sulfoxide reducrases （MSRs）, A and B, specific to the S- and R-diastereomers of MetSO, respectively. MSR genes are found in most organisms from bacteria to human. In the current review, we first compare the organization of the MSR gene families in photosynthetic organisms from cyanobacteria to higher plants. The analysis reveals that MSRs constitute complex families in higher plants, bryophytes, and algae compared to cyanobacteria and all non-photosynthetic organisms. We also perform a classification, based on gene number and structure, position of redox-active cysteines and predicted sub-cellular localization. The various catalytic mechanisms and potential physiological electron donors involved in the regeneration of MSR activity are then de- scribed. data available from higher plants reveal that MSRs fulfill an essential physiological function during environmental constraints through a role in protein repair and in protection against oxidative damage. Taking into consideration the ex- pression patterns of MSR genes in plants and the known roles of these genes in non-photosynthetic cells, other functions of MSRs are discussed during specific developmental stages and ageing in photosynthetic organisms.

关键词： Genome methionine methionine sulfoxide reductase oxidation photosynthetic organisms protein repair.