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Comparative effectiveness of combined antiplatelet treatments in acute minor ischaemic stroke

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Stroke & Vascular Neurology 2022年第1期7卷 13-21页

作者： Shina kim Joon-Tae kim Ji Sung Lee Beom Joon kim Jong-Moo Park Kyusik Kang Soo Joo Lee Jae Guk kim Jae-Kwan Cha Dae-Hyun kim Tai Hwan Park Sang-Soon Park Kyung Bok Lee Jun Lee Keun-Sik Hong Yong-Jin Cho Hong-Kyun Park Byung-Chul Lee Kyung-Ho Yu Mi Sun Oh Dong-Eog kim Wi-Sun Ryu Jay Chol Choi jee-Hyun Kwon Wook-Joo kim Dong-Ick Shin Sung-Il Sohn Jeong-Ho Hong Man-Seok Park Kang-Ho Choi Ki-Hyun Cho Juneyoung Lee Hee-Joon Bae Department of Neurology Chonnam National University HospitalChonnam National University Medical SchoolGwangjuKorea Clinical Research Center Asan Institute for Life SciencesAsan Medical CenterUniversity of Ulsan College of MedicineSeoulKorea Department of Neurology Cerebrovascular CenterSeoul National University Bundang HospitalSeongnamKorea Department of Neurology Uijeongbu Eulji Medical CenterEulji University School of MedicineUijeongbu-siKorea Department of Neurology Nowon Eulji Medical CenterEulji UniversitySeoulKorea Department of Neurology Eulji University HospitalEulji UniversityDaejeonKorea Department of Neurology Dong-a UniversityBusanKorea Department of Neurology Seoul Medical CenterSeoulKorea Department of Neurology Soonchunhyang University HospitalSeoulKorea Department of Neurology Yeungnam University HospitalDaeguKorea Department of Neurology Inje University Ilsan Paik HospitalInje University College of MedicineGoyangKorea Department of Neurology Hallym University Sacred Heart HospitalAnyangKorea Department of Neurology Dongguk University Ilsan HospitalGoyangKorea Department of Neurology Jeju National University HospitalJeju National University School of MedicineJejuKorea Department of Neurology University of Ulsan College of MedicineUlsanKorea Department of Neurology Chungbuk National University HospitalCheongjuKorea Department of Neurology Keimyung University Dongsan Medical CenterDaeguKorea Department of Biostatistics Korea University College of MedicineSeoulKorea

Background No study has thoroughly compared the effectiveness of combined antiplatelet treatments(other than clopidogrel–aspirin)versus clopidogrel–aspirin or aspirin alone for early secondary prevention in acute ischaemic *** We identified patients with acute,minor,non-cardiogenic ischaemic stroke treated with aspirin alone,clopidogrel–aspirin or other combination *** scores considering the inverse probability of treatment weighting were used to adjust for baseline *** primary outcome was the composite of all strokes(ischaemic or haemorrhagic),myocardial infarction and all-cause mortality at 3 *** Among 12234 patients(male:61.9%;age:65.5±13 years)who met the eligibility criteria,aspirin,clopidogrel–aspirin and other combination treatments were administered in 52.2%,42.9%and 4.9%of patients,*** the crude analysis,the primary outcome event at 3 months occurred in 14.5%of the other combination group,14.4%of the aspirin group and 13.0%of the clopidogrel–aspirin *** the weighted Cox proportional hazards analysis,the 3-month primary outcome event occurred less frequently in the clopidogrel–aspirin group than in the other combination group(weighted HR:0.82(0.59–1.13)),while no association was found between the aspirin group(weighted HR:1.04(0.76–1.44))or other combination group and the 3-month primary *** Other combined antiplatelet treatment,compared with aspirin alone or clopidogrel–aspirin,was not associated with reduced risks of primary composite vascular events or recurrent stroke during the first 3 months after ***,the results suggest that other combination treatments,particularly the cilostazol-based combination,may not be effective alternatives for clopidogrel–aspirin to prevent early vascular events in patients with acute minor *** exploration in clinical trials will be needed.

关键词： prevention treatment alone

Clinical implications of fatty pancreas:Correlations between fatty pancreas and metabolic syndrome

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World Journal of Gastroenterology 2009年第15期15卷 1869-1875页

作者： Jun Seok Lee Sang Heum kim Dae Won Jun jee Hye Han Eun Chul Jang Ji Young Park Byung Kwan Son Seong Hwan kim Yoon Ju Jo Young Sook Park Yong Soo kim Department of Internal Medicine Eulji University School of Medicine Department of Radiology Eulji University School of Medicine Department of Family Medicine Eulji University School of Medicine Department of Occupational and Environmental Medicine College of MedicineSoonchunhyang University Department of Radiology Hanyang University School of Medicine

AIM:To investigate the clinical implications of lipid deposition in the pancreas(fatty pancreas). METHODS:The subjects of this study were 293 patients who had undergone abdominal computed tomography(CT)and *** pancreas was diagnosed by sonographic findings and subdivided into mild,moderate,and severe fatty pancreas groups comparing to the retroperitoneal fat echogenicity. RESULTS:Fatty pancreas was associated with higher levels for visceral fat,waist circumference,aspartate aminotransferase(AST),alanine aminotransferase (ALT),total cholesterol,triglyceride,high density lipoprotein,free fatty acid,γ-GTP,insulin,and the homeostasis model assessment of insulin resistance (HOMA-IR)than the control group(P<0.05).HOMAIR,visceral fat,triglyceride,and ALT also tended to increase with the degree of fat deposition in the pancreas on *** a multivariate logistic regression analysis,HOMA-IR,visceral fat,and ALT level were independently related to fatty pancreas after adjustment for age,body mass index,and lipid *** incidence of metabolic syndrome in the fatty pancreas group was significantly higher than in the control group,and the numbers of metabolic syndrome parameters were significantly higher in the fatty pancreas group(P<0.05).CONCLUSION:Sonographic fatty pancrease showed higher insulin resistance,visceral fat area,triglyceride, and ALT levels than normal *** pancreas also showed a strong correlation with metabolic syndrome.

关键词： Fatty pancreas Metabolic syndrome Insulin resistance

Folate-targeted nanostructured chitosan/chondroitin sulfate complex carriers for enhanced delivery of bortezomib to colorectal cancer cells

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Asian Journal of Pharmaceutical Sciences 2019年第1期14卷 40-51页

作者： Zar Chi Soe Bijay Kumar Poudel Hanh Thuy Nguyen Raj Kumar Thapa Wenquan Ou Milan Gautam Kishwor Poudel Sung Giu Jin jee-Heon Jeong Sae Kwang Ku Han-Gon Choi Chul Soon Yong Jong Oh kim College of Pharmacy Yeungnam University Department of Pharmaceutics University of Pharmacy (Yangon) Department of Pharmaceutical Engineering Dankook University College of Korean Medicine Haany University College of Pharmacy Hanyang University

Folate-targeting self-assembled nanoparticles(NPs) using biocompatible and biodegradable natural polymers chitosan(Cs) and chondroitin sulfate(Chs) were developed to address the major challenge in cancer treatment, the selective delivery of nanoparticles to the target site. In this study, we successfully incorporated a hydrophobic drug, bortezomib(Bor), into folic acid(FA)-conjugated Cs/Chs self-assembled NPs(Bor/Cs/Chs-FA) for colorectal cancer therapy. The particle size and polydispersity index of Bor/Cs/Chs-FA were196.5 ± 1.2 nm and0.21 ± 0.5, respectively. A pH-dependent release profile was observed, facilitating cancer cell-targeted drug release under an acidic tumor microenvironment. Moreover, in vitro data revealed enhanced cellular uptake and apoptosis in folate receptor-expressing colorectal cancer cells(HCT-116 and HT-29) as compared to that in lung cancer cells(A549), which do not express folate receptors. Furthermore, intravenous administration of Bor/Cs/Chs-FA in a HCT-116 bearing xenograft mouse model showed that the NPs were a safe and effective drug delivery system. The results suggest that folate-targeted nanoparticle can be effectively applied for efficient chemotherapy of colorectal cancer.

关键词： Bortezomib Chitosan chondroitin sulfate Colorectal cancer Folic acid

Therapeutic effect of protein transduction domain-conjugated methotrexate in imiquimod-induced psoriasiform dermatitis model

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Therapeutic effect of protein transduction domain-conjugated...

Turbulent-Induced Noise around a Circular Cylinder Using Permeable FW-H Method

The Second Eastern Asia Dermatology Congress(EADC2012)

作者： Dashlkhumbe Byamba Hyunjoong jee Do Young kim Dae Suk kim Sang-Kyou Lee Min-Geol Lee Department of Dermatology and Cutaneous Biology Research Institute Yonsei University College of MedicineSeoulKorea Brain Korea 21 Project for Medical Science Yonsei University College of MedicineSeoulKorea Department of Biotechnology Yonsei University College of Life Science and BiotechnologySeoulKorea

＜正＞Systemic methotrexate（MTX） is an effective treatment for psoriasis being used over 50 ***,common drug-related toxicities such as myelosuppresion,gastrointestinal irritation,nephrotoxicity,hepatotoxicity,and pulmonary fibrosis deter physicians from a prolonged prescription of *** adverse effects may be minimized by

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Journal of Applied Mathematics and Physics 2015年第2期3卷 161-165页

作者： Woen-Sug Choi Suk-Yoon Hong jee-Hun Song Hyun-Wung Kwon Chul-Min Jung Tae-Gyoung kim Departmentof Naval Architecture and Ocean Engineering Seoul National University Seoul Republic of Korea Department of Naval Architecture and Ocean Engineering Chonnam National University Yeosu Republic of Korea Department of Naval Architecture and Ocean Engineering Koje College Koje Republic of Korea Advanced Naval Technology Center NSRDI Agency for Defense Development Chinhae Republic of Korea

Varieties of research on turbulent-induced noise are conducted with combinations of acoustic analogy methods and computational fluid dynamic methods to analyse efficiently and accurately. Application of FW-H acoustic analogy without turbulent noise is the most popular method due to its calculation cost. In this paper, turbulent-induced noise is predicted using RANS turbulence model and permeable FW-H method. For simplicity, noise from 2D cylinder is examined using three different methods: direct method of RANS, FW-H method without turbulent noise and permeable FW-H method which can take into account of turbulent-induced noise. Turbulent noise was well predicted using permeable FW-H method with same computational cost of original FW-H method. Also, ability of permeable FW-H method to predict highly accurate turbulent-induced noise by applying adequate permeable surface is presented. The procedure to predict turbulent- induced noise using permeable FW-H is established and its usability is shown.

关键词： Turbulent-Induced Noise Circular Cylinder Acoustic Analogy FW-H Method Permeable FW-H Method

Dramatic Improvement of Long Lasting Post-Inflammatory Hyperpigmentation by Oral and Topical Tranexamic Acid

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Journal of Cosmetics, Dermatological Sciences and Applications 2012年第2期2卷 62-63页

作者： Jae Kyung kim Sung Eun Chang Chong Hyun Won Mi Woo Lee jee Ho Choi Kee Chan Moon Department of Dermatology Asan Medical Center University of Ulsan College of Medicine Seoul Korea

Post-inflammatory hyperpigmentation is common problem, but its treatment still remains challenging. Tranexamic acid has been used to treat or prevent excessive bleeding loss in various medical conditions. There have been some reports of the effect of oral and topical tranexamic acid for treatment of pigmented disorder. Herein we report on a case of female patient who showed improvement of PIH after oral and topical tranexamic acid administration.

关键词： Post-Inflammatory Hyperpigmentation Tranexamic Acid

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大豆叶面茸毛密度和长度的QTL定位

作物学报 2013年第1期39卷 12-20页

作者：邢光南刘泽稀楠谭连美岳汉王宇峰 kim Hyun-jee 赵团结盖钧镒南京农业大学大豆研究所/国家大豆改良中心/农业部大豆生物学与遗传育种重点实验室/作物遗传与种质创新国家重点实验室江苏南京210095

大豆叶茸毛形态对抗虫性、耐旱性等均有重要作用。本研究利用2个重组自交系群体NJRIKY(KY)和NJRIXG(XG)进行叶面茸毛密度和长度的遗传与QTL定位分析。结果表明,2个性状在2个群体中均有大幅度变异,存在不同程度的超亲分离,两者有极显著... 详细信息

大豆叶茸毛形态对抗虫性、耐旱性等均有重要作用。本研究利用2个重组自交系群体NJRIKY(KY)和NJRIXG(XG)进行叶面茸毛密度和长度的遗传与QTL定位分析。结果表明,2个性状在2个群体中均有大幅度变异,存在不同程度的超亲分离,两者有极显著负相关(r=–0.49和–0.62),叶面茸毛密度的遗传率(75.7%～76.8%)高于叶面茸毛长度的遗传率(45.2%～62.9%);检测到2个叶面茸毛密度主效QTL(XG群体的PD1-1和KY群体的PD12-1,表型贡献率分别达20.7%和21.7%);两群体叶面茸毛密度遗传构成中加性QTL贡献率占20.7%～36.2%,互作QTL只占0～1.4%,而未定位到的微效QTL所占份额很大,为38.1%～56.1%,是以往只用定位程序而未注意遗传构成解析所没有发现的特点;未在KY中检测到叶面茸毛长度加性QTL,互作QTL贡献率也仅4.2%,而微效QTL贡献率达58.7%;但在XG中叶面茸毛长度加性QTL PL1-1和PL12-1贡献率分别达18.3%和22.5%,占主要成分,互作QTL和微效QTL贡献均较小,说明该性状两群体的遗传构成有很大差异。大豆叶面茸毛密度和长度的遗传涉及多个效应不同的基因/QTL。

关键词：大豆茸毛密度茸毛长度 QTL定位

A Study on Water Repellent Effectiveness of Natural Oil-Applied Soil as a Building Material

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Open Journal of Civil Engineering 2015年第1期5卷 139-148页

作者： Jong-Kook Lee jee-Eun Lee Seong-Cheol Park Hee-Dong Cho Hye-Woong Yoo Young-Sang kim Seong-Ryong Ryu Woo-Suk kim Dong-Joon Ahn School of Architecture Kumoh National Institute of Technology Gumi Republic of Korea

This study was performed to investigate the water repellent effectiveness of natural oil-applied soil when it is used as a building material. Natural oil types such as olive oil, bean oil, perilla oil and linseed oil, which are being used for producing water repellent timber, are selected for the experiments. It is expected that perilla oil and in seed oil, which are drying oil types will have better water repellent effectiveness than the other types. For the evaluation of water repellence of natural oil-applied soil, a contact angle test was performed. A contact angle of water drop on various surface conditions were tested, and large differences were seen between the natural oil-applied soil and untreated soil. As a result, it is showed that all natural oil types have water repellent effectiveness. However, linseed oil, which is a drying oil type, shows an outstanding water repellent effectiveness value, while perila oil, which is also a drying oil type, shows the lowest value. Additionally, results show that there is no link between water repellent effectiveness and the number of applications of natural oil. Nevertheless, existing commercial water repellents show better performance than natural oil, and it is anticipated that the results of this study will provide essential information for further research to enhance the water repellent effectiveness of soil as a building material.

关键词： Natural Oil Water Repellent Soil as a Building Material Contact Angle Iodine Value

Incomplete High Radial Nerve Palsy Due to Schwannoma of Radial Nerve in the Upper Arm—A Case Report

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Open Journal of Orthopedics 2017年第2期7卷 72-78页

作者： Hyun Seong Kang Chen Tai Teong jee Eun Park Sang Rim kim Kyu Bum Seo Chang Lim Hyun Kwang Hun Song Department of Orthopedic Surgery Jeju National University School of Medicine Jeju Korea Department of Pathology Jeju National University School of Medicine Jeju Korea Department of Orthopedic Surgery SOO Hospital Jeonju Korea

A schwannoma is a benign soft tissue tumor composed of Schwann cells. Clinically, the tumor is slow-growing and usually asymptomatic, rarely developing neurological symptoms. We present a case of a 44-year-old female who was diagnosed with an incomplete high radial nerve palsy, showing a wrist drop and extension of fingers due to schwannoma on the radial nerve of the upper arm. The patient showed excellent result after excision of the schwannoma and neurorrhaphy of the radial nerve.

关键词： Radial Nerve Schwannoma Wrist Drop Incomplete High Radial Nerve Palsy