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Diurnal Variations of Summer Precipitation in the Beijing Area and the Possible Effect of Topography and Urbanization

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Advances in Atmospheric Sciences 2011年第4期28卷 725-734页

作者：殷水清李维京 Deliang CHEN jee-hoon jeong 郭文利 State Key Laboratory of Earth Surface Processes and Resource Ecology Beijing Normal University Beijing 100875 School of Geography Beijing Normal University Beijing 100875 Beijing Climate Center China Meteorological Administration Beijing 100081 Department of Earth Sciences University of Gothenburg Gothenburg 40530 Sweden Beijing Regional Climate Center Beijing Meteorological Bureau Beijing 100089

The present study examined the diurnal variations of summer precipitation in the Beijing area by usingsubdaily precipitation and wind observations. A combined effect of topography and urbanization on thecharacteristics of diurnal variations was suggested. It was shown that stations located in the plain areaexhibited typical night rain peaks, whereas those in the mountainous area exhibited clear afternoon peaks ofprecipitation diurnal variations. The precipitation peaks were associated with wind fields around the Beijingarea, which were found to be highly modulated by mountain-valley circulation and urban-country *** lower-tropospheric wind exhibited a clear diurnal shift in its direction from north at 0800 LST to southat 2000 LST, which reflected mountain-valley circulation. The transitions from valley to mountain windand the opposite generally happened after sunset and sunrise, respectively, and both occurred earlier for thestations located closer to mountains. By comparing the diurnal variations of precipitation at stations in anortheast suburb, an urban area, and a southwest suburb, it was revealed that the northeast suburb grouphad the highest normalized rainfall frequency, but the southwest group had the lowest from late afternoon tolate evening. On the contrary, in the early morning from about 0200 to 1000 LST, the southwest group andurban group had the highest normalized rainfall frequency. This pattern might originate from the combinedeffects of mountain-valley topography and urbanization.

关键词： diurnal variations precipitation mountain-valley circulation urban effect Beijing area

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Characteristics of Atmospheric Circulation Associated with Cold Surge Occurrences in East Asia:A Case Study During 2005/06 Winter

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Advances in Atmospheric Sciences 2008年第5期25卷 791-804页

作者： Tae-Won PARK jee-hoon jeong Chang-Hoi HO Seong-Joong KIM School of Earth and Environmental Sciences Seoul National University Seoul Korea Department of Earth Sciences University of Gothenburg Gothenburg Sweden Korea Polar Research Institute Incheon Korea

The characteristics of the upper-level circulation and thermodynamical properties for the period when two distinct cold surges broke out over East Asia during the 2005/06 winter are investigated. From early December 2005 to early January 2006, exceptionally cold weather lasted for approximately one month due to two successive cold surges that took place on 2 December 2005 and 2 January 2006, respectively. This study reveals that both involve the upper-tropospheric circulation, which induces the amplification and expansion of the surface Siberian high toward East Asia, but arose from different causes： the former is caused by the upper-level blocking originated from the North Pacific and the latter is caused by the upper-level wave train across the Eurasian Continent. In particular, it is suggested that the lower-tropospheric anomalous wind caused by upper-level circulation anomalies and a steep meridional temperature gradient amplified by phase-locked annual cycle combined to induce very strong cold advection in East Asia, which resulted in exceptionally cold weather that lasted for several weeks. The present results emphasize that the characteristics of the upper-tropospheric circulation can be considered as important precursors to cold surge occurrences in East Asia.

关键词： cold surge Siberian high East Asia East Asian winter monsoon upper-tropospheric circulation

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Alveolar macrophage phagocytosis-evading inhaled microgels incorporating nintedanib-PLGA nanoparticles and pirfenidone-liposomes for improved treatment of pulmonary fibrosis

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Bioactive Materials 2024年第3期33卷 262-278页

作者： Woo Tak Lee Hyunjun Lee Juho Kim Yujin Jung Eojin Choi Ji hoon jeong jee-Heon jeong Jung Heon Lee Yu Seok Youn School of Pharmacy Sungkyunkwan University2066 Seobu-roJangan-guSuwonGyeonggi-do16419Republic of Korea Department of Precision Medicine School of MedicineSungkyunkwan University2066 Seobu-roJangan-guSuwon16419Republic of Korea School of Advanced Materials Science and Engineering Sungkyunkwan University2066 Seobu-roJangan-guSuwon16419Republic of Korea

Idiopathic pulmonary fibrosis(IPF)is a chronic inflammatory and fibrotic response-driven lung disease that is difficult to cure because it manifests excessive profibrotic cytokines(e.g.,TGF-β),activated myofibroblasts,and accumulated extracellular matrix(ECM).In an attempt to develop an inhalation formulation with enhanced antifibrotic efficacy,we sought to fabricate unique aerosolizable inhaled microgels(μGel)that contain nintedanib-poly(lactic-co-glycolic acid)(PLGA)nanoparticles(NPs;n-PN)and pirfenidone-liposomes(p-LP).The aero-μGel was~12μm,resisted phagocytosis by alveolar macrophages in vitro and in vivo,and protected inner-entrapped n-PN and *** n-PN/p-LP@aero-μGel caused enhanced/extended antifibrotic efficacy in a bleomycin-induced pulmonary fibrosis mouse presumably due to prolonged lung ***,the results obtained by intratracheal aerosol insufflation of our n-PN/p-LP@aero-μGel twice a week were much better than those by as many as seven doses of single or mixed applications of n-PN or *** antifibrotic/pharmacokinetic results for the n-PN/p-LP@aero-μGel included reduced fibrosis progression,restored lung physiological functions,deactivated myofibroblasts,inhibited TGF-βprogression,and suppressed ECM component production(collagen I andα-SMA)along with prolonged lung retention *** believe that our n-PN/p-LP@aero-μGel increased the local availability of both nintedanib and pirfenidone due to evasion of alveolar macrophage phagocytosis and prolonged lung retention with reduced systemic *** this approach,our inhalation formulation subsequently attenuated fibrosis progression and improved lung ***,these results hold profound implications in the therapeutic potential of our n-PN/p-LP@aero-μGel to serve as a clinically promising platform,providing significant advancements for improved treatment of many respiratory diseases including IFP.

关键词： Aerosolizable microgel Lung retention Extracellular matrix Pro-inflammatory cytokines Idiopathic pulmonary fibrosis

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What is the appropriate strategy for diagnosing NAFLD using ultrasonography in obese children?

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World Journal of Pediatrics 2017年第3期13卷 248-254页

作者： jee Hyun Lee Su Jin jeong Department of Pediatrics Ansan HospitalKorea University Medical CenterCollege of MedicineKorea University Department of Pediatrics Bundang CHA Medical CenterCHA University School of MedicineKorea

Background:The aim of this study is to identify obese children who are candidates for a potential diagnosis of non-alcoholic fatty liver disease (NAFLD).Methods:We enrolled 242 obese children (122 boys and 120 girls) aged 7-16 years who were examined with abdominal ultrasonography in our pediatric obesity *** compared patients in the normal group with those in the NAFLD group (mild disease,moderate to severe disease) and identified the optimal anthropometric parameters among height,weight,body mass index (BMI),waist circumference,hip circumference,waist to height ratio (WHtR),and waist to hip ratio to predict NAFLD using a receiver operating characteristic curve *** also investigated risk factors associated with NAFLD for the anthropometric parameters and the biochemical model using logistic ***:The high-and low-risk groups for hepatic steatosis relative to a WHtR of 0.56 as the standard point showed significant differences in hepatic steatosis severity grade (P0.56 (2.25,1.05-4.81),and waist circumference >90th percentile (20.22,9.21-44.36) in the anthropometric parameter model and elevated alanine aminotransferase levels (boys >25.8 U/L,girls >22.1 U/L) (6.93,2.52-19.03),hypertriglyceridemia (>110 mg/dL) (3.80,1.23-11.75),and triglyceride to HDL cholesterol ratio >3 (9.23,2.95-8.83) in the biochemical parameter ***:A diagnostic approach to hepatic steatosis is recommended as part of the proper screening and stratification of risk factors in obese *** is a simple and convenient method of effectively identifying obese children who are candidates for hep

关键词： hepatic steatosis non-alcoholic fatty liver disease obesity waist-to-height ratio

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Uncontrolled high blood pressure under total intravenous anesthesia with propofol and remifentanil:A case report

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World Journal of Clinical Cases 2022年第26期10卷 9411-9416页

作者： Min Jung Jang jee Hee Kim Hae jeong jeong Anesthesiology and Pain Medicine National Cancer CenterGoyang 10408South Korea

BACKGROUND Although propofol generally reduces blood pressure,rarely,it causes ***,the mechanism by which propofol increases blood pressure has not been established,and so far,there are only a few reported *** SUMMARY A 46-year-old woman,diagnosed with thyroid cancer,was administered general anesthesia with propofol and remifentanil for a thyroid *** increase in the concentrations of intravenous anesthetics further increased her blood *** blood pressure remained stable when anesthesia was maintained with sevoflurane and remifentanil after the interruption of propofol *** We concluded that propofol administration was the cause of increased blood pressure.

关键词： Anesthesia Intravenous Hypertension Propofol Remifentanil Tachycardia Case report

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Primary endoscopic approximation suture under cap-assisted endoscopy of an ERCP-induced duodenal perforation

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World Journal of Gastroenterology 2010年第18期16卷 2305-2310页

作者： Tae hoon Lee Byoung Wook Bang jee In jeong Hyung Gil Kim Seok jeong Seon Mee Park Don Haeng Lee Sang-Heum Park Sun-Joo Kim Division of Gastroenterology Department of Internal MedicineSoon Chun Hyang University College of MedicineCheonan Hospital Division of Gastroenterology Department of Internal MedicineInha University School of Medicine Division of Gastroenterology Department of Internal MedicineChungbuk National University College of Medicine

Duodenal perforation during endoscopic retrograde cholangiopancreatography(ERCP) is a rare complication,but it has a relatively high mortality *** diagnosis and prompt management are key factors for the successful treatment of ERCP-related *** management of perforation can initially be conservative in cases resulting from sphincterotomy or guide wire ***,the current standard treatment for duodenal free wall perforation is surgical ***,several case reports of endoscopic closure techniques using endoclips,endoloops,or fully covered metal stents have been *** describe four cases of iatrogenic duodenal bulb or lateral wall perforation caused by the scope tip that occurred during ERCP in tertiary referral *** the cases were simply managed by endoclips under transparent capassisted *** on the available evidence and our experience,endoscopic closure was a safe and feasible method even for duodenoscope-induced *** results suggest that endoscopists may be more willing to use this treatment.

关键词： Duodenal perforation Endoscopic retrograde cholangiopancreatography Endoscopic therapy Endoclip

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Adiponectin restores the obesity-induced impaired immunomodulatory function of mesenchymal stromal cells via glycolytic reprogramming

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Acta Pharmaceutica Sinica B 2024年第1期14卷 273-291页

作者： Duc-Vinh Pham Thi-Kem Nguyen Bao-Loc Nguyen Jong-Oh Kim jee-Heon jeong Inho Choi Pil-hoon Park Department of Pharmacology Hanoi University of PharmacyHanoi 100000Viet Nam College of Pharmacy Yeungnam UniversityGyeongsan 38541Republic of Korea Department of Medical Biotechnology Yeungnam UniversityGyeongsan 38541Republic of Korea Research Institute of Cell Culture Yeungnam UniversityGyeongsan 38541Republic of Korea Department of Precision Medicine School of MedicineSungkyunkwan UniversitySuwon 16419Republic of Korea

Obesity has been known to negatively modulate the life-span and immunosuppressive potential of mesenchymal stromal cells(MSC).However,it remains unclear what drives the compromised potency of obese *** this study,we examined the involvement of adiponectin,an adipose tissuederived hormone,in obesity-induced impaired therapeutic function of ***-induced obesity leads to a decrease in serum adiponectin,accompanied by impairment of survival and immunomodulatory effects of adipose-derived MSC(ADSC).Interestingly,priming with globular adiponectin(gAcrp)improved the immunomodulatory potential of obese *** effects were also observed in lean *** addition,gAcrp potentiated the therapeutic effectiveness of ADSC in a mouse model of DSS-induced ***,while obesity inhibited the glycolytic capacity of MSC,gAcrp treatment induced a metabolic shift toward glycolysis through activation of adiponectin receptor type 1/p38 MAPK/hypoxia inducible factor-1a *** findings suggest that activation of adiponectin signaling is a promising strategy for enhancing the therapeutic efficacy of MSC against immune-mediated disorders.

关键词： Adiponectin Adipose-derived stromal cells Colitis Glycolytic induction HIF1a Immunomodulation Mesenchymal stromal cells Obesity

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A Delayed Stochastic Volatility Correction to the Constant Elasticity of Variance Model

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Acta Mathematicae Applicatae Sinica 2016年第3期32卷 611-622页

作者： Min-Ku LEE jeong-hoon KIM Department of Mathematics Kunsan National University Department of Mathematics Yonsei University

The Black-Scholes model does not account non-Markovian property and volatility smile or skew although asset price might depend on the past movement of the asset price and real market data can find a non-flat structure of the implied volatility surface. So, in this paper, we formulate an underlying asset model by adding a delayed structure to the constant elasticity of variance （CEV） model that is one of renowned alternative models resolving the geometric issue. However, it is still one factor volatility model which usually does not capture full dynamics of the volatility showing discrepancy between its predicted price and market price for certain range of options. Based on this observation we combine a stochastic volatility factor with the delayed CEV structure and develop a delayed hybrid model of stochastic and local volatilities. Using both a martingale approach and a singular perturbation method, we demonstrate the delayed CEV correction effects on the European vanilla option price under this hybrid volatility model as a direct extension of our previous work [12].

关键词： constant elasticity variance , delay stochastic volatility martingale option pricing

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Pharmacologic treatment of depression in patients with myocardial infarction

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Journal of Geriatric Cardiology 2011年第2期8卷 121-126页

作者： jeong-hoon Ha Cheuk-Kit Wong Department of Cardiology Dunedin School of Medicine Dunedin Public Hospital University of Otago Dunedin 9001 New Zealand

Depression is a common medical problem and is more prevalent among patients with coronary artery disease. Whether early detection and treatment of depression will enhance cardiovascular outcome is uncertain. Obviously, the safety and efficacy of the anti-depression drugs is an important link. This article reviews the patho-physiologic and behavioural links between depression and cardiovascular disease progression, the treatment of depression, and the potential benefits of anti-depressants in patients with coronary disease.

关键词： depression coronary disease pharmacologic treatment

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Influence of external loading and halocline on phosphorus release from sediment in an artificial tidal lake

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International Journal of Sediment Research 2020年第2期35卷 146-156页

作者： Yong-hoon jeong Dong-Heui Kwak Industry-Academia Collaboration Foundation Chonbuk National University Center for jeongeup Industry-Academy Cooperation Chonbuk National University

Many of the dams built in estuaries in the last century have difficulty with water quality *** factors have affected the estuary lake water,most importantly external loadings,tidal currents,and increases in the phosphorus(P) release from sediment,so that most water quality characteristics in the estuary are highly interactive and *** the current study,water quality measurements were made in the laboratory and field,and a series of phosphorus release experiments was done to understand the behavior of P in an estuary *** concentrations of chemical oxygen demand(COD),chlorophyll-a(Chl-a),and total P(TP) showed an increasing trend when the pollutant loading of the influent stream water was *** measurements showed increasing trends,which indicates the constituents are produced in the internal environment of the *** a large amount of freshwater flowed in from the upper watershed,density stratification was observed,which forms strongly because of the salinity of *** the period of stratification,a hypoxic layer formed,which can accelerate P *** the open and dosed conditions of the release experiments,the P release rate was much higher under the closed condition than under the open *** maximum P release rates from the sediment collected from the five main sites of the lake were more than 2.5 times the P loading from the inflowing streams in ***,the release rate was higher mid-reservoir than down-reservoir where a halocline was evident The pollutant load discharged from the tributary watershed was deposited on the bottom mid-reservoir,whereas it was washed out downreservoir because of the density stratification and strong tide in that *** sustainably manage water quality and decrease lake eutrophication in brackish environments formed by freshwater from streams mixing with seawater entering through sluice dikes,different measures than those applied in strictly freshwater environments ar

关键词： Estuary Halocline Phosphorus release Reservoir Sediment Stratification

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