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Real-world Effectiveness and Tolerability of Interferonfree Direct-acting Antiviral for 15,849 Patients with Chronic Hepatitis C:A Multinational Cohort Study

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Journal of Clinical and Translational Hepatology 2024年第7期12卷 646-658页

作者： Fanpu Ji Sally Tran Eiichi Ogawa Chung-Feng huang Takanori Suzuki Yu Jun Wong Hidenori Toyoda Dae Won Jun Liu Li Haruki Uojima Akito Nozaki Makoto Chuma Cheng-Hao Tseng Yao-Chun Hsu Masatoshi Ishigami Takashi Honda Masanori Atsukawa Hiroaki Haga Masaru Enomoto Huy Trinh Carmen Monica Preda Phillip Vutien Charles Landis Dong Hyun Lee Tsunamasa Watanabe Hirokazu Takahashi Hiroshi Abe Akira Asai Yuichiro Eguchi Jie Li Xiaozhong Wang Jia Li Junping Liu Jing Liang Carla Pui-Mei Lam Rui huang Qing Ye Hongying Pan Jiajie Zhang Dachuan Cai Qi Wang Daniel Q.huang Grace Wong Vincent Wai-Sun Wong Junyi Li Son Do Norihiro furusyo Makoto Nakamuta Hideyuki Nomura Eiji Kajiwara Eileen L.Yoon Sang Bong Ahn Koichi Azuma Kazufumi Dohmen Jihyun An Do Seon Song Hyun Chin Cho Akira Kawano Toshimasa Koyanagi Aritsune Ooho Takeaki Satoh Kazuhiro Takahashi Ming-Lun Yeh Pei-Chien Tsai Satoshi Yasuda Yunyu Zhao Yishan Liu Tomomi Okubo Norio Itokawa Mi Jung Jun Toru Ishikawa Koichi Takaguchi Tomonori Senoh Mingyuan Zhang Changqing Zhao Raluca Ioana Alecu Wei Xuan Tay Pooja Devan Joanne Kimiko Liu Ritsuzo Kozuka Elena Vargas-Accarino Ai-Thien Do Mayumi Maeda Wan-Long Chuang jee-fu huang Chia-Yen Dai Ramsey Cheung Maria Buti Junqi Niu Wen Xie Hong Ren Seng Gee Lim Chao Wu Man-fung Yuen Jia Shang Qiang Zhu Yoshiyuki Ueno Yasuhito Tanaka Jun Hayashi Ming-Lung Yu Mindie H.Nguyen Department of Infectious Diseases The Second Affiliated Hospital of Xi’an Jiaotong UniversityXi’anShaanxiChina Division of Gastroenterology and Hepatology Department of MedicineStanford University Medical CenterPalo AltoCAUSA Department of General Internal Medicine Kyushu University HospitalFukuokaJapan Hepatobiliary Division Department of Internal MedicineKaohsiung Medical University HospitalKaohsiung Hepatitis Research Center College of Medicine and Center for Liquid Biopsy and Cohort ResearchKaohsiung Medical UniversityKaohsiung Department of Gastroenterology and Metabolism Nagoya City University Graduate School of Medical SciencesNagoyaJapan Gastroenterology&Hepatology Changi General HospitalSinghealthSingapore Singhealth Duke-NUS Medicine Academic Clinical Program Singapore Department of Gastroenterology Ogaki Municipal HospitalOgakiJapan Department of Internal Medicine Hanyang UniversityCollege of MedicineSeoulKorea Hanyang Institute of Bioscience and Biotechnology Hanyang UniversitySeoulKorea Department of Hepatology The Third People's Hospital of Kunming CityKunmingYunnanChina Department of Gastroenterology Internal MedicineKitasato University School of MedicineSagamiharaJapan Gastroenterological Center Yokohama City University Medical CenterYokohamaJapan Division of Gastroenterology and Hepatology Department of Internal MedicineE-Da Cancer HospitalKaohsiung Department of Gastroenterology and Hepatology Nagoya University Graduate School of MedicineNagoyaJapan Division of Gastroenterology and Hepatology Nippon Medical SchoolTokyoJapan Department of Gastroenterology Yamagata University Faculty of MedicineYamagataJapan Department of Transfusion Medicine and Department of Hepatology Osaka Metropolitan University Graduate School of MedicineOsakaJapan San Jose Gastroenterology San JoseCAUSA Gastroenterology&Hepatology Department Clinic Fundeni InstituteBucharestRomania Division of Gastroenterology and Hepatology University of WashingtonSeattleWAUSA Department of

Background and Aims:As practice patterns and hepatitis C virus(HCV)genotypes(GT)vary geographically,a global real-world study from both East and West covering all GTs can help inform practice policy toward the 2030 HCV elimination *** study aimed to assess the effectiveness and tolerability of DAA treatment in routine clinical practice in a multinational cohort for patients infected with all HCV GTs,focusing on GT3 and ***:We analyzed the sustained virological response(SVR12)of 15,849 chronic hepatitis C patients from 39 Real-World Evidence from the Asia Liver Consortium for HCV clinical sites in Asia Pacific,North America,and Europe between 07/01/2014–07/01/***:The mean age was 62±13 years,with 49.6%*** demographic breakdown was 91.1%Asian(52.9%Japanese,25.7%Chinese/Taiwan residents,5.4%Korean,3.3%Malaysian,and 2.9%Vietnamese),6.4%White,1.3%Hispanic/Latino,and 1%Black/***,34.8%had cirrhosis,8.6%had hepatocellular carcinoma(HCC),and 24.9%were treatment-experienced(20.7%with interferon,4.3%with direct-acting antivirals).The largest group was GT1(10,246[64.6%]),followed by GT2(3,686[23.2%]),GT3(1,151[7.2%]),GT6(457[2.8%]),GT4(47[0.3%]),GT5(1[0.006%]),and untyped GTs(261[1.6%]).The overall SVR12 was 96.9%,with rates over 95%for GT1/2/3/6 but 91.5%for ***12 for GT3 was 95.1%overall,98.2%for GT3a,and 94.0%for ***12 was 98.3%overall for GT6,lower for patients with cirrhosis and treatment-experienced(TE)(93.8%)but≥97.5%for tretment-naive patients regardless of cirrhosis *** multivariable analysis,advanced age,prior treatment failure,cirrhosis,active HCC,and GT3/4 were independent predictors of lower SVR12,while being Asian was a significant predictor of achieving ***:In this diverse multinational realworld cohort of patients with various GTs,the overall cure rate was 96.9%,despite large numbers of patients with cirrhosis,HCC,TE,and GT3/***12 for GT3/6 with cirrhosis and TE was lower but st

关键词： Hepatitis C virus Liver cirrhosis Hepatocellular carcinoma Genotype DAA REAL-C

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Energy absorption behaviors of a novel buffer lander-leg with Yoshimura core

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Chinese Journal of Aeronautics 2024年第4期37卷 333-342页

作者： Yan XU He huang Chao ZHANG Rongji fu School of Aeronautics and Astronautics Zhejiang UniversityHangzhou 310027China School of Mechanics Civil Engineering and Architecture Northwestern Polytechnical UniversityXi’an 710072China

In the current soft-landing system,the lander-leg and the buffer are two independent parts which may cause weight *** traditional mechanical buffers also have their own shortcomings such as small buffer stroke and being non-reusable.A Novel Buffer Lander-leg with Yoshimura core (NBLY) is proposed in this paper,inspired by the Buckling Restrained Brace(BRB).The design details of NBLY and parameter definitions of the core are *** finite element analysis modes have been employed to analyze the nonlinear mechanical behaviors of NBLY subjected to the cyclic *** with four different core styles of hexagon,octagon,dodecagon and hexadecagon are analyzed and *** restraining ratio and cumulative dissipation energy ratio have been obtained to evaluate the energy absorption *** results show that the origami pattern has significant influences on the deformation ductility,plastic energy absorbing and axial load transferring to the *** NBLY with octagon core has outstanding properties,especially the hysteretic energy dissipation and enhancement of compression *** interaction mechanism between the core and encasing member constrains the deformation extensions and contributes to the frictional energy dissipation of the *** paper provides a new conceptual design of buffer lander-leg for soft-landing *** can realize the reuse function as a buffer lander-leg with better loading-bearing and energy absorption behaviors.

关键词： Lander-leg structure Origami Energy absorption Cyclic loading Finite element analysis

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Strip method to construct a two-dimensional quasilattice witheight-fold symmetry

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Chinese Physics B 2024年第9期33卷 462-465页

作者： Weishen huang Xiujun fu School of Physics and Optoelectronics South China University of TechnologyGuangzhou 510640China

Based on the substitution rule and symmetry, we propose a method to generate an octagonal quasilattice consisting ofsquare and rhombus tiles. Local configurations and Ammann lines are used to guide the growth of the tiles in a quasiperiodicorder. The structure obtained is a perfect eight-fold symmetric quasilattice, which is confirmed by the radial distributionfunction and the diffraction pattern.

关键词： quasicrystals eight-fold symmetry Ammann–Beenker tiling

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Treatment efficacy for patients with chronic hepatitis C and preexisting hepatocellular carcinoma by directly acting antivirals

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Hepatoma Research 2020年第4期6卷 30-38页

作者： Chia-Yen Dai Chung-Feng huang Meng-Hsuan Hsieh Ching-I huang Ming-Lun Yeh Pei-ChienTsai Ching-Chih Lin Meng-Szu Lee Jeng-fu Yang Po-Yao Hsu Yu-Ju Wei Cheng-Ting Hsu Po-Cheng Liang Yi-Hung Lin jee-fu huang Wan-Long Chuang Ming-Lung Yu Hepatobiliary Division Department of Internal MedicineKaohsiung Medical University HospitalKaohsiung Medical UniversityKaohsiung 807Taiwan Health Management Center&Department of Community Medicine Kaohsiung Medical University HospitalKaohsiung Medical UniversityKaohsiung 807Taiwan Faculty of Internal Medicine College of MedicineKaohsiung Medical UniversityKaohsiung 807Taiwan Department of Biological Science and Technology College of Biological Science and TechnologyNational Chiao Tung UniversityHsin-ChuKaohsiung 807Taiwan

Aim:Despite the high cure rate of interferon-free directly acting antivirals(DAAs)for chronic hepatitis C(CHC)patients,the treatment efficacy for patients with preexisting hepatocellular carcinoma(HCC)remains *** aimed in the present study to address the issue by using novel DAAs in treating CHC patients who were adherent to treatment in ***:CHC patients with or without HCC were consecutively *** primary objective was sustained virological response(SVR)defined as undetectable HCV RNA throughout 12 weeks of a post-treatment follow-up period(SVR12).Only patients with available SVR12 were enrolled for final ***:A total of 1237 patients(1113 non-HCC,101 inactive HCC and 23 active HCC)were *** overall SVR12 rate was 98.9%,and was similar between HCV patients with and without pre-existing HCC(98.4%vs.98.9%,P=0.64).While HCC patients were classified as those who had active or inactive HCC,the SVR12 was also similar between patients with and without active HCC(95.7%vs.99.0%,P=0.34).Among the 101 patients without viable HCC at the time of DAA initiation,eighty-four patients exhibited curative therapy and the other 17 ;patients experienced HCC recurrence before *** the 23 patients with viable HCC at the time of DAA treatment,10 patients had received curative therapy for HCC whereas the remaining 13 patients had HCC that was never *** SVR12 rates were also similar among the four subpopulations,being 98.8%(83/84),100%(17/17),90%(9/10)and 100%(13/13)***:CHC patients with HCC who were adherent to potent DAAs achieved similar SVR12 rate compared to those without HCC and could be effectively treated.

关键词： Directly acting antiviral chronic hepatitis C hepatitis C virus hepatocellular carcinoma sustained virological response

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Community-centered Disease Severity Assessment of Metabolic Dysfunction-associated Fatty Liver Disease

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Journal of Clinical and Translational Hepatology 2023年第5期11卷 1061-1068页

作者： jee-fu huang Pei-Chien Tsai Ming-Lun Yeh Chung-Feng huang Ching-I huang Mei-Hsuan Lee Po-Yau Hsu Chih-Wen Wang Yu-Ju Wei Po-Cheng Liang Yi-Hung Lin Meng-Hsuan Hsieh Jeng-fu Yang Ming-Yen Hsieh Tyng-Yuan Jang Ming-Jong Bair Zu-Yau Lin Chia-Yen Dai Ming-Lung Yu Wan-Long Chuang Hepatobiliary Division Department of Internal MedicineKaohsiung Medical University HospitalKaohsiung Medical UniversityKaohsiung Graduate Institute of Clinical Medicine Kaohsiung Medical UniversityKaohsiung Faculty of Internal Medicine College of MedicineKaohsiung Medical UniversityKaohsiung Center for Liquid Biopsy and Cohort Research Kaohsiung Medical UniversityKaohsiung Institute of Clinical Medicine National Yang Ming Chiao Tung UniversityTaipei Department of Preventive Medicine Kaohsiung Medical University HospitalKaohsiung Division of Gastroenterology Department of Internal MedicineTaitung Mackay Memorial HospitalTaitung Mackay Medical College New Taipei City School of Medicine and Doctoral Program of Clinical and Experimental Medicine College of MedicineNational Sun Yat-sen UniversityKaohsiung Center of Excellence for Metabolic Associated Fatty Liver Disease National Sun Yat-sen UniversityKaohsiung

Background and Aims:Disease severity across the different diagnostic categories of metabolic dysfunction-associated fatty liver disease(MAFLD)remains *** study assessed the fibrosis stages and features of MAFLD between different *** also aimed to investigate the associations between advanced fibrosis and risk ***:This multicenter cross-sectional study enrolled adults participating in liver disease screening in the *** were stratified following MAFLD diagnostic criteria,to group A(395 patients)for type 2 diabetes,group B(1,818 patients)for body mass index(BMI)>23 kg/m^(2),and group C(44 patients)for BMI≤23kg/m^(2) with at least two metabolic *** fibrosis was defined as a fibrosis-4 index>***:Between 2009 and 2020,1,948 MAFLD patients were recruited,including 478 with concomitant liver *** fibrosis was observed in 125 patients.A significantly larger proportion of patients in group C(25.0%)than in group A(7.6%)and group B(5.8%)had advanced fibrosis (p<0.01).Logistic regression analysis found that hepatitis B virus(HBV)/hepatitis C virus(HCV)coinfection(odds ratio[OR]:12.14,95%confidence interval[CI]:4.04-36.52;p<0.01),HCV infection(OR:7.87,95%CI:4.78-12.97;p<0.01),group C(OR:6.00,95%CI:2.53-14.22;p<0.01),and TC/LDL-C(OR:1.21,95%CI:1.06-1.38;p<0.01)were significant predictors of advanced ***:A higher proportion of lean MAFLD patients with metabolic abnormalities had advanced *** infection was significantly associated with advanced fibrosis.

关键词： Metabolic dysfunction-associated fatty liver disease Fibrosis-4 index Advanced fibrosis Community screening Viral hepatitis

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Solar fuel production through concentrating light irradiation

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Green Energy & Environment 2024年第10期9卷 1550-1580页

作者： Yiwei fu Yi Wang Jie huang Kejian Lu Maochang Liu International Research Center for Renewable Energy State Key Laboratory of Multiphase Flow Xi'an Jiaotong University Suzhou Academy of Xi'an Jiaotong University

The climate crisis necessitates the development of non-fossil energy sources. Harnessing solar energy for fuel production shows promise and offers the potential to utilize existing energy infrastructure. However, solar fuel production is in its early stages of development, constrained by low conversion efficiency and challenges in scaling up production. Concentrated solar energy(CSE) technology has matured alongside the rapid growth of solar thermal power plants. This review provides an overview of current CSE methods and solar fuel production, analyzes their integration compatibility, and delves into the theoretical mechanisms by which CSE impacts solar energy conversion efficiency and product selectivity in the context of photo-electrochemistry, thermochemistry, and photo-thermal co-catalysis for solar fuel production. The review also summarizes approaches to studying the photoelectric and photothermal effects of CSE. Lastly, it explores emerging novel CSE technology methods in the field of solar fuel production.

关键词： Concentrated solar energy Solar fuel Photo-electrochemistry Thermochemistry Photo-thermal co-catalysis

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Risk Assessment of Deep-Water Horizontal X-Tree Installation

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China Ocean Engineering 2024年第2期38卷 210-220页

作者： MENG Wen-bo fu Guang-ming huang Yi LIU Shu-jie huang Liang GAOYong-hai CNOOC China Limited Zhanjiang BranchZhanjiang 524057China Key Laboratory of Unconventional Oil and Gas Development Ministry of Education(China University of Petroleum(East China))Qingdao 266580China

Due to the high potential risk and many influencing factors of subsea horizontal X-tree installation,to guarantee the successful completion of sea trials of domestic subsea horizontal X-trees,this paper established a modular risk evaluation model based on a fuzzy fault ***,through the analysis of the main process oftree down and combining the Offshore&Onshore Reliability Data(OREDA)failure statistics and the operation procedure and the data provided by the job,the fault tree model of risk analysis of the tree down installation was ***,by introducing the natural language of expert comprehensive evaluation and combining fuzzy principles,quantitative analysis was carried out,and the fuzzy number was used to calculate the failure probability of a basic event and the occurrence probability of a top ***,through a sensitivity analysis of basic events,the basic events of top events significantly affected were determined,and risk control and prevention measures for the corresponding high-risk factors were proposed for subsea horizontal X-tree down installation.

关键词： subsea horizontal X-tree risk assessment fuzzy fault tree modular risk evaluation model

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Nickel-catalyzed arylcyanation of alkenes via cyano group translocation:access to 1,n-dinitriles or 4-amino nitriles

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Science China Chemistry 2024年第9期67卷 2975-2981页

作者： Xiaohong Li Shenfan Wang Xiangxiang fu Donghui Xing Zeyuan fu Yuanfu Deng Huanfeng Jiang Liangbin huang State Key Laboratory of Pulp and Paper Engineering School of Chemistry and Chemical EngineeringSouth China University of TechnologyGuangzhou 510640China

Herein,a nickel-catalyzed arylcyanation of unactivated alkenes via cyano group translocation with aryl boronic acids has been *** transformations provided a robust approach to constructing structurally diverse 1,n-dinitriles or 4-amino nitriles from easily prepared and commercially available starting *** cyano group translocation was achieved,involving the addition into the intramolecular C–N triple bond followed by the retro-Thorpe *** studies revealed that high temperature and CsHCO_(3) as the base were crucial for the cyano group translocation.

关键词： arylcyanation nickel catalysis cyano group translocation 1 n-dinitriles 4-amino nitriles

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Regulating the non-effective carriers transport for high-performance lithium metal batteries

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Journal of Energy Chemistry 2024年第5期92卷 132-141页

作者： Simeng Wang Youchun Yu Shaotong fu Hongtao Li Jiajia huang Institute of Process Engineering Chinese Academy of SciencesBeijing 100190China School of Chemical Engineering University of Chinese Academy of SciencesBeijing 100049China Haike Group Research Institute of Innovation&Technology Dongying 257000ShangdongChina

The absence of control over carriers transport during electrochemical cycling,accompanied by the deterioration of the solid electrolyte interphase(SEI)and the growth of lithium dendrites,has hindered the development of lithium metal ***,a separator complexion consisting of polyacrylonitrile(PAN)nanofiber and MIL-101(Cr)particles prepared by electrospinning is proposed to bind the anions from the electrolyte utilizing abundant effective open metal sites in the MIL-101(Cr)particles to modulate the transport of non-effective *** binding effect of the PANM separator promotes uniform lithium metal deposition and enhances the stability of the SEI layer and long cycling stability of ultra-high nickel layered oxide *** PANM as the Li||NCM96 separator enables high-voltage cycling stability,maintaining 72%capacity retention after 800 cycles at a charging and discharging rate of 0.2 C at a cut-off voltage of 4.5 V and 0°***,the excellent high-rate performance delivers a specific capacity of 156.3 mA h g^(-1) at 10 *** addition,outstanding cycling performance is realized from−20 to 60°*** separator engineering facilitates the electrochemical performance of lithium metal batteries and enlightens a facile and promising strategy to develop fast charge/discharge over a wide range of temperatures.

关键词： functional separators Metal-organic frameworks 3D continuous ion transport networks Electrospinning Lithium metal batteries

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Selective recovery of Th(Ⅳ) from radioactive rare earth waste residue by utilizing MoS_(2)-modified ion-absorbed type rare earth tailings

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Journal of Rare Earths 2024年第9期42卷 1782-1791,I0005页

作者： Xirong Chen Xinyu fu Yun Gao Zhiyuan Zeng Bin huang Xiaoqi Sun Faculty of Materials Metallurgy and Chemistry Jiangxi University of Science and TechnologyGanzhou341000China CAS Key Laboratory of Design and Assembly of functional Nanostructures Fujian Key Laboratory of NanomaterialsFujian Institute of Research on the Structure of MatterChinese Academy of SciencesFuzhou350002China fujian Research Center for Rare Earth Engineering Technology Xiamen Institute of Rare Earth MaterialsHaixi InstituteChinese Academy of SciencesXiamen361021China fujian College University of Chinese Academy of SciencesFuzhou350002China Jiangxi Province Key Laboratory of Cleaner Production of Rare Earths Ganjiang Innovation AcademyChinese Academy of SciencesGanzhouJiangxi341000China

In the process of extracting ion-absorbed rare earth ore(IREO),the production of radioactive waste is a major environmental *** address this issue,MoS_(2) was used to modify ion-absorbed rare earth tailings(RET) to synthesize a novel MoS_(2)@RET composite material for the effective handling of radioactive waste generated in IREO separation *** composite material was thoroughly characterized using various analytical techniques,including X-ray diffraction(XRD),X-ray photoelectron spectroscopy(XPS),thermogravimetry(TG),Fourier-transform infrared(FTIR),scanning electron microscopy(SEM),Brunaue r-Emmett-Teller(BET) and energy dispersive spectroscopy(EDS).By optimizing the operating parameters,the optimal experimental conditions were determined to be pH=3,contact time=60 min,liquid-solid ratio=6 g/L,and initial concentration=150 mg/*** adsorption data fitted well with the pseudo second-order rate *** thermodynamic parameters concerning the adsorption of Th(Ⅳ) were analyzed and *** isotherm model is a more fitting choice for the adsorption process compared to the Freundlich isotherm ***_(2)@RET was used in the acid leachate of IREO waste residue,achieving the separation of Th and rare earth *** mechanism of Th(Ⅳ) adsorption by MoS_(2)@RET was investigated,revealing that the adsorption process involves electrostatic interactions,chemical bonding,and redox *** above research results indicate that MoS_(2)@RET composite materials have application potential in the sustainable treatment of IREO radioactive waste.

关键词： Rare earths Thorium Radioactive waste residue Adsorption Separation

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