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Periodontitis combined with smoking increases risk of the ulcerative colitis: A national cohort study

World Journal of Gastroenterology 2020年第37期26卷 5661-5672页

作者： Eun Ae Kang Jaeyoung Chun jee hyun Kim Kyungdo Han Hosim Soh Seona Park Seung Wook Hong Jung Min Moon Jooyoung Lee hyun Jung Lee Jun-Beom Park Jong Pil Im Joo Sung Kim Department of Internal Medicine and Institute of Gastroenterology Yonsei University College of MedicineSeoul 03722South Korea Department of Internal Medicine Gangnam Severance HospitalYonsei University College of MedicineSeoul 06229South Korea Department of Internal Medicine Bundang CHA Medical CenterCHA University School of MedicineSeoul 13496South Korea Department of Statistics and Actuarial Science Soongsil UniversitySeoul 06978South Korea Department of Internal Medicine and Liver Research Institute Seoul National University College of MedicineSeoul 03080South Korea Department of Periodontics the Catholic University of Korea College of MedicineSeoul 06591South Korea

BACKGROUND Periodontitis is a chronic inflammation of periodontal *** effect of periodontitis on the development of inflammatory bowel disease(IBD)remains *** To assessed the risk of IBD among patients with periodontitis,and the risk factors for IBD related to *** A nationwide population-based cohort study was performed using claims data from the Korean National Healthcare Insurance *** total,9950548 individuals aged≥20 years who underwent national health screening in 2009 were *** diagnosed IBD[Crohn’s disease(CD),ulcerative colitis(UC)]using the International Classification of Disease 10th revision and rare intractable disease codes,was compared between the periodontitis and nonperiodontitis groups until *** A total of 1092825 individuals(11.0%)had *** was significantly associated with older age,male gender,higher body mass index,quitting smoking,not drinking alcohol,and regular *** mean age was 51.4±12.9 years in the periodontitis group and 46.6±14.2 years in the nonperiodontitis group(P<0.01),*** mean body mass index was 23.9±3.1 and 23.7±3.2 in the periodontitis and non-periodontitis groups,respectively(P<0.01).Men were 604307(55.3%)and 4844383(54.7%)in the periodontitis and non-periodontitis groups,*** mean follow-up duration was 7.26 *** with periodontitis had a significantly higher risk of UC than those without periodontitis[adjusted hazard ratio:1.091;95%confidence interval(CI):1.008-1.182],but not CD(adjusted hazard ratio:0.879;95%confidence interval:0.731-1.057).The risks for UC were significant in the subgroups of age≥65 years,male gender,alcohol drinker,current smoker,and reduced physical *** smokers aged≥65 years with periodontitis were at a 1.9-fold increased risk of UC than non-smokers aged≥65 years without *** Periodontitis was significantly associated with the risk of developing UC,b

关键词： Inflammatory bowel disease Periodontitis Smoking Ulcerative colitis Crohn’s disease

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Splenic infarction associated with sorafenib use in a hepatocellular carcinoma patient

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World Journal of Gastroenterology 2011年第2期17卷 267-270页

作者： Sang Ock Kim Sang Young Han Yang hyun baek Sung Wook Lee Ji Sun Han Byung Geun Kim Jin Han Cho Kyung Jin Nam Department of Gastroenterology and Hepatology Dong-A University HospitalDongdaesin-dong Seo-gu Busan 602-103 South Korea Dong-A University Collegeof Medicine 3-ga Dongdaesing-dong Seo-gu Busan 602-103South Korea Department of Radiology Dong-AUniversity Hospital Dongdaesin-dong Seo-gu Busan 602-103South Korea

Sorafenib,a multitargeted tyrosine kinase inhibitor,has been shown to improve survival in patients with advanced hepatocellular carcinoma(HCC).As the clinical use of sorafenib increases,many adverse effects have been reported,such as hand-foot skin reaction,diarrhea,anorexia,asthenia,alopecia,weight loss,hypertension and arterial ***,there are no prior reports of splenic infarction as an adverse effect of ***,a case of splenic infarction in a patient with HCC who was treated with sorafenib is reported. The patient had no other predisposing factors to explain the splenic infarction except for the administration of *** splenic infarction improved after sorafenib was discontinued;however,the HCC progressed.

关键词： Hepatocellular carcinoma Sorafenib Tyrosine kinase inhibitor Adverse effects Splenic infarction

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Production of reactive oxygen species by freezing stress and the protective roles of antioxidant enzymes in plants

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Journal of Agricultural Chemistry and Environment 2012年第1期1卷 34-40页

作者： Kwang-hyun baek Daniel Z. Skinner School of Biotechnology Yeungnam University Gyeongsan South Korea USDA/ARS Department of Crop and Soil Sciences Washington State University Pullman USA

As one of the most severe environmental stresses, freezing stress can determine native flora in nature and severely reduce crop production. Many mechanisms have been proposed to explain the damage induced by freezing-thawing cycle, and oxidative stress caused by uncontrollable production of harmful reactive oxygen species (ROS) are partially contributed to causing the injury. Plants in temperate regions have evolved a unique but effective metabolism of protecting themselves called cold acclimation. Cold-acclimating plants undergo a complex but orchestrated metabolic process to increase cold hardness triggered by exposure to low temperature and shortened photoperiod and achieve the maximum freezing tolerance by a concerted regulation and expression of a number of cold responsive genes. A complicated enzymatic system have been evolved in plants to scavenge the ROS to protect themselves from oxidative stress, therefore, cold-acclimating plants are expected to increase the de novo synthesis of the genes of antioxidant genes. Indeed, many antioxidant genes increase the expression levels in response to low temperature. Furthermore, the higher expression of many antioxidant enzymes are positively correlated to inducing higher tolerance levels against freezing. All the information summarized here can be applied for developing crop and horticultural plants to have more freezing tolerance for higher production with better quality. There have been extensive studies on the activities of antioxidant enzymes and the gene regulation, however, more researches will be required in near future to elucidate the most effective antioxidant enzymes to induce highest freezing tolerance in a crop plant in a transformation process or a breeding program.

关键词： Antioxidant Enzymes Cold Acclimation Freezing Stress Manganese Superoxide Dismutase Reactive Oxygen Species

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Correction to:Memristive Devices Based on Two‑Dimensional Transition Metal Chalcogenides for Neuromorphic Computing

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Nano-Micro Letters 2022年第5期14卷 15-17页

作者： Ki Chang Kwon Ji hyun baek Kootak Hong Soo Young Kim Ho Won Jang Department of Materials Science and Engineering Research Institute of Advanced MaterialsSeoul National UniversitySeoul 08826Republic of Korea Interdisciplinary Materials Measurement Institute Korea Research Institute of Standards and Science(KRISS)Daejeon 34133Republic of Korea Department of Materials Science and Engineering Institute of Green Manufacturing TechnologyKorea UniversitySeoul 02841Republic of Korea Advanced Institute of Convergence Technology Seoul National UniversitySuwon 16229Korea

The original version of this article,unfortunately,contained some mistakes and unintentional wrong description of Fig.6 and the caption of Figs.9,*** correct version of Fig.6 is *** mentioned figure name for the Fig.6 on the manuscript should be *** 2D vdW synaptic devices,the length of the tunneling barrier can be increased or decreased on the trapped or detrapped *** et *** memristive and neuromorphic devices composed of vertically grown WS2 layer and ZnO(Fig.6e)[149].The interlayer separation between WS2 and ZnO layers serves as an effective porous medium allowing the ZnO to grow with *** interfacial region of ZnO,the very contiguous to WS2 layer.

关键词： WS2 Transition separation

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Risk prediction platform for pancreatic fistula after pancreatoduodenectomy using artificial intelligence

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World Journal of Gastroenterology 2020年第30期26卷 4453-4464页

作者： In Woong Han Kyeongwon Cho Youngju Ryu Sang hyun Shin Jin Seok Heo Dong Wook Choi Myung Jin Chung Oh Chul Kwon baek Hwan Cho Department of Surgery Samsung Medical CenterSungkyunkwan University School of MedicineSeoul 06351South Korea Medical Artificial Intelligence Research Center Department of Medical Device Management and ResearchSAIHSTSamsung Medical CenterSungkyunkwan University School of MedicineSeoul 06351South Korea Department of Radiology Samsung Medical CenterSungkyunkwan University School of MedicineSeoul 06351South Korea Artificial Intelligence Research Center Medical DataBase IncorporatedSeoul 06048South Korea

BACKGROUND Despite advancements in operative technique and improvements in postoperative managements,postoperative pancreatic fistula(POPF)is a life-threatening complication following pancreatoduodenectomy(PD).There are some reports to predict POPF preoperatively or intraoperatively,but the accuracy of those is *** intelligence(AI)technology is being actively used in the medical field,but few studies have reported applying it to outcomes after *** To develop a risk prediction platform for POPF using an AI *** Medical records were reviewed from 1769 patients at Samsung Medical Center who underwent PD from 2007 to 2016.A total of 38 variables were inserted into AI-driven *** algorithms tested to make the risk prediction platform were random forest(RF)and a neural network(NN)with or without recursive feature elimination(RFE).The median imputation method was used for missing *** area under the curve(AUC)was calculated to examine the discriminative power of algorithm for POPF *** The number of POPFs was 221(12.5%)according to the International Study Group of Pancreatic Fistula definition *** median imputation,AUCs using 38 variables were 0.68±0.02 with RF and 0.71±0.02 with *** maximal AUC using NN with RFE was *** risk factors for POPF were identified by AI algorithm:Pancreatic duct diameter,body mass index,preoperative serum albumin,lipase level,amount of intraoperative fluid infusion,age,platelet count,extrapancreatic location of tumor,combined venous resection,co-existing pancreatitis,neoadjuvant radiotherapy,American Society of Anesthesiologists’score,sex,soft texture of the pancreas,underlying heart disease,and preoperative endoscopic biliary *** developed a web-based POPF prediction platform,and this application is freely available at http://*** This study is the first to predict POPF with multiple risk factors using *** platform is reli

关键词： Postoperative pancreatic fistula Pancreatoduodenectomy Neural networks Recursive feature elimination

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Hydrogen Peroxide Alleviates Hypoxia during Imbibition and Germination of Bean Seeds (<i>Phaseolus vulgaris</i>L.)

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American Journal of Plant Sciences 2014年第24期5卷 3572-3584页

作者： C. B. Rajashekar Kwang-hyun baek Department of Horticulture Forestry and Recreation Resources Kansas State University Manhattan KS USA

Bean seeds (Phaseolus vulgaris L. cv. Tendergreen) were imbibed in water to examine the effects of hypoxia during imbibition and subsequent germination. Hypoxic conditions occurred when seeds were imbibed in water for 24 h or longer and resulted in severe reduction of hypocotyl elongation and stem growth during subsequent germination under non-limiting oxygen conditions. Under continued hypoxic conditions, bean seeds failed to germinate, however, this was reversed in the presence of hydrogen peroxide (20 mM) in the medium. Furthermore, imbibition of seeds in the presence of hydrogen peroxide overcame the adverse hypoxic effects on hypocotyl elongation and stem growth. Exogenous hydrogen peroxide increased the dissolved oxygen levels in the germinating medium, and catalase and transition metal ions such as Fe2+, Cu2+ and Mn2 helped to facilitate the production of oxygen from hydrogen peroxide. In these catalysts, catalase played a major role in the decomposition of hydrogen peroxide as demonstrated by the use of a catalase inhibitor, 3-amino-1, 2, 4-triazole, which reversed the positive effects produced by hydrogen peroxide on germination of seeds under hypoxic conditions. The results show that imbibition is sensitive to oxygen deficits which affect subsequent hypocotyl growth and seedling performance. The adverse effects of hypoxia on germination of bean seeds can be overcome by exogenous hydrogen peroxide.

关键词： Aminotriazole Anoxia Catalase Hydrogen Peroxide Hypoxia Phaseolus vulgaris Seed Germination

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Bacterial entombment by intratubular mineralization following orthograde mineral trioxide aggregate obturation: a scanning electron microscopy study

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International Journal of Oral Science 2014年第4期6卷 227-232页

作者： Jun Sang Yoo Seok-Woo Chang So Ram Oh Hiran Perinpanayagam Sang-Min Lim Yeon-jee Yoo Yeo-Rok Oh Sang-Bin Woo Seung-hyun Han Qiang Zhu Kee-Yeon Kum Department of Dentistry U Dental Hospital Department of Conservative Dentistry School of Dentistry Kyung Hee University Department of Conservative Dentistry Dental Research Institute Seoul National University Dental Hospital Seoul National University School of Dentistry Division of Restorative Dentistry Schulich School of Medicine & Dentistry University of Western Ontario Department of Conservative Dentistry Jukjeon Dental Hospital College of Dentistry Dankook University Department of Oral Microbiology & Immunology Dental Research Institute and BK21 Program Seoul National University School of Dentistry Division of Endodontology Department of Oral Health and Diagnostic Sciences School of Dental Medicine University of Connecticut Health Center

The time domain entombment of bacteria by intratubular mineralization following orthograde canal obturation with mineral trioxide aggregate（MTA） was studied by scanning electron microscopy（SEM）. Single-rooted human premolars（n560） were instrumented to an apical size #50/0.06 using ProF ile and treated as follows： Group 1（n510） was filled with phosphate buffered saline（PBS）; Group 2（n510） was incubated with Enterococcus faecalis for 3 weeks, and then filled with PBS; Group 3（n520） was obturated orthograde with a paste of OrthoM TA（BioM TA, Seoul, Korea） and PBS; and Group 4（n520） was incubated with E. faecalis for 3 weeks and then obturated with OrthoM TA–PBS paste. Following their treatments, the coronal openings were sealed with PBS-soaked cotton and intermediate restorative material（IRM）, and the roots were then stored in PBS for 1, 2, 4, 8 or 16 weeks. After each incubation period, the roots were split and their dentin/MTA interfaces examined in both longitudinal and horizontal directions by SEM. There appeared to be an increase in intratubular mineralization over time in the OrthoM TA-filled roots（Groups 3 and 4）. Furthermore, there was a gradual entombment of bacteria within the dentinal tubules in the E. faecalis inoculated MTA-filled roots（Group 4）. Therefore, the orthograde obturation of root canals with OrthoM TA mixed with PBS may create a favorable environment for bacterial entombment by intratubular mineralization.

关键词： bacterial entombment intratubular mineralization orthograde canal obturation scanning electron microscopy tag-like structure

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Performance Analysis of Multi-Parametric Call Admission Control Strategies in Un-Buffered Multi-Service Cellular Wireless Networks

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Wireless Sensor Network 2010年第3期2卷 218-226页

作者： Jang hyun baek Che Soong Kim Agassi Melikov Mehriban Fattakhova 不详

In this paper model of integrated voice/data cellular wireless networks (CWN) are investigated. The unified approximate approach to calculate the desired Quality of Service (QoS) metrics in an isolated cell of such networks under two multi-parametric call admission control (CAC) strategies is developed. One of them is based on the guard channels scheme while the second is based on a threshold scheme. Results of the numerical experiments are given and a comparison of QoS metrics under different CAC strategies is carried out.

关键词： Cellular Networks Call Admission Control Quality of Service Calculation Algorithm

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Surgical failure after colonic stenting as a bridge to surgery

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World Journal of Gastroenterology 2014年第33期20卷 11826-11834页

作者： Jung Ho Kim Kwang An Kwon Jong Joon Lee Won-Suk Lee Jeong-Heum baek Yoon Jae Kim Jun-Won Chung Kyoung Oh Kim Dong Kyun Park Ju hyun Kim Department of Internal Medicine Gachon University Gil Medical Center Incheon 405760 South Korea Department of Surgery Gachon University Gil Medical Center Incheon 405760 South Korea

AIM: To identify risk factors for surgical failure after colonic stenting as a bridge to surgery in left-sided malignant colonic obstruction.

关键词： Colorectal neoplasms Endoscopy Intesti-nal obstruction Risk factors Stents

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Radar Cross Section Analysis Using Physical Optics and Its Applications to Marine Targets

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Journal of Applied Mathematics and Physics 2015年第2期3卷 166-171页

作者： Joon-Tae Hwang Suk-Yoon Hong jee-Hun Song hyun-Wung Kwon Department of Naval Architecture and Ocean Engineering Seoul National University Seoul Republic of Korea Department of Naval Architecture and Ocean Engineering Seoul National University Seoul Republic of Korea Department of Naval Architecture and Ocean Engineering Chonnam National University Yeosu Republic of Korea Department of Naval Architecture and Ocean Engineering Kojecollege Koje Republic of Korea

Radar Cross Section (RCS) is one of the most considerable parameters for ship stealth design. As modern ships are larger than their predecessors, RCS must be managed at each design stage for its reduction. For predicting RCS of ship, Radar Cross Section Analysis Program (RACSAN) based on Kirchhoff approximation in high frequency range has been developed. This program can present RCS including multi-bounce effect in exterior and interior structure by combination of geometric optics (GO) and physical optics (PO) methods, coating effect by using Fresnel reflection coefficient, and response time pattern for detected target. In this paper, RCS calculations of ship model with above effects are simulated by using this developed program and RCS results are discussed.

关键词： Radar Cross Section (RCS) Kirchhoff Approximation Multi-Bounce Effect Response Time Pattern

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