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Sex-dependent difference in the effect of metformin on colorectal cancer-specific mortality of diabetic colorectal cancer patients

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World Journal of Gastroenterology 2017年第28期23卷 5196-5205页

作者： Jung Won Park Jin ha Lee Ye hyun Park Soo Jung Park Jae Hee Cheon Won Ho Kim Tae Il Kim Department of Internal Medicine and Institute of Gastroenterology Yonsei University College of Medicine Cancer Prevention Center Yonsei University College of Medicine

To assess factors associated with the higher effect of metformin on mortality in diabetic colorectal cancer (CRC) patients, since the factors related to the effectiveness of metformin have not been identified *** January 2000 and December 2010, 413 patients diagnosed with both stage 3/4 CRC and diabetes mellitus were identified. Patients’ demographics and clinical characteristics were analyzed. The effect of metformin on CRC-specific mortality and the interactions between metformin and each adjusted factor were *** follow-up duration was median 50 mo (range: 1-218 mo). There were 85 deaths (45.9%) and 72 CRC-specific deaths (38.9%) among 185 patients who used metformin, compared to 130 total deaths (57.0%) and 107 CRC-specific deaths (46.9%) among 228 patients who did not use metformin. In multivariate analysis, survival benefit associated with metformin administration was identified (HR = 0.985, 95%CI: 0.974-0.997, P = 0.012). Interaction test between metformin and sex after adjustment for relevant factors revealed that female CRC patients taking metformin exhibited a significantly lower CRC-specific mortality rate than male CRC patients taking metformin (HR = 0.369, 95%CI: 0.155-0.881, P = 0.025). Furthermore, subgroup analysis revealed significant differences in CRC-specific mortality between the metformin and non-metformin groups in female patients (HR = 0.501, 95%CI: 0.286-0.879, P = 0.013) but not male patients (HR = 0.848, 95%CI: 0.594-1.211, P = 0.365). There were no significant interactions between metformin and other adjusted factors on CRC-specific *** showed a strong sex-dependent difference in the effect of metformin on CRC-specific mortality in advanced stage CRC patients with diabetes.

关键词： Colorectal cancer Metformin Survival Sex

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Bacterial entombment by intratubular mineralization following orthograde mineral trioxide aggregate obturation: a scanning electron microscopy study

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International Journal of Oral Science 2014年第4期6卷 227-232页

作者： Jun Sang Yoo Seok-Woo Chang So Ram Oh Hiran Perinpanayagam Sang-Min Lim Yeon-jee Yoo Yeo-Rok Oh Sang-Bin Woo Seung-hyun han Qiang Zhu Kee-Yeon Kum Department of Dentistry U Dental Hospital Department of Conservative Dentistry School of Dentistry Kyung Hee University Department of Conservative Dentistry Dental Research Institute Seoul National University Dental Hospital Seoul National University School of Dentistry Division of Restorative Dentistry Schulich School of Medicine & Dentistry University of Western Ontario Department of Conservative Dentistry Jukjeon Dental Hospital College of Dentistry Dankook University Department of Oral Microbiology & Immunology Dental Research Institute and BK21 Program Seoul National University School of Dentistry Division of Endodontology Department of Oral Health and Diagnostic Sciences School of Dental Medicine University of Connecticut Health Center

The time domain entombment of bacteria by intratubular mineralization following orthograde canal obturation with mineral trioxide aggregate（MTA） was studied by scanning electron microscopy（SEM）. Single-rooted human premolars（n560） were instrumented to an apical size #50/0.06 using ProF ile and treated as follows： Group 1（n510） was filled with phosphate buffered saline（PBS）; Group 2（n510） was incubated with Enterococcus faecalis for 3 weeks, and then filled with PBS; Group 3（n520） was obturated orthograde with a paste of OrthoM TA（BioM TA, Seoul, Korea） and PBS; and Group 4（n520） was incubated with E. faecalis for 3 weeks and then obturated with OrthoM TA–PBS paste. Following their treatments, the coronal openings were sealed with PBS-soaked cotton and intermediate restorative material（IRM）, and the roots were then stored in PBS for 1, 2, 4, 8 or 16 weeks. After each incubation period, the roots were split and their dentin/MTA interfaces examined in both longitudinal and horizontal directions by SEM. There appeared to be an increase in intratubular mineralization over time in the OrthoM TA-filled roots（Groups 3 and 4）. Furthermore, there was a gradual entombment of bacteria within the dentinal tubules in the E. faecalis inoculated MTA-filled roots（Group 4）. Therefore, the orthograde obturation of root canals with OrthoM TA mixed with PBS may create a favorable environment for bacterial entombment by intratubular mineralization.

关键词： bacterial entombment intratubular mineralization orthograde canal obturation scanning electron microscopy tag-like structure

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Changes in Small Intestinal Motility and Related Hormones by Acupuncture Stimulation at Zusanli(ST 36) in Mice

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Chinese Journal of Integrative Medicine 2017年第3期23卷 215-220页

作者： Jung-Hee Jang Deuk-Joo Lee Chang-Hwan Bae Ki-Tae ha Sunoh Kwon Hi-Joon Park Dae-hyun hahm Hyejung Lee Seungtae Kim School of Korean Medicine Pusan National University Acupuncture and Meridian Science Research Center Kyung Hee University Department of Psychiatry and Behavioral Sciences Northwestern University Feinberg School of Medicine

Objective： To clarify the effects of acupuncture stimulation at Zusanli（ST 36） on the hormonal changes. Methods： Eight-week-old male C57BL/6 mice received acupuncture stimulation at acupoint ST 36 or Quchi（LI 11） once a day for 3 or 5 days in the acupuncture-stimulated groups, but not received in the normal group（n=6 in each group）. On day 3 or 5, animals were given 0.1 m L of charcoal orally with a bulbed steel needle, 30 min after the last acupuncture stimulation. Ten minutes later, mice were anesthetized, and the intestinal transit and the concentrations of vasoactive intestinal peptide（VIP）, motilin, ghrelin and gastrin in the serum were measured. Results： Compared to no acupuncture stimulation, acupuncture stimulation at ST 36 for 5 days increased the intestinal transit and down-regulated the concentration of VIP and up-regulated the concentrations of motilin, ghrelin and gastrin（P〈0.05 or 0.01）, whereas acupuncture stimulation at LI 11 did not change them significantly（P〉0.05）. Conclusion： Acupuncture stimulation at ST 36 for 5 days enhances the small intestinal motility and regulates the secretion of hormones related to small intestinal motility.

关键词： acupuncture gastrointestinal motility vasoactive intestinal peptide motilin ghrelin gastrin

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T/myeloid mixed-phenotype acute leukemia treated with venetoclax and decitabine:A case report

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世界临床病例杂志 2023年第26期11卷 6200-6205页

作者： Sungwoo Park Eun Jeong Jeong Jung Hun Kang Gyeong-Won Lee Se-Il Go Dong-hyun Lee Eun-ha Koh Division of Hematology and Oncology Department of Internal MedicineGyeongsang National University HospitalGyeongsang National University School of MedicineGyeongsang National UniversityJinju 52727South Korea Department of Internal Medicine Institute of Health SciencesGyeongsang National University Changwon HospitalGyeongsang National University School of MedicineChangwon 52828South Korea Department of Laboratory Medicine Gyeongsang National University HospitalGyeongsang National University School of MedicineGyeongsang National UniversityJinju 52828South Korea

BACKGROUND Mixed-phenotype acute leukemia(MPAL)is characterized by acute undifferentiated leukemia with blasts co-expressing myeloid and lymphoid ***,consensus regarding the ideal management strategy for MPAL is yet to be established,owing to its *** SUMMARY A 55-year-old male was diagnosed with T/myeloid ***,prednisolone,daunorubicin,and L-asparaginase were administered as induction *** shock occurred 10 days after induction,and bone marrow examination following recovery from sepsis revealed refractory *** and decitabine were administered as chemotherapy-free induction therapy to reduce the infection *** were no serious infections,including febrile neutropenia,at the end of the *** receiving two additional cycles of venetoclax/decitabine,the patient underwent haploidentical peripheral blood stem-cell transplantation and achieved complete response(CR)to *** CR was maintained in a patient with MPAL who underwent haploidentical peripheral blood stem-cell transplantation after additional venetoclax/decitabine cycles.

关键词： Mixed-phenotype acute leukemia Venetoclax Decitabine Case report

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Bedside index for severity in acute pancreatitis:comparison with other scoring systems in predicting severity and organ failure

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Hepatobiliary & Pancreatic Diseases International 2013年第6期12卷 645-650页

作者： Ji Young Park Tae Joo Jeon Tae Hwan ha Jin Tae Hwang Dong hyun Sinn Tae-Hoon Oh Won Chang Shin Won-Choong Division of Gastroenterology Department of Internal MedicineInje University Sanggye Paik Hospital

BACKGROUND:The early identification of severe acute pancreatitis is important for the management and for improving *** bedside index for severity in acute pancreatitis(BISAP)has been considered as an accurate method for risk stratification in patients with acute *** study aimed to evaluate the comparative usefulness of the ***:We retrospectively analyzed 303 patients with acute pancreatitis diagnosed at our hospital from March 2007to December ***,APACHE-II,Ranson criteria,and CT severity index(CTSI)of all patients were *** stratified the number of patiants with severe pancreatitis,pancreatic necrosis,and organ failure as well as the number of deaths by BISAP *** used the area under the receiveroperating curve(AUC)to compare BISAP with other scoring systems,C-reactive protein(CRP),hematocrit,and body mass index(BMI)with regard to prediction of severe acute pancreatitis,necrosis,organ failure,and ***:Of the 303 patiants,31(10.2%)were classified as having severe acute *** failure occurred in 23(7.6%)patients,pancreatic necrosis in 40(13.2%),and death in6(2.0%).A BISAP score of 2 was a statistically significant cutoff value for the diagnosis of severe acute pancreatitis,organ failure,and *** for BISAP predicting severe pancreatitis and death were 0.80 and 0.86,respectively,which were similar to those for APACHE-II(0.80,0.87)and Ranson criteria(0.74,0.74)and greater than AUCs for CTSI(0.67,0.42).The AUC for organ failure predicted by BISAP,APACHE-II,Ranson criteria,and CTSI was 0.93,0.95,0.84 and 0.57,*** for BISAP predicting severity,organ failure,and death were greater than those for CRP(0.69,0.80,0.72),hematocrit(0.45,0.35,0.14),and BMI(0.41,0.47,0.17).CONCLUSION:The BISAP predicts severity,death,and especially organ failure in acute pancreatitis as well as APACHE-II does and better than Ranson criteria,CTSI,CRP,hematocrit,and BMI.

关键词： acute pancreatitis scoring system pancreatic necrosis organ failure

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Spectrum of mucin-producing neoplastic conditions of the abdomen and pelvis:Cross-sectional imaging evaluation

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World Journal of Gastroenterology 2011年第43期17卷 4757-4771页

作者： Nam Kyung Lee Suk Kim hyun Sung Kim Tae Yong Jeon Gwang ha Kim Dong Uk Kim Do Youn Park Tae Un Kim Dae Hwan Kang Department of Radiology Pusan National University Hospital Medical Research Institute Pusan National University School of Medicine Pusan National University Department of Surgery Pusan National University Hospital Department of Internal Medicine Pusan National University Hospital Department of Pathology Pusan National University Hospital Department of Radiology Yangsan Pusan National University Hospital Medical Research Institute Pusan National University School of Medicine Department of Internal Medicine Yangsan Pusan National University Hospital

Various mucin-producing neoplasms originate in different abdominal and pelvic *** neoplasms differ from non-mucinous neoplasms because of the differences in clinical outcome and imaging *** carcinoma,in which at least 50%of the tumor is composed of large pools of extracellular mucin and columns of malignant cells,is associated with a worse *** ring cell carcinoma is characterized by large intracytoplasmic mucin vacuoles that expand in the malignant cells with the nucleus displaced to the *** prognosis is also generally *** contrast,intraductal papillary mucinous neoplasm of the bile duct and pancreas,which is characterized by proliferation of ductal epithelium and variable mucin production,has a better prognosis than other malignancies in the pancreaticobiliary *** modalities play a critical role in differentiating mucinous from non-mucinous *** to high water content,mucin has a similar appearance to water on ultrasound(US) ,computed tomography(CT) ,and magnetic resonance imaging,except when thick and proteinaceous,and then it tends to be hypoechoic with fine internal echoes or have complex echogenicity on US,hyperdense on CT,and hyperintense on T1and hypointense on T2-weighted images,compared to ***,knowledge of characteristic mucin imaging features is helpful to diagnose various mucinproducing neoplastic conditions and to facilitate appropriate treatment.

关键词： Mucin Neoplasm Ultrasound Computed tomography Magnetic resonance Abdomen and pelvis

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Effect of Oenanthe Javanica Extract on Antioxidant Enzyme in the Rat Liver

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Chinese Medical Journal 2015年第12期128卷 1649-1654页

作者： Choong-hyun Lee Joon-ha Park Jeong-Hwi Cho In-Hye Kim Ji-Hyeon Ahn Jae-Chul Lee Bai Hui Chen Bich-Na Shin hyun-Jin Tae Eun Joo Bae II-Jun Kang Moo-Ho Won Jong-Dai Kim Department of Pharmacy College of Pharmacy Dankook University Cheonan 330-714 South Korea Department of Neurobiology School of Medicine Kangwon National University Chuncheon 200-701 South Korea Department of Physiology College of Medicine Hallym University Chuncheon 200-702 South Korea Department of Biomedical Science Research Institute for Bioscience and Biotechnology Hallym University Chunchon 200-702 South Korea Department of Pediatrics Chuncheon Sacred Heart Hospital College of Medicine Hallym University Chuncheon 200-701 South Korea Department of Food Science and Nutrition Hallym University Chuncheon 200-702 South Korea Division of Food Biotechnology School of Biotechnology Kangwon National University Chuncheon 200-701 South Korea

Background：Oenanthe javanica （***） has been known to have high antioxidant properties via scavenging reactive oxygen *** examined the effect of *** extract （OJE） on antioxidant enzymes in the rat ***：We examined the effect of the OJE on copper,zinc-superoxide dismutase （SOD1）,manganese superoxide dismutase （SOD2）,catalase （CAT）,and glutathione peroxidase （GPx） in the rat liver using immunohistochemistry and western blot ***-Dawley rats were randomly assigned to three groups;（1） normal diet fed group （normal-group）,（2） diet containing ascorbic acid （AA）-fed group （AA-group） as a positive control,（3） diet containing OJE-fed group （OJE-group）.Results：In this study,no histopathological finding in the rat liver was found in all the experimental *** of SOD1,SOD2,CAT,and GPx immunoreactive cells and their protein levels were significantly increased in the AA-fed group compared with those in the *** the other hand,in the OJE-group,numbers of SOD1,SOD2,CAT,and GPx immunoreactive cells in the liver were significantly increased by about 190%,478%,685%,and 346%,respectively,compared with those in the *** addition,protein levels of SOD 1,SOD2,CAT,and GPx in the OJE-group were also significantly much higher than those in the ***：OJE significantly increased expressions of SOD 1 and SOD2,CAT,and GPx in the liver cells of the rat,and these suggests that significant enhancements of endogenous enzymatic antioxidants by OJE might be a legitimate strategy for decreasing oxidative stresses in the liver.

关键词： Antioxidant Enzymes Immunohistochemistry Liver Oenanthe Javanica Extract Western Blotting

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Gyejibokryeong-Hwan improves recovery of injured muscles in mouse model of muscle contusion

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Journal of Traditional Chinese Medicine 2021年第3期41卷 406-413页

作者： Chi Ho Lee Jeong June Choi Joo Hye Sim Younmin Shin Seung-Joon Oh Ji-Hyang Gu hyun Ju ha Dong Hwi Jeon Eun-Jung Lee Min-Seok Oh Department of Korean Medicine Rehabilitation College of Korean MedicineDaejeon UniversityDaejeon 34520Republic of Korea Laboratory of Molecular Medicine College of Korean MedicineDaejeon UniversityDaejeon 34520Republic of Korea

OBJECTIVE: To investigate the effects of Gyejibokryeong-Hwan(Guizhifuling-wan, GBH) on muscle injury in a mouse model of muscle ***: C57/BL6 mouse biceps femoris muscles were injured using the drop-mass method and injured animals were treated orally with GBH(50,100, or 500 mg/kg) once a day for 7 d. Open field and treadmill running tests were performed to assess functional recovery from muscle injury. The production of pro-inflammatory cytokines was examined by enzyme-linked immunosorbent assay and Western blotting analysis. Expression of the muscle regeneration biomarkers, myoblast determination(Myo D), myogenic factor 5(Myf5), and smooth muscle actin(α-SMA), in the biceps femoris muscle was investigated at the protein and m RNA level by Western blotting and real time-PCR, respectively. Histological analysis was performed using hematoxylin and eosin staining. Finally, myosin heavy chain production was investigated in differentiated C2C12 myoblasts in the presence of ***: GBH treatment markedly improved locomotion and running behavior. GBH significantly inhibited the secretion of monocyte chemoattractant protein-1 into the bloodstream in muscle-contused animals. The levels of Myo D, Myf5, and α-SMA protein and m RNA were significantly up-regulated by GBH in injured muscle tissue. Histological studies suggested that GBH facilitated recovery from muscle damage. However, GBH did not induce the production of myosin heavy chain in ***: Overall, the present study suggested that GBH improves the recovery of the injured muscles in the mouse model of muscle contusion.

关键词： muscles wounds and injuries contusions regeneration muscle skeletal myogenic regulatory factor 5 Gyejibokryeong-Hwan

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Endoscopic removal of gastric ectopic pancreas:An initial experience with endoscopic submucosal dissection

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World Journal of Gastroenterology 2010年第36期16卷 4589-4593页

作者： Dong Yup Ryu Gwang ha Kim Do Youn Park Bong Eun Lee Jae Hoon Cheong Dong Uk Kim hyun Young Woo Jeong Heo Geun Am Song Department of Internal Medicine Pusan National University School of Medicine and Medical Research InstitutePusan National University HospitalBusan 602-739South Korea Department of Pathology Pusan National University School of MedicineBusan 602-739South Korea

AIM:To evaluate the therapeutic usefulness and safety of endoscopic resection in patients with gastric ectopic ***:A total of eight patients with ectopic pancreas were *** of them underwent endoscopic ultrasonography before endoscopic ***-scopic resection was performed by two methods:endo-scopic mucosal resection(EMR)by the injection-and-cut technique or endoscopic mucosal dissection(ESD).RESULTS:We planned to perform EMR in all eight cases but EMR was successful in only four *** the other four cases,saline spread into surrounding normal tissues and the lesions becameattened,which made it impossible to remove them by *** four cases,we performed ESD and removed the lesions without any ***:If conventional EMR is difficult to remove gastric ectopic pancreas,ESD is a feasible alternative method for successful removal.

关键词： Ectopic pancreas Endoscopic resection Endoscopic ultrasonography

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Radar Cross Section Analysis Using Physical Optics and Its Applications to Marine Targets

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Journal of Applied Mathematics and Physics 2015年第2期3卷 166-171页

作者： Joon-Tae Hwang Suk-Yoon Hong jee-Hun Song hyun-Wung Kwon Department of Naval Architecture and Ocean Engineering Seoul National University Seoul Republic of Korea Department of Naval Architecture and Ocean Engineering Seoul National University Seoul Republic of Korea Department of Naval Architecture and Ocean Engineering Chonnam National University Yeosu Republic of Korea Department of Naval Architecture and Ocean Engineering Kojecollege Koje Republic of Korea

Radar Cross Section (RCS) is one of the most considerable parameters for ship stealth design. As modern ships are larger than their predecessors, RCS must be managed at each design stage for its reduction. For predicting RCS of ship, Radar Cross Section Analysis Program (RACSAN) based on Kirchhoff approximation in high frequency range has been developed. This program can present RCS including multi-bounce effect in exterior and interior structure by combination of geometric optics (GO) and physical optics (PO) methods, coating effect by using Fresnel reflection coefficient, and response time pattern for detected target. In this paper, RCS calculations of ship model with above effects are simulated by using this developed program and RCS results are discussed.

关键词： Radar Cross Section (RCS) Kirchhoff Approximation Multi-Bounce Effect Response Time Pattern

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