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endoscopic ultrasonography-guided fine needle aspiration:Relatively low sensitivity in the endosonographer population

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World Journal of Gastroenterology 2012年第19期18卷 2357-2363页

作者： Jean-Marc Dumonceau Thibaud Koessler jeanin e van hooft Paul Fockens Division of Gastroenterology and Hepatology Geneva University Hospital1211 GenevaSwitzerland Division of General Internal Medicine Geneva University Hospital1211 GenevaSwitzerland Gastrointestinal endoscopy Academic Medical Center University of Amsterdam1012 WXAmsterdamThe Netherlands

AIM： To assess the characteristics and quality of endoscopic ultrasonography-guided fine needle aspiration （eUS-FNA） in a large panel of endosonographers.MeTHODS： A survey was conducted during the 13th annual live course of endoscopic ultrasonography （eUS） held in Amsterdam, Netherlands. A 2-page question- naire was developed for the study. Content validity of the questionnaire was determined based on input by experts in the field and a review of the relevant literature. It contained 30 questions that pertained to demographics and the current practice for eUS-FNA of responders, including sampling technique, sample processing, cytopathological diagnosis and sensitivity of eUS-FNA for the diagnosis of solid mass lesions. One hundred and sixty-one endosonographers whoattended the course were asked to answer the survey. This allowed assessing the current practice of eUS-FNA as well as the self-reported sensitivity of eUS-FNA for the diagnosis of solid mass lesions. We also examined which factors were associated with a self-reported sensitivity of eUS-FNA for the diagnosis of solid mass lesions 〉 80%.ReSULTS： Completed surveys were collected from 92 （57.1%） of 161 endosonographers who attended the conference. The endosonographers had been practio ing endoscopy and eUS for 22.5 4. 7.8 years and 4.8 4- 4.1 years, respectively; one third of them worked in a hospital with an annual caseload 〉 100 eUS-FNA. endoscopy practices were located in 29 countries, in- cluding 13 countries in Western europe that totaled 75.3% of the responses. Only one third of endosonog raphers reported a sensitivity for the diagnosis of solid mass lesions 〉 80% （interquartile range of sensitivities, 25.0%-75.0%）. Factors independently associated with a sensitivity 〉 80% were （1）〉 7 needle passes for pancreatic lesions or rapid on-site cytopathological evaluation （ROSe）（P 〈 0.0001）, （2） a high annual hospital caseload （P = 0.024） and （3） routine isolation of microcores from eUS-FNA samples （P =

关键词： Caseload Community surveys Cytopa- thology endoscopic ultrasonography Histopathology Quality improvement

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Pancreatitis and pancreatic cancer:A case of the chicken or the egg

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World Journal of Gastroenterology 2021年第23期27卷 3148-3157页

作者： Devica S Umans Sanne A Hoogenboom Noor J Sissingh Selma J Lekkerkerker Robert C Verdonk jeanin e van hooft Department of Gastroenterology and Hepatology Amsterdam Gastroenterology and MetabolismAmsterdam UMCAmsterdam 1105 AZThe Netherlands Department of Research and Development St.Antonius HospitalNieuwegein 3430 EMThe Netherlands Department of Gastroenterology and Hepatology Leiden University Medical CenterLeiden 2333 ZAThe Netherlands Department of Gastroenterology and Hepatology St.Antonius HospitalNieuwegein 3430 EMThe Netherlands

Acute pancreatitis(AP),chronic pancreatitis(CP)and pancreatic cancer are three distinct pancreatic diseases with different prognoses and treatment ***,it may be difficult to differentiate between benign and malignant *** may be a first symptom of pancreatic cancer,particularly in patients between the ages of 56 and 75 with presumed idiopathic AP who had a concomitant diagnosis of new-onset diabetes mellitus or patients who present with CP at diagnosis of *** these patients,additional imaging is warranted,preferably by endoscopic *** may lead to pancreatic cancer through oncogenic mutations,mostly in patients with hereditary CP,and in patients in whom risk factors for pancreatic cancer(e.g.,nicotine and alcohol abuse)are also *** with PRSS1-mediated CP and patients with a history of autosomal dominant hereditary CP without known genetic mutations may be considered for surveillance for pancreatic *** inflammation may mimic pancreatic cancer by appearing as a focal mass-forming lesion on *** between the above mentioned benign and malignant disease may be facilitated by specific features like the duct-penetrating sign and the duct-to-parenchyma *** efforts are aimed towards developing a superior discriminant between pancreatitis and pancreatic cancer in the form of imaging modalities or *** may aid clinicians in timely diagnosing pancreatic cancer in a potentially curable stage.

关键词： Pancreatic diseases Pancreatic neoplasms Pancreatitis Pancreas Chronic Pancreatitis exocrine pancreatic

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Artificial intelligence in gastroenterology: A state-of-the-art review

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World Journal of Gastroenterology 2021年第40期27卷 6794-6824页

作者： Paul T Kröner Megan ML engels Benjamin S Glicksberg Kipp W Johnson Obaie Mzaik jeanin e van hooft Michael B Wallace Hashem B el-Serag Chayakrit Krittanawong Division of Gastroenterology and Hepatology Mayo ClinicJacksonvilleFL 32224United States Cancer Center Amsterdam Department of Gastroenterology and HepatologyAmsterdam UMCLocation AMCAmsterdam 1105The Netherlands The Hasso Plattner Institute for Digital Health Icahn School of Medicine at Mount SinaiNew YorkNY 10029United States Department of Gastroenterology and Hepatology Leiden University Medical CenterAmsterdam 2300The Netherlands Division of Gastroenterology and Hepatology Sheikh Shakhbout Medical CityAbu Dhabi 11001United Arab Emirates Section of Gastroenterology and Hepatology Michael E.DeBakey VA Medical Center and Baylor College of MedicineHoustonTX 77030United States Section of Health Services Research Michael E.DeBakey VA Medical Center and Baylor College of MedicineHoustonTX 77030United States Section of Cardiology Michael E.DeBakey VA Medical CenterHoustonTX 77030United States

The development of artificial intelligence(AI)has increased dramatically in the last 20 years,with clinical applications progressively being explored for most of the medical *** field of gastroenterology and hepatology,substantially reliant on vast amounts of imaging studies,is not an *** clinical applications of AI systems in this field include the identification of premalignant or malignant lesions(e.g.,identification of dysplasia or esophageal adenocarcinoma in Barrett’s esophagus,pancreatic malignancies),detection of lesions(e.g.,polyp identification and classification,small-bowel bleeding lesion on capsule endoscopy,pancreatic cystic lesions),development of objective scoring systems for risk stratification,predicting disease prognosis or treatment response[e.g.,determining survival in patients post-resection of hepatocellular carcinoma),determining which patients with inflammatory bowel disease(IBD)will benefit from biologic therapy],or evaluation of metrics such as bowel preparation score or quality of endoscopic *** objective of this comprehensive review is to analyze the available AI-related studies pertaining to the entirety of the gastrointestinal tract,including the upper,middle and lower tracts;IBD;the hepatobiliary system;and the pancreas,discussing the findings and clinical applications,as well as outlining the current limitations and future directions in this field.

关键词： Artificial intelligence Machine learning Deep learning Clinical applications Gastroenterology

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Self-expandable metal stents for malignant gastric outlet obstruction: A pooled analysis of prospective literature

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World Journal of Gastroenterology 2015年第43期21卷 12468-12481页

作者： emo e van Halsema erik AJ Rauws Paul Fockens jeanin e van hooft Department of Gastroenterology and Hepatology Academic Medical Center

AIM: To provide an overview of the clinical outcomes of self-expandable metal stent(SeMS) placement for malignant gastric outlet obstruction(MGOO).MeTHODS: A systematic literature search was performed in Pub Med of the literature published between January 2009 and March 2015. Only prospective studies that reported on the clinical success of stent placement for MGOO were included. The primary endpoint was clinical success,defined according to the definition used in the original article. Data were pooled and analyzed using descriptive statistics. Subgroup analyses were performed for partially covered SeMSs(PCSeMSs) and uncovered SeMSs(UCSeMSs) using Fisher's exact ***: A total of 19 studies,including 1281 patients,were included in the final analysis. Gastric(42%) and pancreatic(37%) cancer were the main causes of MGOO. UCSeMSs were used in 76% of patients and PCSeMSs in 24%. The overall pooled technical success rate was 97.3% and the clinical success rate was 85.7%. Stent dysfunction occurred in 19.6% of patients,mainly caused by re-obstruction(12.6%) and stent migration(4.3%),and was comparable between PCSeMSs and UCSeMSs(21.2% vs 19.1%,respectively,P = 0.412). Re-obstruction was more common with UCSeMSs(14.9% vs 5.1%,P ent migration was more frequent after PCSeMS placement(10.9% vs 2.2%,P e overall perforation rate was 1.2%. Bleeding was reported in 4.1% of patients,including major bleeding in 0.8%. The median stent patency ranged from 68 to 307 d in five studies. The median overall survival ranged from 49 to 183 d in 13 ***: The clinical outcomes in this large population showed that enteral stent placement was feasible,effective and safe. Therefore,stent placement is a valid treatment option for the palliation of MGOO.

关键词： Stents Gastric outlet obstruction Stomach neoplasm

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Occurrence of seeding metastases in resectable perihilar cholangiocarcinoma and the role of low-dose radiotherapy to prevent this

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World Journal of Hepatology 2020年第11期12卷 1089-1097页

作者： Lotte C Franken eva Roos Job Saris jeanin e van hooft Otto M van Delden Joanne Verheij Joris I erdmann Marc G Besselink Olivier R Busch Geertjan van Tienhoven Thomas M van Gulik Department of Surgery Cancer Center AmsterdamAmsterdam UMCUniversity of AmsterdamAmsterdam 1105 AZNetherlands Department of Pathology Amsterdam UMCUniversity of AmsterdamAmsterdam 1105 AZNetherlands Department of Gastroenterology Amsterdam UMCUniversity of AmsterdamAmsterdam 1105 AZNetherlands Department of Interventional Radiology Amsterdam UMCUniversity of AmsterdamAmsterdam 1105 AZNetherlands Department of Radiation Oncology Amsterdam UMCUniversity of AmsterdamAmsterdam 1105 AZNetherlands

BACKGROUND Preoperative biliary drainage in patients with presumed resectable perihilar cholangiocarcinoma(PHC)is hypothesized to promote the occurrence of seeding *** metastases can occur at the surgical scars or at the site of postoperative drains,and in case of percutaneous biliary drainage,at the catheter *** prevent seeding metastases after resection,we routinely treated PHC patients with preoperative radiotherapy(RT)for over 25 years until January *** To investigate the incidence of seeding metastases following resection of *** All patients who underwent resection for pathology proven PHC between January 2000 and March 2019 were included in this retrospective *** 2000-January 2018,patients received preoperative RT(3×3.5 Gray).RT was omitted in patients treated after January *** A total of 171 patients underwent resection for PHC between January 2000 and March *** 171 patients undergoing resection,111 patients(65%)were treated with preoperative *** bile cytology showed no difference in the presence of viable tumor cells in bile of patients undergoing preoperative RT or ***,two patients(1.2%)with seeding metastases were identified,both in the laparotomy scar and both after preoperative RT(one patient with endoscopic and the other with percutaneous and endoscopic biliary drainage).CONCLUSION The incidence of seeding metastases in patients with resected PHC in our series was low(1.2%).This low incidence and the inability of providing evidence that preoperative low-dose RT prevents seeding metastases,has led us to discontinue preoperative RT in patients with resectable PHC in our center.

关键词： Perihilar cholangiocarcinoma Seeding metastases Preventive radiotherapy

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Therapeutic anticoagulation for splanchnic vein thrombosis in acute pancreatitis: A national survey and case-vignette study

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World Journal of Gastroenterology 2023年第21期29卷 3328-3340页

作者： Noor J Sissingh Jesse V Groen Hester C Timmerhuis Marc G Besselink Bas Boekestijn Thomas L Bollen Bert A Bonsing Frederikus A Klok Hjalmar C van Santvoort Robert C Verdonk Casper H J van eijck jeanin e van hooft Jan Sven D Mieog Department of Gastroenterology and Hepatology Leiden University Medical CentreLeiden 2333 ZANetherlands Department of Research and Development St.Antonius HospitalNieuwegein 3420 EMNetherlands Department of Surgery Leiden University Medical CentreLeiden 2333 ZANetherlands Department of Surgery St.Antonius HospitalNieuwegein 3420 EMNetherlands Department of Surgery Amsterdam UMCLocation University of AmsterdamAmsterdam 1081 HZNetherlands Amsterdam Gastroenterology endocrinology Metabolism Amsterdam 1105 AZNetherlands Department of Radiology Leiden University Medical CentreLeiden 2333 ZANetherlands Department of Radiology St.Antonius HospitalNieuwegein 3420 EMNetherlands Department of Medicine-Thrombosis and Hemostasis Leiden University Medical CentreLeiden 2333 ZANetherlands Department of Surgery University Medical Centre UtrechtUtrechtUtrecht 3584 CXNetherlands Department of Gastroenterology and Hepatology St.Antonius HospitalNieuwegein 3420 EMNetherlands Department of Surgery Erasmus Medical CentreRotterdam 3015 GDNetherlands

BACKGROUND Splanchnic vein thrombosis(SVT)is a major complication of moderate and severe acute *** is no consensus on whether therapeutic anticoagulation should be started in patients with acute pancreatitis and *** To gain insight into current opinions and clinical decision making of pancreatologists regarding SVT in acute *** A total of 139 pancreatologists of the Dutch Pancreatitis Study Group and Dutch Pancreatic Cancer Group were approached to complete an online survey and case vignette *** threshold to assume group agreement was set at 75%.ReSULTS The response rate was 67%(n=93).Seventy-one pancreatologists(77%)regularly prescribed therapeutic anticoagulation in case of SVT,and 12 pancreatologists(13%)for narrowing of splanchnic vein *** most common reason to treat SVT was to avoid complications(87%).Acute thrombosis was the most important factor to prescribe therapeutic anticoagulation(90%).Portal vein thrombosis was chosen as the most preferred location to initiate therapeutic anticoagulation(76%)and splenic vein thrombosis as the least preferred location(86%).The preferred initial agent was low molecular weight heparin(LMWH;87%).In the case vignettes,therapeutic anticoagulation was prescribed for acute portal vein thrombosis,with or without suspected infected necrosis(82%and 90%),and thrombus progression(88%).Agreement was lacking regarding the selection and duration of long-term anticoagulation,the indication for thrombophilia testing and upper endoscopy,and about whether risk of bleeding is a major barrier for therapeutic *** In this national survey,the pancreatologists seemed to agree on the use of therapeutic anticoagulation,using LMWH in the acute phase,for acute portal thrombosis and in the case of thrombus progression,irrespective of the presence of infected necrosis.

关键词： Acute pancreatitis Splanchnic vein thrombosis Therapeutic anticoagulation Bleeding Recanalization Outcomes

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Clinical outcomes of self-expandable stent placement for benign esophageal diseases: A pooled analysis of the literature

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World Journal of Gastrointestinal endoscopy 2015年第2期7卷 135-153页

作者： emo e van Halsema jeanin e van hooft Department of Gastroenterology and Hepatology Academic Medical Center

AIM: To analyze the outcomes of self-expandable stent placement for benign esophageal strictures and benign esophageal leaks in the ***: The Pub Med, embase and Cochrane databases were searched for relevant articles published between January 2000 and July 2014. eight prospective studies were identified that analyzed the outcomes of stent placement for refractory benign esophageal strictures. The outcomes of stent placement for benign esophageal leaks, perforations and fistulae were extracted from 20 retrospective studies that were published after the inclusion period of a recent systematic review. Data were pooled and analyzed using descriptive ***: Fully covered self-expandable metal stents(FC SeMS)(n = 85), biodegradable(BD) stents(n = 77) and self-expandable plastic stents(SePS)(n = 70) were inserted in 232 patients with refractory benign esophageal strictures. The overall clinical success rate was 24.2% and according to stent type 14.1% for FC SeMS, 32.9% for BD stents and 27.1% for SePS. Stent migration occurred in 24.6% of cases. The overall complication rate was 31.0%, including major(17.7%) and minor(13.4%) complications. A total of 643 patients were treated with self-expandable stents mainly for postsurgical leaks(64.5%), iatrogenic perforations(19.6%), Boerhaave's syndrome(7.8%) and fistulae(3.7%). FC SeMS and partially covered SeMS were used in the majority of patients. Successful closure of the defect was achieved in 76.8% of patients and according to etiology in 81.4% for postsurgical leaks, 86.0% for perforations and 64.7% for fistulae. The pooled stent migration rate was 16.5%. Stent-related complications occurred in 13.4% of patients, including major(7.8%) and minor(5.5%) ***: The outcomes of stent placement for refractory benign esophageal strictures were poor. However, randomized trials are needed to put this into perspective. The evidence on successful stent placement for benign esophageal leaks,

关键词： Self-expandable stents Benign esophagealstrictures esophageal perforation esophageal fistula Anastomotic leak Systematic review

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Avian introgression in the genomic era

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Avian Research 2017年第4期8卷 181-191页

作者： Jente Ottenburghs Robert H.S.Kraus Pim van hooft Sipke e.van Wieren Ronald C.Ydenberg Herbert H.T.Prins Resource ecology Group Wageningen UniversityDroevendaalsesteeg 3a6708 PB WageningenThe Netherlands Department of Biology University of Konstanz78457 ConstanceGermany Department of Migration and Immuno-ecology Max Planck Institute for OrnithologyAm Obstberg 178315 RadolfzellGermany Centre of Wildlife ecology Simon Fraser UniversityBurnabyBC V5A 1S6Canada

Introgression,the incorporation of genetic material from one(sub)species into the gene pool of another by means of hybridization and backcrossing,is a common phenomenon in birds and can provide important insights into the speciation *** the last decade,the toolkit for studying introgression has expanded together with the development of molecular *** this review,we explore how genomic data,the most recent step in this methodological progress,impacts different aspects in the study of avian ***,the detection of hybrids and backcrosses has improved *** most widely used software package is *** discordance(*** loci resulting in discordant gene trees) is another means for the detection of introgression,although it should be regarded as a starting point for further analyses,not as a definitive proof of ***,disentangling introgression from other biological processes,such as incomplete lineage sorting,remains a challenging endeavour,although new techniques,such as the D-statistic,are being *** addition,phylogenetics might require a shift from trees to ***,the study of hybrid zones by means of geographical or genomic cline analysis has led to important insights into the complex interplay between hybridization and ***,because each hybrid zone study is just a single snapshot of a complex and continuously changing interaction,hybrid zones should be studied across different temporal and/or spatial scales.A third powerful tool is the genome *** debate on which evolutionary processes underlie the genomic landscape is still ongoing,as is the question whether loci involved in reproductive isolation cluster together in ‘islands of speciation' or whether they are scattered throughout the *** genomic landscapes across the avian tree of life will be an exciting field for further ***,the findings from these different methods shoul

关键词： Admixture Cline theory D-statictic Genomic landscape Hybridization Phylogenetic discordance

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FAIR Principles:Interpretations and Implementation Considerations

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Data Intelligence 2020年第1期2卷 10-29,293-302,322页

作者： Annika Jacobsen Ricardo de Miranda Azevedo Nick Juty Dominique Batista Simon Coles Ronald Cornet Melanie Courtot Merce Crosas Michel Dumontier Chris T.evelo Carole Goble Giancarlo Guizzardi Karsten Kryger Hansen Ali Hasnain Kristina Hettne Jaap Heringa Rob W.W.hooft Melanie Imming Keith G.Jeffery Rajaram Kaliyaperumal Martijn GKersloot Christine R.Kirkpatrick Tobias Kuhn Ignasi Labastida Barbara Magagna PeterMcQuilton Natalie Meyers Annalisa Montesanti Mirjam van Reisen Philippe Rocca-Serra Robert Pergl Susanna-Assunta Sansone Luiz Olavo Bonino da Silva Santos Juliane Schneider George Strawn Mark Thompson Andra Waagmeester Tobias Weigel Mark D.Wilkinson egon L.Willighagen Peter Wittenburg Marco Roos Barend Mons erik Schultes Leiden University Medical Center Leiden2333 ZAThe Netherlands Institute of Data Science Maastricht UniversityUniversiteitssingel 60Maastricht 6229 ERThe Netherlands Department of Computer Science The University of ManchesterOxford RoadManchester M139PLUK Oxford e-Research Centre Department of Engineering SciencesUniversity of OxfordOxford OX13PJUK School of Chemistry Faculty of Engineering and Physical SciencesUniversity of SouthamptonSO171BJUK Amsterdam UMC University of AmsterdamAmsterdam 1000 GGThe Netherlands european Bioinformatics Institute(eMBL-eBI) HinxtonCambridgeCB101SDUK Harvard University CambridgeMassachusetts 02138USA Department of Bioinformatics–BiGCaT NUTRIMMaastricht UniversityMaastricht 6229 ERThe Netherlands Conceptual and Cognitive Modeling Research Group(CORe) Free University of Bozen-BolzanoBolzano 39100Italy Aalborg University Aalborg DK-9220Denmark Insight Centre for Data Analytics National University of Ireland GalwayH91 TK33Ireland Centre for Digital Scholarship Leiden University LibrariesLeiden2333 ZAThe Netherlands Department of Computer Science Vrije Universiteit AmsterdamDe Boelelaan 11051081 HV AmsterdamThe Netherlands Dutch Techcentre for Life Sciences(DTL) UtrechtThe Netherlands SURF Utrecht 3511 EPThe Netherlands Keith G Jeffery Consultants FaringdonUK Castor eDC Paasheuvelweg 25Wing 5D1105 BPAmsterdamThe Netherlands San Diego Supercomputer Center University of California San DiegoLa JollaCalifornia 92093USA Learning and Research Resources Centre(CRAI) Universitat de Barcelona08007 BarcelonaSpain environment Agency Austria A-1090 ViennaAustria University of Notre Dame 75004 ParisFrance Health Research Board(HRB) Dublin 2DO2 H638Ireland Liacs Institute of Advanced Computer Science Leiden University2311 GJ LeidenThe Netherlands Czech Technical University in Prague Faculty of Information Technology(FIT CTU)16000 Prague 6Czech Republic GO FAIR International Support&Coordination Office(GFISCO) LeidenThe Netherlands Harvard Catalys

The FAIR principles have been widely cited,endorsed and adopted by a broad range of stakeholders since their publication in *** intention,the 15 FAIR guiding principles do not dictate specific technological implementations,but provide guidance for improving Findability,Accessibility,Interoperability and Reusability of digital *** has likely contributed to the broad adoption of the FAIR principles,because individual stakeholder communities can implement their own FAIR ***,it has also resulted in inconsistent interpretations that carry the risk of leading to incompatible ***,while the FAIR principles are formulated on a high level and may be interpreted and implemented in different ways,for true interoperability we need to support convergence in implementation choices that are widely accessible and(re)-*** introduce the concept of FAIR implementation considerations to assist accelerated global participation and convergence towards accessible,robust,widespread and consistent FAIR *** self-identified stakeholder community may either choose to reuse solutions from existing implementations,or when they spot a gap,accept the challenge to create the needed solution,which,ideally,can be used again by other communities in the ***,we provide interpretations and implementation considerations(choices and challenges)for each FAIR principle.

关键词： FAIR guiding principles FAIR implementation FAIR convergence FAIR communities choices and challenges

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