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A strategy for Multi-objective Optimization under Uncertainty in Chemical Process Design

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Chinese Journal of Chemical Engineering 2008年第1期16卷 39-42页

作者：孙力 helen H.Lou Department of Chemical Engineering Dalian University of Technology Dalian 116023 China Department of Chemical Engineering Lamar University Beaumont Texas 77710 USA

In many circumstances, chemical process design can be formulated as a multi-objective optimization （MOO） problem. Examples include bi-objective optimization problems, where the economic objective is maximized and environmental impact is minimized simultaneously. Moreover, the random behavior in the process,property, market fluctuation, errors in model prediction and so on would affect the performance of a process. Therefore, it is essential to develop a MOO methodology under uncertainty. In this article, the authors propose a generic and systematic optimization methodology for chemical process design under uncertainty. It aims at identifying the optimal design from a number of candidates. The utility of this methodology is demonstrated by a case study based on the design of a condensate treatment unit in an ammonia plant.

关键词： multi-objective optimization uncertainty chemical process design

Adiponectin signalling in bone homeostasis,with age and in disease

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Bone Research 2021年第1期9卷 15-25页

作者： Jonathan W.Lewis James R.Edwards Amy J.Naylor helen M.McGettrick Rheumatology Research Group Institute of Inflammation and AgeingUniversity of BirminghamBirmingham B152TTUK Ageing&Regeneration Research Group Botnar Research CentreUniversity of OxfordOxford OX37LDUK

Adiponectin is the most abundant circulating adipokine and is primarily involved in glucose metabolism and insulin *** the bone,osteoblasts and osteoclasts express the adiponectin receptors,however,there are conflicting reports on the effects of adiponectin on bone formation and *** studies have shown a pro-osteogenic role for adiponectin in in vivo murine models and in vitro:with increased osteoblast differentiation and activity,alongside lower levels of ***,human studies often demonstrate an inverse relationship between adiponectin concentration and bone ***,the presence of multiple isoforms of adiponectin and multiple receptor subtypes has the potential to lead to more complex signalling and functional *** such,we still do not fully understand the importance of the adiponectin signalling pathway in regulating bone homeostasis and repair in health,with age and in *** this review,we explore our current understanding of adiponectin bioactivity in the bone;the significance of its different isoforms;and how adiponectin biology is altered in ***,furthering our understanding of adiponectin regulation of bone biology is key to developing pharmacological and non-pharmacological(lifestyle)interventions that target adiponectin signalling to boost bone growth and repair in healthy ageing,following injury or in disease.

关键词： homeostasis metabolism consequences

Research on the Relationship Between Garlic and Young Garlicshoot Based on Big Data

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Computers, Materials & Continua 2019年第2期58卷 363-378页

作者： Feng Guo Pingzeng Liu Wanming Ren Ning Cao Chao Zhang Fujiang Wen helen Min Zhou College of information science and engineering Shandong Agricultural UniversityTai’an271000China shandong Provincial Department of Agriculture Information Center Jinan250013China College of Information Engineering Qingdao Binhai UniversityQingdaoChina school of Engineering Manukau Institute of TechnologyAucklandNew Zealand

In view of the problems such as frequent fluctuation of garlic price, lack ofefficient forecasting means and difficulty in realizing the steady development of garlicindustry, combined with the current situation of garlic industry and the collected datainformation. Taking Big Data platform of garlic industry chain as the core, using themethods of correlation analysis, smoothness test, co-integration test, and Grangercausality test, this paper analyzes the correlation, dynamic, and causality between garlicprice and young garlic shoot price. According to the current situation of garlic industry,the garlic industry service based on Big Data is put forward. It is concluded that there is apositive correlation between garlic price and young garlic shoot price, and there is a longtermstable dynamic equilibrium relationship between young garlic shoot price and garlicprice fluctuation, and young garlic shoot price can affect garlic price. Finally, it isproposed to strengthen the infrastructure construction of garlic Big Data, increase thetechnological innovation and application of garlic Big Data technology, and promote thesafety and security ability of the whole industry to promote the development of garlicindustry.

关键词： Big Data big data in agriculture granger causality test big data platform

Building skills for the TOEFL iBT. 中高级

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Genomic regions underlying agronomic traits in linseed(Linum usitatissimum L.) as revealed by association mapping

丛书名：北极星英语系列教程

2006年

作者： helen s. solorzano

本书分北极星新TOEFL考试单元练习和ETs新TOEFL考试练习两部分,前者从媒体,克服障碍,医学,自然灾害,自然资源的保护,慈善事业,教育,食物,移民,技术等方面给出练习,后者包括听力,阅读,写作,口语,听力原文等内容。

ISBN: (纸本)7302134596

关键词：英语

来源：畅想之星图书光盘版（南... 评论

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Journal of Integrative Plant Biology 2014年第1期56卷 75-87页

作者： Braulio J.soto-Cerda scott Duguid helen Booker Gordon Rowland Axel Diederichsen sylvie Cloutier Department of Plant science University of Manitoba 66 Dafoe Road Cereal Research Center Agriculture and Agri-Food Canada 195 Dafoe Road Morden Research station Agriculture and Agri-Food Canada 101 Route 100 Unit 100 Morden Department of Plant sciences College of Agriculture and Bioresources University of Saskatchewan 51 Campus Drive Plant Gene Resources of Canada Agriculture and Agri-Food Canada 107 Science Place

The extreme climate of the Canadian Prairies poses a major chal enge to improve yield. Although it is possible to breed for yield per se, focusing on yield-related traits could be advantageous because of their simpler genetic architecture. The Canadian flax core col ection of 390 accessions was genotyped with 464 simple sequence repeat markers, and phenotypic data for nine agronomic traits including yield, bol s per area, 1,000 seed weight, seeds per bol , start of flowering, end of flowering, plant height, plant branching, and lodging col ected from up to eight environments was used for association mapping. Based on a mixed model （principal component analysis （PCA） t kinship matrix （K））, 12 significant marker-trait associations for six agronomic traits were identi-fied. Most of the associations were stable across environments as revealed by multivariate analyses. statistical simulation for five markers associated with 1000 seed weight indicated that the favorable al eles have additive effects. None of the modern cultivars carried the five favorable al eles and the maximum number of four observed in any accessions was mostly in＆amp;nbsp;breeding lines. Our results confirmed the complex genetic architecture of yield-related traits and the inherent difficulties associated with their identification while il ustrating the potential for improvement through marker-assisted selection.

关键词： Linum usitatissimum marker-assisted selection

The actin-bundling protein Fascin-1 modulates ciliary signalling

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Journal of Molecular Cell Biology 2023年第4期15卷 1-16页

作者： Lena Brücker stefanie Kornelia Becker Vanessa Maissl Gregory Harms Maddy Parsons helen Louise May-simera Cilia Cell Biology Institute of Molecular PhysiologyJohannes Gutenberg University Mainz55128 MainzGermany Imaging Core Facility Cell Biology UnitUniversity Medical CentreJohannes Gutenberg University Mainz55101 MainzGermany Randall Centre for Cell and Molecular Biophysics King's College LondonLondon SE11ULUK

Primary cilia are microtubule-based cell organelles important for cellular communication. since they are involved in the regulation of numerous signalling pathways, defects in cilia development or function are associated with genetic disorders, collectively called ciliopathies. Besides their ciliary functions, recent research has shown that several ciliary proteins are involved in the coordination of the actin cytoskeleton. Although ciliary and actin phenotypes are related, the exact nature of their interconnection remains incompletely understood. Here, we show that the protein BBs6, associated with the ciliopathy Bardet–Biedl syndrome, cooperates with the actin-bundling protein Fascin-1 in regulating filopodia and ciliary signalling. We found that loss of Bbs6 affects filopodia length potentially via attenuated interaction with Fascin-1. Conversely, loss of Fascin-1 leads to a ciliary phenotype, subsequently affecting ciliary Wnt signalling, possibly in collaboration with BBs6. Our data shed light on how ciliary proteins are involved in actin regulations and provide new insight into the involvement of the actin regulator Fascin-1 in ciliogenesis and cilia-associated signalling. Advancing our knowledge of the complex regulations between primary cilia and actin dynamics is important to understand the pathogenic consequences of ciliopathies.

关键词： cilia actin Wnt signalling ciliopathy Bardet–Biedl syndrome filopodia

Improving First Year Nursing student’s Test scores through Pediatric simulation

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Open Journal of Nursing 2015年第8期5卷 735-739页

作者： jeanette Harris Tamara Berghout Pamela Anderson school of Nursing Weber State University Ogden UT USA

Background: student test scores in the pediatric portion were at a national percentile rank of 30, which was concerning. It was theorized that the main contributor to this dilemma was that the majority of students were not able to have a pediatric clinical experience. Objective: The purpose of this project was to determine if the addition of pediatric simulation scenarios would have an impact on student learning as evidenced by end of level test scores. Method: A convenience sample (n = 100) of first year nursing students attending a university in the western United states participated in this project. This was a mixed methods study. A quasi-experimental design was used to compare test scores of both a non-intervention group and an intervention group of students. A 5 point Likert scale questionnaire was also using post-intervention to assess for changes in perceptions of self-confidence. Results: After implementation of the pediatric focused scenarios, students’ test scores increased to the 95th percentile. This 65 percentile increase is a significant change that suggests that pediatric simulation is effective in improving student exam performance. In addition, 81% of students also reported perceptions of increased levels of self-confidence after implementation of simulation scenarios. Conclusion: The findings suggest that simulation is an effective way to create alternative pediatric clinical experiences which can, in turn, increase student comprehension, test scores, and self-confidence.

关键词： simulation simulation in Nursing Education Nursing Education Nursing study & Teaching Experiential Learning simulation in Nursing Practice Pediatric simulation

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Let's run.

小朋友 2016年第21期 22-23页

作者： helen