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Recurrent Clostridium difficile infections:The importance of the intestinal microbiota

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World Journal of Gastroenterology 2014年第23期20卷 7416-7423页

作者： Marie Céline Zanella Terrier Martine louis Simonet Philippe Bichard jean.louis frossard Service of General Internal Medicine Geneva University Hospital1211 GenevaSwitzerland Service of Gastroenterology and Hepatology Geneva University Hospital1211 GenevaSwitzerland

Clostridium difficile infections(CDI)are a leading cause of antibiotic-associated and nosocomial *** effective antibiotic treatments,recurrent infections are *** the recent emergence of hypervirulent isolates of ***,CDI is a growing epidemic with higher rates of recurrence,increasing severity and *** microbiota transplantation(FMT)is an alternative treatment for recurrent CDI.A better understanding of intestinal microbiota and its role in CDI has opened the door to this promising therapeutic *** is thought to resolve dysbiosis by restoring gut microbiota diversity thereby breaking the cycle of recurrent *** the first reported use of FMT for recurrent CDI in 1958,systematic reviews of case series and case report have shown its effectiveness with high resolution rates compared to standard antibiotic *** article focuses on current guidelines for CDI treatment,the role of intestinal microbiota in CDI recurrence and current evidence about FMT efficacy,adverse effects and acceptability.

关键词： Clostridium difficile infection Clostridium difficile recurrence Fecal microbiota transplantation Stool transplantation Microbiota

Lateral ring compression test applied to a small caliber steel jacket:Identification of a constitutive model

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Defence Technology（防务技术） 2024年第6期36卷 133-148页

作者： Yann Coget Yael Demarty Christophe Czarnota Anthony Bracq jean-Sebastien Brest Alexis Rusinek French-German Research Institute of Saint-louis 5 Rue Du General Cassagnou68300 Saint-LouisFrance Laboratoire d'Etude des Microstructures et de Mecanique des Materiaux(LEM3) CNRSUniversite de LorraineArts&Metiers ParisTechF-57000 MetzFrance

The evolution of threats and scenarios requires continuous performance improvements of ballistic protections for armed *** a modeling point of view,it is necessary to use sufficiently precise material behavior models to accurately describe the phenomena observed during the impact of a projectile on a protective *** this context,the goal of this paper is to characterize the behavior of a small caliber steel jacket by combining experimental and numerical *** experimental method is based on the lateral compression of ring specimens directly machined from the thin and small *** speeds and temperatures are considered in a quasi-static regime in order to reveal the strain rate and temperature dependencies of the tested *** Finite Element Updating Method(FEMU)is *** results are coupled with an inverse optimization method and a finite element numerical model in order to determine the parameters of a constitutive model representative of the jacket *** of the present model are verified against experimental results and a parametric study as well as a discussion on the identified material parameters are *** results indicate that the strain hardening parameter can be neglected and the behavior of the thin steel jacket can be described by a modeling without strain hardening sensitivity.

关键词： Full metal jacket ammunition Lateral ring compression Inverse identification Numerical simulation

Emoti-Shing: Detecting Vishing Attacks by Learning Emotion Dynamics through Hidden Markov Models

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Journal of Intelligent Learning Systems and Applications 2024年第3期16卷 274-315页

作者： Virgile Simé Nyassi Franklin Tchakounté Blaise Omer Yenké Duplex Elvis Houpa Danga Magnuss Dufe Ngoran jean.louis Kedieng Ebongue Fendji Department of Mathematics and Computer Science Faculty of Science University of Ngaoundr Ngaoundr Cameroon Department of Computer Engineering University Institute of Technology University of Ngaoundr Ngaoundr Cameroon

This study examines vishing, a form of social engineering scam using voice communication to deceive individuals into revealing sensitive information or losing money. With the rise of smartphone usage, people are more susceptible to vishing attacks. The proposed Emoti-Shing model analyzes potential victims’ emotions using Hidden Markov Models to track vishing scams by examining the emotional content of phone call audio conversations. This approach aims to detect vishing scams using biological features of humans, specifically emotions, which cannot be easily masked or spoofed. Experimental results on 30 generated emotions indicate the potential for increased vishing scam detection through this approach.

关键词： Social Engineering Hidden Markov Model Vishing Voice Mining

Neutrophil depletion-but not prevention of Kupffer cell activation-decreases the severity of cerulein-induced acute pancreatitis

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World Journal of Gastroenterology 2006年第8期12卷 1219-1224页

作者： Catherine M Pastor Alain Vonlaufen Fabianna Georgi Antoine Hadengue Philippe Morel jean.louis frossard Laboratoire de Physiopathologie Hépatique et Imagerie Moléculaire H■pitaux Universitaires de GenèveB■timent CRoom 6-79524 Rue Micheli-du-Crest1205 GenevaSwitzerland Division of Gastroentérologie et Hépatologie H■pitaux Universitaires de Genève24 Rue Micheli-du-Crest1205 GenevaSwitzerland Département APSI H■pitaux Universitaires de Genève24 Rue Micheli-du-Crest1205 GenevaSwitzerland Département de Chirurgie H■pitaux Universitaires de Genève24 Rue Micheli-du-Crest1205 GenevaSwitzerland

AIM： To determine whether neutrophil depletion and Kupffer cell inhibition might combine their protective effects to decrease the severity of acute pancreatitis. METHODS： Nice had cerulein administration to induce acute pancreatitis and were pretreated with either anti-mouse neutrophil serum or gadolinium chloride （GdCh） to prevent Kupffer cell activation, or both treatments. Injury was assessed in pancreas and lungs. Myeloperoxidases （MPO） assessed neutrophil infiltration. Interleukin-6 （IL-6） and IL-10 were measured in serum, pancreas, lungs and liver. RESULTS： In mice with acute pancreatitis, neutrophil depletion reduced the severity of pancreatitis and pancreatitis-associated lung injury. Kupffer cell inactivation by GdCh had less protective effect, although IL-6 and IL-10 concentrations were significantly decreased. The protective treatment brought by neutrophil depletion was not enhanced by Kupffer cell inactivation and both treatments did not combine their protective effects. CONCLUSION： Our results confirm the role of activated neutrophils in aggravating organ injury in acute pancreatitis while the role of Kupffer cell activation is less obvious.

关键词： Acute pancreatitis Cytokines Neutrophils Kupffer cells Pulmonary injury

Recent advances in gastrointestinal cancers

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World Journal of Gastroenterology 2021年第28期27卷 4493-4503页

作者： Natacha Bordry Christoforos Astaras Marie Ongaro Nicolas Goossens jean.louis frossard Thibaud Koessler Department of Oncology University Hospital of Geneva(HUG)Genève 1205Switzerland Divison of Gastroenterology and Hepatology University Hospital of Geneva(HUG)Genève 1205Switzerland

Gastrointestinal cancers occur in a total of eight different locations,each of them with a different standard of *** article is not an exhaustive review of what has been published in *** have concentrated on the thirteen phase III randomized studies that are *** these studies are oral presentations which have been given in one of the four major oncology congresses,namely American Society of Clinical Oncology(ASCO),ASCO gastrointestinal(GI),European Society of Medical Oncology(ESMO)and *** provide a concise view of these major trials and their main outcomes,and put these results into context.

关键词： Practice changing trials Immunotherapy Gastrointestinal cancers Gastrointestinal Gastric cancer

Molecular Characterization of Gastrointestinal Stromal Tumors (Gist) and Contribution of Immunohistochemistry in Congolese from Kinshasa

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Open Journal of Gastroenterology 2024年第4期14卷 109-116页

作者： Rive Lukuaku Jérémie Okumadi Fabrice Bokambandja Andy Mbangama Vincent Mbatu Georges Mvumbi jean.louis Mumbere David Azako Serge Pezo Dieudonné Mvumbi Faculty of Medicine Bel Campus Technological University Kinshasa DR Congo Department of Anatomy and Pathological Cytology University Clinics of Kinshasa Kinshasa DR Congo Department of Gyneco-Obstetrics University Clinics of Kinshasa Kinshasa DR Congo Molecular Biology Department Faculty of Medicine University of Kinshasa Kinshasa DR Congo Institute of Medical Immunology Free University of Brussels Ixelles Belgium

Introduction: The differentiation of digestive tumors very often requires the use of techniques currently not widely in use in the Democratic Republic of Congo (DRC), such as immunohistochemistry. This is perfectly verified for GISTs whose precise, or at least highly certain, diagnosis can only be made using immunohistochemical markers. This underuse of these techniques due to lack of equipment and human skills explains the limited epidemiological data available to date, thus leading to untargeted and too often late treatment of patients. Research question: What contribution can immunohistochemical markers make to the diagnosis of digestive tract tumours? Objective: Discuss the contribution of immunohistochemical markers in the diagnosis of GIST and provide basic data on the epidemiology of these nosological entities in Kinshasa. Methodology: This was a retrospective study carried out at the LEBOMA private anatomy and pathological cytology centre. The main inclusion criterion was any digestive tract block or slide whose diagnosis of GIST had been requalified after review by at least 2 pathologists. An immuhistochemical study was performed using an automated technique (with a Ventana XT machine) using a panel of antibodies: CD-117 and DOG-1 which are listed in the literature as strongly correlated with the occurrence of GIST, all slides were made at Hj Hospital using an OLYMPUS BX41 co-observation microscope. Results: Of 601 cases of digestive tumors recorded during the concerned period, 32 (5.32%) concerned GIST. This prevalence was confirmed by our immunohistochemical results where the expression of CD117 and that of DOG-1 were positive in 90.6% and 100% of cases which prevalence is high compared with the worldwide prevalence according to the literature, respectively. The distribution of the patients concerned was made with a sex ratio of 1.6 women/men with a median age of 53 years. Most cases (81%) had a gastric location and were fusiform GISTs. Conclusion: Gastro

关键词： Digestive Tumors GIST Immunohistochemistry CD117 DOG-1

Phytochemical Analysis and Antioxidant Activity of Aqueous and Hydroethanolic Extracts from Three Anticancerous Fabaceae of Northern Cameroon Pharmacopoeia

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Journal of Biosciences and Medicines 2024年第6期12卷 19-32页

作者： Halmata Mohamadou Landry Lienou Lienou Richard Simo Tagne Herve Pabamé Kada Elisee Libert Enyengue Embolo Grace Kembaou Nganwa jean.louis Oyono Essame Piere Michel Dongmo Jazet Anatomy and Cytology Pathology Laboratory Institute of Medical Research and Medicinal Plants Studies (IMPM) Yaound Cameroon Department of Biochemistry Faculty of Science University of Douala Douala Cameroon Department of Biomedical Sciences University of Ngaoundere Ngaoundere Cameroon General Hospital of Garoua (HGG) Garoua Cameroon Anatomo-Cytopathology Department of Biological Sciences Faculty of Medicine and Pharmacy University of Douala Douala Cameroon

Background: Cancer continues to pose a significant threat to our society, representing one of the most pressing health concerns worldwide. This study aimed to evaluate the chemical composition and the antioxidant activity of aqueous and hydroethanolic extracts from Acacia nilotica (An), Bauhinia reticulate (Br), and Tamarindus indica (Ti) of Fabaceae family, traditionally used in Northern Cameroon for cancer treatment. Methods: The phytochemical screening of the three plants was conducted using conventional colorimetric methods, followed by the measurement of total phenol content, flavonoids, and tannins. The antiradical and antioxidant activities of both plant extracts were assessed through FRAP, ABTS, and DPPH methods. A principal components analysis was employed to correlate the quantities of the evaluated secondary metabolites with the activities. Results: Both types of extracts from the three plants contain alkaloids, saponins, flavonoids, phenolic compounds, tannins, glycosides, terpenoids, coumarins, anthocyanins, and anthraquinones. The aqueous extracts of Br and An are significantly richer (p Conclusion: The three Fabaceae plants from northern Cameroon, prepared in different solvents, can be utilized for their antiradical properties in cancer treatment.

关键词： Cancer Antioxidant Fabaceae Phenolic Compounds Aqueous Extract Hydroethanolic Extract

Comparative Study of Solar PV Power Plant Dimensionnement Connected to Network Based on Monofacial and Bifacial Modules

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Journal of Environmental Science and Engineering(A) 2024年第1期13卷 36-44页

作者： DJOSSOU Ayihaou Armand VODOUNNOU Edmond Claude FANNOU jean.louis Comlan DANSOU MidokpêRomuald SEMASSOU Guy Clarence HOUNGAN Comlan Aristide GUIDI Tognon Clotilde Thierno Amadou Barry Laboratory of Processes and Technological Innovation(LaPIT)/National Higher Institute of Industrial Technology(INSTI)of Lokossa/UNSTIM PB 133-Lokossa(Benin) Laboratory of Energetics and Applied Mechanics(LEMA)/Polytechnic School of Abomey-Calavi(EPAC)/UAC 01 PB 2009-Cotonou(Benin) National Higher School of Energy and Process Engineering(ENSGEP)of Abomey/UNSTIM National Higher School of Technical Education(ENSET)of Lokossa/UNSTIM 不详

This article presents the results of comparative study of two PV solar modules technologies,namely monofacial and *** study main objective is to identify conditions and parameters that make it possible to obtain better energy and economic efficiency from one or other of two *** study reason lies in revival observed on bifacial module in recent years where all the major manufacturers of PV solar panels are developing them where in a few years,this technology risks being at the same price as the monofacial solar panel with better *** indicator used is energy levelized cost(LCOE)which is function technology type,energy productivity,annual investment and operation *** achieve this,a 3.685 MWc solar PV power plant was dimensioned and simulated under Matlab for a 3.5 ha site with a 2,320,740,602 FCFA budget for monofacial installation,against 1,925,188,640 FCFA for 2.73 MWc bifacial *** LCOE comparative analysis of two technologies calculated over a period of 25 years,showed that plant with bifacial panels is more beneficial if bifacial gain is greater than 9%.It has further been found that it is possible to gain up to 40%of invested cost if bifacial gain reaches 45%.Finally,a loss of about 10%of invested cost could be recorded if bifacial gain is less than 9%.

关键词： Solar PV power plant Sizing Monofacial panels Bifacial panels LCOE.

Supervised Learning Method: Critical Analysis and Updating of Cubing Rate Formulas for Determining Bark Masses of Prunus africana (Hook. f.) Kalkman (Rosaceae) in Cameroon

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Open Journal of Forestry 2024年第3期14卷 346-368页

作者： Armand Ndedy Bile Alain Mpouam Benoit Fouadjio Lorette Guedeu Kambale Muhesi Steve Tassiamba Paulette Kouam Eric Wete Marius Ela Michèle Yimga Joseph Ambara louis Aimé Fono jean Lagarde Betti Department of Plant Biology Faculty of Science The University of Douala Douala Cameroon Department of Wood and Forest Sciences ISABEE University of Bertoua Bertoua Cameroon Department of Water and Forests Higher Institute of Agronomic Veterinary and Forestry Studies of Butembo Butembo Democratic Republic of Congo Department of Forestry Faculty of Agronomy and Agricultural Sciences University of Dschang Dschang Cameroon Department of Biology and Plant Faculty of Sciences University of Maroua Maroua Cameroon Deutsche Gresellschaft fur Internationale Zusammenarbeit GmbH (GIZ) Bertoua Cameroon Department of Mathematics and Computer Science Faculty of Science The University of Douala Douala Cameroon

The stem barks of Prunus africana are used in the treatment of the benign prostate. Cameroon is one of the important exporters of the barks. Despite the important measures adopted in Cameroon for sustaining its harvesting, some many chalenges still remain. The objective of this work is to refine the forest management parameters in relation to P. africana in the regions of Adamaoua and the South-West by developing a volume rate which makes it possible to estimate the production for a new stem. The work took place in two phases: in the South-West in 2010 and in Adamaoua in 2011. Data collection used the semi-direct method, while the cubing equation was deduced by the multiple linear regression method. Two models for volume estimation and three models for mass prediction were developed. The predictive parameters retained are diameter, height of the bole and thickness of the bark. Results show that the average mass of the dry bark for a given P. africana tree species is 27.55 ± 14.44 kg and this varies according to the site. The strong adjusted coefficient of determination (adjusted R2) observed illustrates the reliability of the proposed models. These models provide a reliable tool that can be adopted as a standard in Cameroon for P. africana.

关键词： Prunus africana Prostate Quota Mass Model Sustainable Management