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Journal of Magnesium and Alloys 2024年第3期12卷 954-965页

作者： Yimeng Chen Manuel Legrée jean.louis Bobet Alexander Kvit CAMECA Instruments Inc MadisonWI 53711USA ICMCB Universitéde BordeauxPessacCEDEX 33608France NIAC&Materials Science Department University of WisconsinMadisonWI 53706USA

The long-period-stacking-ordered(LPSO)structure affects the mechanical,corrosion and hydrolysis properties of Mg *** current work employs high angle annular dark field-scanning transmission electron microscopy(HAADF-STEM)and atom probe tomography(APT)to investigate the structural and local chemical information of LPSO phases formed in Mg-Ni-Y/Sm ternary alloys after extended isothermal *** on the alloying elements and their concentrations,Mg-Ni-Y/Sm develops a two-phase LPSO+α-Mg structure in which the LPSO phase contains defects,hybrid LPSO structure,and Mg ***-STEM and APT indicate non-stoichiometric LPSO with incomplete Ni_(6)(Y/Sm)_(8) *** addition,the APT quantitatively determines the local composition of LPSO and confirms the presence of Ni within the Mg bonding *** results provide insight into a better understanding of the structure and hydrolysis properties of LPSO-Mg alloys.

关键词： Magnesium alloys Long-range ordering Atom probe tomography(APT) STEM HAADF Hydrolysis properties.

Joint Management of Shared Resources, Issues and Conflicts of the Nso and Oku Tribes in the Ngongbaa Montane Forest Area, NWR of Cameroon

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Natural Resources 2024年第6期15卷 149-172页

作者： jean.louis Tatah Elvis Kah Department of Geography Faculty of Arts Letters and Social Sciences University of Yaounde I Yaounde Cameroon School of Geology and Mining Engineering University of Ngaoundere Ngaoundere Cameroon

Wherever people live together in or near homelands that harbour joint natural resources such as forest, water, minerals, oil etc., they must collaborate, co-exist and share these resources irrespective of their genetic, social, cultural, and political peculiarities. This is not always the case when self-interest, ethnic divisions, elitist politics, economic interest and power tussle set in. The Nso and Oku people who reside in the Ngongbaa Forest area constitute an example of joint management of resources where at one period, their relationship over the management of the Oku Mountain Forest was cordial and at another, the relationship became conflictive. This study was designed to study the influence of the KIFP forest management policies on the Nso indigenous forest Management system in Ngongbaa Forest, and its implications. The data collected for the study was secured through the administration of a questionnaire to residents of 10 villages adjacent to the Ngongbaa Forest, and forest users who carried out livelihood activities there between 1963 and 2015. These forest user groups include beekeepers, rat trappers, grazers, mushroom gatherers, ground honey/tree honey harvesters, carvers, etc. The investigation also extended to the traditional leaders of Nso and Oku who are in charge of the land tenure systems. The findings show that the Oku Mountain Forest is jointly owned by the Nso and Oku people. The Nso own the eastern half of the forest known as Ngongbaa Forest while the Oku own the western half, known as the Kilum Forest. The cordial relationship that existed between these people ensured the conservation of the forest. But the conflicts that later set in, especially due to the creation of the Kilum Mountain Forest Project in 1987 later changed to the Kilum Ijim Forest Project (KIFP) in 1992 sidelined the local communities which was contrary to the dispositions of the new Cameroon forest law enacted in 1994. Thus, the indigenous conservation practices became ig

关键词： Conflict Joint Management Shared Resources Ngongbaa Kilum Conservation

Statistical Study of the Geoeffectivity of Halo Coronal Mass Ejections Associated with X-Class Flares during Solar Cycles 23 and 24

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Open Journal of Applied Sciences 2024年第4期14卷 950-960页

作者： Younoussa Diakite Christian Zoundi M’Bi Kabore jean.louis Zerbo Laboratoire de Chimie Analytique de Physique Spatiale et Energ&#233tique (L@CAPSE) Physics Department Universit&#233 Norbert Zongo Koudougou Burkina Faso Laboratoire de Maté riaux d&#8217H&#233liophysique et Environnement (LAMHE) Physics Department Universit&#233 Nazi Boni Bobo-Dioulasso Burkina Faso

By analysing a long series of data (1996-2019), we show that solar cycle 23 was more marked by violent solar flares and coronal mass ejections (CMEs) compared to solar cycle 24. In particular, the halo coronal mass ejections associated with X-class flares appear to be among the most energetic events in solar activity given the size of the flares, the speed of the CMEs and the intense geomagnetic storms they produce. Out of eighty-six (86) X-class halo CMEs, thirty-seven (37) or 43% are highly geoeffective;twenty-four (24) or approximately 28% are moderately geoeffective and twenty-five (25) or 29% are not geoeffective. Over the two solar cycles (1996 to 2019), 71% of storms were geoeffective and 29% were not. For solar cycle 23, about 78% of storms were geoeffective, while for solar cycle 24, about 56% were geoeffective. For the statistical study based on speed, 85 halo CMEs associated with X-class flares were selected because the CME of 6 December 2006 has no recorded speed value. For both solar cycles, 75.29% of the halo CMEs associated with X-class flares have a speed greater than 1000 km/s. The study showed that 42.18% of halo (X) CMEs with speeds above 1000 km/s could cause intense geomagnetic disturbances. These results show the contribution (in terms of speed) of each class of halo (X) CMEs to the perturbation of the Earth’s magnetic field. Coronal mass ejections then become one of the key indicators of solar activity, especially as they affect the Earth.

关键词： CME Halo (X) Geoeffectivity Geomagnetic Storm Solar Flare Solar Cycle

Experimental evidence of obesity as a risk factor for severe acute pancreatitis

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World Journal of Gastroenterology 2009年第42期15卷 5260-5265页

作者： jean.louis frossard Pierre Lescuyer Catherine M Pastor Service of Gastroenterology Geneva University HospitalsGeneva 1205Switzerland Laboratory of pathophysiology and molecular imaging Geneva University HospitalsGeneva 1205Switzerland Service of Genetics and Central Laboratory Geneva University HospitalsGeneva 1205Switzerland

The incidence of acute pancreatitis, an inflammation of the pancreas, is increasing worldwide. Pancreatic injury is mild in 80%-90% of patients who recover without complications. The remaining patients may develop a severe disease with local complications such as acinar cell necrosis, abscess and remote organ injury including lung injury. The early prediction of the severity of the disease is an important goal for physicians in management of patients with acute pancreatitis in order to optimize the therapy and to prevent organ dysfunction and local complications. For that purpose, multiple clinical scale scores have been applied to patients with acute pancreatitis. Recently, a new problem has emerged： the increased severity of the disease in obese patients. However, the mechanisms by which obesity increases the severity of acute pancreatitis are unclear. Several hypotheses have been suggested：（1） obese patients have an increased inflammation within the pancreas; （2） obese patients have an increased accumulation of fat within and around the pancreas where necrosis is often located; （3） increase in both peri- and intra-pancreatic fat and inflammatory cells explain the high incidence of pancreatic inflammation and necrosis in obese patients; （4） hepatic dysfunction associated with obesity might enhance the systemic inflammatory response by altering the detoxiflcation of inflammatory mediators; and （5） ventilation/perfusion mismatch leading to hypoxia associated with a low pancreatic flow might reduce the pancreatic oxygenation and further enhance pancreatic injury. Recent experimental investigations also show an increased mortality and morbidity in obese rodents with acute pancreatitis and the implication of the adipokines leptin and adiponectin. Such models are important to investigate whether the inflammatory response of the disease is enhanced by obesity. It is exciting to speculate that manipulation of the adipokine milieu has the potential to influence the severi

关键词： Acute pancreatitis Obesity Adiponectin Leptin

Clopidogrel and proton pump inhibitors-where do we stand in 2012?

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World Journal of Gastroenterology 2012年第18期18卷 2161-2171页

作者： Michael D Drepper Laurent Spahr jean.louis frossard Division of Gastroenterology Department of Internal MedicineGeneva University Hospital14 Geneva CH-1211Switzerland

Clopidogrel in association with aspirine is considered state of the art of medical treatment for acute coronary syndrome by reducing the risk of new ischemic *** treatment with proton pump inhibitors in order to prevent gastrointestinal side effects is recommended by clinical *** needs metabolic activation predominantly by the hepatic cytochrome P450 isoenzyme Cytochrome 2C19(CYP2C19) and proton pump inhibitors(PPIs) are extensively metabolized by the CYP2C19 isoenzyme as *** pharmacodynamic studies investigating a potential clopidogrel-PPI interaction found a significant decrease of the clopidogrel platelet antiaggregation effect for omeprazole,but not for *** clinical cohort studies in 2009 reported an increased risk for adverse cardiovascular events,when under clopidogrel and PPI treatment at the same *** observations led the United States Food and Drug Administration and the European Medecines Agency to discourage the combination of clopidogrel and PPI(especially omeprazole) in the same *** contrast,more recent retrospective cohort studies including propensity score matching and the only existing randomized trial have not shown any difference concerning adverse cardiovascular events when concomitantly on clopidogrel and PPI or only on *** meta-analyses report an inverse correlation between clopidogrel-PPI interaction and study quality,with high and moderate quality studies not reporting any association,rising concern about unmeasured confounders biasing the low quality ***,no definite evidence exists for an effect on *** PPI induced risk reduction clearly overweighs the possible adverse cardiovascular risk in patients with high risk of gastrointestinal bleeding,combination of clopidogrel with the less CYP2C19 inhibiting pantoprazole should be recommended.

关键词： Clopidogrel Thienopyridine Proton pump inhibitors Drug interaction Platelet reactivity Antiplatelet therapy Cytochromes Acute coronary syndrome Gastrointestinal bleeding

Experimental Assessment of the Thermal Performance of Two Corrugated Metal Roofs

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Open Journal of Applied Sciences 2024年第9期14卷 2374-2392页

作者： Kouamé jean.louis Kouakou Ekoun Paul Magloire Koffi Bi Tra Désiré Zinla Prosper Gbaha Laboratoire des Procds Industriels de Synthse de lEnvironnement et des Energies Nouvelles Institut National Polytechnique Felix Houphout-Boigny Yamoussoukro Cte dIvoire

This experimental study is a contribution to the search for solutions to reduce indoor heat gain through sheet metal roofing in hot weather. It has evaluated the thermal impact of two different sheet metal roofs inside of two identical test buildings in sunny weather and cloudy weather conditions. Test building 1 has a single sheet corrugated roof and the building 2 is covered with roof made from top to bottom with corrugated sheet metal, a 12 mm thick serpentine copper tube in which water is circulated, a sheet of aluminium foil acting as a heat reflector, a 4 cm thick polystyrene panel and a 1.5 cm thick plywood. A maximum reduction of 15.1˚C in the temperature of the inner face of the test Building 2 roof was obtained comparatively to the temperature of the inner face of the test Building 1 roof consisting of a single sheet of metal at the warmest hours. In addition, the simple corrugated sheet metal roof of the test building generates high and varied temperatures inside the building. Whereas the proposed heat recovery roof favours low and relatively uniform temperatures inside the building. The proposed sheet metal roof construction technique is very effective in reducing the heat gain through the roof considerably;thus improving the thermal comfort inside sheet metal roofed dwellings. Hot water has been produced by recovering heat from the metal sheet of the roof of test building 2. The temperature of the hot water produced reached of 39˚C. This study could be also an alternative for the reduction of energy consumption due to the use of mechanical means for cooling of sheet metal roofed houses and the reduction of the use of fossil fuels for domestic hot water production.

关键词： Metal Roof Corrugated Time Lag Decrement Factor

High prevalence of cholestasis, with increased conjugated bile acids in inflammatory bowel diseases patients

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World Journal of Clinical Cases 2018年第4期6卷 44-53页

作者： Marc Girardin Antoine Hadengue jean.louis frossard Service of Gastroenterology and Hepatology Geneva University Hospital

AIM To investigate the prevalence and causes of cholestasis in patients with inflammatory bowel diseases in the Swiss Inflammatory Bowel Diseases Cohort. METHODS A retrospective cohort study was performed of all the patients in the Swiss Inflammatory bowel disease Cohort. Total bile acid was measured for all patients and cholestasis was defined as a concentration > 8 μmol/L. The characteristics of patients with or without cholestasis were compared. Bile acid profiles were then determined for 80 patients with high total bile acid and 80 matched patients with low total bile acid. Bile acid profiles were compared for smokers vs nonsmokers, ileal vs colonic disease, and inflammatory vs non inflammatory *** Ninety-six patients had more than 8 μmol/L total bile acid, giving a prevalence of 7.15%. Patients with an obvious cause of cholestasis, such as primary sclerosing cholangitis, were then excluded, leaving 1190 participants with total bile acid 8 μmol/L. In multivariate analysis, calcium supplementation was significantly associated with cholestasis(odds ratio, 2.36, 95%CI: 1.00-5.21, P = 0.040) whereas current smoking significantly reduced the risk of cholestasis(odds ratio, 0.42, 95%CI: 0.17-0.91, P = 0.041). Levels of all conjugated bile acids were higher in the cholestasis group than in the control group. When we compared patients with ileal vs colonic disease, the former had higher levels of primary, secondary, and tertiary bile acids whereas patients with colonic disease had higher levels of conjugated bile *** Prevalence of cholestasis is high. Smoking appears to reduce cholestasis. Conjugated bile acids are higher in cholestasis and in colonic disease whereas unconjugated in ileal disease.

关键词： Lipid Liver Crohn’s disease Ulcerative colitis Cholestasis

Interpretation of Geological and Gravity Data from the Bamiléké Plateau (West-Cameroon): Implication for the Understanding of Its Underground Lithotectonic Geometry

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Journal of Geoscience and Environment Protection 2024年第9期12卷 283-314页

作者： louis Christian Kamgang Chendjou jean Victor Kenfack Jules Tcheumenak Kouémo Fidèle Koumetio Armand Kagou Dongmo Department of Earth Sciences Faculty of Science University of Dschang Dschang Cameroon Department of Earth Sciences Faculty of Sciences University of Douala Douala Cameroon Department of Physics Faculty of Sciences University of Dschang Dschang Cameroon

The Bamiléké Plateau represents a key domain in the understanding of the geodynamics associated with the central Cameroon shear. The study aimed to highlight the subsurface architecture of the plateaus basement setting with focus on high potential areas for hydrogeological and mining development projects. To this end, geological field observations were carried out. Since the structures sought were near-surface, a separation approach based on the upward continuation method was applied to the Bouguer anomaly grid. A set of processing techniques, including vertical derivative or DZ, analytical signal or SA and categorization of gravity signatures, was applied to generate the residual map. The synthesis geological model, obtained from analysis and interpretation of the various transformed maps and 2.5D modeling of two gravity profiles P1 and P2 highlights the following features: 1) intrusions of steep-sided granitic batholiths from Dschang to Bandjoun (profile P1), increasing in width from NW (Dschang) to SE (Bandjoun);2) larger volume batholiths with moderate sides located at Bafang and Bangangté (profile P1). These plutonic massifs were weakened by brittle deformation, which favored the emplacement of phonolite or anorthosite dykes within them. The emplacement of these dykes was accompanied by compressional faults with high dip between Dschang and Bandjoun and extensional faults with medium dip between Bafang and Bangangté. These fault zones (trending N85E to N95E) are ideal for hydrogeological investigations in a basement setting, as well as a series of dyke networks that could potentially be preferred zones for the circulation and accumulation of useful substances. The resulting geological sections P1 and P2 highlight the influence of granitic intrusions in the geological system of the study area, as well as the structural control associated with the various dyke intrusions. All the models obtained can serve as fundamental references for hydrogeological and mining e

关键词： Bamiléké Plateau Gravity Measurement Gravity Anomalies Lineaments

Concomitant autoimmune and genetic pancreatitis leads to severe inflammatory conditions

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World Journal of Gastroenterology 2008年第16期14卷 2596-2598页

作者： jean.louis frossard jean Marc Dumonceau Catherine Pastor Laurent Spahr Antoine Hadengue Division de Gastroentérologie et Hépatologie Geneva University Hospital

Chronic pancreatitis characterized by an early onset should be extensively investigated including the search for a mutation of the PRSS1, SPINK-1 or CFTR genes and potential features of autoimmune pancreatitis. We here describe a case of chronic pancreatitis with an onset at a very young age in which a mutation of the PRSS1 and several features of autoimmune pancreatitis were identified.

关键词： Chronic pancreatitis Genetics Autoimmunepancreatltis SPINK-1 CFTR PRSS1

Recent advances in the management of autoimmune pancreatitis in the era of artificial intelligence

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World Journal of Gastroenterology 2022年第48期28卷 6867-6874页

作者： Sahar Mack Yves Flattet Philippe Bichard jean.louis frossard Division of Gastroenterology Department of Medical SpecialtiesUniversity Hospital of GenevaGeneva 1205Switzerland

Autoimmune pancreatitis(AIP)is a type of immune-mediated pancreatitis subdivided into two subtypes,type 1 and type 2 ***,type 1 AIP is considered to be the pancreatic manifestation of the immunoglobulin G4(IgG4)-related ***,AIP is increasingly researched and recognized,although its diagnosis represents a challenge for several reasons:False positive ultrasound-guided cytological samples for a neoplastic process,difficult to interpret levels of IgG4,the absence of biological markers to diagnose type 2 AIP,and the challenging clinical identification of atypical ***,60%and 78%of type 1 and type 2 AIP,respectively,are retrospectively diagnosed on surgical specimens of resected pancreas for suspected *** distinguishing AIP from pancreatic ductal adenocarcinoma can be challenging,obtaining a definitive diagnosis can therefore prove difficult,since endoscopic ultrasound fine-needle aspiration or biopsy of the pancreas are *** paper focuses on recent innovations in the management of AIP with regard to the use of artificial intelligence,new serum markers,and new therapeutic approaches,while it also outlines the current management recommendations.A better knowledge of AIP can reduce the recourse to surgery and avoid its overuse,although such an approach requires close collaboration between gastroenterologists,surgeons and *** knowledge on AIP and IgG4-related disease remains necessary to diagnose and manage patients.

关键词： Autoimmune pancreatitis Pancreatic ductal adenocarcinoma Immunoglobulin G4-related disease Prednisone Rituximab Artificial intelligence Plasmablasts