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Vitamin D, Parathyroid Hormone, Insulin Sensitivity and Islet β -Cell Secretory Function in Diabetic Patients from South Kivu in the Democratic Republic of Congo: Cross-Sectional Study

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Anatomical and electrophysiological plasticity of locomotor networks following spinal transection in the salamander

Journal of Diabetes Mellitus（糖尿病） 2024年第2期 81页

作者： Dieudonne Masemo Bihehe Ahadi Birindwa Bwihangane jean-Paulin Mukonkole Mbo Michel Hermans philippe Bianga Katchunga

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Neuroscience Bulletin 2013年第4期29卷 467-476页

作者： jean-Marie Cabelguen Stéphanie Chevallier Ianina Amontieva-Potapova Céline philippe Neurocentre Magendie INSERM U 862 - Bordeaux University

Recovery of locomotor behavior following spinal cord injury can occur spontaneously in some vertebrates, such as fish, urodele amphibians, and certain reptiles. This review provides an overview of the current status of our knowledge on the anatomical and electrophysiological changes occurring within the spinal cord that lead to, or are associated with the [e-expression of locomotion in spinally-transected salamanders. A better understanding of these processes will help to devise strategies for restoring locomotor function in mammals, including humans.

关键词： salamander spinal cord locomotor recovery regeneration

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High-Density Nanowells Formation in Ultrafast Laser-Irradiated Thin Film Metallic Glass

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Nano-Micro Letters 2022年第6期14卷 308-322页

作者： Mathilde Prudent Djafar Iabbaden Florent Bourquard Stéphanie Reynaud Yaya Lefkir Alejandro Borroto jean-François Pierson Florence Garrelie jean-philippe Colombier Univ Lyon UJM-Saint-EtienneCNRSInstitute of Optics Graduate SchoolLaboratoire Hubert CurienUMR CNRS 551642023 St-EtienneFrance Universitéde Lorraine CNRSIJL54000 NancyFrance

We present an effective approach for fabricating nanowell arrays in a one-step laser process with promising applications for the storage and detection of chemical or biological *** thin films of metallic glasses are manufactured with a selected composition of Zr_(65)Cu_(35),known to exhibit remarkable mechanical properties and glass forming *** nanowell arrays spontaneously form in the ultrafast laser irradiation spot with dimensions down to 20 *** flared shape observed by transmission electron microscopy is ideal to ensure chemical or biological material immobilization into the *** also indicates that the localization of the cavitation-induced nanopores can be tuned by the density and size of the initial nanometric interstice from the columnar structure of films deposited by magnetron *** addition to the topographic functionalization,the laser-irradiated amorphous material exhibits structural changes analyzed by spectroscopic techniques at the nanoscale such as energy-dispersive X-ray spectroscopy and electron energy loss *** reveal structural changes consisting of nanocrystals of monoclinic zirconia that grow within the amorphous *** mechanism is driven by local oxidation process catalyzed by extreme temperature and pressure conditions estimated by an atomistic simulation of the laser-induced nanowell formation.

关键词： Nanowell Nanoripple Metallic glass Surface functionalization Femtosecond laser

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Determinants of invasive strategy in elderly patients with non-ST elevation myocardial infarction

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Journal of Geriatric Cardiology 2017年第7期14卷 465-472页

作者： Antonin Negers Jacques Boddaert Lucie Mora jean-Louis Golmard Laura Moisi Ariel Cohen jean-philippe Collet Alice Breining Acute Geriatric Care Unit Saint-Antoine University Hospital Paris France Department of Geriatrics Pitie-Salpetriere University Hospital Paris France Department of Biostatistics Pitie-Salpetriere University Hospital Paris France Department of Cardiology Saint-Antoine University Hospital Paris France Department of Cardiology Pitie-Salpetrere University Hospital Paris France Department of Geriatrics Charles Foix University Hospital Paris France

Background Knowledge gaps across literature prevent current guidelines from providing the profile of elderly patients most likely to derive benefit fi^om invasive strategy （IS） in non ST-elevation myocardial infarction （NSTEMI）. Furthermore, the benefit of IS in a real-world elderly population with NSTEMI remains unclear. The aims of this study were to determine factors that lead the cardiologist to opt for an IS in elderly patients with NSTEMI, and to assess the impact of IS on the 6-month all-cause mortality. Methods This multicenter prospective study enrolled all consecutive patients aged 〉 75 years old who presented a NSTEMI and were hospitalized in cardiology intensive care unit between February 2014 and February 2015. Patients were compared on the basis of reperfusion strategy （invasive or conservative） and living status at six months, in order to determine multivariate predictors of the realization of an IS and multivariate predictors of 6-month mor- tality. Results A total of 141 patients were included; 87 （62%） underwent an IS. The strongest independent determinants of IS were younger age [odds ratio （OR）： 0.85, 95%-confidence interval （CI）： 0.78-0.92; P 〈 0.001） and lower ＂Cumulative Illness Rating Scale-Geriatric＂ number of categories score （OR： 0.83, 95%CI： 0.73-0.95; P = 0.002）. IS was not significantly associated with 6-month survival （OR： 0.80, 95%CI： 0.27-2.38; P = 0.69）. Conclusions In real-world elderly patients with NSTEMI, younger patients with fewer comorbidities profited more often from an IS. However, IS did not modify 6-month all-cause mortality.

关键词： Comorbidity Coronary angiography Decision making Mortality Myocardial infarction

Tunnel junctions in a III-V nanowire by surface engineering

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Nano Research 2015年第3期8卷 980-989页

作者： Salman Nadar Chloe Rolland jean-Frangois Lampin Xavier Wallart philippe Caroff Renaud Leturcq Institute of Electronics Microelectronics and Nanotechnology CNRS-UMR 8520 ISEN Department Avenue Poincare CS 60069 59652 Villeneuve d'Ascq Cedex France Department of Electronic Materials Engineering Research School of Physics and Engineering The Australian National University Canberra ACT0200 Australia Departement Science et Analyse des Mat~riaux Centre de Recherche Public-Gabriel Lippmann 41 rue du Brill L-4422 Belvaux Luxembourg

We demonstrate a simple way of fabricating high performance tunnel devices from p-doped InAs nanowires by tailoring the n-doped surface accumulation layer inherent to InAs surfaces. By using appropriate ammonium sulfide based surface passivation before metallization without any further thermal treatment, we demonstrate characteristics of tunnel p-n junctions, namely Esaki and backward diodes, with figures of merit better than previously published for InAs homojunctions. The further optimization of both the surface doping, in a quantitative way, and the device geometry allows us to demonstrate that these nanowire-based technologically-simple diodes have promising direct current characteristics for integrated high frequency detection or generation.

关键词： semiconductor nanowire tunnel junction indium arsenidecompounds doping Ⅲ-Ⅴ semiconductors

Guillain-Barrésyndrome following hepatitis E

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World Journal of Gastroenterology 2009年第13期15卷 1645-1647页

作者： jean philippe Loly Estelle Rikir Maxime Seivert Emile Legros Pierre Defrance Jacques Belaiche Gustave Moonen jean Delwaide Department of Hepato-Gastroenterology CHU Sart TilmanUniversitéde Liège Department of Neurology CHU Sart TilmanUniversitéde Liège General Practitioner Department of Hepato-Gastroenterology CHPLT La Tourelle

Guillain-Barrésyndrome(GBS)is often triggered by a preceding bacterial or viral ***,it has been observed in association with acute hepatitis A,B and C,and three cases have been previously described in India in which GBS was associated with acute hepatitis E.A molecular mimicry mechanism is supposed to be involved in the pathogenesis of GBS triggered by infectious agents,although the nature of the shared epitopes has not been characterized in most instances,including that in the case of hepatotropic *** report a case of GBS following acute hepatitis E in a European *** presence of antiganglioside GM2 antibodies in this patient suggested molecular mimicry involving ganglioside GM2 in the pathogenesis of GBS associated with hepatitis E.

关键词： Gangliosides Guillain-Barré syndrome Hepatitis E Molecular mimicry Viral hepatitis

Nonlinear increase,invisibility,and sign inversion of a localized fs-laser-induced refractive index change in crystals and glasses

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Light(Science & Applications) 2020年第1期9卷 1398-1409页

作者： Jerome Lapointe jean-philippe Berube Yannick Ledemi Albert Dupont Vincent Fortin Younes Messaddeq Real Vallee Centre d’Optique Photonique et Laser2375 Rue de la TerrasseUniversite LavalG1V 0A6 QuebecQCCanada

Multiphoton absorption via ultrafast laser focusing is the only technology that allows a three-dimensional structural modification of transparent ***,the magnitude of the refractive index change is rather limited,preventing the technology from being a tool of choice for the manufacture of compact photonic integrated *** propose to address this issue by employing a femtosecond-laser-induced electronic band-gap shift(FLIBGS),which has an exponential impact on the refractive index change for propagating wavelengths approaching the material electronic resonance,as predicted by the Kramers–Kronig *** by theoretical calculations,based on a modified Sellmeier equation,the Tauc law,and waveguide bend loss calculations,we experimentally show that several applications could take advantage of this ***,we demonstrate waveguide bends down to a submillimeter radius,which is of great interest for higher-density integration of fs-laser-written quantum and photonic *** also demonstrate that the refractive index contrast can be switched from negative to positive,allowing direct waveguide inscription in ***,the effect of the FLIBGS can compensate for the fs-laser-induced negative refractive index change,resulting in a zero refractive index change at specific wavelengths,paving the way for new invisibility applications.

关键词： waveguide millimeter refractive

Soil and vegetation water content identify the main terrestrial ecosystem changes

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National Science Review 2023年第5期10卷 167-179页

作者： Diego Bueso Maria Piles philippe Ciais jean-Pierre Wigneron álvaro Moreno-Martínez Gustau Camps-Valls Image Processing Laboratory Universitat de València Laboratoire des Sciences du Climat et de l'Environnement Université Paris Saclay INRA Centre de Bordeaux Aquitaine Image Processing Laboratory Universitat deValència

Environmental change is a consequence of many interrelated *** vegetation responds to natural and human activity still needs to be well establishe d,quantified and *** cent satellite missions providing hydrologic and ecological indicators enable better monitoring of Earth system changes,yet there is no automatic way to address this issue directly from ***,we develop an observation-based methodology to capture evidence of changes in global terrestrial ecosystems and attribute these changes to natural or anthropogenic *** use the longest time record of global microwave L-band soil moisture and vegetation optical depth as satellite data and build spatially explicit maps of change in soil and vegetation water content and biomass reflecting large ecosystem changes during the last decade,*** of prominent trends(from-8% to 9% per year) are observed,especially in humid and semi-arid *** further combine such trends with land cover change maps,vegetation greenness and precipitation variability to assess their relationship with major documented ecosystem *** regions emerge from our *** cluster changes according to human activity drivers,including deforestation(Amazon,Central Africa) and wildfires(East Australia),artificial reforestation(South-East China),abandonment of farm fields(Central Russia) and climate shifts related to changes in precipitation variability(East Africa,North America and Central Argentina).Using the high sensitivity of soil and vegetation water content to ecosystem changes,microwave satellite observations enable us to quantify and attribute global vegetation responses to climate or anthropogenic activities as a direct measure of environmental changes and the mechanisms driving them.

关键词： soil moisture vegetation water content ecosystem trend remote sensing soil moisture and ocean salinity satellite

Microstructural evolution of a recycled aluminum alloy deformed by equal channel angular pressing process

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International Journal of Minerals,Metallurgy and Materials 2012年第11期19卷 1016-1022页

作者： Thabet Makhlouf Atef Rebhi jean-philippe Couzinié Yannick Champion Nabil Njah Applied Metallurgy Laboratory Faculty of SciencesUniversity of SfaxBP.1171 (3000) Sfax Institut de Chimie et des Matériaux Paris-Est (ICMPE) CNRS 2-8 rue Henri Dunant 94320 Thiais

The microstructural evolution of a recycled aluminum alloy after equal channel angular pressing （ECAP） up to four passes was investigated using X-ray diffxaction （XRD） analysis and transmission electron microscopy （TEM）. Microhardness tests were performed to determine the associated changes in mechanical properties. An ultrafine-grained material has been obtained with a microstructure showing a mixture of highly strained crystallites. A high density of dislocations was achieved as a result of severe plastic deformation （SPD） through the die. Changes in mechanical behavior are also revealed after ECAP due to strain hardening. Thermal analysis and TEM micrographs ob- tained after annealing indicate the succession of the recovery, recrystallization, and grain growth phenomena. Moreover, the energy stored during ECAP may be related to the dislocation density introduced by SPD. We finally emphasize the role played by the precipitates in this alloy.

关键词： aluminum alloys equal channel angular pressing (ECAP) microstructural evolution precipitates

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