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Journal of Analytical Sciences, Methods and Instrumentation 2015年第4期5卷 59-65页

作者： Andre Ricard Hayat Zerrouki jean-philippe Sarrette Laplace Toulouse France

Early afterglows of Ar-N2 flowing microwave discharges are characterized by optical emission spectroscopy. The N and O atoms, the N2(A) and N2(X, v > 13) metastable molecules and N2+ ion densities are determined by optical emission spectroscopy after calibration by NO titration for N and O-atoms and measurements of NO and N2 band intensities. For an Ar-xN2 gas mixture with × increasing from 2 to 100% at 4 Torr, 100 Watt and an afterglow time of 3 × 10- 3 s at the 5 liter reactor inlet, it is found densities in the ranges of (2 - 6) × 1014 cm- 3 for N-atoms, one order of magnitude lower for N2(X, v > 13) and for O-atoms (coming from air impurity), of 1010 - 1011 cm- 3 for N2(A) and of 108 - 109 cm- 3 for N2+.

关键词： Ar-N2 Microwave Discharge Flowing Afterglow N-Atoms N2 Metastables N2+ Ions

Paracetamol Sensitive Cellulose-Based Electrochemical Sensors

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Journal of Renewable Materials 2018年第3期6卷 242-250页

作者： Maxime Pontie Serge Foukmeniok Mbokou jean-philippe Bouchara Bienvenue Razafimandimby Sylvie Egloff Ornella Dzilingomo Pierre-Yves Pontalier Ignas Kenfack Tonle Host-Pathogen Interaction Study Group(GEIHP EA 3142)UNIV AngersUNIV BrestBretagne Loire UniversityInstitute of Health Biology-IRISCHU4 rue Larrey49933 AngersFrance Electrochemistry and Chemistry of Materials Department of ChemistryUniversity of DschangP.O.Box 67 DschangCameroon Toulouse University INP-ENSIACETLCA(Laboratory of Agro-industrial Chemistry)31030 Toulouse France

Electrochemical determination of paracetamol(PCT)was successfully performed using carbon paste electrodes(CPEs)modified with treated coffee husks(CHt)or cellulose powder(Ce).Scanning electron microscopy was used to characterize unmodified or modified CPEs prior to their *** electrochemical oxidation of PCT was investigated using square wave voltammetry(SWV)and cyclic voltammetry(CV).The oxidation current density of PCT was two-fold higher with the CPE-CHt sensor and 30%higher with CPE-Ce in comparison with the unmodified CPE,and this correlated with the higher hydrophilicity of the modified *** SWV for the electrochemical analysis of PCT,carbon paste electrode modified with raw coffee husks(CPE-CHr)showed the presence of impurities at+0.27 V/SCE,showing the interest in using pure cellulose for the present analytical ***,CPE-Ce presented a higher real area compared to CPE-CHr,which explains the increase in the limit of saturation from 400 mg/L to 950 mg/*** better saturation limit exhibited by CPE-Ce justifies its choice for electroanalysis of PCT in commercialized *** proposed method was successfully applied in the determination of PCT in commercialized tablets(DolipraneR 500)with a recovery rate close to 100%,and no interference with the excipients contained in the tablets analyzed was *** novel sensor opens the way for sustainable development of electroanalytical control of drugs sold individually in developing countries.

关键词： Paracetamol carbon paste electrode coffee husks cellulose fibers square wave voltammetry electroanalysis

How botulinum toxin in neurogenic detrusor overactivity can reduce upper urinary tract damage?

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World Journal of Nephrology 2016年第2期5卷 195-203页

作者： Maximilien Baron philippe Grise jean-Nicolas Cornu Department of Urology Rouen University Hospital

Intradetrusor injections of botulinum toxin are the cornerstone of medical treatment of neurogenic detrusor overactivity. The primary aim of this treatment is to ensure a low pressure regimen in the urinary bladder, but the mechanisms leading to long-term protection of the urinary tract remain poorly understood. In this paper, we highlight the potential benefts of intradetrusor injections of botulinum toxin regarding local effects on the bladder structures, urinary tract infections, stone disease, vesico ureteral refux, hydronephrosis, renal function based on a comprehensive literature review.

关键词： Botulinum toxin Urinary tract infection Kidney function Neurogenic detrusor overactivity Hydronephrosis Urolithiasis

Honeydew volatile emission acts as a kairomonal message for the Asian lady beetle Harmonia axyridis （Coleoptera： Coccinellidae）

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Insect Science 2012年第4期19卷 498-506页

作者： Pascal D. Leroy Stephanie Heuskin Ahmed Sabri Fran( ois J. Verheggen Julien Farmakidis Georges Lognay philippe Thonart jean-Paul Wathelet Yves Brostaux Eric Haubruge Departments of Functional and Evolutionary Entomology Departments of Analytical Chemistry University of Liege Gembloux Agro-BioTech Walloon Center of Industrial Biology University of Liege B40 4000 Sart-Tilman Departments of General and Organic Chemistry Departments of Appfied Statistics Computer Science and Mathematics University of Liege Gembloux Agro-Bio Tech Gembloux Belgium

The Asian lady beetle Harmonia axyridis Pallas is considered as an invasive species in most territories where it has been introduced. Because aphid honeydew acts as an attraetant for many aphid predators and parasitoids, the objectives of this work were to collect and identify the volatile compounds released from the aphid excretory product to evaluate how these semiochemicals could affect the H. axyridis foraging behavior. Twelve volatile chemicals were identified from the Megoura viciae Buckton honeydew including four alcohols, three ketones, three aldehydes, a pyrazine and a monoterpene. The volatiles 3-methyl-l-butanol and 3-methyl-butanal were highlighted as the two most abundant semiochemicals released from the M. viciae honeydew. Vieia faba L. plants treated with crude honeydew attracted more than 80% of the tested individuals with 40% of attracted beetles located on the plant. Four volatile compounds （3-hydroxy-2-butanone, 3-methyl-butanal, 3-methyl-1-butanol and limonene） were also highlighted to attract more than 75% of the coccinellids toward the odor source and to locate about 35% of them on the plants. Limonene was the most efficient attractant since 89% of the H. axyridis responded to this odor. The use of the identified semiochemicals as well as the composition of an artificial honeydew could certainly be helpful to control the dispersal of the Asian lady beetle H. axyridis.

关键词： aphid honeydew attractant Harmonia axyridis kairomone semiochemicals

A Phelipanche ramosa KAI2 protein perceives strigolactones and isothiocyanates enzymatically

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Plant Communications 2021年第5期2卷 132-147页

作者： Alexandre de Saint Germain Anse Jacobs Guillaume Brun jean-Bernard Pouvreau Lukas Braem David Cornu Guillaume Clavé Emmanuelle Baudu Vincent Steinmetz Vincent Servajean Susann Wicke Kris Gevaert philippe Simier Sofie Goormachtig philippe Delavault François-Didier Boyer Institut jean-Pierre Bourgin INRAEAgroParisTechUniversitéParis-Saclay78000 VersaillesFrance Department of Plant Biotechnology and Bioinformatics Ghent University9052 GentBelgium Center for Plant Systems Biology VIB9052 GentBelgium Department of Biomolecular Medicine Ghent University9000 GhentBelgium Center for Medical Biotechnology VIB9000 GhentBelgium Laboratoire de Biologie et Pathologie Végétales(LBPV) Equipe d’Accueil 1157Universitéde Nantes44000 NantesFrance Institute for Biology Humboldt-Universit€at zu Berlin10115 BerlinGermany UniversitéParis-Saclay CEACNRSInstitute for Integrative Biology of the Cell(I2BC)91198Gif-sur-YvetteFrance UniversitéParis-Saclay CNRSInstitut de Chimie des Substances NaturellesUPR 230191198Gif-sur-YvetteFrance

Phelipanche ramosa is an obligate root-parasitic weed that threatens major crops in central *** order to germinate,it must perceive various structurally divergent host-exuded signals,including isothiocyanates(ITCs)and strigolactones(SLs).However,the receptors involved are still ***,we identify five putative SL receptors in *** and show that PrKAI2d3 is involved in the stimulation of seed *** demonstrate the high plasticity of PrKAI2d3,which allows it to interact with different chemicals,including *** SL perception mechanism of PrKAI2d3 is similar to that of endogenous SLs in non-parasitic *** provide evidence that PrKAI2d3 enzymatic activity confers hypersensitivity to ***,we demonstrate that methylbutenolide-OH binds PrKAI2d3 and stimulates *** germination with bioactivity comparable to that of *** study demonstrates that *** has extended its signal perception system during evolution,a fact that should be considered for the development of specific and efficient biocontrol methods.

关键词： a/b-hydrolase receptor seed germination stimulant strigolactones isothiocyanates Phelipanche ramosa

Implicit Hypotheses Are Hidden Power Droppers in Family-Based Association Studies of Secondary Outcomes

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Open Journal of Statistics 2015年第1期5卷 35-45页

作者： jean Gaschignard Quentin BVincent jean-philippe Jais Aurelie Cobat Alexandre Alcais Laboratoire de Génétique des Maladies Infectieuses Institut National de la Sante et de la Recherche MédicaleParisFrance Universite Paris Descartes Sorbonne Paris CiteInstitut ImagineParisFrance Biostatistique et Informatique Médicale Hopital NeckerParisFarnce URC CICNecker and Cochin HospitalsParisFrance

Family-based tests of association between a genetic marker and a disease constitute a common design to dissect the genetic architecture of complex traits. The FBAT software is one of the most popular tools to perform such studies. However, researchers are also often interested in the genetic contribution to a more specific manifestation of the phenotype (e.g. severe vs. non-severe form) known as a secondary outcome. Here, what we demonstrate is the limited power of the classical formulation of the FBAT statistic to detect the effect of genetic variants that influence a secondary outcome, in particular when these variants also impact on the onset of the disease, the primary outcome. We prove that this loss of power is driven by an implicit hypothesis, and we propose a derivation of the original FBAT statistic, free from this implicit hypothesis. Finally, we demonstrate analytically that our new statistic is robust and more powerful than FBAT for the detection of association between a genetic variant and a secondary outcome.

关键词： Family-Based Association Test FBAT Genetic Association Studies Null Hypothesis Secondary Outcome Homogeneity Test

乳腺非典型性小叶增生及小叶原位癌52例随访报告

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中华外科杂志 2007年第13期45卷 874-876页

作者：厉红元任国胜 Nasrin Arnould jean-philippe Brettes 重庆医科大学附属第一医院普外科 400016 法国斯特拉斯堡大学医学院附属医院乳腺外科

目的探讨乳腺非典型小叶增生和小叶原位癌的生物学行为及治疗方法。方法回顾性分析1982年7月至1996年1月问的17例非典型小叶增生、35例小叶原位癌的临床及随访资料。随访时行门诊体检、乳腺钼靶摄片、乳腺 B 超等检查;随访时间为3～257... 详细信息

目的探讨乳腺非典型小叶增生和小叶原位癌的生物学行为及治疗方法。方法回顾性分析1982年7月至1996年1月问的17例非典型小叶增生、35例小叶原位癌的临床及随访资料。随访时行门诊体检、乳腺钼靶摄片、乳腺 B 超等检查;随访时间为3～257个月,平均146.6个月。结果非典型小叶增生和小叶原位癌多发生于绝经前妇女(69.2%);52例患者均因各种良性病变行手术,术后病理证实为非典型小叶增生或小叶原位癌,其中25例(48.1%)有微钙化病变;有8例在随访期间癌变(5例在同侧乳房,3例在对侧乳房),平均癌变问期为9.4年;尽管4例(50%)有乳腺癌或卵巢癌家族史,但未发现非典型小叶增生和小叶原位癌癌变与乳腺癌或卵巢癌家族史有关(P>0.05);同样,也未发现非典型小叶增生与小叶原位癌发生癌变的差异有统计学意义(P>0.05)。结论非典型小叶增生和小叶原位癌局部切除是必要的。

关键词：乳腺肿瘤癌原位

Building an Earth Observations Data Cube: lessons learned from the Swiss Data Cube (SDC) on generating Analysis Ready Data (ARD)

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Big Earth Data 2017年第1期1卷 100-117页

作者： Gregory Giuliani Bruno Chatenoux Andrea De Bono Denisa Rodila jean-philippe Richard Karin Allenbach Hy Dao Pascal Peduzzi Institute for Environmental Sciences/g D-geneva University of genevagenevaSwitzerland Institute for Environmental Sciences/EnviroSPaCE University of genevagenevaSwitzerland Institute for Environmental Sciences/Environmental governance and territorial Development University of genevagenevaSwitzerland Science Division United Nations Environment ProgrammegenevaSwitzerland

Pressures on natural resources are increasing and a number of challenges need to be overcome to meet the needs of a growing population in a period of environmental *** of these environmental issues can be monitored using remotely sensed Earth Observations(EO)data that are increasingly available from a number of freely and openly accessible ***,the full information potential of EO data has not been yet *** remain still underutilized mainly because of their complexity,increasing volume,and the lack of efficient processing *** Data Cubes(DC)are a new paradigm aiming to realize the full potential of EO data by lowering the barriers caused by these Big data challenges and providing access to large spatio-temporal data in an analysis ready *** and regular provision of Analysis Ready Data(ARD)will significantly reduce the burden on EO data ***,ARD are not commonly produced by data providers and therefore getting uniform and consistent ARD remains a challenging *** paper presents an approach to enable rapid data access and pre-processing to generate ARD using interoperable services *** approach has been tested and validated generating Landsat ARD while building the Swiss Data Cube.

关键词： Data Cube Earth Observations Landsat automatic processing analysis ready Data

Endothelial nitric oxide synthase regulation is altered in pancreas from cirrhotic rats

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World Journal of Gastroenterology 2006年第2期12卷 228-233页

作者： jean-Louis Frossard Rafael Quadri Antoine Hadengue philippe Morel Catherine M Pastor Division de Gastroenterologie Hpitaux Universitaires de Geneve Departement de Chirurgie Hopitaux Universitaires de Geneve Laboratoire de Physiopathologie Hepatique et Imagerie Moleculaire Hpitaux Universitaires de Geneve

AIM： To determine whether biliary cirrhosis could induce pancreatic dysfunction such as modifications in endothelial nitric oxide synthase（eNOS） expression and whether the regulation of eNOS could be altered by the regulatory proteins caveolin and heat shock protein 90 （Hsp90）, as well as by the modifications of calmodulin binding to eNOS. METHODS： Immunoprecipitations and Western blotting analysis were performed in pancreas isolated from sham and cirrhotic rats. RESULTS： Pancreatic injury was minor in cirrhotic rats but eNOS expression importantly decreased with the length （and the severity） of the disease. Because coimmunoprecipitation of eNOS with both Hsp90 and caveolin similarly decreased in cirrhotic rats, eNOS activity was not modified by this mechanism. In contrast, drrhosis decreased the calmodulin binding to eNOS with a concomitant decrease in eNOS activity. CONCLUSION： In biliary cirrhosis, pancreatic injury is minor but the pancreatic nitric oxide （NO） production is significantly decreased by two mechanisms： a decreased expression of the enzyme and a decreased binding of calmodulin to eNOS.

关键词： Pancreas Biliary cirrhosis Endothelial NO synthase Caveolin Heat shock protein 90

Prior appendectomy and the phenotype and course of Crohn's disease

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World Journal of Gastroenterology 2006年第8期12卷 1235-1242页

作者： Jacques Cosnes philippe Seksik Isabelle Nion-Larmurier Laurent Beaugerie jean-Pierre Gendre Service de Gastroentérologie et Nutrition h■pital St-AntoineParisFrance

AIM： To determine whether prior appendectomy modifies the phenotype and severity of Crohn＇s disease. METHODS： Appendectomy status and smoking habits were specified by direct interview in 2838 patients consecutively seen between 1995 and 2004. Occurrence of complications and therapeutic needs were reviewed retrospectively. Additionally, annual disease activity was assessed prospectively between 1995 and 2004 in patients who had not had ileocecal resection and of a matched control group. RESULTS： Compared to 1770 non-appendectomized patients, appendectomized patients more than 5 years before Crohn＇s disease diagnosis （n=716） were more often females, smokers, with ileal disease. Cox regression showed that prior appendectomy was positively related to the risk of intestinal stricture （adjusted hazard ratio, 1.24; 95% confidence interval, 1.13 to 1.36; P=0.02） and inversely related to the risk of perianal fistulization （adjusted hazard ratio, 0.75; 95% confidence interval, 0.68 to 0.83; P=0.002）. No difference was observed between the two groups regarding the therapeutic needs, except for an increased risk of surgery in appendectomized patients, attributable to the increased prevalence of ileal disease. Between 1995 and 2004, Crohn＇s disease was active during 50% of years in appendectomized patients （1318 out of 2637 patientyears） and 51% in non-appendectomized patients （1454 out of 2841 patient-years; NS）. CONCLUSION： Prior appendectomy is associated with a more proximal disease and has an increased risk of stricture and a lesser risk of anal fistulization. However, the severity of the disease is unaffected.

关键词： Crohn's disease Appendectomy Surgery Smoking