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Functional Nanostructures and Dynamic Materials through Self-Organization

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复旦学报（自然科学版） 2007年第5期46卷 554-页

作者： jean-marie LEHN ISIS Université Louis PasteurStrasbourg and Collège de France

1 Results Supramolecular chemistry is actively exploring systems undergoing *** design of molecular information controlled,"programmed"and functional self-organizing systems provides an original approach to nanoscience and *** spontaneous but controlled generation of well-defined,functional molecular and supramolecular architectures of nanometric size through self-organization represents a means of performing programmed engineering and processing of functional nanostruct...

关键词： nanostructure dynamic materials self-organization

Phenotypic, Cytological and Molecular (AFLP) Analyses of the Cotton Synthetic Allohexaploid Hybrid (G. hirsutum×G. longicalyx)²

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Open Journal of Genetics 2020年第2期10卷 35-49页

作者： N’Guessan Olivier Konan jean-marie Jacquemin jean-Pierre Baudoin Guy Mergeai Laboratory of Crop Improvement Agroforestry Unit Jean Lorougnon Guédé University Daloa C&#244 te D’Ivoire Laboratory of Tropical Agroecology Gembloux Agro-Bio Tech Liège University Gembloux Belgium Department of Life Sciences Bioengineering Unit Walloon Agricultural Research Centre (CrAw) Gembloux Belgium

The wild cotton diploid species (2n = 2x = 26) are important sources of useful traits such as high fiber quality, resistance to biotic and abiotic stresses etc., which can be introgressed into the cultivated tetraploid cotton Gossypium hirsutum L (2n = 4x = 52), for its genetic improvement. The African wild diploid species G. longicalyx Hutchinson and Lee could be used as donor of the desirable traits of fiber fineness and resistance to reniform nematode. However, hybridization of wild diploid species and cultivated tetraploid cotton encounters a sterility problem of the triploid (2n = 3x = 59), mainly due to ploidy. The restoration of the fertility can be done by creating an allohexaploid (2n = 6x = 78) through the doubling with colchicine of the sterile triploid chromosomes. With this method, a synthetic allohexaploid hybrid (G. hirsutum × G. longicalyx)2 has been obtained. This genotype was studied using phenotypic, cytological and molecular (AFLP) analyses in order to confirm its hybridity and its caryotype, and also to verify the expression of the desirable traits coming from G. longicalyx. The studied genotype showed a quite good level of pollen fertility (83%), and apart from larger seeds and some minor seedling anomalies, most of its morphological characteristics were intermediate between the two parental species. It had 78 chromosomes, proving its hexaploid status. Molecular analysis revealed 136 AFLP loci in this hexaploid, all from G. hirsutum and G. longicalyx, demonstrating its hybrid status. In addition, the hexaploid exhibited the useful traits of G. longicalyx with regard to its remarkable fiber fineness and its high resistance to the reniform nematode. This allohexaploid hybrid constitutes an interesting agronomic material, which can be used as a bridge for the transfer of useful agronomic traits from wild species to varieties of G. hirsutum.

关键词： Gossypium spp Hexaploid Hybrid Chromosomes AFLP Marker Plant Breeding

Anatomical and electrophysiological plasticity of locomotor networks following spinal transection in the salamander

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Neuroscience Bulletin 2013年第4期29卷 467-476页

作者： jean-marie Cabelguen Stéphanie Chevallier Ianina Amontieva-Potapova Céline Philippe Neurocentre Magendie INSERM U 862 - Bordeaux University

Recovery of locomotor behavior following spinal cord injury can occur spontaneously in some vertebrates, such as fish, urodele amphibians, and certain reptiles. This review provides an overview of the current status of our knowledge on the anatomical and electrophysiological changes occurring within the spinal cord that lead to, or are associated with the [e-expression of locomotion in spinally-transected salamanders. A better understanding of these processes will help to devise strategies for restoring locomotor function in mammals, including humans.

关键词： salamander spinal cord locomotor recovery regeneration

Bladder-colon chronic cross-sensitization involves neuro-glial pathways in male mice

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World Journal of Gastroenterology 2022年第48期28卷 6935-6949页

作者： Karim Atmani Fabien Wuestenberghs Maximilien Baron Illona Bouleté Charlène Guérin Wafa Bahlouli David Vaudry jean Claude do Rego jean-Nicolas Cornu Anne-marie Leroi Moïse Coëffier Mathieu Meleine Guillaume Gourcerol Nutrition Gut and Brain Unit(Inserm U1073)Institute for Research and Innovation in BiomedicineUniversitéde Rouen NormandieRouen 76000France Department of Gastroenterology and Hepatology UniversitéCatholique de LouvainCHU UCL NamurYvoir 5530Belgium Department of Physiology CHU RouenUniversitéde Rouen NormandieRouen 76031France Department of Urology CHU RouenUniversitéde Rouen NormandieRouen 76000France Inserm UMR 1245Team Epigenetics and Pathophysiology of Neurodevelopmental DisordersUniversitéde Rouen NormandieRouen 76000France Behavioural Analysis Platform(SCAC) HeRacLeS Inserm US51-CNRS UAR2026Institute for Research and Innovation in BiomedicineUniversitéde Rouen NormandieRouen 76000France Department of Nutrition CHU RouenUniversitéde Rouen NormandieRouen 76000France Inserm U1107 NeuroDolClermont Auvergne UniversityClermont-Ferrand 63000France

BACKGROUND Irritable bowel syndrome and bladder pain syndrome often overlap and are both characterized by visceral *** pelvic organs share common sensory pathways,it is likely that those syndromes involve a cross-sensitization of the bladder and the *** precise pathophysiology remains poorly *** To develop a model of chronic bladder-colon cross-sensitization and to investigate the mechanisms *** Chronic cross-organ visceral sensitization was obtained in C57BL/6 mice using ultrasound-guided intravesical injections of acetic acid under brief isoflurane *** sensitivity was assessed in conscious mice by measuring intracolonic pressure during isobaric colorectal ***,used as a marker of colorectal inflammation,was measured in the colon,and colorectal permeability was measured using chambers.c-Fos protein expression,used as a marker of neuronal activation,was assessed in the spinal cord(L6-S1 level)using *** fluorescent protein on the fractalkine receptor-positive mice were used to identify and count microglia cells in the L6-S1 dorsal horn of the spinal *** expression of NK1 receptors and MAPK-p38 were quantified in the spinal cord using western *** Visceral hypersensitivity to colorectal distension was observed after the intravesical injection of acetic acid vs saline(P<0.0001).This effect started 1 h post-injection and lasted up to 7 d *** increased permeability or inflammation was shown in the bladder or colon 7 d *** hypersensitivity was associated with the increased expression of c-Fos protein in the spinal cord(P<0.0001).In green fluorescent protein on the fractalkine receptor-positive mice,intravesical acetic acid injection resulted in an increased number of microglia cells in the L6-S1 dorsal horn of the spinal cord(P<0.0001).NK1 receptor and MAPK-p38 levels were increased in the spinal cord up to 7 d after

关键词： Cross-organ sensitization MAPK-p38 Microglia NK1 receptor Pain Visceral hypersensitivity

Characterization of Personal Clothing Worn by Pesticide Sprayers in Foumbot Agricultural Area (Cameroon)

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Agricultural Sciences 2019年第8期10卷 1056-1072页

作者： Sonchieu jean Bitsoga marie Gracile Ngassoum Martin Benoit Department of Social Economy and Family Management Higher Technical Teacher Training College University of Bamenda Bamenda Cameroon Department of Applied Chemistry ENSAI University of Ngaoundere Ngaoundere Cameroon

Personal protective equipment is intended to protect worker from risks that cannot be eliminated for more effective safety. This study was aimed at evaluating the type of cloth worn by pesticide users in Foumbot agricultural area (West Region of Cameroon) and to identify signs and symptoms related to pesticides effects on human health. A survey was conducted on seventy (70) farmers randomly selected using a questionnaire made up of closed and opened questions. Specimens of cloth were collected, identified and analyzed for the water and vapor absorbency and permeability. The identification was done by burning and solubility tests. Results showed that no farmer used adequate protective clothing, they all presented many pesticide-related signs and symptoms such as dizziness, skin irritation, eye-watering and breathing difficulties;the permeation of clothes that they wear is high with high vapor and water absorbency capacity;they were made up with Cotton fiber, blended cotton fibre, wool, polyester and polyethylene;a local laminated fabric manufactured with Tri-acetate fiber was identified with great capacity of protection. This study raised inappropriate characteristics of protective materials used by farmers in Foumbot agricultural area. However, a local fabric was identified to have been adapted to pesticide applications and may be promoted after further study on the comfortability.

关键词： Pesticides Personal Protective Equipment Safety Health Farmers

Methodology for Constructing a Short-Term Event Risk Score in Heart Failure Patients

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Applied Mathematics 2018年第8期9卷 954-974页

作者： Kévin Duarte jean-marie Monnez Eliane Albuisson CNRS INRIA Institut Elie Cartan de Lorraine Université de Lorraine Nancy France CHRU Nancy INSERM Université de Lorraine CIC Plurithématique Nancy France IUT Nancy-Charlemagne Université de Lorraine Nancy France Institut Elie Cartan de Lorraine Université de Lorraine CNRS Nancy France CHRU Nancy BIOBASE P&ocirc le S2R Université de Lorraine Nancy France Faculté de Médecine InSciDenS Université de Lorraine Nancy France

We present a methodology for constructing a short-term event risk score in heart failure patients from an ensemble predictor, using bootstrap samples, two different classification rules, logistic regression and linear discriminant analysis for mixed data, continuous or categorical, and random selection of explanatory variables to build individual predictors. We define a measure of the importance of each variable in the score and an event risk measure by an odds-ratio. Moreover, we establish a property of linear discriminant analysis for mixed data. This methodology is applied to EPHESUS trial patients on whom biological, clinical and medical history variables were measured.

关键词： Ensemble Predictor Linear Discriminant Analysis Logistic Regression Mixed Data Scoring Supervised Classification

Perturbation-Iteration Method for Solving Mathematical Model of Glucose and Insulin in Diabetic Human during Physical Activity

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Open Journal of Applied Sciences 2016年第12期6卷 826-838页

作者： Marcel Gahamanyi jean marie Ntaganda Mahamat Saleh Daoussa Haggar Department of Mathematics College of Science and Technology School of Science University of Rwanda Kigali Rwanda Department of Applied Mathematics N’djamena University N’djamena Chad

In this paper, we aim to solve a two compartmental mathematical model of ordinary differential equations for cardiovascular-respiratory system using a new recent method: Perturbation Iteration method. The description of this method for different order derivatives in the Taylor Series expansion is discussed. This method provides the solution in the form of an infinite series for ordinary differential equation. The efficiency of the method used is investigated by a comparison of Euler method and Runge Kutta. Numerical simulations of all these three methods are implemented in Matlab. The validation has been carried out by taking the values of determinant parameters of cardiovascular-respiratory system for a 30 years old woman who is supposed to make practice of three regular physical activities: Walking, Jogging and Running fast. The results are in good agreement with experimental data.

关键词： Perturbation-Iteration Method Glucose Insulin Heart Rate Alveolar Ventilation Physical Activity Numerical Simulation

Moyamoya Disease Associated with Hyperhomocysteinemia: A Rare Cause of Stroke in Sub-Saharan Africa

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World Journal of Neuroscience 2022年第1期12卷 22-28页

作者： Raphael marie Kabore Habib A. K. Ouiminga jean Kabore jean-Michel Vallat Department of Neurology Tengandogo Teaching Hospital Ouagadougou Burkina Faso Department of Neurosurgery Tengandogo Teaching Hospital Ouagadougou Burkina Faso Department of Neurology Yalgado Teaching Hospital Ouagadougou Burkina Faso Department of Neurology Dupuytren Teaching Hospital Limoges France

Introduction: Moyamoya disease (MMD) is a chronic cerebrovascular disorder characterized by progressive bilateral occlusion of the supraclinoid internal carotid artery (ICA) and its main branches, associated with the development of fine collateral networks, especially adjacent to the site of occlusion in the deep areas of the brain. MMD frequently occurs in East Asian populations, including pediatric and adult patients, and may lead to ischemic or hemorrhagic stroke, headache, epilepsy or transient ischemic attack. The majority is presumed to be of genetic origin and few cases of thrombophilia have been reported in MMD. We report a case of MMD in a young sub-Saharan African woman associated with Hyperhomocysteninemia (HHCys). Observation: A 33-year-old female was seen for aphasia, which had suddenly appeared fourteen days before, and was associated with memory impairment. She mentioned chronic headaches during the 10 previous years, of frontal seat, without migraine criteria. She had no history of hypertension, no obesity, no known dyslipidemia, and there was no family history of stroke. Neurological examination noted Wernicke’s aphasia, with discreet right central facial palsy, associated with memory impairment. The brain MRI revealed semi recent infarct in the left parietal lobe, sequelae in the left temporo-occipital and right frontal with lacunar ischemic lesions, associated with several foci of sub- cortical demyelination. MRA showed stenosis of the supraclinoid carotid arteries and their division branches. In addition, there was a stenosis of the posterior cerebral arteries, with a network of anastomosis at the level of the base of the skull. An investigation of thrombophilia showed hyperhomocysteinemia (HHCys). The diagnosis of moyamoya disease associated with hyperhomocysteinemia was mentioned. She was treated by Aspirin combined to folic acid. After a 3-year setback the patient was asymptomatic. Conclusion: MMD is a rare cause of stroke in sub-Saharan Afric

关键词： Moyamoya Headache Silent Infarcts Hyperhomocysteinemia Diagnosis Treatment

Immunodetection of Tau microtubule-associated protein in human sperm and testis

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Asian Journal of Andrology 2014年第6期16卷 927-928页

作者： Juiien Sigala Fanny Jumeau marie-raure Caillet-Boudin Nicolas Sergeant Caroline Ballot jean-Marc Rigot Franqois Marcelli Meryem Tardivel Luc Buee Valerie Mitchell EA 4308 Gametogenese et Qualite du Gamete Institut de Biologie de la Reproduction-Spermiolegie-gECOS H(Spital Jeanne de Flandre Centre Hospitalier Regional Universitaire de Lille Lille France INSERM U837 Alzheimer et Tauopathies Place de Verdun Lille France Departement d'Andrologie Hopital Calmette Lille France BICeL Universite Lille Nord de France-Centre Hospitalier Regional Universitaire de Lille-IFR114 Lille France

Dear Editor, The cytosolic protein Tau is naturally present in human neurons, where it has a pivotal role in controlling microtubule stability. Hyperphosphorylation of Tau （observed during neurodegenerative diseases, such as Alzheimer＇s disease） impairs the protein＇s ability to bind microtubules. This results in microtubule disassembly and the formation of Tau aggregates, Tau protein is also widely expressed in peripheral tissues. In the male reproductive system, screening for Tau has focused solely on the rodent and bovine testis. In the present study, we used immunofluorescence and immunoenzymatic techniques （with a Tau-specific antibody） to investigate the presence of Tau protein in human ejaculated sperm and testicular tissue.

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