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Antioxidant, Anti-Inflammatory Efficacy and HPLC Analysis of <i>Annona muricata</i>Leaves Extracts from Republic of Benin

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American Journal of Plant Sciences 2020年第6期11卷 803-818页

作者： Kohonou Arnaud Chabi Nicodème Dah-Nouvlessounon durand Nounagnon Martial Sognigbe Basile Sina Haziz N’Tcha Christine Kohonou A. Christian Lehmane Halfane Dougnon Victorien Pacôme Noumavo Baba-Moussa Lamine Laboratory of Research in Applied Biology Polytechnic School of Abomey-Calavi University of Abomey-Calavi Cotonou Benin Laboratory of Biology and Molecular Typing in Microbiology Department of Biochemistry and Cell Biology Faculty of Science and Technology University of Abomey-Calavi Cotonou Bénin Research Unit in Applied Microbiology and Pharmacology of Natural Substances Laboratory of Research in Applied Biology Polytechnic School of Abomey-Calavi University of Abomey-Calavi Cotonou Benin

Annona muricata L. (Soursop or Graviola) is a naturally occurring plant seen in Southern part of Africa, traditionally used in Benin to treat various diseases. The present study aimed to investigate phytochemical composition and antioxidant, anti-inflammatory activities of A. muricata leaves extracts. The secondary metabolites of ethanolic and hemi-ethanolic extracts were analysed by HPLC method. The DPPH and FRAP methods were used to evaluate the antioxidant activity. Inhibition of albumin denaturation method was used to evaluate anti-inflammatory activity of the tested extracts of which larval cytotoxicity was studied. The major identified compounds were gallic acid, chlorogenic acid, cafeic acid, tannic acid, ferrulic acid, Rutin. Ascorbic acid exhibited the highest inhibition percentage (83.33% ± 0.50%) of DPPH radical with the lowest IC50 (45.1 ± 0.28 μg/ml). The inhibition of the ferric ion Fe3+ varied (p = 0.0013) according to the extracts type. IC50 values of ferric ion inhibition range from 119.5 ± 3.10 to 250.8 ± 2.13 μg/ml respectively for A. muricata

关键词： A. muricata Secondary Metabolites Extracts Screening Biological Activities Benin

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换热器设计中的平均温度估算

化工装备技术 1992年第5期13卷 48-50页

作者： Alejandro Anaya durand Marco Antonio Osorio Boniua 寇立森陈翠英墨西哥

在计算对流给热系数(HTCs)时,为查取流体的物性值,须先确定温度。确定这个温度的步骤是相当简单的,但对高粘度物质或无油基流体就变得复杂。对这种情况,现已通过非常简单的计算步骤,导出了相互关系。在确定用以估算流体物理性质的温度... 详细信息

在计算对流给热系数(HTCs)时,为查取流体的物性值,须先确定温度。确定这个温度的步骤是相当简单的,但对高粘度物质或无油基流体就变得复杂。对这种情况,现已通过非常简单的计算步骤,导出了相互关系。在确定用以估算流体物理性质的温度时如果在热交换终了时流体的性质大体上不变化,通常使用进、出口状况下的算术平均温度。当涉及多变情况时,Kern推荐估算换热器进、出口两端的给热系数(U_h和U_c)。

关键词：换热器温度设计

Global prevalence of occult hepatitis C virus: A systematic review and meta-analysis

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World Journal of Methodology 2022年第3期12卷 179-190页

作者： Donatien Serge Mbaga Sebastien Kenmoe Jacky Njiki Bikoï Guy Roussel Takuissu Marie Amougou-Atsama Etienne Atenguena Okobalemba jean Thierry Ebogo-Belobo Arnol Bowo-Ngandji Martin Gael Oyono jeannette Nina Magoudjou-Pekam Ginette Irma Kame-Ngasse Alex durand Nka Alfloditte Flore Feudjio Cromwel Zemnou-Tepap Elie Adamou Velhima Juliette Laure Ndzie Ondigui Rachel Audrey Nayang-Mundo Sabine Aimee Touangnou-Chamda Yrene Kamtchueng Takeu jean Bosco Taya-Fokou Chris Andre Mbongue Mikangue Raoul Kenfack-Momo Cyprien Kengne-Ndé Carole Stephanie Sake Seraphine Nkie Esemu Richard Njouom lucy Ndip Sara Honorine Riwom Essama Department of Microbiology The University of Yaounde IYaounde 00237Cameroon Department of Microbiology and Parasitology University of BueaBuea 00237Cameroon Department of Virology Centre Pasteur of CameroonYaounde 00237Cameroon Centre of Research in Food Food Security and NutritionInstitute of Medical Research and Medicinal Plants StudiesYaounde 00237Cameroon Centre de Recherche sur les Maladies Emergentes et Re-Emergentes Institute of Medical Research and Medicinal Plants StudiesYaounde 00237Cameroon Faculty of Medicine and Biomedical Science The University of Yaounde IYaounde 00237Cameroon Medical Research Centre Institute of Medical Research and Medicinal Plants StudiesYaounde 00237Cameroon Laboratory of Parasitology and Ecology The University of Yaounde IYaounde 00237Cameroon Department of Biochemistry The University of Yaounde IYaounde 00237Cameroon Virology Laboratory Chantal Biya International Reference Center for Research on HIV/AIDS Prevention and ManagementYaounde 00237Cameroon

BACKGROUND Occult hepatitis C infection(OCI)is characterized by the presence of hepatitis C virus(HCV)RNA in the liver,peripheral blood mononuclear cells(PBMC)and/or ultracentrifuged serum in the absence of detectable HCV-RNA in *** has been described in several categories of populations including hemodialysis patients,patients with a sustained virological response,immunocompromised individuals,patients with abnormal hepatic function,and apparently healthy *** To highlight the global prevalence of *** We performed a systematic and comprehensive literature search in the following 4 electronic databases PubMed,EMBASE,Global Index Medicus,and Web of Science up to 6th May 2021 to retrieve relevant studies published in the *** studies were unrestricted population categories with known RNA status in serum,PBMC,liver tissue and/or ultracentrifuged *** were extracted independently by each author and the Hoy et al tool was used to assess the quality of the included *** used the random-effect meta-analysis model to estimate the proportions of OCI and their 95%confidence intervals(95%CI).The Cochran's Q-test and the I2 test statistics were used to assess heterogeneity between *** plot and Egger test were used to examine publication bias.R software version 4.1.0 was used for all *** The electronic search resulted in 3950 *** obtained 102 prevalence data from 85 included *** pooled prevalence of seronegative OCI was estimated to be 9.61%(95%CI:6.84-12.73)with substantial heterogeneity[I^(2)=94.7%(95%CI:93.8%-95.4%),P<0.0001].Seropositive OCI prevalence was estimated to be 13.39%(95%CI:7.85-19.99)with substantial heterogeneity[I^(2)=93.0%(90.8%-94.7%)].Higher seronegative OCI prevalence was found in Southern Europe and Northern Africa,and in patients with abnormal liver function,hematological disorders,and kidney *** seropositive OCI prevalence was found in Southern Europe,Northern

关键词： Occult hepatitis C virus infection Prevalence Worldwide Peripheral blood mononuclear cells Hepatitis C virus

Hélène durand:2021年份，让人惊讶的一年！

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Hélène durand:2021年份圣埃美隆期酒品鉴报告

葡萄酒 2022年第7期

作者： Hélène durand 梁同正

2021是一个很异质化的年份，特别是在同一个产区里分层鲜明。所以，在期酒购买时尤其需要参考专家的品鉴笔记，因他们可以在酒最黄金的年轻期作出判断。（共6页)

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Purification of Moringa oleifera Leaves Protease by Three-Phase Partitioning and Investigation of Its Potential Antibacterial Activity

葡萄酒 2022年第9期

作者： Hélène durand 梁同正

本篇为法国酒评家Hélène durand女士的2021年份波尔多期酒品鉴中关于圣埃美隆部分的酒评。下文以酒庄首字母进行排序，包含部分酒庄的副牌酒款。（共6页)

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American Journal of Plant Sciences 2023年第1期14卷 64-76页

作者： Adam Abdoulaye Agossou D. P. Noumavo durand Dah-Nouvlessounon Messan A. B. Ohin Hasan Bayraktar Farid T. Bade Honoré S. Bankole Lamine Baba-Moussa Farid Baba-Moussa Laboratoire de Microbiologie et des Technologies Alimentaires Faculté des Sciences et Techniques Université d’Abomey-Calavi Abomey-Calavi Bénin Laboratory of Biology and Molecular Typing in Microbiology Faculty of Science and Technology University of Abomey-Calavi Abomey Calavi Benin Department of Nutrition and Dietetics Faculty of Health Sciences Yuksek Ihtisas University Balgat-Ankara Turkey Unité de Recherche en Microbiologie Appliquée et Pharmacologie des Substances Naturelles Ecole Polytechnique d’Abomey-Calavi Abomey-Calavi Benin

One of plant-based products for dental care is plant-based proteolytic enzymes which are principally proteases. In order not to damage the protein and bioactive content, an efficient method should be employed for their purifications. As such, three-phase partitioning (TPP) was used to purify protease from moringa (Moringa oleifera). TPP is an emerging, promising, non-chromatographic and economical technology which is simple, quick, efficient and often one-step process for the separation and purification of bioactive molecules from natural sources. It involves the addition of salt (ammonium sulphate) to the crude extract followed by the addition of an organic solvent (butanol). The protein appears as an interfacial precipitate between upper organic solvent and lower aqueous phases. The various conditions such as ammonium sulphate, ratio of crude extract to t-butanol and pH which are required for attaining efficient purification of the protease fractions were optimized. Under optimized conditions, it was seen that, 35% of ammonium sulphate saturation with 1:0.75 ratio of crude extract to t-butanol at pH 7 gave 4.94-fold purification with 96.20% activity yield of protease in the middle phase of the TPP system. The purified enzyme from Moringa oleifera has no antimicrobial effect on the pathogenic bacteria tested. However, this purified enzyme, can be considered as a promising agent, cheap, and safe source which is suitable for using in various industries.

关键词： Three-Phase Partitioning Moringa oleifera Protease Protein Purification Antimicrobial

Phytochemical Screening and Antimicrobial Activity of <i>Desmodium ramosissimum</i>

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American Journal of Plant Sciences 2020年第1期11卷 51-63页

作者： Badé Farid Toyigbénan Dah-Nouvlessounon durand Sina Haziz Nanoukon Chimène Moussè Wassiyath Nabéde Aklesso Assogba Sylvestre Tohoyéssou Majoie Nounagnon Martial Halfane Lehmane Adjanohoun Adolphe Savadogo Aly Baba-Moussa Lamine

Microbial infections threaten the health of the Beninese population. Objectives: To identify bioactive phytochemical groups and evaluate the antimicrobial activity of Desmodium ramosissimum used in traditional medicine in Benin against microbial infections. Methodology & Results: The classic reactions in solution helped highlight alkaloids, anthocyanins, flavonoids, quinones, saponins, steroids, tannins, terpenoids, mucilage, Coumarin, reducing compounds, anthracene, glycosides. The antibacterial activity was evaluated by extracts dilution’s method (ethanol extracts, methanol extracts and hexane extracts). The methanol extract inhibited the growth of all tested germs, with a significant effect on E. coli and S. aureus strains whose MIC values are equal to 1.25 mg/ml. On the contrary, this extract has a low activity on P. vulgaris strain with a MIC of 10 mg/ml. The ethanol extract also inhibited the growth of all the tested strains, but with more intense activity than the methanol extract. The strains of C. albicans and S. oralis were more sensitive to the extract with 0.625 mg/ml for MIC, while S. aureus and P. vulgaris were less sensitive (MIC = 5 mg/ml). The residual ethanol extract exerted inhibition on all microorganisms at a concentration of 20 mg/ml, except the strain of E. foecalis that was resistant. Conclusion & Applications: This study shows that besides its food virtues of this plant, there are antibacterial and antifungal properties.

关键词： Desmodium Benin Extracts Antimicrobial Screening

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肌营养不良患者的梭内肌纤维功能保留

世界核心医学期刊文摘（神经病学分册） 2005年第10期1卷 45-46页

作者： Aimonetti J.-M. Ribot-Ciscar E. Rossi-durand C. 陈海 Laboratoire de Neurobiologie Humaine Universit' e de Provence- CNRS Centre de Saint- Charles 3 Place Victor Hugo 13331 Marseille France Dr.

In a previous study, we showed that patients with muscular dystrophies (MDs) perceive passive movements, experience sensations of illusory movement induced b y muscle tendon vibration, and have proprioceptive- regulated sways in response to vibratory stimulation applied to the neck and ankle muscle tendons. These fi ndings argue for preserved proprioceptive functions of muscle spindles. However, it is unclear whether the function of intrafusal muscle fibers is spared, i.e., whether they retain their ability to contract when submitted to a fusimotor dri ve. To answer this question, we analyzed the effects of reinforcement maneuvers (mental computation and the Jendrassik maneuver) that are known to increase musc le spindle sensitivity via fusimotor drive in healthy subjects. Nine patients wi th different MDs participated in the study. Reinforcement maneuvers increased bo th the mean amplitude of the Achilles tendon reflex (187 ± 52.9% of the mean control amplitude) and the sensitivity of muscle spindle afferents to imposed mo vements of the ankle. The same reinforcement maneuvers failed to alter the ampli tude of the Hoffmann reflex in the triceps surae muscle. These results suggest t hat the intrafusal muscle fibers preserve their contractile abilities in slowly progressive MDs. The reasons for a differential impairment of intrafusal and ext rafusal muscle fibers and the clinical implications of the present results are d iscussed.

关键词：肌营养不良梭内肌纤维强化操作复合运动肌梭健康受试者动反应收缩能力小腿三头肌强迫运动

体外膜式人工氧合法应用于婴儿胎粪吸入综合征:静脉-静脉体外膜式氧合法10年的经验

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世界核心医学期刊文摘（儿科学分册） 2005年第12期1卷 48-49页

作者： Kugelman A. Gangitano E. Taschuk R. M. durand 王经纬 LAC- USC Medical Center Women's and Children's Hospital 1240 N. Mission Rd Los Angeles CA 90033 United States

Despite the emergence of new therapies for respiratory failure of the newborn with meconium aspiration syndrome (MAS), extracorporeal membrane oxygenation (ECMO) has a significant role as a rescue modality in these infants. Our objective was to compare the use of venovenous (VV) vs venoarterial (VA) ECMO in newborns with MAS who need ECMO and to ascertain the impact of new therapies in these infants during the last decade. We also evaluated how disease severity or time of ECMO initiation affected mortality and morbidity. Methods: A report of 12 years experience (1990- 2002) of a single center, comparing VV and VA ECMO, is given. Venovenous ECMO was the preferred rescuemodality for respiratory failure unresponsive to maximal medical therapy. Venoarterial ECMO was used only when the placement of a VV ECMO 14- F catheter was not possible; 128 patients met ECMO criteria, 114 were treated with VV ECMO, and 12 with VA ECMO. Two patients were converted from VV to VA ECMO. Results: Venovenous and VA ECMO patients had comparable birth weight (mean ± SEM, 3.48 ± 0.05 vs 3.35 ± 0.15 kg) and gestational age (40.3 ± 0.1 vs 40.7 ± 0.3 weeks). Before ECMO, there was no difference between VV and VA ECMO patients in oxygenation index (60 ± 3 vs 63 ± 8), mean airway pressure (19.5 ± 0.4 vs 20.8 ± 1.5 cm H2O), alveolar-arterial O2 gradient (630 ± 2 vs 632 ± 4 torr), ECMO cannulation age (median [25th- 75th percentiles], 23 [14- 47] vs 26 [14- 123] hours),or in the % of patients who needed vasopressors/ inotropes (98% vs 100% ). From November 1994, inhaled nitric oxide (NO) was available. Before VV ECMO, 67% of the patients received NO, 24% received surfactant, and 48% were treated with high-frequency ventilation (HFV). There was no significant difference bet-ween VV and VA ECMO patients in survival rate (94% vs 92% ), ECMO duration (88 [64- 116] vs 94 [55- 130] hours), time of extubation (9 [7- 11] vs 14 [9- 15] days), age at discharge (23 [18- 30] vs 27 [15- 41] days), or incidence o

关键词：胎粪吸入综合征体外膜式氧合膜式表面活性物质法应平均气道压呼吸衰竭颅内合并症动脉氧分压套管插入术