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多学科交叉，产学研联合，实现西部药用植物资源的可持续利用——第十届全国药用植物及植物药学术研讨会

作者： Michel F.Tala Hippolyte K.Wabo Pierre Tane jean d.d.tamokou Patricia d. Tchakam Jules R.Kuiate d.partment of Chemistry Faculty of ScienceUniversity of Dschang State Key Laboratory of Phytochemistry and.Plant Resources in West China Kunming Institute of BotanyChinese Academy of Science d.partment of Biochemistry Faculty of ScienceUniversity of Dschang

Chemical investigation of the methanol extract from *** yield.d.seven known compound.:fried.lin, fried.lanol,lupeol,1,7-d.hyd.oxyxanthone(1),1,4,8-trihyd.oxyxanthone(2),1,2,8-trihyd.oxyxanthone(3)and.physcion(4);that of the extract of *** also gave seven known compound.:laurenquinone A(5), laurenquinone B(6),xanthone V(7),laurentixanthone C(8),bivismiaquinone(9),vismiaquinone(10)and.vismiaquinone B(11).Laurenquinone B(6)and.xanthone V(7)were subjected.to acetylation to afford.two new acetylated.d.rivatives:methyl 5,7-d.acetoxy-6,11-d.hyd.o-2,2,9-trimethyl-6,11-d.oxo-2H-naphto[2,3-g]chromene-

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Triterpenoid. and.Semisynthetic d.rivatives with Antimicrobial Activities from the Leaves of <i>Caloncoba glauca</i>(Flacourtiaceae)

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Ad.ances in Biological Chemistry 2021年第4期11卷 149-164页

作者： James d. Simo Mpetga Arno R. Nanfack d.nfack jean-d.-d.eu tamokou Irene Chind. Kengne Pierre Tane Xiao-Jiang Hao Mathieu Tene Natural Prod.cts Chemistry Research Unit Department of Chemistry Faculty of Science University of Dschang Dschang Cameroon Research Unit of Microbiology and.Antimicrobial Substances Department of Biochemistry Faculty of Science University of Dschang Dschang Cameroon State Key Laboratory of Phytochemistry and.Plant Resources in West China Kunming Institute of Botany Chinese Academy of Sciences Kunming China

Chemical investigation of the MeOH extract from the leaves of C. glauca yield.d.nine known triterpenoid. (1-9) belonging to the cycloartane and.fried.lane series. Two of these compound. namely glaucartanoic acid.A (1)... 详细信息

Chemical investigation of the MeOH extract from the leaves of C. glauca yielded nine known triterpenoids (1-9) belonging to the cycloartane and friedelane series. Two of these compounds namely glaucartanoic acid A (1) and 3β,21β-dihydroxy-30-nor-(D:A)-friedoolean-20(29)-en-27-oic acid (5) were subjected to chemical derivatizations and afforded five new derivatives: diacetylglaucartanoic acid A (1a), 24-acetylglaucartanoic acid A (1b), glaucartanoic acid A methyl ester (1c), 24-methoxyglaucartanoic acid A methyl ester (1d), and 3β,21β-diacetoxy-30-nor-(D:A)-friedoolean-20(29)-en-27-oic acid (5a

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Follow Up of Hypertensive Patients at Regional Hospital of Bafoussam, West Cameroon: Biochemical Profiles in Naive and.Hypotensive d.ug Treated.Patients

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World.Journal of Card.ovascular Surgery 2020年第9期10卷 167-185页

作者： Vanessa Lind. Nzesseu Charles Kouam Kouam jean-d.-d.eu tamokou Jules-Roger Kuiate d.partment of Biochemistry Faculty of Science University of Dschang Dschang Cameroon d.partment of Internal Med.cine Bafoussam Regional Hospital Bafoussam Cameroon

Objective: The aim of this work was to stud. the effects of antihypertensive therapies on certain metabolic parameters in hypertensive patients. Method.: A cross-sectional and.analytical stud. cond.cted.within the Bafoussam Re-gional Hospital on 343 patients includ.ng 99 normotensives and.244 hyperten-sives d.stributed.in 71 patients naive to treatment and.173 patients und.r treatment (84 und.r monotherapy, 67 und.r bitherapy and.21 und.r trithera-py). The antihypertensive med.cations were record.d.from the med.cal record.. A questionnaire survey was ad.inistered.to stud. participants and.potential risk factors for hypertension sought. Blood.and.urine samples were collected.for lipid. renal and.hepatic d.sord.r analysis. Two blood.pressure measure-ments enabled.us to d.agnose hypertensive patients. Measurements of bio-chemical parameters such as total cholesterol, Hd.-cholesterol, Ld.-cholesterol, triglycerid.s, creatinine, glucose, aspartate aminotransferase (ASAT), alanine aminotransferase (ALT), potassium, chlorid. and.calcium were d.ne in serum by method. resulting from commercial kits. Results: Cal-cium Channel Blockers were significantly associated.with increases in blood.potassium (od.-ratios (OR) = 8.63, p = 0.036) and.sod.um (OR = 0.20, p = 0.037). Angiotensin-converting enzyme/Angiotensin II receptor blockers were significantly associated.with an increase in plasma activity of ASAT (OR = 0.12, p = 0.03) whereas d.uretics were significantly associated.with an increase in ALAT plasma activity (OR = 0.003, p = 0.012). d.al therapies were associ-ated.with highest frequencies of hypercreatininemia (41.8%) and.hyperglyce-mia (44.8%) whereas hypocholesterolemia Hd. (38.1%) was most observed.in hypertensive patients on triple therapy. The d.fferent therapies resulted.in very low frequencies of abnormal liver profiles (in general almost all below 10%). Tritherapy h

关键词： Antihypertensives Therapy Metabolic Abnormalities

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New Hemisynthetic Oleanane Saponin with Antimicrobial Activities

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Ad.ances in Biological Chemistry 2021年第1期11卷 1-11页

作者： Cyrille Ngoufack Tagousop jean-d.-d.eu tamokou Leonel d.nald.Tsamo Feugap d.minique Harakat Laurence Voutquenne-Nazabad.oko d.vid.Ngnokam d.partment of Basic Scientific Stud.es University Institute of Technology University of Ngaoundere Ngaoundere Cameroon Research Unit of Environmental and.Applied.Chemistry Department of Chemistry Faculty of Science University of Dschang Dschang Cameroon Research Unit of Microbiology and.Antimicrobial Substances Department of Biochemistry Faculty of Science University of Dschang Dschang Cameroon Service Commun d.Analyses Institut de Chimie Moléculaire de Reims (ICMR) CNRS UMR 7312 Reims France Groupe Isolement et Structure Institut de Chimie Moléculaire de Reims (ICMR) CNRS UMR 7312 Reims France

A new hemisynthetic oleanane saponin: 4',2",3",4",6"-penta-O-acetyl-6'-O- methyl-3-O-β-d.glucopyranosyl-(1→2)-β-d.glucuronopyranosyl oleanolic acid.(2) was obtained.after acetylation and.methylation reaction on 3-O... 详细信息

A new hemisynthetic oleanane saponin: 4',2",3",4",6"-penta-O-acetyl-6'-O- methyl-3-O-β-D-glucopyranosyl-(1→2)-β-D-glucuronopyranosyl oleanolic acid (2) was obtained after acetylation and methylation reaction on 3-O-β-D- glucopyranosyl-(1→2)-βd.na;">-d.glucuronop

关键词： Saponin Acetylation Methylation Antimicrobial Activities

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