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Machine learning approach to assess the association between anthropometric,metabolic,and nutritional status and semen parameters

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Asian Journal of Andrology 2024年第4期26卷 349-355页

作者： Guillaume Bachelot Antonin Lamaziere sebastien Czernichow Celine Faure Chrystelle Racine Rachel Levy Charlotte Dupont Nutrition and Fertility(ALIFERT)Group Author Information Sorbonne University School of Medicine Saint-Antoine Research CenterINSERM UMR 93827 rue ChalignyParis 75012France Reproductive Biology Department-CECOS Tenon HospitalAP-HP.Sorbonne UniversityParis 75020France Clinical Metabolomics Department Saint-Antoine HospitalAP-HP27 rue ChalignyParis 75012France Nutrition Department Obesity Specialist CentreGeorges Pompidou European HospitalAP-HPParis 75015France 不详

Many lifestyle factors,such as nutritional imbalance leading to obesity,metabolic disorders,and nutritional deficiency,have been identified as potential risk factors for male *** aim of this study was to evaluate the relationship between semen parameters and anthropometric,metabolic and nutritional *** was first assessed individually,then after the application of a previously constructed and validated machine learning score that allows their ***,metabolic,antioxidant,micronutrient,and sperm parameters from 75 men suffering from idiopathic infertility from four infertility centers in France(jean-Verdier ART Center Hospital,Bondy;North Hospital ART Center,Saint-Étienne;Navarre Polyclinic ART Center,Pau;and Cochin Hospital ART Center,Paris)between September 2009 and December 2013 were *** assessing standard correlation analysis,a previously built machine learning model,providing a score ranging from 0(the poorest)to 1(the most favorable),was calculated for each man in the study *** machine learning model,which separates infertile/fertile men with unexplained infertility on the basis of their bioclinical signature,provides a more holistic evaluation of the influence of the considered markers(anthropometric,metabolic,and oxidative status).We observed a significant correlation of some anthropometric,metabolic,and nutritional disorders with some sperm ***,an unfavorable machine learning score was associated with a high level of sperm DNA *** anthropometric,metabolic,and oxidative patterns,which may reflect an appropriate lifestyle,appear to positively impact overall health,in particular reproductive *** study,consistent with previous publications,suggests that beyond semen quality parameters,in an essential assessment of male fertility,other key factors should be taken into *** this regard,the application of emerging artificial intelligence t

关键词： lifestyle machine learning metabolism nutrition sperm DNA fragmentation

AB038. Pathological neovascularization in retinopathy of prematurity is regulated by heme-derived iron trafficking

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Annals of Eye Science 2019年第1期 213-213页

作者： Tapan Agnihotri Nicholas Kim Gael Cagnone Jin Sung Kim Emilie Heckel Sheetal Pundir Perrine Gaub Florian Wunnemann Walter Szarek Hyman Schipper jean-sebastien joyal Department of Pharmacology and Therapeutics McGill UniversityMontréalQCCanada Department of Pediatrics Pharmacology and OphthalmologyCHU Sainte-Justine Research CenterUniversitéde MontrealMontréalQCCanada Department of Chemistry Queen’s UniversityKingstonONCanada

Background:Retinopathy of prematurity(ROP)is an eye disease of the immature newborn characterized by pathological neovascularization(NV).ROP classically arises due to changes in oxygen availability in the ***,other factors,such as red blood cell(RBC)transfusion,independently contribute to disease *** molecules,rich in RBC,are the primary source of endogenous *** is metabolized by heme oxygenase(HO)into biliverdin,carbon monoxide,and ferrous *** iron levels stabilize hypoxia-inducible factor 1α(HIF1α),the main transcription factor of vascular endothelial growth factor(VEGF)that drives *** we investigate the role of heme metabolism in pathological ***:ROP was studied using the well-characterized oxygen-induced retinopathy(OIR)mouse ***-type(WT)pups are exposed to high oxygen concentrations(FiO275%)for 5 days,from the post-natal day(P)7 to 12,and subsequently returned to room air until retinal collection at P12,P14,&*** are then analyzed via single-cell RNAseq,RT-qPCR,western blot,Prussian blue staining,and immunostaining techniques to elucidate the effect of OIR on iron metabolism and *** OIR,we quantified vaso-obliteration(VO)and pathologic neovascular(NV)areas at P17 to assess the effects of1 Hmox1 competitive inhibition,and2Hmox1 allosteric ***:Iron trafficking genes across different retinal cell-types were upregulated in OIR,including CP,FTH1,IREB2,TF,and ***,Prussian blue staining suggests iron accumulation in retinal vessels exposed to ***1 mRNA(n=7,P<0.01 at P17)and protein expression(n=3,P<0.05)were increased 3.8-fold from P12 to *** and single-cell RNAseq confirmed that Hmox1 predominantly resides in retinal microglial *** and allosterically Hmox1 inhibition decreased NV by 15%(n=15,P=0.02)and 60%(n=5,P<0.01)***:Iron metabolism has seldom been explored in the context of *** microglial heme metabolis

关键词： Retinopathy of prematurity(ROP) iron metabolism microglia

***-cell transcriptomics identifies cell-specific signatures of pathological angiogenesis

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Annals of Eye Science 2019年第1期 215-215页

作者： Gael Cagnone Sheetal Pundir Nick Kim Emilie Heckel Jin Sung Kim Perrine Gaub Florian Wunnemann Piet van Vliet Severine Leclerc Gregor Andelfinger Sylvain Chemtob jean-sebastien joyal CHU Ste-Justine Research Center Universitéde MontréalMontréalQCCanada Faculty of Medicine Department of Pharmacology and PhysiologyUniversitéde MontréalMontréalQCCanada Faculty of Medicine Department of PediatricsUniversity of MontrealUniversitéde MontréalMontréalQCCanada Department of Pharmacology and Therapeutics McGill UniversityMontréalQCCanada

Background:To treat vascular proliferative diseases,anti-VEGF therapies have shown systemic adverse effects attributable to the lack of selectivity between pathological and physiological ***,identifying the molecular mechanisms that are only specific to pathological cell types is crucial to develop better precision ***:Here,we used different cell type enrichment approaches combined with single-cell RNA sequencing to define the transcriptomic changes within each retinal cell types in a mouse model of ischemic *** retinal model develops pathological neovascularization(NV)in response to local hypoxia following oxygen-induced vessel obliteration(P7 to P12).The NV phenotype is characterized by the progressive appearance of vascular tufts resulting from misguided,abnormal proliferation of endothelial cells that we monitored at 3 consecutive time points-P12,P14 and P17(peak of NV).Results:By following the dynamic response to hypoxia,our experimental design reveals how pathological angiogenesis is specifically associated with significant metabolic adaptations in different subtypes of endothelial cells(i.e.,Tips vs Stalk cells).We also identify a pathological subtype of glial cells over-expressing VEGFA and pro-inflammatory IL-1 receptor *** subtype of activated glial cells was targeted using selective IL1R antagonist treatment which reduced glial activation,inflammation,NV and promotes physiological angiogenesis,therefore improving tissue ***:Our results illustrate how analyzing cell type heterogeneity in tissues developing pathological angiogenesis allows establishing better targeting therapies to restore vascular integrity.

关键词： Single-cell RNAseq angiogenesis pathological vascularization metabolism inflammation

Tidal triggering of seismicity in the region of Palu, Central Sulawesi, Indonesia

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Geodesy and Geodynamics 2023年第4期14卷 377-384页

作者： Ibnu Nurul Huda sebastien Lambert jean Souchay Research Center for Computing National Research and Innovation AgencyBogorIndonesia Department of Astronomy and Bosscha Observatory FMIPAInstitut Teknologi BandungBandungIndonesia SYRTE Observatoire de ParisUniversité PSLCNRSSorbonne UniversitéLNEParisFrance

This paper investigates the correlation between tidal stress and earthquakes for periods ranging from hours to months in the limited zone of the Palu region(Central Sulawesi,Indonesia).Through Schuster and binomial tests,we examined the relation between the seismicity(time density of seismic events)and tidal potential arising from the Moon and Sun,using all tidal components simultaneously and focusing on the estimation of specific *** results show significant correlations between the seismicity and tidal potential for S2(0.5 d)and O1(1.075 d)tidal components in the case of solely isolated earthquake events,particularly for shallow ***,there is a strong relationship between aftershocks and tidal components larger than the Mf period(13.661 d).Finally,the analysis of the temporal variation of the earthquake-tide relation reveals an optimal correlation for about six years before the 2018 great Palu *** correlation becomes insignificant afterwards.

关键词： Tidal triggering Earth tides Palu region Statistical test

Anion Channel Blockage by ATP as a Means for Membranes to Perceive the Energy Status of the Cell

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Molecular Plant 2016年第3期9卷 320-322页

作者： Alexis De Angeli sebastien Thomine jean-Marie Frachisse nstitute for Integrative Biology of the Cell (12BC) CEA CNRS Univ. Paris-Sud Universite Paris-Saclay 91198 Gif-sur-Yvette cedex France

ATP harbors three phosphoric groups linked by two highly energetic phospho-anhydride *** exergonic hydrolysis of the phospho-anhydride bonds of ATP can be used in biochemical reactions to couple the released energy to another endergonic ***,ATP is a timing belt of cellular metabolism and energy distribution in *** cytosolic concentration of ATP and of its hydrolysis products,ADP,AMP,and PPi,is a function of the metabolic activity and defines the energetic status of cells.

关键词： phospho couple products

Kinetic Slip Boundary Condition for Isothermal Rarefied Gas Flows through Static Non-Planar Geometries Based on the Regularized Lattice-Boltzmann Method

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Communications in Computational Physics 2022年第3期31卷 816-868页

作者： jean-Michel Tucny David Vidal sebastien Leclaire Francois Bertrand Mechanical Engineering Department Polytechnique MontralP.O.Box 6079Stn.CVMontrealQCCANADAH3C 3A7 Chemical Engineering Department Polytechnique MontralP.O.Box 6079Stn.CVMontrealQCCANADAH3C 3A7

The simulation of rarefied gasflows through complex porous media is chal-lenging due to the tortuousflow pathways inherent to such *** Lattice Boltzmann method(LBM)has been identified as a promising avenue to solveflows through complex geometries due to the simplicity of its scheme and its high parallel computational *** has been proposed to model the stress-strain relationship with the extended Navier-Stokes equations rather than attempting to directly solve the Boltzmann ***,a regularization technique is required tofilter out non-resolved higher-order components with a low-order velocity *** slip boundary conditions(BCs)have been proposed for the non-regularized multiple relaxation time LBM(MRT-LBM)for planar geometries,previous slip BCs have never been verified extensively with the regularization *** this work,following an extensive literature review on the imposition of slip BCs for rarefiedflows with the LBM,it is proven that earlier values for kinetic parameters developed to impose slip BCs are inaccurate for the regularized MRT-LBM and differ between the D2Q9 and D3Q15 *** error was eliminated for planarflows and good agreement be-tween analytical solutions for arrays of cylinders and spheres was found with a wide range of Knudsen numbers.

关键词： Lattice Boltzmann method(LBM) boundary condition(BC) rarefiedflow nonplanar geometry

The effect of landscape complexity and microclimate on the thermal tolerance of a pest insect

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Insect Science 2018年第5期25卷 905-915页

作者： Lucy Alford Kevin Tougeron jean-sebastien Pierre Francoise Burel Joan van Baaren UMR 6553 ECOBIO Centre National de la Recherche Scientitique Universite de Rennes I Rennes Cedex France Departement de Sciences Biologiques Insfitut de Recherche en Biologie Vegetale Universite de Montreal Montreal QC Canada Universite Europeenne de Bretagne (UEB) Rennes France

Landscape changes are known to exacerbate the impacts of climate change. As such, understanding the combined effect of climate and landscape on agroecosystems is vital if we are to maintain the fimction of agroecosystems. This study aimed to elucidate the effects of agricultural landscape complexity on the microclimate and thermal tolerance of an aphid pest to better understand how landscape and climate may interact to affect the thermal tolerance of pest species within the context of global climate change. Meteo- rological data were measured at the landscape level, and cereal aphids （Sitobion avenae, Metopolophium dirhodum and Rhopalosiphum padi） sampled, from contrasting landscapes （simple and complex） in winter 2013/2014 and spring 2014 in cereal fields of Brittany, France. Aphids were returned to the laboratory and the effect of landscape of origin on aphid cold tolerance （as determined by CTmin） was investigated. Results revealed that local landscape complexity significantly affected microclimate, with simple homogenous landscapes being on average warmer, but with greater temperature variation. Landscape complexity was shown to impact aphid cold tolerance, with aphids from complex land- scapes being more cold tolerant than those from simple landscapes in both winter and spring, but with differences among species. This study highlights that future changes to land use could have implications for the thermal tolerance and adaptability of insects. Fur- thermore, not all insect species respond in a similar way to microhabitat and microclimate, which could disrupt important predator-prey relationships and the ecosystem service they provide.

关键词： agroecosystems biological control cereal aphids climate change coldtolerance landscape ecology

Transcatheter embolization therapy in liver cancer:an update of clinical evidences

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Chinese Journal of Cancer Research 2015年第2期27卷 96-121页

作者： Yi-Xiang J.Wang Thierry De Baere jean-Marc Idee sebastien Ballet Department of Imaging and Interventional Radiology Faculty of MedicineThe Chinese University of Hong KongPrince of Wales Hospital Gustave Roussy Department of Interventional Radiology Guerbet Division of Research & Innovation

Transarterial chemoembolization （TACE） is a form of intra-arterial catheter-based chemotherapy that selectively delivers high doses of cytotoxic drug to the tumor bed combining with the effect of ischemic necrosis induced by arterial embolization. Chemoembolization and radioembolization are at the core of the treatment of liver hepatocellular carcinoma （HCC） patients who cannot receive potentially curative therapies such as transplantation, resection or percutaneous ablation. TACE for liver cancer has been proven to be useful in local tumor control, to prevent tumor progression, prolong patients＇ life and control patient symptoms. Recent evidence showed in patients with single-nodule HCC of 3 cm or smaller without vascular invasion, the 5-year overall survival （OS） with TACE was similar to that with hepatic resection and radiofrequency ablation. Mthough being used for decades, Lipiodol~ （Lipiodol~ Ultra Fluid~, Guerbet, France） remains important as a tumor-seeking and radio-opaque clrug delivery vector in intervendonal oncology. There have been efforts to improve the delivery of chemotherapeutic agents to tumors. Drug-eluting bead （DEB） is a relatively novel drug delivery embolization system which allows for fixed dosing and the ability to release the anticancer agents in a sustained manner. Three DEBs are available, i.e., Tandem~ （CeloNova Biosciences Inc., USA）, DC-Beads~ （BTG, UK） and HepaSphere~ （BioSphere Medical, Inc., USA）. Transarterial radioembolization （TARE） technique has been developed, and proven to be efficient and safe in advanced liver cancers and those with vascular complications. Two types of radioembolization microspheres are available i.e., SIR-Spheres~ （Sirtex Medical Limited, Australia） and TheraSphere~ （BTG, UK）. This review describes the basic procedure of TACE, properties and efficacy of some chemoembolization systems and radioembolization agents which are commercially available and/or currently under clinical evaluation. The key clinical tr

关键词： Transarterial chemoembolization hepatocellular carcinoma (HCC) drug-eluting particles microspheres Lipiodol radioembolization yttrium-90

Lattice Boltzmann Modeling of Miscible Multicomponent Gas Mixtures in the Rarefied Regime

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Communications in Computational Physics 2022年第9期32卷 1179-1216页

作者： Michel Ho Sami Ammar sebastien Leclaire Marcelo Reggio jean-Yves Trepanier Departement of Mechanical Engineering Polytechnique Montreal2500 Chemin de PolytechniqueMontreal H3T 1J4Canada

An extension to rarefied flow regimes of the lattice Boltzmann methodbased model for miscible mixtures developed by Vienne et al.(Physical Review E 100.2(2019):023309)is *** model is applied to study the gas phase separation phenomenon in mixture flows that traditional macroscopic approaches fail to *** extension includes a wall function approach with an empirical coefficient to define an effectivemean free path in solid geometries,which locally defines the kinematic viscosity and binary diffusion *** algorithm is also modified by a local multi-relaxation time collision operator and slip boundary conditions at solid *** mixture flow simulations are conducted through a 2D plane microchannel within the slip and early transition flow *** a miscible gaseous phase,the mixture loses its homogeneity and independent velocity profiles for each component are observed in the rarefied regime and captured with the current *** addition,the gas separation phenomenon increases with the rarefaction rate and the molecular mass *** individual treatment of the species within mixture flows in the developed lattice Boltzmann model helps understanding the increasing independent behavior of the individual specieswithin themixture as the regime becomesmore rarefied.

关键词： Lattice Boltzmann gaseous mixtures rarefied regimes