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Infectious Diseases & Immunity 2022年第2期2卷 122-124页

作者： Yaling Chen Jing Ouyang Stéphane Isnard Cecilia T.Costiniuk Jiangyu Yan Xin Zhou jean-pierre routy Yaokai Chen Chongqing Public Health Medical Center Chongqing 400030China Infectious Diseases and Immunity in Global Health Program Research InstituteMcGill University Health CentreMontréalQCCanada Chronic Viral Illness Service McGill University Health CentreMontréalQCCanada Division of Hematology McGill University Health CentreMontréalQCCanada

Increased microbial translocation and chronic immune activation are two critical problems for people living with HIV(PLWH)in the antiretroviral therapy(ART)*** with numerous studies on bacterial microbiomic communities,there are only a limited number of studies focusing on fungal microbiomic composition and products in *** study protocol is used to evaluate the changes in bacterial and fungal microbiome populations induced by terbinafine treatment,which is an antifungal agent widely used amongst ***-two PLWH on a stable ART regimen for more than six months,who require treatment for onychomycosis,will be *** participants will be followed-up for a 12-week treatment period(oral terbinafine 250mg daily)and another 12-weeks of terbinafine *** and fecal samples will be collected before and after terbinafine treatment,and for 12weeks after the discontinuation of *** gut injury and microbial translocation biomarker assays,in addition to testing for gut microbiome composition,will be *** this pilot study,we will perform formal sample size calculations and test study feasibility for a possible full-scale study.

关键词： HIV Fungal translocation Microbial translocation Onychomycosis Terbinafine

Potential therapeutic options for coronavirus disease 2019:using knowledge of past outbreaks to guide future treatment

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Chinese Medical Journal 2020年第11期133卷 1350-1352页

作者： John Lin Jing Ouyang Xiao-Rong Peng Stephane Isnard Brandon Fombuena jean-pierre routy Yao-Kai Chen infectious Diseases and Immunity in Global Health Program Research InstituteMcGill University Health CentreMontrealQC H4A 3J1Canada Chronic Viral Illness Service McGill University Health CentreMontrealQC H4A 3J1Canada Division of Infectious Diseases Chongqing Public Health Medical CenterChongqing 400036China State Key Laboratory for Diagnosis and Treatment of Infectious Diseases National Clinical Research Center for Infectious DiseasesCollaborative Innovation Center for Diagnosis and Treatment of Infectious DiseasesThe First Affiliated HospitalCollege of MedicineZhejiang UniversityHangzhouZhejiang 310000China Department of Microbiology and Immunology McGill UniversityMontrealQC H3A 0G4Canada Division of Hematology McGill University Health CentreMontrealQC H4A 3J1Canada

In December 2019,initial cases of the novel coronavirus(2019-nCoV)infection,termed coronavirus disease 2019(COVID-19),were first reported in Wuhan,China.[1]In humans,infections with the human coronavirus 229E,OC43,NL63,and HKU1 usually result in mild,selflimiting upper respiratory tract ***,other variants have rapid transmission rates and can cause severe respiratory syndrome and *** variants include severe acute respiratory syndrome coronavirus(SARSCoV),Middle East respiratory syndrome coronavirus(MERS-CoV),and the current 2019-nCoV.

关键词： respiratory acute China.

HIV Compartmentalization in Male Genital Tract:Relevance for Viral Eradication

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Infectious Diseases & Immunity 2021年第2期1卷 86-92页

作者： Xiaorong Peng Stéphane Isnard John Lin Brandon Fombuena Lena Royston jean-pierre routy Infectious Diseases and Immunity in Global Health Program Research InstituteMcGill University Health CentreMontréalQCCanada Chronic Viral Illness Service McGill University Health CentreMontréalQCCanada State Key Laboratory for Diagnosis and Treatment of Infectious Diseases National Clinical Research Center for Infectious DiseasesCollaborative Innovation Center for Diagnosis and Treatment of Infectious Diseasesthe First Affiliated HospitalCollege of MedicineZhejiang UniversityHangzhouZhejiang 310006China CIHR Canadian HIV Trials Network VancouverBCCanada Division of Hematology McGill University Health CentreMontréalQCCanada

Human immunodeficiency virus(HIV)has been shown to evolve independently in different anatomical *** HIV genetic evolution in different tissues and cells provides insights into the mechanisms that maintain the viral *** compartmentalization has been well documented in the semen but rarely in male genital tract(MGT)*** precise mechanisms that result in the development of HIV compartmentalization in multiple genitourinary sites have been poorly explored due to the difficulty in accessing these *** on evidence from lymph nodes and gut tissues,mechanisms that may influence compartmentalization include immune pressures,local concentrations of antiviral drugs,clonal expansion of different cell types and inflammation that alters the cellular *** reviewed phylogenetic evidences supporting viral compartmentalization between the blood and multiple genitourinary sites in HIV-infected *** distinct viral subpopulations enhances our overall understanding of the HIV reservoir inMGTand could ultimately lead to the development of novel therapies to eradicate the virus in tissues.

关键词： HIV Compartmentalization Male genital tract Reservoir Testes

Strategies to increase CD4 T cells recovery in patients receiving antiretroviral therapy

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Strategies to increase CD4 T cells recovery in patients rece...

Monitoring absolute vertical land motions and absolute sea-level changes from GPS and tide gauges data over French Polynesia

中华医学会第五次全国艾滋病、病毒性丙型肝炎暨全国热带病学术会议

作者： jean-pierre routy McGill University

来源： cnki会议评论

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Geodesy and Geodynamics 2024年第1期15卷 13-26页

作者： Xianjie Li jean-pierre Barriot Bernard Ducarme Marania Hopuare Yidong Lou Geodesy Observatory of Tahiti University of French PolynesiaFaa'a 98702French Polynesia Catholic University of Louvain Georges Lemaître Centre for Earth and Climate Research(ELI)1348 Louvain-la-NeuveBelgium GNSS Research Center Wuhan UniversityWuhan 430079China State Key Laboratory of Information Engineering in Surveying Mapping and Remote SensingWuhan UniversityWuhan 430079China

In this study,we estimate the absolute vertical land motions at three tidal stations with collocated Global Navigation Satellite System(GNSS)receivers over French Polynesia during the period 2007-2020,and obtain,as ancillary results,estimates of the absolute changes in sea level at the same *** verify our processing approach to determining vertical motion,we first modeled vertical motion at the International GNSS Service(IGS)THTI station located in the capital island of Tahiti and compared our estimate with previous independent determinations,with a good *** obtained the following estimates for the vertical land motions at the tide gauges:Tubuai island,Austral Archipelago-0.92±0.17 mm/yr,Vairao village,Tahiti Iti:-0.49±0.39 mm/yr,Rikitea,Gambier Archipelago-0.43±0.17 mm/*** absolute variations of the sea level are:Tubuai island,Austral Archipelago 5.25±0.60 mm/yr,Vairao village,Tahiti Iti:3.62±0.52 mm/yr,Rikitea,Gambier Archipelago 1.52±0.23 mm/*** discuss these absolute values in light of the values obtained from altimetric measurements and other means in French Polynesia.

关键词： GPS Tide gauges Sea level changes Vertical land motion

Re-evaluation of recent research on metabolic utilization of energy in poultry: Recommendations for a net energy system for broilers

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Animal Nutrition 2024年第1期16卷 62-72页

作者： jean Noblet Aye-Cho Tay-Zar Shu-Biao Wu Pairat Srichana pierre Cozannet pierre-Andre Geraert Mingan Choct INRAE Charoen Pokphand Foods Public Company Limited (CPF) School of Environmental and Rural Science University of New England Adisseo France S.A.S.

Different energy systems have been proposed for energy evaluation of feeds for domestic animals. The oldest and most commonly used systems take into account the fecal energy loss to obtain digestible energy(DE), and fecal, urinary and fermentation gases energy losses to calculate metabolizable energy(ME). In the case of ruminants and pigs, the net energy(NE) system, which takes into account the heat increment associated with the metabolic utilization of ME, has progressively replaced the DE and ME systems over the last 50 years. For poultry, apparent ME(AME) is used exclusively and NE is not yet used widely. The present paper considers some important methodological points for measuring NE in poultry feeds and summarizes the available knowledge on NE systems for poultry. NE prediction equations based on a common analysis of three recent studies representing a total of 50 complete and balanced diets fed to broilers are proposed; these equations including the AME content and easily available chemical indicators have been validated on another set of 30 diets. The equations are applicable to both ingredients and complete diets. They rely primarily on an accurate and reliable AME value which then represents the first limiting predictor of NE value. Our analysis indicates that NE would be a better predictor of broiler performance than AME and that the hierarchy between feeds is dependent on the energy system with a higher energy value for fat and a lower energy value for protein in an NE system. Practical considerations for implementing such an NE system from the commonly used AME or AMEn(AME adjusted for zero nitrogen balance) systems are presented. In conclusion, there is sufficient information to allow the implementation of the NE concept in order to improve the accuracy of feed formulation in poultry.

关键词： Poultry Feed evaluation Net energy Energy system

Prediction of net energy of feeds for broiler chickens

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Animal Nutrition 2024年第1期16卷 241-250页

作者： Aye-Cho Tay-Zar Manoosak Wongphatcharachai Pairat Srichana pierre-André Geraert jean Noblet Charoen Pokphand Foods Public Company Limited(CPF) BangkokThailand Adisseo France S.A.S. AntonyFrance INRAE RennesFrance

Net energy(NE)enables the prediction of more accurate feed energy values by taking into account the heat increment which is approximately 25%of apparent metabolizable energy(AME)in ***,application of NE in poultry industry has not been practiced *** predict the NE values of broiler diets,23 diets were prepared by using 13 major ingredients(wheat,corn,paddy rice,broken rice,cassava pellets,full-fat soybean,soybean meal,canola meal,animal protein,rice bran,wheat bran,palm kernel meal and palm kernel oil).The diets were formulated in order to meet the birds'requirements and get a wide range of chemical compositions(on DM basis;33.6%to 55.3%for starch;20.8%to 28.4%for CP,2.7%to 10.6%for ether extract[EE]and 7.0%to 17.2%for NDF),with low correlations between these nutrients and low correlations between the inclusion levels of ingredients allowing for the calculation of robust prediction equations of energy values of diets or *** diets were fed to Ross 308 broilers raised in 12 open-circuit respiratory chambers from 18 to 23 d of age(4 birds per cage)and growth performance,diet AME content and heat production were measured,and dietary NE values were *** trial was conducted on a weekly basis with 12 diets measured each week(1per chamber),1 of the 23 diets(reference diet)being measured each *** diet was tested at least *** total,235 energy balance data values were available for the final *** performance,AME(15.3 MJ/kg DM on average)and AME/GE(79.4%on average)values were as *** NE/AME value averaged 76.6%and was negatively influenced by CP and NDF and positively by EE in connection with efficiencies of AME provided by CP,EE and starch for NE of 73%,87%and 81%,*** best prediction equation was:NE=(0.815×AME)—(0.026×CP)+(0.020×EE)—(0.024×NDF)with NE and AME as MJ/kg DM,and CP,EE and NDF as%of *** NE prediction equations from this study agree with other recently reported equation

关键词： Net energy Broiler Poultry Feed evaluation Energy system

Baseline Naive CD4＋ T-cell Level Predicting Immune Reconstitution in Treated HIV-infected Late Presenters

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Chinese Medical Journal 2016年第22期129卷 2683-2690页

作者： Fu-Ping Guo Yi-Jia Li Zhi-Feng Qiu Wei Lv Yang Han Jing Xie Yan-Ling Li Xiao-Jing Song Shan-Shan Du Vikram Mehraj Tai-Sheng Li jean-pierre routy Department of Infectious Diseases Peking Union Medical College Hospital Chinese Academy of Medical Sciences Beijing 100730 China Division of Hematology Research Institute and Chronic Viral Illness Service McGill University Montreal Quebec Canada

Background：Among HlV-infected patients initiating antiretroviral therapy （ART）,early changes in CD4＋ T-cell subsets are well ***,HIV-infected late presenters initiating treatment present with a suboptimal CD4＋ T-cell reconstitution and remain at a higher risk for AIDS and non-AIDS ***,factors associated with CD4＋ T-cell reconstitution need to be determined in this population,which will allow designing effective immunotherapeutic ***：Thirty-one adult patients with baseline CD4＋ T-cell count 〈350 cells/mm^3 exhibiting viral suppression after ART initiation were followed in the HIV/AIDS research center of Peking Union Medical College Hospital in Beijing,China,from October 2002 to September *** in T-cell subsets and associated determinants were ***：Median baseline CD4＋ T-cell count was 70 cells/*** found a biphasic reconstitution ofT-cell subsets and immune activation：a rapid change during the first 6 months followed by a more gradual change over the subsequent 8 *** CD4＋ T-cell count 〉200 cells/ mm3 in comparison to CD4＋ T-cell count ≤200 cells/mm3 was associated with more complete immune Reconstitution （77.8% vs.27.3% respectively;P =0.017） and normalized CD4/CD8 *** showed that the baseline percentage of naive CD4＋ T-cell was a predictive marker for complete immune reconstitution （area under receiver operating characteristic curve 0.907）,and 12.4% as cutoffvalue had a sensitivity of 84.6% and a specificity of 88.2%.Conclusions：Baseline naive CD4＋ T-cell percentage may serve as a predictive marker for optimal immune reconstitution during long-term *** study findings suggest that increasing thymic output should represent an avenue to improve patients who are diagnosed late in the course of infection.

关键词： Antiretroviral Therapy HIV Immune Activation Naive CD4+ T-cell Thymic Function

It’s not all in your feet: Improving penalty kick performance with humanavatar interaction and machine learning

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The Innovation 2024年第2期5卷 115-121页

作者： jean-Luc Bloechle Julien Audiffren Thibaut Le Naour Andrea Alli Dylan Simoni Gabriel Wüthrich jean-pierre Bresciani Control and Perception Laboratory University of FribourgBd Perolles 901700 FribourgSwitzerland Motion-up Le PrismePlace Albert Einstein56000 VannesFrance FC Basel 1893 Birsstrasse 320A4002 BaselSwitzerland

Penalty kicks are increasingly decisive in major international football ***,over 30%of shootout kicks are *** outcome of the kick often relies on the ability of the penalty taker to exploit anticipatory movements of the goalkeeper to redirect the kick toward the open side of the ***,this ability is difficult to train using classical *** used an augmented reality simulator displaying an holographic goalkeeper to test and train penalty kick performance with 13 young elite *** learning algorithms were used to optimize the learning rate by maintaining an optimal level of training *** training sessions of 20 kicks reduced the redirection threshold by 120 ms,which constituted a 28%reduction with respect to the baseline ***,redirection threshold reduction was observed for all trained players,and all things being equal,it corresponded to an estimated 35%improvement of the success rate.

关键词： kick penalty learning

Combination of Tripterygium Wilfordii Hook F With Antiretroviral Therapy Delayed Viral Rebound in A Patient of Acute HIV-1 Infection

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Infectious Diseases & Immunity 2021年第2期1卷 108-114页

作者： Wei Cao Yizhi Cui Huiling Weng Yongsong Yue Zhibiao Mai Yang Han Zhifeng Qiu Xiaojing Song Jing Xie Wei Lyu Gong Zhang Jianhua Wang jean-pierre routy Tong Wang Taisheng Li Department of Infectious Diseases Peking Union Medical College HospitalChinese Academy of Medical SciencesBeijing 100730China Institute of Life and Health Engineering Jinan UniversityGuangzhou 510632China Guangzhou Institutes of Biomedicine and Health Chinese Academy of SciencesGuangzhou 510530China Research Institute McGill University Health CentreMontrealQuebecCanada Chronic Viral Illness Service McGill University Health CentreMontrealQuebecCanada Department of Basic Medical Sciences School of MedicineTsinghua UniversityBeijing 100084China Tsinghua-Peking Center for Life Sciences Beijing 100084China

Prolonged antiretroviral therapy(ART)-free remission post-treatment has been observed and reported in human immunodeficiency virus-1(HIV-1)*** primary factors for such achievement have been linked to the transcriptional inactivation of HIV-1 DNA and immune ***,we reported a patient with acute HIV-1 infection who immediately received intensified quadruple *** month 9(M9),an old CFDA-approved immuno-suppressive herbal medicine,Tripterygium Wilfordii Hook F(TwHF),was used in addition to *** patient was closely *** and immunological tests as well as transcriptome analysis were carried out at each *** results showed that TwHF reduced serum IP-10 level and inhibited T cell *** ART and TwHF were discontinued in M24,and levels of peripheral blood HIV-1 RNA and DNA remained suppressed for consecutive *** transcriptome analysis,we found pattern changes linking immuno-activation and amino acid metabolism with viral suppression and *** indicates that the intentional suppression of immuno-activation is a promising approach for a functional cure of HIV-1 infection.

关键词： Transcriptome Immune activation Immune regulation Primary HIV-1 infection Remission Tripterygium Wilfordii Hook F