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Platelet-Activating Factor Induces Du-al-Specificity Phosphatase 1 and 5 Gene Expression

Pharmacology & Pharmacy 2015年第9期6卷 442-450页

作者： Fanny Lapointe Michael Stiffel jean-philippe auger Marek Rola-Pleszczynski Jana Stankova Division of Immunology and Allergy Department of Pediatrics Faculty of Medicine and Health Sciences Université de Sherbrooke Sherbrooke Canada

Platelet-activating factor (PAF) is a potent inflammatory phospholipid mediator that is known to play a role in early-phase responses in asthma and other diseases. Through its high affinity receptor, PAFR, PAF is known to activate multiple signalling pathways contributing to its proinflammatory effects. Of these pathways, the mitogen-activated protein kinase (MAPK) cascade is initiated upon PAF stimulation, leading to the activation of the conventional MAPKs ERK1/2, p38 and JNK. Since dual-specificity phosphatases (DUSP) downregulated MAPK activity, we postulated that PAF could also enhance DUSP expression and thus induced an autoregulatory loop. In this report, we studied the effect of PAF on DUSP mRNA expression in human monocytes. Our results demonstrate that PAF induces DUSP1 and DUSP5 gene expression in a time- and concentration-dependent manner, with maximal effects at PAF 100 nM and at 20 - 30 min of stimulation. In contrast, DUSP2 and DUSP6 gene expression was not enhanced by PAF. Moreover, leukotriene D4, another lipid mediator of inflammation, was unable to modulate DUSP expression. PAF-induced DUSP expression was prevented by the PAFR antagonist WEB2170 and by pretreatment with the transcriptional inhibitor Actinomycin D. Moreover, enhanced DUSP5, but not DUSP1 expression was prevented by pretreatment with the ERK inhibitor PD98059 or the PI3K inhibitor Wortmannin. Taken together, our results indicate that PAF selectively enhances DUSP1 and DUSP5 gene expressions through PAFR activation, and suggest that PAF may have an active role in the resolution of inflammation by its ability to upregulate the two DUSPs and thus provide a negative auto-regulatory signalling mechanism.

关键词： Inflammation Asthma PAF Dual-Specificity Phosphatase MAPK PI3K

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Telencephalic stab wound injury induces regenerative angiogenesis and neurogenesis in zebrafish:unveiling the role of vascular endothelial growth factor signaling and microglia

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Neural Regeneration Research 2025年第10期20卷 2938-2954页

作者： Danielle Fernezelian philippe Rondeau Laura Gence Nicolas Diotel Universitéde La Réunion INSERMUMR 1188Diabète athérothrombose Thérapies Réunion Océan Indien(DéTROI)Saint PierreLa RéunionFrance

After brain damage,regenerative angiogenesis and neurogenesis have been shown to occur simultaneously in mammals,suggesting a close link between these ***,the mechanisms by which these processes interact are not well *** this work,we aimed to study the correlation between angiogenesis and neurogenesis after a telencephalic stab wound *** this end,we used zebrafish as a relevant model of neuroplasticity and brain repair ***,using the Tg(fli1:EGFP×mpeg1.1:mCherry)zebrafish line,which enables visualization of blood vessels and microglia respectively,we analyzed regenerative angiogenesis from 1 to 21 days *** parallel,we monitored brain cell proliferation in neurogenic niches localized in the ventricular zone by using *** found that after brain damage,the blood vessel area and width as well as expression of the fli1 transgene and vascular endothelial growth factor(vegfaa and vegfbb)were *** the same time,neural stem cell proliferation was also increased,peaking between 3 and 5 days post-lesion in a manner similar to angiogenesis,along with the recruitment of ***,through pharmacological manipulation by injecting an anti-angiogenic drug(Tivozanib)or Vegf at the lesion site,we demonstrated that blocking or activating Vegf signaling modulated both angiogenic and neurogenic processes,as well as microglial ***,we showed that inhibition of microglia by clodronate-containing liposome injection or dexamethasone treatment impairs regenerative neurogenesis,as previously described,as well as injury-induced *** conclusion,we have described regenerative angiogenesis in zebrafish for the first time and have highlighted the role of inflammation in this *** addition,we have shown that both angiogenesis and neurogenesis are involved in brain repair and that microglia and inflammation-dependent mechanisms activated by Vegf signaling are important contributors to

关键词： angiogenesis cerebral damage inflammation neurogenesis stab wound telencephalon vascular endothelial growth factor zebrafish

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Redox and acetylation coordinate ABA-independent osmotic stress response

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Molecular Plant 2022年第4期15卷 583-585页

作者： Christophe Belin jean-philippe Reichheld Laboratoire Génome et Développement des Plantes UniversitéPerpignan Via Domitia66860 PerpignanFrance Laboratoire Génome et Développement des Plantes CNRS66860 PerpignanFrance

Osmotic stress caused by drought or high salt concentrations is a major threat that limits plant development and affect crop *** the context of climate change,understanding the mechanisms by which plants perceive their environment to adapt to their development is a major question.A common feature of plants being exposed to osmotic stress is the accumulation of excessive reactive oxygen species(ROS)(Martinière et al.,2019).ROS can oxidatively damage biological molecules,such as nucleic acids,proteins,and lipids,but also play important signaling *** protect from ROS-induced oxidation,living organisms have developed a large panel of enzymatic and non-enzymatic systems to remove ROS and oxidized molecules.

关键词： functions. enzymatic coordinate

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Hepatocyte nuclear factor 4-alpha involvement in liver and intestinal inflammatory networks

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World Journal of Gastroenterology 2014年第1期20卷 22-30页

作者： jean-philippe Babeu Franois Boudreau Département d’ Anatomie et de Biologie Cellulaire Faculté de Médecine et des Sciences de la SantéUniversité de SherbrookeSherbrooke J1E 4K8QuébecCanada

Hepatocyte nuclear factor 4-alpha (HNF4-α) is a nuclear receptor regulating metabolism, cell junctions, differentiation and proliferation in liver and intestinal epithelial cells. Mutations within the HNF4A gene are associated with human diseases such as maturity-onset diabetes of the young. Recently, HNF4A has also been described as a susceptibility gene for ulcerative colitis in genome-wide association studies. In addition, specific HNF4A genetic variants have been identified in pediatric cohorts of Crohn’s disease. Results obtained from knockout mice supported that HNF4-α can protect the intestinal mucosae against inflammation. However, the exact molecular links behind HNF4-α and inflammatory bowel diseases remains elusive. In this review, we will summarize the current knowledge about the role of HNF4-α and its isoforms in inflammation. Specific nature of HNF4-α P1 and P2 classes of isoforms will be summarized. HNF4-α role as a hepatocyte mediator for cytokines relays during liver inflammation will be integrated based on documented examples of the literature. Conclusions that can be made from these earlier liver studies will serve as a basis to extrapolate correlations and divergences applicable to intestinal inflammation. Finally, potential functional roles for HNF4-α isoforms in protecting the intestinal mucosae from chronic and pathological inflammation will be presented.

关键词： Hepatocyte nuclear factor 4-alpha Inflammatory bowel diseases Colitis-associated cancer Gastrointestinal tract Intestinal epithelium barrier Inflammation

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Recent Advances on Graphene Quantum Dots for Electrochemical Energy Storage Devices

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Energy & Environmental Materials 2022年第1期5卷 201-214页

作者： Noura Zahir Pierre Magri Wen Luo jean Jacques Gaumet philippe Pierrat CNRS L2CM UMR 7053 Universit e de Lorraine LCP-A2MC EA4632 Institut Jean Barriol Universit e de Lorraine State Key Laboratory of Advanced Technology for Materials Synthesis and Processing Wuhan University of Technologywuhan 430070china

Graphene quantum dots(GQDs)which are nanofragments of graphene with an average size between 2 and 50 nm have attracted much attention due to their outstanding properties such as high conductivity,high surface area,and good solubility in various *** combine the quantum confinement and edges effects and the properties of ***,GQDs offers a broad range of applications in various fields(medicine,energy conversion,and energy storage devices).This review will present the recent research based on the introduction of GQDs in batteries,supercapacitors,and microsupercapacitors as electrodes materials or mixed with an active material as an auxiliary ***,discussed on selected examples,summarize the electrochemical performances and finally,challenges and perspectives are recalled for the subsequent optimization strategy of electrode *** review is expected to appeal a broad interest on functional GQDs materials and promote the further development of high-performance energy storage device.

关键词： energy storage graphene quantum dots lithium ion batteries sodium ion batteries supercapacitor

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One-Pot Microwave-Assisted Synthesis of Graphene/Layered Double Hydroxide(LDH) Nanohybrids

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Nano-Micro Letters 2015年第4期7卷 332-340页

作者： Sunil P.Lonkar jean-Marie Raquez philippe Dubois Laboratory of Polymeric and Composite Materials Center of Innovation and Research in Materials and PolymersUniversity of Mons Department of Chemical Engineering The Petroleum Institute

A facile and rapid method to synthesize graphene/layered double hydroxide(LDH)nanohybrids by a microwave technique is *** synthesis procedure involves hydrothermal crystallization of Zn–Al LDH at the same time in situ reduction of graphene oxide(GO)to *** microstructure,composition,and morphology of the resulting graphene/LDH nanohybrids were *** results confirmed the formation of nanohybrids and the reduction of graphene *** growth mechanism of LDH and in situ reduction of GO were *** LDH sheet growth was found to prevent the scrolling of graphene layers in resulting *** electrochemical properties exhibit superior performance for graphene/Zn–Al LDH hybrids over pristine *** present approach may open a strategy in hybridizing graphene with multimetallic nano-oxides and hydroxides using microwave method.

关键词： Graphene LDHs Nanostructures Microwave Composite materials

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On the relevance of analytical film thickness EHD equations for isothermal point contacts: Qualitative or quantitative predictions?

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Friction 2016年第4期4卷 369-379页

作者： jean-David WHEELER philippe VERGNE Nicolas FILLOT David PHILIPPON Univ Lyon INSA Lyon CNRS LaMCoS-UMR5259 Villeurbanne F-69621 France

Thin film and elastohydrodynamic lubrication regimes are rather young domains of tribology and they are still facing unresolved *** they rely upon a full separation of the moving surfaces by a thin (or very thin) fluid film,the knowledge of its thickness is of paramount importance,as for instance to developing lubricated mechanisms with long lasting and efficient *** a consequence,a large collection of formulae for point contacts have been proposed in the last 40 ***,their accuracy and validity have rarely been *** purpose of this paper is to offer an evaluation of the most widespread analytical formulae and to define whether they can be used as qualitative or quantitative *** methodology is based on comparisons with a numerical model for two configurations,circular and elliptical,considering both central and minimum film thicknesses.

关键词： thin film lubrication elastohydrodynamic lubrication (EHL) film thickness prediction EHD analytical equation central film thickness minimum film thickness circular contacts elliptical contacts

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Comment on:“Impact of portable normothermic blood-based machine perfusion on outcomes of liver transplant:the OCS Liver PROTECT randomized clinical trial”

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Hepatobiliary Surgery and Nutrition 2022年第2期11卷 267-269页

作者： Arthur Marichez jean-philippe Adam Department of Hepato-Bilio-Pancreatic Surgery and Liver Transplantation Haut Lévêque HospitalCHU de BordeauxFrance

We read with great interest the paper by Markmann et ***“Impact of portable normothermic blood-based machine perfusion on outcomes of liver transplant:The OCS Liver PROTECT randomized clinical trial”(1).In this multicenter randomized clinical trial,the authors compared posttransplant outcomes for recipients who received donation after brainstem death(DBD)or donation after circulatory death(DCD)livers preserved using ischemic cold storage(ICS)or a portable normothermic machine perfusion(NMP)[Organ Care System(OCS)Liver].The primary endpoint was the incidence of early allograft dysfunction(EAD)as defined by Olthoff et ***(2).The trial was methodologically designed to test both non-inferiority on the primary endpoint,and superiority if non-inferiority was *** study was conducted from 2016 to 2019 at 20 US liver transplant programs.

关键词： Impact portable Liver

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The Challenges of Identifying and Managing Epistemic Inequalities in PHIR(Population Health Intervention Research):An Illustration in the Conception and Implementation of a TPE(Therapeutic Patient Education)Program in Oncology

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Psycho-Oncologie 2023年第3期17卷 181-189页

作者： philippe Terral Charlotte Bruneau jean-Paul Génolini CreSco University of ToulouseToulouse31000France

Aims:The joint dynamics of knowledge(of patients,health professionals,decision-makers,researchers)and of the powers(of speech and action,asymmetries,and hierarchies established between individuals and their knowledge)of the people who carry them at the heart of the PHIR,are analyzed from the perspective of the management of epistemic *** study the nature of knowledge sharing or non-sharing between these different categories of agents involved in health ***:The qualitative methodology is based on 36 interviews and six years of ethnographic observations of the TPE program(design or implementation),as well as steering committees and workshops of the PHIR where researchers,decisionmakers,health professionals,and patients share their experiences and ***:The research highlights three major theoretical and methodological issues of PHIR concerning epistemic *** argue for broadening the spectrum of health expertise(researchers,decision-makers,health professionals,patients)and for their *** account for the nature and evolution of collaborations,it is necessary to closely study the dynamics of the avenues of coordination between these fields of ***,we call to identify the resources(knowledge,values,material elements,etc.)and strengths that enable these hybrid groups to bind(or not)and to potentially generate ***:Considering these three major issues allows PHIR to reflect and take action to reduce inequalities by linking epistemic and social issues.

关键词： Epistemic inequalities intervention research theoretical issues methodological issues

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Video Based Fire Detection Systems on Forest and Wildland Using Convolutional Neural Network

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Journal of Donghua University(English Edition) 2019年第2期36卷 149-157页

作者： HICINTUKA jean philippe ZHOU Wuneng College of Information Science and Technology Donghua University

The devastating effects of wildland fire are an unsolved problem,resulting in human losses and the destruction of natural and economic *** neural network(CNN)is shown to perform very well in the area of object *** network has the ability to perform feature extraction and classification within the same *** this paper,we propose a CNN for identifying fire in videos.A deep domain based method for video fire detection is proposed to extract a powerful feature representation of *** on real video sequences,the proposed approach achieves better classification performance as some of relevant conventional video based fire detection methods and indicates that using CNN to detect fire in videos is *** balance the efficiency and accuracy,the model is fine-tuned considering the nature of the target problem and fire *** results on benchmark fire datasets reveal the effectiveness of the proposed framework and validate its suitability for fire detection in closed-circuit television surveillance systems compared to state-of-the-art methods.

关键词： fire detection wildland fires convolutional neural network(CNN) video sequences video analysis object analysis

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