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Redox and acetylation coordinate ABA-independent osmotic stress response

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Molecular Plant 2022年第4期15卷 583-585页

作者： Christophe Belin jean-philippe Reichheld Laboratoire Génome et Développement des Plantes UniversitéPerpignan Via Domitia66860 PerpignanFrance Laboratoire Génome et Développement des Plantes CNRS66860 PerpignanFrance

Osmotic stress caused by drought or high salt concentrations is a major threat that limits plant development and affect crop *** the context of climate change,understanding the mechanisms by which plants perceive their environment to adapt to their development is a major question.A common feature of plants being exposed to osmotic stress is the accumulation of excessive reactive oxygen species(ROS)(Martinière et al.,2019).ROS can oxidatively damage biological molecules,such as nucleic acids,proteins,and lipids,but also play important signaling *** protect from ROS-induced oxidation,living organisms have developed a large panel of enzymatic and non-enzymatic systems to remove ROS and oxidized molecules.

关键词： functions. enzymatic coordinate

Hepatocyte nuclear factor 4-alpha involvement in liver and intestinal inflammatory networks

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World Journal of Gastroenterology 2014年第1期20卷 22-30页

作者： jean-philippe Babeu Franois Boudreau Département d’ Anatomie et de Biologie Cellulaire Faculté de Médecine et des Sciences de la SantéUniversité de SherbrookeSherbrooke J1E 4K8QuébecCanada

Hepatocyte nuclear factor 4-alpha (HNF4-α) is a nuclear receptor regulating metabolism, cell junctions, differentiation and proliferation in liver and intestinal epithelial cells. Mutations within the HNF4A gene are associated with human diseases such as maturity-onset diabetes of the young. Recently, HNF4A has also been described as a susceptibility gene for ulcerative colitis in genome-wide association studies. In addition, specific HNF4A genetic variants have been identified in pediatric cohorts of Crohn’s disease. Results obtained from knockout mice supported that HNF4-α can protect the intestinal mucosae against inflammation. However, the exact molecular links behind HNF4-α and inflammatory bowel diseases remains elusive. In this review, we will summarize the current knowledge about the role of HNF4-α and its isoforms in inflammation. Specific nature of HNF4-α P1 and P2 classes of isoforms will be summarized. HNF4-α role as a hepatocyte mediator for cytokines relays during liver inflammation will be integrated based on documented examples of the literature. Conclusions that can be made from these earlier liver studies will serve as a basis to extrapolate correlations and divergences applicable to intestinal inflammation. Finally, potential functional roles for HNF4-α isoforms in protecting the intestinal mucosae from chronic and pathological inflammation will be presented.

关键词： Hepatocyte nuclear factor 4-alpha Inflammatory bowel diseases Colitis-associated cancer Gastrointestinal tract Intestinal epithelium barrier Inflammation

Accumulation of Flavonoids in an ntra ntrb Mutant Leads to Tolerance to UV-C

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Molecular Plant 2009年第2期2卷 249-258页

作者： Talaat Bashandy Ludivine Taconnat jean-Pierre Renou Yves Meyer jean-philippe Reichheld Laboratoire Genome et Developpement des Plantes Universite de Perpignan UMR CNRS 5096 52 avenue Paul Alduy 66860 Perpignan France Unite de Recherche en Genomique Vegetale 91057 Evry cedex France

NADPH-dependent thioredoxin reductases （NTRs） are key regulatory enzymes determining the redox state of thioredoxins. There are two genes encoding NTRs （NTRA and NTRB） in the Arabidopsis genome, each encoding a cytosolic and a mitochondrial isoform. A double ntra ntrb mutant has recently been characterized and shows slower plant growth, slightly wrinkled seeds and a remarkable hypersensitivity to buthionine sulfoximine （BSO）, a specific inhibitor of gluta- thione biosynthesis. In this paper, we demonstrate that this mutant also accumulates higher level of flavonoids. Analysis of transcriptome data showed that several genes of the flavonoid pathway are overexpressed in the ntra ntrb mutant. Accumulation of flavonoids is generally considered a hallmark of plant stress. Nevertheless, no elevation of the expression of genes encoding ROS-detoxification enzymes was observed, suggesting that the ntra ntrb plants do not suffer from oxidative disease. Another hypothesis suggests that flavonoids are specifically synthesized in the ntra ntrb mutant in order to rescue the inactivation of NTR. To test this, the ntra ntrb mutant was crossed with transparent testa 4 （tt4） plants with a mutation in the gene encoding the first enzyme in flavonoid biosynthesis. As ntra ntrb plants are more resistant to UV-C treatment than wild-type plants, this higher resistance was abolished in the ntra ntrb tt4 mutant, suggesting that accumulation of flavonoids in the ntra ntrb mutant protects plants against UV-light.

关键词： abiotic/environmental stress oxidative and photo-oxidative stress secondary metabolism - phenylpropanoidsand phenolics gene expression Arabidopsis.

Recent Advances on Graphene Quantum Dots for Electrochemical Energy Storage Devices

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Energy & Environmental Materials 2022年第1期5卷 201-214页

作者： Noura Zahir Pierre Magri Wen Luo jean Jacques Gaumet philippe Pierrat CNRS L2CM UMR 7053 Universit e de Lorraine LCP-A2MC EA4632 Institut Jean Barriol Universit e de Lorraine State Key Laboratory of Advanced Technology for Materials Synthesis and Processing Wuhan University of Technologywuhan 430070china

Graphene quantum dots(GQDs)which are nanofragments of graphene with an average size between 2 and 50 nm have attracted much attention due to their outstanding properties such as high conductivity,high surface area,and good solubility in various *** combine the quantum confinement and edges effects and the properties of ***,GQDs offers a broad range of applications in various fields(medicine,energy conversion,and energy storage devices).This review will present the recent research based on the introduction of GQDs in batteries,supercapacitors,and microsupercapacitors as electrodes materials or mixed with an active material as an auxiliary ***,discussed on selected examples,summarize the electrochemical performances and finally,challenges and perspectives are recalled for the subsequent optimization strategy of electrode *** review is expected to appeal a broad interest on functional GQDs materials and promote the further development of high-performance energy storage device.

关键词： energy storage graphene quantum dots lithium ion batteries sodium ion batteries supercapacitor

On the relevance of analytical film thickness EHD equations for isothermal point contacts: Qualitative or quantitative predictions?

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Friction 2016年第4期4卷 369-379页

作者： jean-David WHEELER philippe VERGNE Nicolas FILLOT David PHILIPPON Univ Lyon INSA Lyon CNRS LaMCoS-UMR5259 Villeurbanne F-69621 France

Thin film and elastohydrodynamic lubrication regimes are rather young domains of tribology and they are still facing unresolved *** they rely upon a full separation of the moving surfaces by a thin (or very thin) fluid film,the knowledge of its thickness is of paramount importance,as for instance to developing lubricated mechanisms with long lasting and efficient *** a consequence,a large collection of formulae for point contacts have been proposed in the last 40 ***,their accuracy and validity have rarely been *** purpose of this paper is to offer an evaluation of the most widespread analytical formulae and to define whether they can be used as qualitative or quantitative *** methodology is based on comparisons with a numerical model for two configurations,circular and elliptical,considering both central and minimum film thicknesses.

关键词： thin film lubrication elastohydrodynamic lubrication (EHL) film thickness prediction EHD analytical equation central film thickness minimum film thickness circular contacts elliptical contacts

One-Pot Microwave-Assisted Synthesis of Graphene/Layered Double Hydroxide(LDH) Nanohybrids

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Nano-Micro Letters 2015年第4期7卷 332-340页

作者： Sunil P.Lonkar jean-Marie Raquez philippe Dubois Laboratory of Polymeric and Composite Materials Center of Innovation and Research in Materials and PolymersUniversity of Mons Department of Chemical Engineering The Petroleum Institute

A facile and rapid method to synthesize graphene/layered double hydroxide(LDH)nanohybrids by a microwave technique is *** synthesis procedure involves hydrothermal crystallization of Zn–Al LDH at the same time in situ reduction of graphene oxide(GO)to *** microstructure,composition,and morphology of the resulting graphene/LDH nanohybrids were *** results confirmed the formation of nanohybrids and the reduction of graphene *** growth mechanism of LDH and in situ reduction of GO were *** LDH sheet growth was found to prevent the scrolling of graphene layers in resulting *** electrochemical properties exhibit superior performance for graphene/Zn–Al LDH hybrids over pristine *** present approach may open a strategy in hybridizing graphene with multimetallic nano-oxides and hydroxides using microwave method.

关键词： Graphene LDHs Nanostructures Microwave Composite materials

In-process failure analysis of thin-wall structures made by laser powder bed fusion additive manufacturing

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Journal of Materials Science & Technology 2022年第3期98卷 233-243页

作者： Apratim Chakraborty Reza Tangestani Rasim Batmaz Waqas Muhammad philippe Plamondon Andrew Wessman lang Yuan Étienne Martin University of Waterloo 200 University Avenue WestWaterlooON N2L 3G1Canada Polytechnique Montréal 2500 Chemin de PolytechniqueMontréalQC H3T 1J4Canada University of Arizona 1235 E.James E.Rogers WayTucsonAZ 85721-0012United States University of South Carolina 301 Main StreetColumbiaSC 29208United States

Fabrication of thin-wall components using the laser powder bed fusion(LPBF)additive manufacturing(AM)technology was investigated for two“hard-to-weld”high gamma prime Ni-based superalloys RENé65(R65)and RENé108(R108).Simple block parts with wall thicknesses of 0.25 mm,1.00 mm,and5.00 mm are printed using a bidirectional laser scanning strategy without layer-wise *** with walls thinner than 5 mm fail before reaching the designated build *** indicate that reduction of limiting build height(LBH)corresponds to the reduction of part thickness and is unaffected by alloy *** the contrary,the number of internal micro-cracks along columnar grain boundaries in the build direction(BD)increases with part thickness and is significantly higher in R108 than *** findings suggest that reduced LBH in parts with thinner walls is not caused by internal micro-crack *** and finite element analysis(FEA)of the in-process thermal stresses show that the LBH trend is not explained by the conventional cracking *** suggest that part thickness affects stress distribution leading to more substantial distortion and consequent failure to add layers for continued fabrication of thinner parts.

关键词： Laser powder bed fusion Superalloys Thin-wall Residual stress Additive manufacturing

Comment on:“Impact of portable normothermic blood-based machine perfusion on outcomes of liver transplant:the OCS Liver PROTECT randomized clinical trial”

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Hepatobiliary Surgery and Nutrition 2022年第2期11卷 267-269页

作者： Arthur Marichez jean-philippe Adam Department of Hepato-Bilio-Pancreatic Surgery and Liver Transplantation Haut Lévêque HospitalCHU de BordeauxFrance

We read with great interest the paper by Markmann et ***“Impact of portable normothermic blood-based machine perfusion on outcomes of liver transplant:The OCS Liver PROTECT randomized clinical trial”(1).In this multicenter randomized clinical trial,the authors compared posttransplant outcomes for recipients who received donation after brainstem death(DBD)or donation after circulatory death(DCD)livers preserved using ischemic cold storage(ICS)or a portable normothermic machine perfusion(NMP)[Organ Care System(OCS)Liver].The primary endpoint was the incidence of early allograft dysfunction(EAD)as defined by Olthoff et ***(2).The trial was methodologically designed to test both non-inferiority on the primary endpoint,and superiority if non-inferiority was *** study was conducted from 2016 to 2019 at 20 US liver transplant programs.

关键词： Impact portable Liver

Video Based Fire Detection Systems on Forest and Wildland Using Convolutional Neural Network

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Journal of Donghua University(English Edition) 2019年第2期36卷 149-157页

作者： HICINTUKA jean philippe ZHOU Wuneng College of Information Science and Technology Donghua University

The devastating effects of wildland fire are an unsolved problem,resulting in human losses and the destruction of natural and economic *** neural network(CNN)is shown to perform very well in the area of object *** network has the ability to perform feature extraction and classification within the same *** this paper,we propose a CNN for identifying fire in videos.A deep domain based method for video fire detection is proposed to extract a powerful feature representation of *** on real video sequences,the proposed approach achieves better classification performance as some of relevant conventional video based fire detection methods and indicates that using CNN to detect fire in videos is *** balance the efficiency and accuracy,the model is fine-tuned considering the nature of the target problem and fire *** results on benchmark fire datasets reveal the effectiveness of the proposed framework and validate its suitability for fire detection in closed-circuit television surveillance systems compared to state-of-the-art methods.

关键词： fire detection wildland fires convolutional neural network(CNN) video sequences video analysis object analysis