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Biology-Physics the Missing Link?

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Journal of Modern Physics 2014年第6期5卷 359-363页

作者： jean-paul Auffray Ex Courant Institute of Mathematical Sciences New York UniversityNew YorkUSA Ex American Institute of Physics New YorkUSA

Writing in 1943, renowned Austrian physicist Edwin Schrodinger asked “What is Life?” thereby invigorating the debate which preoccupied biologists at the time. He proposed an answer to this question rooted in considerations borrowed from Thermodynamics and Statistical Mechanics. To reveal the missing link in Biology-Physics, the present Note investigates an alternate answer in which dynamical action, rather than thermodynamics and energy, plays the fundamental role. It reviews in particular the process of biological cell replication which may be considered to define “Life” and might be the macroscopic manifestation of an underlying quantum physical process in which xons, conveyors of dynamical action, are the determining agents.

关键词： Schrodinger Dynamical Action Planck Quantum Physics Biological Cells Molecules Electrons Strings Branes Xons

Developmental pathways associated with cancer metastasis:Notch,Wnt,and Hedgehog

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Cancer Biology & Medicine 2017年第2期14卷 109-120页

作者： Armel Herve Nwabo Kamdje paul Takam Kamga Richard Tagne Simo Lorella Vecchio paul Faustin Seke Etet jean Marc Muller Giulio Bassi Erique Lukong Raghuveera Kumar Goel Jeremie Mbo Amvene Mauro Krampera Department of Biomedical Sciences University of Ngaoundere Laboratory University of Verona Department of Basic Health SciencesCollege of Applied Medical SciencesQassim University Faculty of Science University of Poitiers Department of Biochemistry College of MedicineUniversity of Saskatchewan

Master developmental pathways, such as Notch, Wnt, and Hedgehog, are signaling systems that control proliferation, cell death,motility, migration, and stemness. These systems are not only commonly activated in many solid tumors, where they drive or contribute to cancer initiation, but also in primary and metastatic tumor development. The reactivation of developmental pathways in cancer stroma favors the development of cancer stem cells and allows their maintenance, indicating these signaling pathways as particularly attractive targets for efficient anticancer therapies, especially in advanced primary tumors and metastatic cancers. Metastasis is the worst feature of cancer development. This feature results from a cascade of events emerging from the hijacking of epithelial-mesenchymal transition, angiogenesis, migration, and invasion by transforming cells and is associated with poor survival, drug resistance, and tumor relapse. In the present review, we summarize and discuss experimental data suggesting pivotal roles for developmental pathways in cancer development and metastasis, considering the therapeutic potential. Emerging targeted antimetastatic therapies based on Notch, Wnt, and Hedgehog pathways are also discussed.

关键词： Cancer metastasis developmental pathways Notch Wnt Hedgehog therapeutic targets

Geochemistry and zircon U–Pb ages of the Paleoproterozoic ultramafic rocks of the Mbi Valley, Boali area, Central African Republic

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Acta Geochimica 2022年第3期41卷 515-535页

作者： Evine Laure Njiosseu Tanko Prince Emilien Danguene Philomene Nga Essomba Tsoungui Sylvestre Ganno Jonas Didero Takodjou Wambo Bertin Guy Takam Tchoupe Gus Djibril Kouankap Nono Timoleon Ngnotue Boniface Kankeu jean Biandja jean paul Nzenti Department of Earth Sciences University of DschangP.O.Box 67DschangCameroon Department of Earth Sciences University of BanguiP.O.Box 908BanguiCentral African Republic Department of Mining Engineering and Mineral Processing School of Mines and Petroleum IndustriesUniversity of MarouaP.O.Box 08Kaélé-MarouaCameroon Department of Earth Sciences University of YaoundéIP.O.Box 812YaoundéCameroon Department of Geology HTTCUniversity of BamendaP.O.Box 39BambiliBamendaCameroon Institute for Geological and Mining Researches(IGMR) P.O.Box 4110YaoundéCameroon

This paper investigates the geochemistry of bulk rock and infers the petrogenesis of ultramafic rocks in the Boali Precambrian terrane in Mbi Valley,in the North of the Central African Republic(CAR).The studied rocks comprise coarse primary olivine and orthopyroxene relics(dominant phase),magnesio-hornblende,magnetite,and ***-rock analysis indicates low SiO_(2)(average of 43.14 wt%)and high MgO(19.84–26.98 wt%)contents and their Mg number(Mg#)ranges from 74 to ***(526–865 ppm),Cr(1500–3680 ppm)***(Na_(2)O-K_(2)O)-FeO-MgO)and ACM(Al_(2)O_(3)-CaO-MgO)ternary diagrams have revealed that the studied samples correspond to arc-related ultramafic ***-normalized REE plots display an increasing trend from La to Sm(CeN/SmN:0.74–1.81),weak negative to no Eu(Eu/Eu*=0.72–1.05)and strong negative Ce(Ce/Ce*=0.33–0.98)*** mantle normalized of multi-element diagrams exhibit LREE enrichment and large ion lithophile elements(LILE)relative to high field strength elements(HFSE),and notable negative anomalies in *** suggests the generation of the parent melt by slab dehydration and wedge melting *** addition,incompatible trace element composition and ratios assumed that the source magma had an enhanced mantle source associated with a prominent influence of continental *** of mantle wedge by plate-dehydrated,LILE-rich fluids and the incorporation of sediments derived from subduction explain the enhancement of the *** major and trace element compositions jointly with the tectonic reconstruction of this region and LA-ICP-MS U–Pb data on zircon constrain the emplacement age at ca.2099 Ma in a continental margin arc setting involving subduction of an oceanic plate beneath the continental lithosphere,dehydration of the slab and mantle wedge *** result intimate that the remnants of Paleoproterozoic oceanic crust or subduction event and subsequent basins closure extended from

关键词： Atlantic supercontinent Central African Republic Ultramafic cumulate LILE-enriched fluids Arc setting

Discours prononcéàl′occasion du 5e anniversaire de la coopé-ration et de la communication culturelles entre la France et l′Universitéde wuhan

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法国研究 1985年第4期 7-8页

作者： jean-paul Réau

Monsieur le président,Messieur les Directeurs,Mesdames,Messieurs,Chers Amis,L′Ambassadeur de France ayant étéappelé pour consultation par *** DUMAS,Ministre des Relations Extérieures,l′honneur m′échoitde le r... 详细信息

关键词：外物

转换酶抑制剂培哚普利拉非激肽酶依赖性地加强由激肽引起的内皮依赖性血管松弛(英文)

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Acta Pharmacologica Sinica 2002年第3期23卷 15-19页

作者： jean Vivien MOMBOULI,Kevin D BALLARD,paul M VANHOUTTE University of Marien Ngouabi Brazzaville Republic of Congo Center for Experimental Therapeutics Baylor College of Medicine Houston Texas USA Institut de Recherches Internationales Servier 92415 Courbevoie Cedex France

The present study examined whether or not the resistance to degradation of bradykinin analogs affects the kinin-potentiating action of the inhibitor of converting enzyme, perindoprilat. METHODS: Hydrolysis of [Hyp3,Tyr(Me)8]-bradykinin by ACE present in isolated canine coronary arteries was assessed by determination of peptide metabolites using electrospray mass spectrometry, and compared to that of bradykinin. Contractions and relaxations of isolated rings of coronary arteries, with and without endothelium, were recorded as changes in isometric force. RESULTS: After a 30 min incubation, most of the bradykinin was degraded by the arteries, while less than 10 % of [Hyp3 Tyr(Me)8]-bradykinin was hydrolysed. In organ chambers, [Hyp3, Tyr(Me)8]-bradykinin like bradykinin caused relaxations of isolated canine coronary arteries with endothelium that could be attributed to both NO and endothelium-derived hyperpolarizing factor (EDHF). Perindoprilat caused a comparable leftward shift in the concentration-relaxa

关键词：缓激肽受体一氧化氮内皮血管紧张素转换酶抑制药肽基-二肽酶A

Oculoplastic publication trends in general ophthalmology journals

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International Journal of Ophthalmology(English edition) 2022年第11期15卷 1852-1856页

作者： jean-paul Dray Nur Khatib Eric Souied Peerooz Saeed Guy Ben Simon Juliana Gildener-Leapman Ofira Zloto Department of Ophthalmology Centre Hospitalier Intercommunal de CreteilCreteil 94000France Orbital Center Department of OphthalmologyAmsterdam University Medical CentersAmsterdam 1105the Netherlands Goldschleger Eye Institute Sheba Medical CenterAffiliated to the Sackler Faculty of MedicineTel Aviv UniversityTel Aviv6997801Israel Meir Medical Center Kfar Saba 4428164Israel

AIM: To examine the publication trend of oculoplastic articles throughout the last decade in general ophthalmology ***: A review of all abstracts published between Januar y 2010 to December 2019 in general, clinical ophthalmic journals was conducted. Articles that were categorized as original articles in general and clinical journals were included in the ***: Totally 10 281 abstracts were included. Of them 465(4.5%) were oculoplastic publications. The mean number of annual-publications was 46.5 and the mean annual-rate of oculoplastic publications was 4.51%. A significant decreasing trend in the number of oculoplastic publication in the last decade was found(P<0.01, R^(2)=0.770). However, there was no significant change in the annual-rate of oculoplastic publications during the last decade(P=0.191, R2=0.203). From the 465 oculoplastic articles: 179(38.5%) were articles about eyelid diseases, 160(34.40%) were about orbit diseases, 92(19.80%) were about lacrimal diseases and 34(7.30%) were about thyroid eye disease(TED). A significant decreasing trends in the number of orbital and eyelids publications were found(P<0.01, P<0.01). However, there were no significant changes in the annual-rate of orbital, eyelids, TED and lacrimal-diseases publications throughout the last ***: Oculoplastic subspecialty deals with a wide range of pathologies in different ages. However, less than 5% of the articles in general, clinical, high impact factor ophthalmology journals are about oculoplastic diseases. One of the best way for ophthalmologists from different subspecilties, nowadays, to be updated, is to read highimpact-factor, general ophthalmology journals. Therefore, it is important that those journals will include articles about breakthroughs in oculoplastic.

关键词： oculoplastic publications journals general articles ophthalmology

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消泡剂对超滤膜的影响

食品与发酵工业 2007年第5期33卷 51-53页

作者： jean-paul Lecomte 道康宁公司上海200001

膜污垢已成为作为分离和净化系统的超滤膜的主要缺陷。有关膜污垢的原因和理论，以及系统优化、污垢对膜寿命的影响。等研究已广泛开展。特别是人们发现，消泡剂可导致显著的膜污垢。本论文旨在讨论消泡剂膜污垢问题，研究膜污垢产生的... 详细信息

膜污垢已成为作为分离和净化系统的超滤膜的主要缺陷。有关膜污垢的原因和理论，以及系统优化、污垢对膜寿命的影响。等研究已广泛开展。特别是人们发现，消泡剂可导致显著的膜污垢。本论文旨在讨论消泡剂膜污垢问题，研究膜污垢产生的主要原因，并介绍了用于超滤顺流工艺的无污垢消泡剂的开发。

关键词：超滤膜消泡剂净化系统污垢膜寿命原因分离

Morphology Change of Electrodeposited Calcium Phosphate Coating on Ti6Al4V Substrate Under High Magnetic Field

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Journal of Iron and Steel Research International 2012年第S2期19卷 1162-1165页

作者： DALTIN Anne-Lise BAUDART Patrick DEBRAY Francois CHOPART jean-paul LISM URCAB.P.103951687 Reims Cedex 2France LNCMI-CNRS-UJF-UPS-INSA B.P.16638042 Grenoble Cedex 9France

The present study reports on the growth of calcium phosphate coatings on Ti6Al4V substrate by electrodeposition under high magnetic *** electrodeposition is conducted by potentiostatic method on horizontal electrode whose roughness was modified to reach a value of 3μ*** coatings are obtained from an electrolyte containing calcium nitrate as the Ca^(2+) source and ammonium phosphate as the P source with a Ca/P ratio equal to *** LNCMI high field continuous magnet in a 170 mm bore with homogeneity of 600.10~6 in I cm^3 has been *** magnetic field with a magnitude up to 12 T is applied perpendicularly to the electrode *** surface morphology and chemical composition of the obtained coatings were characterized by 3D digital microscope and scanning electron microscopy associated with X-ray microanalysis(SEM-EDX).The phase composition was analyzed by X-Ray *** presence of several crystalline phases comprising octacalcium phosphate and hydroxyapatite is obtained and magnetic field seems to change the relative importance of these *** coating morphology changes from belt shape crystallites to needle shape crystallites with high magnetic field superimposition without important modification of Ca/P ratio in the *** the other hand formation of volcano-like structures due to the presence of hydrogen bubbles during deposition is considerably reduced in the presence of magnetic field.

关键词： biomaterials calcium phosphates electrodeposition magnetic field magnetoelectrolysis MHD effect

Iron in the NEEM ice core relative to Asian loess records over the last glacial–interglacial cycle

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National Science Review 2021年第7期8卷 110-123页

作者： Cunde Xiao Zhiheng Du Mike J Handley paul A Mayewski Junji Cao Simon Schupbach Tong Zhang jean-Robert Petit Chuanjin Li Yeongcheol Han Yuefang Li Jiawen Ren State Key Laboratory of Earth Surface Processes and Resource Ecology Beijing Normal University State Key Laboratory of Cryospheric Science Northwest Institute of Eco-Environment and Resources Chinese Academy of Sciences Climate Change Institute School of Earth and Climate Sciences University of Maine Key Laboratory of Aerosol Science and Technology SKLLQG Institute of Earth Environment Chinese Academy of Sciences Climate and Environmental Physics Physics Institute University of Bern 6. Institute of Tibetan Plateau and Polar Meteorology Chinese Academy of Meteorological Sciences 7. Institut des Geosciences de I'Environment (IGE) University Grenoble Alpes 8. Korea Polar Research Institute

Mineral dust can indirectly affect the climate by supplying bioavailable iron(Fe) to the ocean. Here, we present the records of dissolved Fe(DFe) and total Fe(TDFe) in North Greenland Eemian Ice Drilling(NEEM) ice core over the past 110 kyr BP. The Fe records are significantly negatively correlated with the carbon-dioxide(CO2) concentrations during cold periods. The results suggest that the changes in Fe fluxes over the past 110 kyr BP in the NEEM ice core are consistent with those in Chinese loess records because the mineral-dust distribution is controlled by the East Asian deserts. Furthermore, the variations in the dust input on a global scale are most likely driven by changes in solar radiation during the last glacial–interglacial cycle in response to Earth’s orbital cycles. In the last glacial–interglacial cycle, the DFe/TDFe ratios were higher during the warm periods(following the post-Industrial Revolution and during the Holocene and last interglacial period) than during the main cold period(i.e. the last glacial maximum(LGM)), indicating that the aeolian input of iron and the iron fertilization effect on the oceans have a non-linear relationship during different periods. Although the burning of biomass aerosols has released large amounts of DFe since the Industrial Revolution, no significant responses are observed in the DFe and TDFe variations during this period, indicating that severe anthropogenic contamination has no significant effect on the DFe(TDFe)release in the NEEM ice core.

关键词： Greenland NEEM ice core iron fertilization carbon dioxide Chinese loess glacial–interglacial cycle