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Subclinical proximal tubulopathy in hepatitis B:The roles of nucleot(s)ide analogue treatment and the hepatitis B virus

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World Journal of Hepatology 2020年第12期12卷 1326-1340页

作者： Anais Brayette Marie Essig paul Carrier Marilyne Debette-Gratien Anais Labrunie Sophie Alain Marianne Maynard Nathalie Ganne-Carrie Eric Nguyen-Khac pauline Pinet Victor De Ledinghen Christophe Renou Philippe Mathurin Claire Vanlemmens Vincent Di Martino Anne Gervais Juliette Foucher Fouchard-Hubert Isabelle Julien Vergniol Isabelle Hourmand-Ollivier Daniel Cohen Xavier Duval Thierry Poynard Marc Bardou Armand Abergel Manh-Thong Dao Thierry Thevenot jean-Baptiste Hiriart Valerie Canva Guillaume Lassailly Christine Aurières Nathalie Boyer Dominique Thabut Pierre-Henri Bernard Matthieu Schnee Dominique Larrey Bertrand Hanslik Severine Hommel Jeremie Jacques Veronique Loustaud-Ratti U1248 INSERM Department of Hepatology and GastroenterologyUniv.LimogesCHU LimogesLimoges F-87000France U1248 INSERM Department of Nephrology and TransplantationCHU LimogesLimoges F-87000France Department of Center of Epidemiology Biostatistics and Research MethodologyCHU LimogesLimoges F-87000France U1092 INSERM Department of VirologyCHU LimogesLimoges F-87000France Department of Hepatology Croix-Rousse University Hospital of LyonLyon 69004France Department of Hepatology Jean Verdier University Hospital of BondyBondy 93140France Department of Hepato-Gastroenterology Amiens University HospitalAmiens 80054France Department of Infectious Diseases CHU LimogesLimoges F-87000France Department of Hepatology Haut Leveque HospitalBordeaux University HospitalPessac 33604France Department of Gastroenterology Hyeres HospitalHyeres 83407France Department of Hepato-Gastroenterology Claude Huriez University HospitalLille 59037France Department of Hepatology Jean Minjoz University HospitalBesançon 25030France Department of Infectious Diseases Bichat University HospitalParis 75018France Department of Hepatology University Hospital of AngersAngers 49933France Department of Hepato-Gastroenterology and Nutrition University Hospital of CaenCaen 14033France Department of General Medecine University Hospital of CaenCaen 14000France Department of Hepatology La Pitié-Salpêtrière University HospitalParis 75651France Department of Hepatology and Gastroenterology Dijon University HospitalDijon 21079France Department of Hepatology and Gastroenterology Estaing University HospitalClermont Ferrand 63003France Department of Hepatology Beaujon University HospitalClichy 92110France Department of Hepatology Saint-AndréUniversity HospitalBordeaux 33000France Department of Hepatology and Gastroenterology La Roche-Sur-Yon Hospital CenterLa Roche-Sur-Yon 85000France Department of Hepatology and Gastroenterology University Hospital of MontpellierMontpellier 34295France Department of Addictology Hospita

BACKGROUND The recommended monitoring tools for evaluating nucleot(s)ide analogue renal toxicity,such as estimated glomerular filtration rate(eGFR)and phosphatemia,are late markers of proximal *** early markers are available,but no consensus exists on their *** To determine the 24 mo prevalence of subclinical proximal tubulopathy(SPT),as defined with early biomarkers,in treated vs untreated hepatitis B virus(HBV)-monoinfected *** A prospective,non-randomized,multicenter study of HBV-monoinfected patients with a low number of renal comorbidities was *** patients were separated into three groups:Naïve,starting entecavir(ETV)treatment,or starting tenofovir disoproxil(TDF)*** on the early markers of SPT,the eGFR and phosphatemia,were collected *** was defined as a maximal tubular reabsorption of phosphate/eGFR below 0.8 mmoL/L and/or uric acid fractional excretion above 10%.The prevalence and cumulative incidence of SPT at month 24(M24)were *** data were analyzed using analyses of variance or Kruskal-Wallis tests,whereas chi-squared or Fisher’s exact tests were used to analyze qualitative *** analyses were used to adjust for any potential confounding *** Of the 196 patients analyzed,138(84 naïve,28 starting ETV,and 26 starting TDF)had no SPT at *** M24,the prevalence of SPT was not statistically different between naïve and either treated group(21.1%vs 30.7%,P<0.42 and 50.0%vs 30.7%,P=0.32 for ETV and TDF,respectively);no patient had an eGFR lower than 50 mL/min/1.73 m²or phosphatemia less than 0.48 mmoL/*** the multivariate analysis,no explanatory variables were identified after *** cumulative incidence of SPT over 24 mo(25.5%,13.3%,and 52.9%in the naïve,ETV,and TDF groups,respectively)tended to be higher in the TDF group vs the naïve group(hazard ratio:2.283,P=0.05).SPT-free survival at M24 was 57.6%,68.8%,and 23.5%for the naïve,ETV,and TD

关键词： Hepatitis B virus Proximal tubulopathy Biomarkers Renal insufficiency Nucleoside analogues

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Outcome and prognostic factors in 110 consecutive patients with primary uterine leiomyosarcoma:A Rare Cancer Network study

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Chinese Journal of Cancer Research 2017年第6期29卷 521-532页

作者： Alessandra Franzetti Pellanda Berardino De Bari Elisabeth Deniaud-Alexandre MarcoKrengli paul Van Houtte Antonella Riehetti Salvador Villa Hadassah Goldberg EwaSzutowiez-Zielifiska Michel Bolla Heidi Rutten Marc Van Eijkeren Philip Poortmans Guido Henke Yavuz Anaeak Steve Chan Christine Landmann Carine Kirkove LueianoScandolaro Jacques Bernier Rene-Olivier Mirimanof Mahmut Ozsahin Centre Hospitalier Universitaire Vaudois(CHUV) 1011 LausanneSwitzerland Clinica Luganese Moncucco 6903 LuganoSwitzerland Centre Hospitalier R6gional Universitaire"jean Minjoz" INSERMUMR109825030 BesangonFrance Hopital Tenon 75970 ParisFrance Centre Hospitalier Departemental 85925 VendeeFrance degli Studi del Piemonte Orientale e Ospedale Maggiore della Carifi 28100 NovaraItaly University Institut Jules Bordet 1000 BrusselsBelgium 8Ospedale di Circolo 21100 VareseItaly Ospedale di Circolo 21100 VareseItalyt Istituto Oncologico della Svizzera Italiana EOC6500 BellinzonaSwitzerland Catalan Institute of Oncology Universitat Autbnoma de Barcelona08916 Barcelona 08916Spain Rambam Medical Center 31096 HaifaIsrael Medical University 80210 GdanskPoland Hopital Michallon BP21738043Grenoble cedex 09France Radboud University Medical Center 6525 NijmegenThe Netherlands Ghent University Hospital 9000 GentBelgium Institute Verbeeten 90120 TilburgThe Netherlands Kantonsspital St.Gallen 9007St.GallenSwitzerland Karadeniz Technical University 61080 TrabzonTurkey Nottingham University Hospital NHS trustNG5 1PB NottinghamUnited Kingdom Kantonsspital Basel 4031 BaselSwitzerland UCL St.Luc 1200 BrusselsBelgium presidio Ospedaliero Sant'Anna 22100 ComoItaly Ospedale San Giovanni 6500 BellinzonaSwitzerland Clinique de Genolier Genolier1272 Switzerland Department of Radiation Oncology Centre Hospitalier Universitaire Vaudois(CHUV)University of LausanneSwitzerland

Objective： Primary uterine leiomyosarcomas （ULMS） are rare, and the optimal treatment is controversial. We aimed to assess the outcome and prognostic factors in a multicenter population of women treated for primary ULMS. Methods： We retrospectively collected data of 110 women treated in 19 institutions of the Rare Cancer Network （RCN）. Inclusion criteria consisted of a pathology report confirming the diagnosis of ULMS, aged 18-80 years, complete International Federation of Gynecology and Obstetrics （FIGO） stage information, complete information on treatment, and a minimum follow-up of 6 months. Local control （LC） and locoregional control （LRC）, overall survival （OS） and disease-free survival （DFS） rates were computed using the Kaplan-Meier method. Univariate analysis was implemented using the log rank test, and multivariate analysis using the Cox model. Results： All patients underwent surgery. Seventy-five patients （68%） received adjuvant radiotherapy （RT）, including brachytherapy in 18 （I 6%）. Seventeen patients （15 %） received adjuvant chemotherapy. Median follow-up was 58 （range, 6-240） months. Five-year OS and DFS rates were 50% and 34%, and LC and LRC rates were 88% and 72%, respectively. On multivariate analysis, independent favorable prognostic factors were younger age, FIGO stage I, small tumor size, previous uterine disease, and no vascular invasion for OS and DFS. FIGO stage was the only favorable factor influencing LRC. Adjuvant local or systemic treatments did not improve the outcomes. Eight patients treated with RT presented a grade 3 acute toxicity, and only one patient with grade 3 late toxicity. Conclusions： In this large population of primary ULMS patients, we found good results in terms of LC and LRC. Nevertheless, OS remains poor, mainly due to the occurrence of distant metastases. An early diagnosis seemed to improve the prognosis of the patients. Adjuvant local or systemic treatments, or more aggressive surgical procedures such as the Wertheim p

关键词： Uterine leiomyosarcoma prognostic factors radiotherapy overall survival local control

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弯曲荷载下混杂合成/金属螺栓连接的分析

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钢结构(中英文) 2008年第4期 92-92页

作者： Vincent Caccese jean-paul Kabche Keith A.Berube

采用试验研究和有限元分析方法,研究了混杂聚合物/金属螺栓连接的结构响应。主要研究目的是采用模数混合建筑方法为传统的船体建造技术提供比较方案。主要目标是实现防水混合连接的构思,为船体上使用的可移动板提供连接方法。改进的混... 详细信息

采用试验研究和有限元分析方法,研究了混杂聚合物/金属螺栓连接的结构响应。主要研究目的是采用模数混合建筑方法为传统的船体建造技术提供比较方案。主要目标是实现防水混合连接的构思,为船体上使用的可移动板提供连接方法。改进的混合节点用于连接玻璃纤维增强复合材料板与金属底部基础。对各种几何尺寸及弯曲荷载的混合节点的性能进行了定量试验研究。试验结果显示,承受弯曲荷载时,带有金属盖板的节点比标准的螺栓节点具有更高的强度和转动刚度,同时也减小了节点的缝隙,因此提高了连接的整体防水能力。介绍了连接的局部壳单元和详细的实体单元有限元分析。简化的壳单元有限元模型被拓展到结构的整体模型中,并观察到了连接刚度与试验结果良好的相关性。采用详细的平面应变接触模型获取三维效果来预测连接的非线性响应。用本研究的结果选择连接的几何尺寸,并进行一个足尺四块板装配的静水压力试验。

关键词：混合连接循环试验非线性有限元分析接触分析

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人工双胞胎犊牛和冷冻胚胎

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世界农业 1983年第3期 49-49页

作者： jean-paul Renard ,Yvan Heyman ,许志成

法国第一批由一个受精卵分割为二个胚胎培育成的犊牛出生了。这个惊人的成果是J.P.奥吉勒(jean-Pierre Ozil)在国家农业研究院茹昂若亚动物生理中心站(Station Centrale de Physiologie Animale, Jouy-en-Josas, INRA)取得的,并在1981... 详细信息

法国第一批由一个受精卵分割为二个胚胎培育成的犊牛出生了。这个惊人的成果是J.P.奥吉勒(jean-Pierre Ozil)在国家农业研究院茹昂若亚动物生理中心站(Station Centrale de Physiologie Animale, Jouy-en-Josas, INRA)取得的,并在1981年12月于英国剑桥召开的不育性和能育性大会上作了介绍。此外,至今世界上仅英国维莱森

关键词：冷冻胚胎中心站动物生理昂若胚胎移植技术透明带犊牛双胞胎

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Conversion of Unresectable to Resectable Liver Metastases from Colorectal Carcinoma Using Hepatic Arterial Chronomodulated Chemotherapy: A Case Report and Short Literature Review

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Surgical Science 2018年第10期9卷 358-366页

作者： Evgeny Y. Parnes Maria S. Sayapina Alexey A. Tryakin Mohamed Bouchahda Pasquale F. Innominato jean-Francois Morere Francis A. Levi Rene Adam The Central Clinical Hospital of Civil Aviation Moscow Russia N.N. Blokhin Russian Oncology Research Center Moscow Russia Department of Medical Oncology Assistance Publique H&ocirc pitaux de Paris H&ocirc pital paul Brousse Villejuif France INSERM UMRS 776 “Biological Rhythms and Cancers” Campus CNRS Villejuif France Cancer Chronotherapy Team Warwick Medical School Coventry United Kingdom Hepato-Biliary Center Assistance Publique H&ocirc pitaux de Paris H&ocirc pital paul Brousse Villejuif France

Background: The regional chronomodulated hepatic arterial infusion chemotherapy (HAIC) is an effective regimen for the treatment of patients with unresectable liver metastases from colorectal cancer, especially for the conversion into resectability. Aim: To demonstrate that chronomodulated HAI triplet chemotherapy according to OPTILIV protocol is well tolerated and displayed high antitumor activity in this heavily-pretreated patient. Case Presentation: A 54 years old patient from Russia was treated for a tumor in the ascending colon presented with 13 hepatic metastases ranging from 0.3 to 2.7 cm in diameter. He underwent a laparoscopic right hemicolectomy, 12 cycles of FOLFIRINOX combined to bevacizumab for the last 5 cycles, resulting in a partial response according to CT scan. It was decided to perform a two-stage hepatectomy at paul Brousse hospital: left partial hepatectomy allowed the excision of 9 lesions. Radio frequency ablation was performed in 2 nodular lesions. Afterwards, the patient received 5 cycles of chronomodulated triplet chemotherapy into the hepatic artery, according to the OPTILIV protocol design, yet without cetuximab, because of the KRAS mutation in the liver metastases, with a partial re-sponse. The patient could then undergo the second stage of the planned right hepatectomy, which turned out to be an R0 resection followed by receiving three courses of chronomodulated HAIC. Disease progression was documented after 3 months. Chronomodulated FOLFIRI chemotherapy was re-started intravenously, in combination with Aflibercept and it was associated with further disease progression. The genetic analysis of our patient’s cancer revealed a high level of MSI. The patient was included in the Phase 2 CheckMate-142 trial and received nivolumab 3 mg/kg every 2 weeks within 3 months. Treatment was discontinued due to ineffectiveness. Then the patient underwent radiotherapy geared towards reduction of pain. Afterwards, the patient died from the disease progr

关键词： The Regional Chronomodulated Hepatic Arterial Infusion Chemotherapy Metastatic Colorectal Cancer Conversion of Unresectable to Resectable Liver Metastases

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Pharmacochemical Aspects of the Evolution from Erythromycin to Neomacrolides, Ketolides and Neoketolides

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Open Journal of Medicinal Chemistry（药物化学期刊） 2020年第3期

作者： Ouattara Mahama Coulibaly Songuigama N'Guessan Deto jean-paul

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《数论》书评

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数学译林 2023年第2期42卷 166-167页

作者： jean-paul Allouche 陆柱家(译) 童欣(校) 不详

Andrej Dujella,Number *** of the University of Zagreb,Skolska knjiga,Zagreb,2021,621 pages,translated by Petra Svob,ISBN 978-953-0-30897-8.作为学数论的学生,我非常欣赏***(哈代)和***(赖特)的名著^(1))而我的一些朋友经常提到***和***(沙法列维奇)的书^(2)).当然,即使是这两本书也没有涵盖数论的整个(巨大)领域,也可以引用其他几本优秀的书.最近,许多书都致力于(部分的)这个广阔领域,其特点是既是主要的又不是主要的(双关语).

关键词：数论维奇赖特

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陶哲轩和Syracuse猜想

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数学译林 2022年第3期41卷 209-215页

作者： jean-paul Allouche 陆柱家(译) 童欣(校) 不详

我们首先回顾一下Syracuse猜想(也称为“3n+1”问题),并快速概述该主题的已知结果。然后我们将尝试给出一些陶哲轩最近关于这个猜想的一个精彩结果背后的想法.

关键词：陶哲轩猜想精彩尝试

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在熔锥型光纤耦合器上写入光栅的特性研究

在熔锥型光纤耦合器上写入光栅的特性研究

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全国第十一次光纤通信暨第十二届集成光学学术会议（OFCIO’2003）

作者：罗爱平 Emmanuel Marin jean-PierreMeunier 瞿荣辉方祖捷中科院上海光学精密机械研究所信息光学实验室 Laboratoire TSI UMR CNRS 5516-Universite Jean Monnet21Rue du Docteur Paul-Michelon42023 Saint-etienne Cedex2France

本文从实际测量的耦合器的形状出发,运用耦合的超模理论分析了在普通2×2耦合器的熔锥区写入光栅的波长响应特性,并对不同类型的耦合器进行了比较。研究表明,当在适当的位置写入适当长度的光栅时,可以获得高下载效率的多端口波长选择滤... 详细信息

本文从实际测量的耦合器的形状出发,运用耦合的超模理论分析了在普通2×2耦合器的熔锥区写入光栅的波长响应特性,并对不同类型的耦合器进行了比较。研究表明,当在适当的位置写入适当长度的光栅时,可以获得高下载效率的多端口波长选择滤波器,我们可以据此设计符合需要的不同类型的普通耦合器,同时提出了获得窄线宽、边带抑制的滤波器的新方法。在实验上获得了反射率大于10dB的滤波器。

关键词：熔锥耦合器布拉格光栅滤波器

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The Algebraic Immersed Interface and Boundary Method for Elliptic Equations withJump Conditions

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Open Journal of Fluid Dynamics（流体动力学） 2020年第3期

作者： Arthur Sarthou Stéphane Vincent Philippe Angot jean-paul Caltagirone

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