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New targeted therapies for breast cancer: A focus on tumor microenvironmental signals and chemoresistant breast cancers

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World Journal of Clinical Cases 2014年第12期2卷 769-786页

作者： Armel Hervé Nwabo Kamdje paul Faustin Seke Etet Lorella Vecchio Richard Simo Tagne Jeremie Mbo Amvene jean-Marc Muller Mauro Krampera Kiven Erique Lukong Department of Biomedical Sciences Faculty of Sciences University of NgaoundéréPO Box 454 NgaoundéréCameroon Department of Basic Health Sciences College of Applied Medical Sciences Qassim UniversityBuraydah 52571 Saudi Arabia Université de Poitiers Faculté des Sciences P?le Biologie-Santé Bat B36 1 rue Georges Bonnet-BP633 86022 Poitiers cedex France Department of Medicine Section of Hematology Stem Cell Research Laboratory University of Verona 37129 Verona Italy Department of Biochemistry College of Medicine University of Saskatchewan Saskatoon S7N 5E5 Canada

Breast cancer is the most frequent female malignancy worldwide. Current strategies in breast cancer therapy,including classical chemotherapy, hormone therapy, and targeted therapies, are usually associated with chemoresistance and serious adverse effects. Advances in our understanding of changes affecting the interactome in advanced and chemoresistant breast tumors have provided novel therapeutic targets, including, cyclin dependent kinases, mammalian target of rapamycin,Notch, Wnt and Shh. Inhibitors of these molecules recently entered clinical trials in mono- and combination therapy in metastatic and chemo-resistant breast cancers. Anticancer epigenetic drugs, mainly histone deacetylase inhibitors and DNA methyltransferase inhibitors, also entered clinical trials. Because of the complexity and heterogeneity of breast cancer, the future in therapy lies in the application of individualized tailored regimens. Emerging therapeutic targets and the implications for personalized-based therapy development in breast cancer are herein discussed.

关键词： Breast cancer Microenvironment Signaling molecule Targeted therapy Chemoresistance

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佩皮尼昂 :欧洲城市的未来

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技术经济与管理研究 2005年第3期 13-14页

作者：让.保尔.阿尔杜伊法国佩皮尼昂市市长

佩皮尼昂市以其城市规划,以其过去和未来在社会经济文化方面的巨大发展变化,正无可争辩地列入欧洲都市的网络之中.她的地位也从"大的小城市"变为"小的大城市".

关键词：欧洲社会经济文化城市规划发展变化大城市小城市

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A Cross-Sectional Study According to Risk Factors Associated with Erectile Dysfunction in Men

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Advances in Sexual Medicine 2020年第3期10卷 104-118页

作者： Matthieu Marc Loposso Nkumu Christian Kane Kapinga Mafuta Tsita Alpha Dieu Donné Moningo Molamba Nkodila Aliosha Augustin Punga Maole Monga-Lembe jean paul Esika Mokumo Diangienda Nkutima Pablo Mujinga Lukusa Elisabeth Dirk De Ridder Urology Division Kinshasa University Hospital Kinshasa DR Congo Urology Department UZ Leuven Leuven Belgium

Background: Erectile dysfunction (ED) is a common condition in general population. It has a negative impact on the couple’s quality of life. In 1995, it was estimated that it affected 152 million people worldwide, and that it would affect more than 322 million people in 2025 with a large increase in developing countries. Several studies have suggested a causal link between ED and cardiovascular disease. In the Democratic Republic of Congo, no studies exist on this subject. Nonetheless, we are seeing increased promotion on the management of sexual disorders in our media, which could testify to the extent of this problem. Objective: To assess the extent of cardiovascular risk factors for ED in Kinshasa. Material and Methods: This is a cross-sectional study for analytical purposes. It collected several categories of individuals from May 1 to October 31, 2018. The severity of ED was assessed by the IIEF-5 score and the associated risk factors sought via logistic regression. Results: The mean age of the respondents was 59.9 ± 19.2 years, more than half of the respondents were over the age of 60 years old (60%). The ED proportion was 78.8%, and 75% of respondents had at least moderate ED. This anomaly was significantly elevated among respondents aged over 60 years (94.8%), diabetics (87.5%), hypertensive patients (92.3%) and stroke victims (86%). The independently associated risk factors were: age > 60 years [ORa: 9.87;95% CI: 6.42 - 10.48, p p = 0.013] and the stroke [ORa: 2.1;95% CI: 1.36 - 3.39;p = 0.012%]. The age threshold predicting ED was 67 years. Conclusion: ED is a frequent disorder in our environment and likely to affect the quality of life of men who suffer from it. There is an ED and cardiovascular risk factors correlation. A proactive attitude of the caregiver in current practice would allow early detection of ED with a view to early and optima

关键词： Risk Factors Erectile Dysfunction IIEF-5 Cardiovascular Diseases Simple Linear Correlation

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Integration of Post Abortion Care Package in the Activity of 56 Health Facilities by the Burkina Faso Society of Obstetricians and Gynecologists (SOGOB)

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Open Journal of Obstetrics and Gynecology 2016年第8期6卷 457-462页

作者： Sibraogo Kiemtoré Hyacinthe Zamané Yobi Alexis Sawadogo Charlemagne Marie Ouédraogo Dantola paul Kaïn Abdoule Azize Diallo Issa Ouédraogo Adama Dembélé Ali Ouédraogo Blandine Thiéba jean Lankoandé Department of Obstetrics and Gynecology Yalgado Ouedraogo Teaching Hospital in Ouagadougou Ouagadougou Burkina Faso Unity of Training and Research in Health Sciences (UFR/SDS) University of Ouagadougou Ouagadougou Burkina Faso Department of Obstetrics and Gynecology Centre Hospitalier Régional de Ouahigouya Ouahigouya Burkina Faso Department of Obstetrics and Gynecology and Reproductive Health Sanou Sourou Teaching Hospital Bobo-Dioulasso Burkina Faso Higher Institute of Science Health Polytechnic University of Bobo-Dioulasso Bobo-Dioulasso Burkina Faso

Introduction: This article is an analysis of post-abortion care in 56 health facilities after their capacity building by the Burkina Faso Society of Obstetricians and Gynecologists (SOGOB). Patients and Methods: In 2012, with funds from Safe Abortion Action Fund, the SOGOB trained care providers and equipped 56 health facilities for post abortion care. Statistical data on the management of incomplete abortions after the capacity building were analyzed. The significance level was set at 0.05. Results: There were 6316 cases of abortion that have been managed in 56 health facilities. The evacuation of the uterine contents for incomplete abortion has been provided to 6167 patients. Manual vacuum aspiration (MVA) and misoprostol were used respectively in 69.4% and 26.9% of cases to evacuate uterine content. Post-treatment complications were 1.8% for MVA and 0.9% for misoprostol (p = 0.004). MVA’s complication rate in the health facilities of the 1st level of care (1.7%) was not different from the third level of care (1.2%) with p = 0.21. A modern method of contraception was provided after abortion to 65.7% of the patients. In addition to the post abortion care, 7.3% of the patients received other reproductive health services. The community was involved in the development process of post abortion care in the facilities of the first level of care. Conclusion: The support of health facilities by SOGOB has provided post abortion care to thousands of women with little complications. Given the good results, an extension to other health facilities is desirable.

关键词： Post-Abortion Care MVA Misoprostol Family Panning Burkina Faso

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Triptych Knowledge—Skills—Payroll and Business Performance: Application of an Operational Model for an Accounting Rating of the Human Capital in the Area of Distribution

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Chinese Business Review 2021年第4期20卷 119-130页

作者： Jimmy Feige jean-paul Méreaux University of Reims Champagne-Ardenne ReimsFrance

The human capital’s accounting could allow companies to better manage the acquired knowledge and the skills developed by the employees when they join the *** operational model,suitable for a business enterprise’s HR manager and validated by its headboard,needs to include the employees’expertise and skills relative to their“cost”for the employer—the wage bill—and an assessment of the commercial *** human capital’s valuation includes methodological ***,the notion of human capital seems hardly understandable as a whole:The human capital gathers nevertheless components,such as knowledge—skills for which a first valuation can be proposed to test an accounting evaluation model for the operational human *** a perspective of a responsible management and a good HR policy,the method used must be able to better manage the knowledge and the competences employees acquired by accompanying them with the appropriate human resource management *** paper aims to show that the accounting valuation of human capital can become a tool in order to manage the knowledge and skills acquired and able to support a company’s human resources policy while being useful to its commercial performance—here in the distribution *** a research-intervention frame led in a responsible group,we use a model based on a triptych—wage bill,knowledge,and skills—to evaluate the human capital’s accounting,with an analytical highlight on the components measurement of the used“knowledge”and“skills”indexes in particular.A reflection on the operational model’s enrichment is proposed.

关键词： human capital knowledge and skills indices accounting valuation operational model distribution sector

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The Bilingual Competence of Local Council Staffers in the Centre and Littoral Regions of Cameroon

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Journal of Linguistics and Education Research 2019年第2期2卷 19-27页

作者： Kouega jean paul Sama Alexandre Sihna Department of English Faculty of ArtsUniversity of Yaounde IYaoundeCameroon

This work sets out to appraise the state of individual bilingualism in francophone local councils in *** work checks the use of English by francophone local council workers and of French by their anglophone mates with the focus on the four communicative language skills,i.e.,speaking,reading,writing and *** ethnographic approach to data collection was adopted,and self-rating through a questionnaire was the major tool *** eight-item questionnaire was administered to 192 local council *** were 177(91.14%of 192)francophone workers selected out of a pool of over 500 workers in six local councils situated in two big francophone towns i.e.,Douala and Yaounde on the one hand,and 15(8.85%of 192)out of a total of 16 anglophone workers in these same *** analysis of the data collected revealed that very low percentages of francophone workers could perform the following tasks using English:discuss office issues with their bosses(10.16%of 177 subjects),read out a speech(8.47%),write a letter to their collaborators(4.51%),and listen to someone with understanding(20.33%).Conversely,a high proportion of anglophone workers were able to perform these same tasks using French i.e.,discuss office issues with their bosses(73.33%of 15 subjects),read out a speech(20%),write a letter to a collaborator(33.33%),and listen to someone with understanding(80%).In short,63.28%of 177 francophone workers reported having a low performance in receptive skills in English as opposed to 20%of 15 anglophone workers who said the same for French;similarly,7.34%of 177 francophones claimed to have a good command of productive skills in English as opposed to 53.33%of 15 anglophones who claimed to have a command of *** implications for the study are that official French-English bilingualism in Cameroon is a mere political wish which is not a reality on the field.

关键词： Cameroon Bilingual competence measurement Individual bilingualism Institutional bilingualism Local council

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Unusual Aggregation Pheromone of the Melanesian Rhinoceros Beetle Scapanes australis BSDV. (Coleoptera,Scarabaeidae)

Unusual Aggregation Pheromone of the Melanesian Rhinoceros B...

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The First Asia—Pacific Conference on Chemical Ecology

作者： Didier ROCHAT jean-paul MORIN Titus KAKUL Laurence B EAUDOIN-O LLIVIER Robert P RIOR Christian MALOSSE Isabelle DECRUZ-MALOSSE Michel RENOU Sebastian E MBUPA INRA Phytopharmacie & Meiateurs ChimiquesRD 1078026 Versailles CedexFrance CIRAD-CP Avenue du Val de MontferrandBP 503534032 Montpellier Cedex 1France

Scapanes austmlis is a major coconut pest,endemic in Papua New Guinea(PNG) and near *** 6-cm long insect has caused a complete stop in the development of coconut in New Britain for the past 15 *** investigated its chemical ecology to work out a new control method using semiochemical-based trapping. Extensive behaviour studies showed that males settled in galleries in coconut palm galleries performed a peculiar calling behaviour early in the night for 1 to 2 hrs:at the gallery entrance,they raised the abdomen and the hind legs and emitted a rectal liquid secretion,rhythmically smeared by crossing the *** amount

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Laser produced electromagnetic pulses: generation, detection and mitigation

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High Power Laser Science and Engineering 2020年第2期8卷 88-146页

作者： Fabrizio Consoli Vladimir TTikhonchuk Matthieu Bardon Philip Bradford David CCarroll Jakub Cikhardt Mattia Cipriani Robert JClarke Thomas ECowan Colin NDanson Riccardo De Angelis Massimo De Marco jean-Luc Dubois Bertr Etchessahar Alejro Laso Garcia David IHillier Ales Honsa Weiman Jiang Viliam Kmetik Josef Krása Yutong Li FredériéLubrano paul McKenna Josefine Metzkes-Ng Alexre Poyé Irene Prencipe Piotr Ra¸czka Rol ASmith Roman Vrana Nigel CWoolsey Egle Zemaityte Yihang Zhang Zhe Zhang Bernhard Zielbauer David Neely ENEA Fusion and Technologies for Nuclear Safety DepartmentC.R.Frascati00044 FrascatiItaly CELIA University of BordeauxCNRSCEA33405 TalenceFrance ELI Beamlines Institute of PhysicsCzech Academy of Sciences25241 Dolni BrezanyCzech Republic CEA DAMCESTA33116 Le BarpFrance Department of Physics York Plasma InstituteUniversity of YorkHeslingtonYork YO105DDUK Central Laser Facility Rutherford Appleton LaboratorySTFCUKRIChiltonDidcotOxfordshire OX110QXUK Czech Technical University in Prague Faculty of Electrical Engineering16627 Prague 6Czech Republic Institute of Plasma Physics of the Czech Academy of Sciences Za Slovankou 318200 PragueCzech Republic Helmholtz-Zentrum Dresden-Rossendorf Institut fur Strahlenphysik01328 DresdenGermany AWE plc AldermastonReadingBerkshire RG74PRUK OxCHEDS Clarendon LaboratoryDepartment of PhysicsUniversity of OxfordOxford OX13PUUK CIFS The Blackett LaboratoryImperial College LondonLondon SW72AZUK Centro de Laseres Pulsados(CLPU) 37185 VillamayorSalamancaSpain Beijing National Laboratory for Condensed Matter Physics Institute of PhysicsChinese Academy of SciencesBeijing 100190China Institute of Physics of the Czech Academy of Sciences Na Slovance 218221 PragueCzech Republic School of Physical Sciences University of Chinese Academy of SciencesBeijing 100049China Department of Physics Scottish Universities Physics Alliance(SUPA)University of StrathclydeGlasgow G40NGUK Laboratory PIIM University Aix-Marseille-CNRS13397 MarseilleFrance Institute of Plasma Physics and Laser Microfusion 01-497 WarsawPoland The Blackett Laboratory Imperial College LondonLondon SW72AZUK PHELIX Group GSI Helmholtzzentrum fur SchwerionenforschungD-64291 DarmstadtGermany

This paper provides an up-to-date review of the problems related to the generation,detection and mitigation of strong electromagnetic pulses created in the interaction of high-power,high-energy laser pulses with different types of solid *** includes new experimental data obtained independently at several international *** mechanisms of electromagnetic field generation are analyzed and considered as a function of the intensity and the spectral range of emissions they *** major emphasis is put on the GHz frequency domain,which is the most damaging for electronics and may have important *** physics of electromagnetic emissions in other spectral domains,in particular THz and MHz,is also *** theoretical models and numerical simulations are compared with the results of experimental measurements,with special attention to the methodology of measurements and complementary *** the underlying physical processes is the basis for developing techniques to mitigate the electromagnetic threat and to harness electromagnetic emissions,which may have promising applications.

关键词： electromagnetic pulses high-power lasers diagnostics mitigation techniques

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药物产品的高分辨固体核磁共振研究

药物产品的高分辨固体核磁共振研究

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2021第二十一届全国波谱学学术年会

作者：卢星宇苏永超 Yu Tsutsumi jean-paul Amoureux 西湖大学默沙东肯尼沃斯布鲁克拜厄斯宾里尔第一大学

在药物固体剂型设计中,一个关键的任务是选择药物活性成分的结晶形式,以获得所需的物理化学稳定性和生物利用度。而想了解结晶药物的结构和物理化学性质之间的关系,需要高分辨率的分子信息。固体核磁共振是分析分子结构不可缺少的工具,...

在药物固体剂型设计中,一个关键的任务是选择药物活性成分的结晶形式,以获得所需的物理化学稳定性和生物利用度。而想了解结晶药物的结构和物理化学性质之间的关系,需要高分辨率的分子信息。固体核磁共振是分析分子结构不可缺少的工具,但在天然丰度药物材料的表征中,常常遇到谱图分辨率和灵敏度低的挑战。此外,药物晶体中相对较长的自旋晶格弛豫时间导致了耗时的数据采集。最近,通过发展超快魔角旋转（UF-MAS）下的二维和三维固体核磁共振方法,我们在几种商业化药物上开展了一系列关于基本结构基础信息的研究,以了解固态下药物分子间相互作用和物理化学性质1-5。

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药物产品的高分辨固体核磁共振研究

药物产品的高分辨固体核磁共振研究

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2021第二十一届全国波谱学学术年会

作者：卢星宇苏永超 Yu Tsutsumi jean-paul Amoureux 西湖大学默沙东肯尼沃斯布鲁克拜厄斯宾里尔第一大学

＜正＞在药物固体剂型设计中,一个关键的任务是选择药物活性成分的结晶形式,以获得所需的物理化学稳定性和生物利用度。而想了解结晶药物的结构和物理化学性质之间的关系,需要高分辨率的分子信息。固体核磁共振是分析分子结构不可缺少...

＜正＞在药物固体剂型设计中,一个关键的任务是选择药物活性成分的结晶形式,以获得所需的物理化学稳定性和生物利用度。而想了解结晶药物的结构和物理化学性质之间的关系,需要高分辨率的分子信息。固体核磁共振是分析分子结构不可缺少的工具,但在天然丰度药物材料的表征中,常常遇到谱图分辨率和灵敏度低的挑战。此外,药物晶体中相对较长的自旋晶格弛豫时间导致了耗时的数据采集。最近,通过发展超快魔角旋转（UF-MAS）下的二维和三维固体核磁共振方法,我们在几种商业化药物上开展了一系列关于基本结构基础信息的研究,以了解固态下药物分子间相互作用和物理化学性质1-5。

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