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CRISPR-Cas-like system in giant viruses:why MIMIVIRE is not likely to be an adaptive immune system

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Virologica Sinica 2016年第3期31卷 193-196页

作者： jean-michel Claverie Chantal Abergel Structural and Genomic Information Laboratory (UMR7256) CNRS Aix Marseille UniversityMediterranean Institute of Microbiology (FR 3479)

Giant viruses from the Mimiviridae family（Mimivirus,Megavirus,etc.）replicate inside their Acanthamoeba host by the mean of a large intracytoplasmic virion factory within which DNA transcription and replication take ... 详细信息

关键词： likely dsDNA Giant factory replication encoded silencing destruction discrimination clade

Multivariate Approach to Characterizing Soil Quality of Gabonese’s Ferralitic Soils

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Effects of Institut Georges Lopez-1 and Celsior preservation solutions on liver graft injury

Open Journal of Soil Science（土壤科学期刊） 2024年第4期 237页

作者： Neil-Yohan Musadji Rolf Gaël Mabicka Obame michel Mbina Mounguengui jean Aubin Ondo Lydie-Stella Koutika Eric Ravire Claude Geffroy

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World Journal of Gastroenterology 2015年第14期21卷 4159-4168页

作者： Donia Tabka Mohamed Bejaoui James Javellaud Joan Roselló-Catafau jean-michel Achard Hassen Ben Abdennebi Unité de recherche "Biologie et anthropologie moléculaire appliquées au développe- mentetàla santé" (UR12ES11) University of MonastirFaculty of Pharmacy Experimental Hepatic Ischemia--Reperfusion Unit Institut d’Investigacions Biomèdiques de Barcelona--Consejo Superior de Investigaciones Cientificas INSERM Unité Mixte de Recherche S-8508000 LimogesFrance

AIM: To compare Institut Georges Lopez(IGL-1) and Celsior preservation solutions for hepatic endothelium relaxation and liver cold ischemia reperfusion injury(IRI).METHODS: Two experimental models were *** the first one, acetylcholine-induced endotheliumdependent relaxation(EDR) was measured in isolated ring preparations of rat hepatic arteries preserved or not in IGL-1 or Celsior solutions(24 h at 4 ℃).To determine nitric oxide(NO) and cyclooxygenase EDR, hepatic arteries were incubated with L-NG-nitroarginine methyl ester(L-NAME), an inhibitor of endothelium nitric oxide synthase(e NOS), or with L-NAME plus indomethacin, an inhibitor of *** the second experiment, rat livers were cold-stored in IGL-1 or Celsior solutions for 24 h at 4 ℃ and then perfused "ex vivo " for 2 h at 37 ℃.Liver injury was assessed by transaminase measurements, liver function by bile production and bromosulfophthalein clearance, oxidative stress by malondialdehyde levels and catalase activity and alterations in cell signaling pathways by pA kt, pA MPK, eN OS and MAPKs proteins ***: After cold storage for 24 h with either Celsior or IGL-1, EDR was only slightly *** isolated arteries, EDR was exclusively mediated by ***, cold-stored arteries showed NOand COX-dependent *** decrease in NO-dependent relaxation after cold storage was significantly more marked with *** second study indicated that IGL-1 solution obtained better liver preservation and protection against IRI than *** injury was reduced, function was improved and there was less oxidative ***-1 solution activated Akt and AMPK, which was concomitant with increased eN OS expression and nitrite/nitrate ***, MAPKs kinases were regulated in livers preserved with IGL-1 solution since reductions in p-p38, p-ERK and p-JNK protein levels were ***: IGL-1 solution preserved NO-dependent relaxation better than Celsior storage solutio

关键词： Organ preservation solutions Institut Georges Lope

Hepatitis C virus: Virology, diagnosis and management ofantiviral therapy

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World Journal of Gastroenterology 2007年第17期13卷 2461-2466页

作者： Stéphane Chevaliez jean-michel Pawlotsky French National Reference Center for Viral Hepatitis B C and deltaDepartment of Virology & INSERM U841 Henri Mondor Hospital University of Paris XII Créteil France

Hepatitis C virus (HCV) infects approximately 170 million individuals worldwide. Prevention of HCV infection complications is based on antiviral therapy with the combination of pegylated interferon alfa and ribavirin. The use of serological and virological tests has become essential in the management of HCV infection in order to diagnose infection, guide treatment decisions and assess the virological response to antiviral therapy. Anti- HCV antibody testing and HCV RNA testing are used to diagnose acute and chronic hepatitis C. The HCV genotype should be systematically determined before treatment, as it determines the indication, the duration of treatment, the dose of ribavirin and the virological monitoring procedure. HCV RNA monitoring during therapy is used to tailor treatment duration in HCV genotype 1 infection, and molecular assays are used to assess the end-of-treatment and, most importantly the sustained virological response, i.e. the endpoint of therapy.

关键词： Hepatitis C virus serological tests HepatitisC virus genotype HCV RNA quantification Interferon alpha Ri-bavirin-

基于氢氧基平面激光诱导荧光法的稀释燃烧机理实验研究

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中国电机工程学报 2008年第32期28卷 61-65页

作者：刘玉英 jean-michel Most Philippe Bauer 北京航空航天大学能源与动力工程学院北京市海淀区100083 法国国家科学研究中心燃烧与爆炸实验室

为探讨反应物预热温度和稀释率对稀释燃烧机理的影响,该文以氮气稀释的甲烷–空气对冲扩散火焰为研究对象,采用氢氧基平面激光诱导荧光法(hydroxy radical planar laser induced fluorescence,OH-PLIF)进行实验研究。以OH基反应区厚度... 详细信息

为探讨反应物预热温度和稀释率对稀释燃烧机理的影响,该文以氮气稀释的甲烷–空气对冲扩散火焰为研究对象,采用氢氧基平面激光诱导荧光法(hydroxy radical planar laser induced fluorescence,OH-PLIF)进行实验研究。以OH基反应区厚度表征火焰厚度,实验结果表明,在反应物预热温度较低情况下,当预热温度一定时火焰厚度随反应物稀释率增大(或者浓度减小)而减小,当反应物稀释率一定时火焰厚度随预热温度升高而增大。但进一步分析表明,在反应物预热温度足够高时,火焰厚度将随反应物稀释率增加而增大。根据预热对化学反应速度的增大与稀释对化学反应速度的减小的共同作用,从火焰厚度随反应物预热温度与稀释率的变化情况可推断,在低预热温度稀释燃烧过程中,预热温度是影响火焰结构的主要因素;在预热温度足够高的稀释燃烧过程中,稀释率是火焰结构的主要影响因素,此时由于稀释引起化学反应速度大大降低,因此火焰厚度或体积显著增大。

关键词：对冲火焰稀释燃烧氢氧基平面激光诱导荧光法

International Oil Price Fluctuations and China's Energy Strategy

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World Economy & China 2001年第2期9卷 35-41页

作者： jean-michel Plassard Professor and Vice-president

Mechanism of friction reduction of unsaturated fatty acids as additives in diesel fuels

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Friction 2013年第3期1卷 252-258页

作者： jean michel MARTIN Christine MATTA Maria-Isabel De Barros BOUCHET Cyrielle FOREST Thierry Le MOGNE Thomas DUBOIS Michael MAZARIN Laboratory of Tribology and System Dynamics Ecole Centrale de Lyon69134 EcullyFrance TOTAL CReSBP2269360 Solaize CedexFrance

This paper investigates the effect of unsaturated fatty acid additives on the lubricating properties of a biodiesel,composed of a blend of fatty acid methyl esters(FAMEs)and a conventional diesel *** presence of fatty acids as additives for biodiesel improves their lubricating properties at elevated temperature *** formation of a protective lubricating tribochemical film on the steel contact surfaces has been *** temperature conditions and possibly oxygen are needed to form this film that reduces friction and limits *** analytical tools have revealed the insulating nature of the formed tribofilm and its chemical ***-induced reticulation is thought to play a major role in the growth of this insulating film.

关键词： biodiesel low friction fatty acids tribochemistry surface analysis

Moisture-Induced Non-Equilibrium Phase Segregation in Triple Cation Mixed Halide Perovskite Monitored by In Situ Characterization Techniques and Solid-State NMR

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Energy & Environmental Materials 2023年第2期6卷 185-194页

作者： Mohammad Ali Akhavan Kazemi Nicolas Folastre Parth Raval michel Sliwa jean Marie Vianney Nsanzimana Sema Golonu Arnaud Demortiere jean Rousset Olivier Lafon Laurent Delevoye G.N.Manjunatha Reddy Frédéric Sauvage Laboratoire de Réactivité et Chimie des Solides(LRCS) UMR CNRS 7314-Institut de Chimie de Picardie FR 3085Université de Picardie Jules Verne33 rue Saint LeuAmiens Cedex FR-80039France CNRS Centrale LilleUMR 8181UCCSUnitéde Catalyse et Chimie du SolideUniversité de LilleUniversitéd’ArtoisLille F-59000France UMR 8516-LASIRE-Laboratoire de Spectroscopie pour les Interactions la Réactivité et l’EnvironnementCNRSUniversitéde LilleLille F-59000France EDF R&D EDF LabBoulevard Gaspard MongePalaiseau 91120France

Environmental stability is a major bottleneck of perovskite solar *** a handful of studies are investigating the effect of moisture on the structural degradation of the *** mostly rely on ex situ experiments and on completely degraded samples,which restrict the assessment on initial and final *** combining in situ X-ray diffraction under controlled 85%relative humidity,and live observations of the water-induced degradation using liquid-cell transmission electron microscopy,we reveal two competitive degradation paths leading on one hand to the decomposition of state-of-theart mixed cation/anion(Cs_(0.05)(MA_(0.17)FA_(0.83))_(0.95)Pb(Br_(0.17)I_(0.83))_(3)(CsMAFA)into PbI_(2) through a dissolution/recrystallization mechanism and,on the other hand,to a non-equilibrium phase segregation leading to CsPb_(2)Br_(5) and a Cesium-poor/iodide-rich Cs_(0.05)-x(MA_(0.17)FA_(0.83))_(0.95)Pb(Br_(0.17-2y)I_(0.83)+2y)_(3) *** degradation mechanism is corroborated at atomic-scale resolution through solid-state ^(1)H and ^(133)Cs NMR *** to moisture leads to a film containing important heterogeneities in terms of morphology,photoluminescence intensities,and *** results provide new insights and consensus that complex perovskite compositions,though very performant as champion devices,are comparatively metastable,a trait that limits the chances to achieve long-term stability.

关键词： liquid-cell transmission electron microscopy moisture degradation perovskite stability phase segregation solid-state NMR

Removing harvest residues from hardwood stands affects tree growth, wood density and stem wood nutrient concentration in European beech (Fagus sylvatica) and oak (Quercus spp.)

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Forest Ecosystems 2022年第2期9卷 147-159页

作者： Sanjoy Roy jean-michel Leban Bernhard Zeller Gregory van der Heijden Arnaud Reichard Marie-Christine Gehin Philippe Santenoise Laurent Saint-Andre INRAE BEFF-54000 NancyFrance IGN Laboratoire de l’Inventaire ForestierNancyF-54000France Universite de Lorraine AgroParisTechINRAESILVAF-54000 NancyFrance

Background:Higher exportation of harvest residues from forests due to increased demand for woody biomass,has reportedly diminished soil mineral resources and may lead to degraded tree nutrition as well as ***,as nutrients become less available in the soil,the remobilization of nutrients in biomass tissues(plant internal cycling)helps sustain tree *** study aims to quantify the impact of Removing Harvest Residues and Litter(RHRL)during five years on tree growth,wood density,and stem wood nutrient concentrations in young beech and oak forest ***:Our study found that,RHRL significantly decreased tree growth ring width by 14%,and wood density by 3%,in beech trees,in near bark *** also significantly reduced nutrient concentration in near bark and near pith areas of both studied ***,Na and S were found lower by 44%,76%,and 56%,respectively,in near bark area of beech *** near bark area of oak trees,K,Ca,Mg,Na,S,and Fe were lower by 20%,25%,41%,48%,41%,and 16%,respectively.K and Mg concentrations decreased more strongly in near pith area compared to near bark area suggesting internal translocation of these two ***:In beech trees,wood density proved to be an important factor while quantifying the effect of removing harvest residuals on tree growth and *** nutrient loss intensified the remobilization of nutrients con-tained in older tree rings(close to the pith)towards newly formed rings(close to bark).In our study,in beech trees,K was found to be the most recycled major *** results demonstrate the potential of such analysis for providing valuable insight into the effect of RHRL in premature stands on the physiological adaptive strategies of trees and an indication of soil fertility status.

关键词： Harvest residues Fagus sylvatica Quercus petraea Dendroecology Dendrochemistry Radial growth Wood density Tree growth Ring width Translocation