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CRISPR-Cas-like system in giant viruses:why MIMIVIRE is not likely to be an adaptive immune system

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Virologica Sinica 2016年第3期31卷 193-196页

作者： jean-michel Claverie Chantal Abergel Structural and Genomic Information Laboratory (UMR7256) CNRS Aix Marseille UniversityMediterranean Institute of Microbiology (FR 3479)

Giant viruses from the Mimiviridae family（Mimivirus,Megavirus,etc.）replicate inside their Acanthamoeba host by the mean of a large intracytoplasmic virion factory within which DNA transcription and replication take ... 详细信息

关键词： likely dsDNA Giant factory replication encoded silencing destruction discrimination clade

Efficacy and tolerability of chitin-glucan combined with simethicone(GASTRAP^(■)DIRECT)in irritable bowel syndrome:A prospective,open-label,multicenter study

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World Journal of Gastrointestinal Pharmacology and Therapeutics 2024年第3期15卷 10-22页

作者： Nathalie Talbodec Pauline Le Roy Peggy Fournier Benoit Lesage Elodie Lepoutre François Castex jean michel Godchaux Lionel Vandeville Benjamin Bismuth Xavier Lesage Pauline Bayart Michael Genin Christel Rousseaux Veronique Maquet Salvatore Modica Pierre Desreumaux Caroline Valibouze Department of Gastroenterology Hôpital privéLe BoisLille 59000France Department of Gastroenterology Hôpital privéde Villeneuve d’AscqVilleneuve d’Ascq 59650France Univ.Lille CHU LilleULR 2694–METRICSÉvaluation des Technologies de Santéet des Pratiques MédicalesLille 59000France Development of Intestinal Biotech 1 Avenue Oscar LambretLille 59045France KitoZyme SA Parc Industriel des hauts Sarts Zone 2Rue de MilmortHerstal 4040Belgium BiOkuris A Parc Industriel des hauts Sarts Zone 2Rue de MilmortHerstal 4040Belgium Department of Hepato-Gastroenterology Lille University HospitalLille 59000France U1286-INFINITE Institute for Translational Research in InflammationUniv.LilleInsermCHU LilleLille 59000France Department of Digestive Surgery and Transplantation Lille University HospitalLille 59037France

BACKGROUND Irritable bowel syndrome(IBS),defined according to the Rome IV diagnostic criteria,is a chronic functional gastrointestinal disorder characterized by recurrent abdominal pain related to altered bowel ***-line recommended treatments are limited to combining drugs targeting predominant symptoms,particularly pain(antispasmodics),constipation(laxatives),and diarrhea(loperamide),yielding only a limited therapeutic ***^(■)DIRECT is a class IIa medical formulation composed of a combination of chitin-glucan and simethicone indicated for the symptomatic treatment of gas-related gastrointestinal disorders by combining different mechanisms of *** To evaluate the efficacy,tolerability,and safety of 4-week GASTRAP^(■)DIRECT treatment in patients with *** In this prospective,multicenter,open-label trial,120 patients with IBS received three sticks of GASTRAP^(■)DIRECT(1.5 g/d of chitin-glucan and 0.75 mg/d of simethicone)per day for 4 *** primary endpoint was the responder rate,defined as the number of patients whose abdominal pain score decreased by≥30%from baseline to week(W)*** analysis was performed using the per-protocol *** symptoms,impact of global symptoms on daily life,change in stool consistency,and improvement in defecatory disorders were *** Overall,100 patients were *** W4,67%(95%CI:57-75)showed improvement in abdominal pain(score:5.8±2.4 vs 2.9±2.0,P<0.0001).Similar improvements were observed for bloating[8.0±1.7 vs 4.7±2.9,P<0.0001;60%(95%CI:50-70)responders],abdominal distension[7.2±2.1 vs 4.4±3.1,P<0.0001;53%(95%CI:43-63)responders],and impact of global symptoms on daily life[7.1±2.0 vs 4.6±2.9,P<0.0001;54%(95%CI:44-64)responders].Stool consistency improved in most patients(90%and 57%for patients with liquid and hard stools,respectively).Overall,42%of patients with defecatory disorders reported very much/considerable improvements by *** severe adverse event occurred,and tolerabil

关键词： Chitin-glucan Irritable bowel syndrome Abdominal pain Flatulence Defecatory disorders Stool consistency Natural non-pharmacological treatment

Feedback Stabilization for a Scalar Conservation Law with PID Boundary Control

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Chinese Annals of Mathematics,Series B 2015年第5期36卷 763-776页

作者： jean michel CORON Simona Oana TAMASOIU Sorbonne Universités UPMC University Paris 06 NUMR 7598 Laboratoire Jacques-Louis Lions F-75005Paris France Université Paris Sud F-91405 Orsay France

This paper deals with a scalar conservation law in 1-D space dimension, and in particular, the focus is on the stability analysis for such an equation. The problem of feedback stabilization under proportional-integral-derivative(PID for short) boundary control is addressed. In the proportional-integral(PI for short) controller case, by spectral analysis, the authors provide a complete characterization of the set of stabilizing feedback parameters, and determine the corresponding time delay stability interval. Moreover, the stability of the equilibrium is discussed by Lyapunov function techniques, and by this approach the exponential stability when a damping term is added to the classical PI controller scheme is proved. Also, based on Pontryagin results on stability for quasipolynomials, it is shown that the closed-loop system sub ject to PID control is always unstable.

关键词： Boundary feedback FID controllers Linear scalar conservation law

Assessment of Technical and Economic Impacts of EV User Behavior on EV Aggregator Smart Charging

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Journal of Modern Power Systems and Clean Energy 2020年第2期8卷 356-366页

作者： jean-michel Clairand Javier Rodriguez-Garcia Carlosalvarez-Bel the Facultad de Ingenieria y Ciencias Agropecuarias Universidad de las Americas-Ecuador170122 QuitoEcuador the Institute for Energy Engineering Universitat Politecnica de Valencia46022 ValenciaSpain

The increase in global electricity consumption has made energy efficiency a priority for ***,there has been a focus on the efficient integration of a massive penetration of electric vehicles(EVs)into energy *** study presents an assessment of various strategies for EV *** this analysis,the smart charging methodology proposed in a previous study is *** smart charging technique employs charging power rate modulation and considers user *** adopt several strategies,this study simulates the effect of these actions in a case study of a distribution system from the city of Quito,*** actions are simulated,and the EV aggregator costs and technical conditions are evaluated.

关键词： Electric vehicle(EV) smart grid aggregator smart charging charging power modulation charging strategies

Osteoarticular Lesions of the Shoulder Girdle by Hippopotamus Bite: Highly Septic Lesion

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Open Journal of Orthopedics 2024年第2期14卷 114-121页

作者： Jr Pierre Germain Ochou Achié jean Régis Akobe Yao Aboh Ganyn Robert Arnaud Assere Kouamé jean-Eric Kouassi Adelaïde Aya Natacha Kouassi Ibrahim Soumahoro Zolopégué Marcel Soro Sédi Loues De Randolphe Akpro Gbalé Yannick Blé Kouamé Innocent M’bra Loukou Blaise Yao Bada Juste Léopold NiaoréSery Koffi Léopold Krah michel Kodo Department of Orthopaedic and Traumatological Surgery Bouaké University Hospital Bouaké Ivory Coast Raoul Follereau Institute Manikro Centre Bouaké Ivory Coast

Hippopotamus bites are rare in medical consultations, despite several studies exposing their aggressive character. A case of a hippopotamus bite on the shoulder of a fisherman has been reported. In addition to the osteoarticular aspect representing a therapeutic problem, the infectious aspect was marked by sepsis, with a death in less than 48 hours. Based on this observation, a protocol for the initial management of large animal bites was submitted.

关键词： Bite Hippopotamus Septic Shock

Convergence to a Single Wave in the Fisher-KPP Equation(Dedicated to Haim Brezis,with admiration and respect)

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Chinese Annals of Mathematics,Series B 2017年第2期38卷 629-646页

作者： James NOLEN jean-michel ROQUEJOFFRE Lenya RYZHIK Department of Mathematics Duke UniversityDurhamNC 27708USA Institut de Mathématiques(UMR CNRS 5219) Université Paul Sabatier118 route de Narbonne31062 Toulouse cedexFraxlce Department of Mathematics Stanford UniversityStanford CA94305USA.

The authors study the large time asymptotics of a solution of the Fisher-KPP reaction-diffusion equation, with an initial condition that is a compact perturbation of a step function. A well-known result of Bramson states that, in the reference frame moving as 2t-(3/2 )log t+x∞, the solution of the equation converges as t → +∞ to a translate of the traveling wave corresponding to the minimal speed c_* = 2. The constant x∞ depends on the initial condition u(0, x). The proof is elaborate, and based on probabilistic *** purpose of this paper is to provide a simple proof based on PDE arguments.

关键词： Traveling waves, KPP, Front propagation, Asymptotic analysis,Reaction-diffusion

Zircon U-Pb and Lu-Hf isotope constraints on Archean crustal evolution in Southeastern Guyana Shield

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Geoscience Frontiers 2019年第4期10卷 1477-1506页

作者： Joao Marinho Milhomem Neto jean-michel Lafon Programa de Pos-graduacao em Geologia e Geoquimica-PPGG Instituto de Geociencias-IGUniversidade Federal do Para-UFPA66075-110BelemParaBrazil Laboratório de Geologia Isotópica-Pará-Iso IG-UFPA66075-110BelémParáBrazil

The southeastern Guyana Shield,northeast Amazonian Craton,in the north of Brazil,is part of a widespread orogenic belt developed during the Transamazonian orogenic cycle(2.26-1.95 Ga)that includes a large Archean continental landmass strongly reworked during the Transamazonian orogeny,named Amapa *** consists mainly of a high-grade metamorphic granulitic-migmatitic-gneiss complex,of Meso-to Neoarchean age and Rhyacian granitoids and supracrustal *** the first time,coupled U-Pb and Lu-Hf isotope data were obtained on zircon by LA-ICP-MS from five tectono-stratigraphic units of the Archean basement and one Paleoproterozoic intrusive rock,in order to investigate the main episodes of crustal growth and ***-rock Sm-Nd isotope data were compared to the zircon Lu-Hf *** main magmatic episodes were defined by U-Pb zircon dating,two in the Mesoarchean(~3.19 Ga and 2.85 Ga)and one in the Neoarchean(~2.69-2.65 Ga).SubchondriticεHf(t)values obtained for almost all investigated units indicate that crustal reworking processes were predominant during the formation of rocks that today make up the Amapa ***-TDMC model ages,ranging from2.99 Ga to 3.97 Ga,indicate that at least two important periods of mantle extraction and continental crust formation occurred during the Archean in southeastern Guyana Shield,an older one in the Eoarchean(~4.0 Ga)and a younger one in the Mesoarchean(~3.0-3.1 Ga).The latter is recognized as an important period of crustal accretion *** recognition of an Eoarchean episode to the southeastern most part of the Guyana Shield is unprecedented and was not recorded by whole-rock Sm-Nd data,which were restricted to the Meso-Paleoarchean(2.83 Ga to 3.51 Ga).This finding reveals t hat continental crust generation in the Amazonian Craton began at least 500 Ma earlier than previously suggested by the SmNd systematics.

关键词： U-Pb-Lu-Hf isotopes Zircon Archean crustal evolution Southeastern Guyana Shield Amazonian Craton

A Clinical Study to Assess the Effectiveness of Oral Combination Kit Therapy in Syndromic Management of Abnormal Vaginal Discharge (FEMINE Study) in Kinshasa, Democratic Republic of Congo

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Open Journal of Obstetrics and Gynecology 2024年第1期14卷 193-208页

作者： Feruzi michel Mangala Muela Andy Mbangama Di-Mosi-Nkoy Roger Wumba Ambis Joëlle Lumaya Nkongolo Freddy Muamba Tshitadi jean Mukendi Ndombasi Neilda Lemba Otem Christian Ndesanzim Nkashama Bienvenu Kazadi Banza Jesual Lotoy Umba Adrien Tandu Mushengezi Dieudonné Sengeyi Mwimba Roger Mbungu Department of Gynecology and Obstetrics University Clinics of Kinshasa Kinshasa DR Congo Congolese Society of Gynecology and Obstetrics Kinshasa DR Congo Department of Gynecology and Obstetrics Kinshasa Provincial General Reference Hospital Kinshasa DR Congo Departement of Tropical Medicine University Clinics of Kinshasa Kinshasa DR Congo

Background: Vaginal discharge is one of most common and nagging problems that women face. About 20% - 25% of women who visit gynecology department complain of vaginal discharge and leucorrhoea. An orally administered combination kit, containing 2 g secnidazole, 1 g azithromycin and 150 mg fluconazole (Azimyn FS Kit), has been successfully evaluated in clinical trials and used in several countries for management syndromic vaginal discharge due to infections. Methods: This is a longitudinal study which aimed to verify the clinical efficacy of the combined oral kit containing secnidazole, azithromycin and fluconazole (Azimyn FS Kit®) in the syndromic treatment of abnormal vaginal discharge in patients received in outpatient consultations in Kinshasa/DR Congo from March to September 2023. Results: Majority of patients had whitish vaginal discharge (51.6%) of average abundance (56.2%), accompanied by pruritus in 72.1% of cases, and dyspareunia in 23.5% of cases and hypogastralgia in 40.2% of cases. One week after treatment with the Azimyn FS® combined kit, at the greatest majority of patients (97.3%), abnormal vaginal discharge had decreased by more than 50% (84.1%). Two weeks after treatment with the Azimyn FS® combined kit, almost all patients (97.3%) no longer had abnormal vaginal discharge which had completely disappeared. Conclusion: A single dose of secnidazole, azithromycin and fluconazole in the form of an oral combi-kit (Azimyn FS Kit) has shown excellent therapeutic effectiveness in the syndromic treatment of abnormal vaginal discharge wherein patients were treated without diagnostic confirmation.

关键词： Oral Combination Kit Therapy Syndromic Management Abnormal Vaginal Discharge

Modelling and mathematical results arising from ferromagnetic problems

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Science China Mathematics 2012年第5期55卷 1053-1067页

作者： DESCLOUX jean FLUECK michel RAPPAZ Jacques Department of Mathematics Ecole Polytechnique Fdrale de Lausanne (EPFL)Lausanne 1015Switzerland

Abstract In this article, we investigate the equations of magnetostaties for a configuration where a ferromagnetic material occupies a bounded domain and is surrounded by vacuum. Furthermore, the ferromagnetic law takes the form B=μ0μr（｜H｜）Hi i.e., the magnetizing field H and the magnetic induction B are collinear, but the relative permeability μr is allowed to depend on the modulus of H. We prove the well-posedness of the magnetostatic problem under suitable convexity assumptions, and the convergence of several iterative methods, both for the original problem set in the Beppo-Levi space W1（R3）, and for a finite-dimensional approximation. The theoretical results are illustrated by numerical examples, which capture the known physical phenomena.

关键词： ferromagnetism nonlinear elliptic problems finite element methods optimisation algorithms