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Does the Animal Origin Influence the Calcification of Xenograft Tissue Heart Valve Substitutes? Comparison between Bovine and Camel Pericardium in a Subcutaneous Rat Model

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International Journal of Clinical Medicine 2015年第9期6卷 700-709页

作者： Fatima Al Harmoodi Salah Al Shafy michel Guichardant jean-Jacques Lebrun Francoise Thivolet Olivier Jegaden Department of biomedical engineering Khalifa University Abu Dhabi UAE Department of cardiac surgery Zayed Military Hospital Abu Dhabi UAE Chemistry-Biology Health Area Institut Multidisciplinaire de Biochimie des lipides Institut National des Sciences Appliquées Lyon France Institute of Analytic Sciences Centre National de la Recherche Scientifique Villeurbanne France Department of Biology Hospices Civils de Lyon Claude Bernard University Lyon1 Lyon France Department of Cardiac Surgery Cleveland Clinic Abu Dhabi Abu Dhabi UAE Claude Bernard University Lyon1 Lyon France Cleveland Clinic Lerner College of Medicine—Case Western Reserve University Cleveland Ohio USA

Objective: To validate the hypothesis that camel pericardium could be more protected than bovine pericardium against calcification process according to the huge difference in their respective lifestyle and lifetime. Methods: Glutaraldehyde (GA) fixed bovine and camel pericardium samples (BP and CP respectively) were both implanted in 30 New Zealand white rats (2 BP and 2 CP matched specimens in each animal) and explanted after 60 days. Unimplanted GA-fixed samples of both species served as control. Matched implanted samples and unimplanted samples were randomly submitted to elemental analysis by spectroscopy, phospholipid extraction, macroscopic and X-ray examination and histology. Results: At 60 days, calcium and phosphorus content were respectively 9.54% ± 3.1% and 4.79% ± 1.4% of tissue dry weight in BP, and 12.52% ± 2.7% and 6.14% ± 1.3% of tissue dry weight in CP (ns). In X-ray analysis, the calcification score was 1.28 ± 0.45 and 2.14 ± 0.98 in BP and CP samples respectively without significant difference (p < 0.08). In histology, calcifications were lower in BP than in CP: 1.37 ± 0.85 vs 2.28 ± 0.83 (ns);collagen fibers were better conserved in BP than in CP: 2.4 ± 0.48 vs 1.87 ± 0.78 (ns), and less disoriented: 25% vs 62% (ns). In unimplanted samples, there was a higher but not significant rate of extracted lipids in CP: 5.7 ± 1.8 vs 9.5 ± 3.8 nanomoles in PS fraction and 11.3 ± 3.7 vs 19 ± 7.7 nanomoles in total fatty acids, in BP and CP samples respectively. All results were in conjunction and demonstrated a higher but not significant rate of mineralization in camel pericardium after implantation, which could be related to a higher but not significant basic rate of phospholipid and fatty acids. Conclusion: This experiment study in a subcutaneous rat model has failed to valid our hypothesis. Because the differences observed between bovine and camel pericardium did not reach the significance, at the best, there is no difference between both species and at th

关键词： Pericardium Calcification Bovine Camel Xenograft Tissue Heart Valve Substitutes

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Clinical research in febrile neutropenia in cancer patients: Past achievements and perspectives for the future

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World Journal of Clinical Infectious Diseases 2016年第3期6卷 37-60页

作者： jean Klastersky Marianne Paesmans michel Aoun Aspasia Georgala Angela Loizidou Yassine Lalami Lissandra Dal Lago Institut Jules Bordet Service de Médecine Centre des Tu-meurs de l’Université Libre de Bruxelles

Febrile neutropenia(FN) is responsible for significant morbidity and mortality. It can also be the reason for delaying or changing potentially effective treatments and generates substantial costs. It has been recognized for more than 50 years that empirical administration of broad spectrum antibiotics to patients with FN was associated with much improved outcomes; that has become a paradigm of management. Increase in the incidence of microorganisms resistant to many antibiotics represents a challenge for the empirical antimicrobial treatment and is a reason why antibiotics should not be used for the prevention of neutropenia. Prevention of neutropenia is best performed with the use of granulocyte colonystimulating factors(G-CSFs). Prophylactic administration of G-CSFs significantly reduces the risk of developing FN and consequently the complications linked to that condition; moreover, the administration of G-CSF is associated with few complications, most of which are not severe. The most common reason for not using G-CSF as a prophylaxis of FN is the relatively high cost. If FN occurs, in spite of prophylaxis, empirical therapy with broad spectrum antibiotics is mandatory. However it should be adjusted to the risk of complications as established by reliable predictive instruments such as the Multinational Association for Supportive Care in Cancer. Patients predicted at a low level of risk of serious complications, can generally be treated with orally administered antibiotics and as out-patients. Patients with a high risk of complications should be hospitalized and treated intravenously. A short period of time between the onset of FN and beginning of empirical therapy is crucial in those patients. Persisting fever in spite of antimicrobial therapy in neutropenic patients requires a special diagnostic attention, since invasive fungal infection is a possible cause for it and might require the use of empirical antifungal therapy.

关键词： Fever Neutropenia Prophylaxis Algorithm Cancer

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Two-photon absorption towards pulse modulation in mechanically exfoliated and CVD monolayer cascaded MoS2 structures

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Chinese Optics Letters 2019年第8期17卷 71-75页

作者： Yafeng Xie Saifeng Zhang Xiaoyan Zhang Ningning Dong Ivan M.Kislyakov Song Luo Zhanghai Chen jean-michel Nunzi Long Zhang Jun Wang Laboratory of Micro-Nano Photonic and Optoelectronic Materials and Devices Key Laboratory of Materials for High- Power Laser Shanghai Institute of Optics and Fine Mechanics Chinese Academy of Sciences Shanghai 201800 China Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of Sciences Beijing 100049 China State Key Laboratory of Surface Physics Key Laboratory of Micro and Nano Photonic Structures of Ministry of Education Department of Physics Collaborative Innovation Center of Advanced Microstructures Fudan University Shanghai 200433 China Department of Physics Engineering Physics Sz Astronomy and Department of Chemistry Queers University Kingston K7L-3N6 Ontario Canada State Key Laboratory of High Field Laser Physics Shanghai Institute of Optics and Fine Mechanics Chinese Academy of Sciences Shanghai 201800 China

Mechanical exfoliation(ME) and chemical vapor deposition(CVD) MoS2 monolayers have been extensively studied, but the large differences of nonlinear optical performance between them have never been clarified. Here,we prepared MoS2 monolayers using ME and CVD methods and investigated the two-photon absorption(TPA)response and its saturation. We found that the TPA coefficient of the ME monolayer was about(1.88 ± 0.21)× 10^3 cm/GW, nearly two times that of the CVD one at(1.04 ± 0.15)× 10^3 cm/GW. Furthermore,we simulated and compared the TPA-induced optical pulse modulation in multilayer cascaded structures, which is instructive and meaningful for the design of optical devices such as a beam shaper and optical limiter.

关键词： ME CVD limiter

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Influence of Cell Confluency on the Expression of the α4 Integrin Subunit of Retinal Pigment Epithelial Cells

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Advances in Biological Chemistry 2015年第2期5卷 73-82页

作者： jean-michel Bourget Mohib Morcos Karine Zaniolo Sylvain L. Guérin Stéphanie Proulx Centre de recherche du CHU de Québec and Centre de recherche en organogénèse expérimentale de l’Université Laval/LOEX axe médecine régénératrice Hopital du Saint-Sacrement Québec Canada Département d’anatomie et de cytologie pathologiques CHU de Québec Hopital du Saint-Sacrement Québec Canada Département de biologie moléculaire biochimie médicale et pathologie Faculté de médecine Université Laval Québec Canada Département d’Ophtalmologie Faculté de médecine Université Laval Québec Canada

Integrins are a family of transmembrane glycoproteins that mediate cell-cell and cell-extracellular matrix interactions. The integrin α4 subunit is widely expressed by cells from the immune system and its expression by non-hematopoietic cells is scarce. In the present study, gene and protein expression of this integrin subunit was characterized in proliferating and quiescent human RPE cells. Immunofluorescent studies confirm that the α4 subunit is expressed in vitro by RPE cells, a result that has been validated by immunofluorescence and FACS analyses. The accumulation of the α4 integrin at cell-cell junctions in post-confluent RPE cell cultures negatively correlated with the level of expression of the mRNA transcript. Accordingly, transient transfection analyses reveal that the α4 promoter activity is considerably reduced when RPE cells form a confluent monolayer. Moreover, transfection of recombinant constructs bearing 5’-deletions of the α4 promoter segment allows the localization of strong negative regulatory elements on the -76 to -300 region of the α4 gene suggesting that its expression is intimately linked to the proliferative state of primary cultured RPE cells.

关键词： Retinal Pigment Epithelium Integrin Alpha 4 Subunit Cell Culture Confluency Promoter

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Hospital Hygiene Maternity Hospital Public Lubumbashi Democratic Republic of Congo

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Open Journal of Preventive Medicine 2017年第4期7卷 74-85页

作者： Kaj Francoise Malonga Hendrick Lukuke Mbutshu jean-Jacques Lunda Ngandu Mukengeshayi Abel Ntambue michel Makoutode School of Public Health University of LubumbashiLubumbashiDR Congo Regional Institute of Public Health OuidahBenin Republic

Introduction: Public hospitals in the DRC are of significant disrepair, while there is a strong link between the failure of hospital hygiene and the incidence of nosocomial infections. We have conducted a study with the objective of evaluating the structural-functional conditions of hospital hygiene maternity wards of public hospitals in Lubumbashi. Methodology: It was a descriptive cross-sectional study and structural-functionalist whose population consisted of nurses responsible for 7 of 12 maternity hospitals which were selected based on the inclusion criteria. The observation with an observation guide and maintenance using a questionnaire we used to collect data. Results: The results showed that hospital hygiene conditions in maternity wards of public hospitals in Lubumbashi are not good because almost all maternity services and surgery are not always water in the taps (14.3%). The bins were a means for care units, no coding system exists to distinguish the type of waste. The medical waste are mixed and the other waste are burned in the open or in makeshift incinerator with other types of waste. Conclusion: These maternity wards have poor hygiene, staff responsible for this sector did not follow any training in this area. There is need to regulate the sector and train them.

关键词： Hospital Hygiene Maternity Hospital Waste Management

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Comparison of alternative arterial anastomosis site during liver transplantation when the recipient’s hepatic artery is unusable

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Hepatobiliary Surgery and Nutrition 2022年第1期11卷 1-12页

作者： jean Marie Beaurepaire Francesco Orlando Giovanni Battista Levi Sandri Caroline Jezequel Edouard Bardou-Jacquet Christophe Camus Mohamed Lakehal Veronique Desfourneaux Aude Merdrignac Elodie Gaignard Alexandre Thobie Damien Bergeat Bernard Meunier michel Rayar CHU Rennes Service de Chirurgie Hépatobiliaire et DigestiveRennesFrance UniversitéRennes 1 Facultéde MédecineRennesFrance CHU Rennes Service des Maladies du FoieRennesFrance INSERM CIC 1414RennesFrance CHU Rennes Service de Maladies Infectieuses et Réanimation MédicaleRennesFrance

Background:Few studies have analyzed outcomes of liver transplantation(LT)when the recipient hepatic artery(HA)was not ***:We retrospectively evaluated the outcomes of LT performed using the different alternative sites to ***:Between 2002 and 2017,1,677 LT were performed in our institution among which 141(8.4%)with unusable recipient HA were *** groups were defined according to the site of anastomosis:the splenic artery(SA group,n=26),coeliac trunk(CT group,n=12),aorta using or not the donor’s vessel(Ao group,n=91)and aorta using a vascular prosthesis(Ao-P group,n=12)as *** median number of intraoperative red blood cell transfusions was significantly increased in the Ao and Ao-P groups(5,5,8.5 and 16 for SA,CT,Ao and Ao-P group respectively,P=0.002),as well as fresh frozen plasma(4.5,2.5,10,17 for the SA,CT,Ao and Ao-P groups respectively,P=0.001).Hospitalization duration was also significantly increased in the Ao and Ao-P groups(15,16,24,26.5 days for the SA,CT,Ao and Ao-P groups respectively,P<0.001).The occurrence of early allograft dysfunction(EAD)(P=0.07)or arterial complications(P=0.26)was not statistically *** of factor V,INR,bilirubin and creatinine during the 7th postoperative days(POD)was significantly improved in the SA *** difference was observed regarding graft(P=0.18)and patient(P=0.16)***:In case of unusable HA,intraoperative and postoperative outcomes are improved when using the SA or CT compared to aorta.

关键词： Liver transplantation(LT) hepatic artery(HA) arterial anastomosis splenic artery(SA)

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Technological Impact on the Quality of Palm Oil from Burundi: Elaeis guineensis, Variety of Dura and Tenera

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Food and Nutrition Sciences 2024年第8期15卷 759-769页

作者： Severin Sindayikengera jean Felix Karikurubu Josiane Manirakiza Dévote Ndayikengurukiye michel Baseka Prudent Nsabiyumva Jonathan Niyukuri Department of Food Science and Technology Faculty of Agronomy and Bioengineering University of Burundi Bujumbura Burundi Food Science and Technology Research Center-CRSTA University of Burundi Bujumbura Burundi Burundi Bureau of Standards and Quality Control (BBN) Bujumbura Burundi Department of Health and Animal Productions Faculty of Agronomy and Bioengineering University of Burundi Bujumbura Burundi Research Centre for Animal Plant and Environmental Sciences-CRAVE University of Burundi Bujumbura Burundi

The objective of this study is to determine the factors responsible for the acidification of Burundi palm oils. The investigation of the duration of fermentation of palm fruits performed among artisanal producers found that more than 89% of producers from commune of Rumonge ferment for more than 5 days while more than 61% of those from commune of Mutimbuzi ferment for 4 days. The determination of acid value using the method of ISO 660:2009 showed that Dura and Tenera varieties fermented for 4 days had respectively 5.9 ± 2.3 and 5.8 ± 1.8 mg of KOH/g of oil for clustered fruits, 7.03 ± 3.4 and 7.02 ± 3.2 mg of KOH/g for destemmed fruits. After 8 days, the acid values of Dura and Tenera varieties obtained were respectively 10.9 ± 4.7 and 12.5 ± 5.4 mg KOH/g for clustered fruits, 12.5 ± 5.4 and 12.5 ± 4.1 mg KOH/g for destemmed fruits. No significant difference was recorded between varieties. On the other hand, a highly significant difference at p < 0.05 was obtained between fruits fermented in the open air (e.g. around the foot of the oil palm, FFOA), in a shed when the fruits were not covered (SFNC) and in a shed when the fruits were covered by branches or straw (SFC). At 8 days of fermentation, the acid values of FFOA, SFNC and SFC were 9.1 ± 0.7 < 12.6 ± 0.8 < 17.7 ± 1.4 for destemmed fruit and 9.1 ± 0.7 < 13.2 ± 1.3 < 13.2 ± 3.2 for clustered fruit, respectively. In light of these results, the acidity of Rumonge palm oil is probably due to the long fermentation time and the technique of covering the fruits during fermentation. These results will allow producers to extract good quality oil and consequently improve the health of consumers.

关键词： Burundi Dura Tenera Acid Value Oil Palm

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静止的时光威尼斯安缦大运河酒店

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室内设计与装修 2015年第10期 118-123页

作者： jean-michel Gathy viola

威尼斯安缦大运河酒店（AMAN CANAL GRANDE VENJCE）是座拥有两个金色方形尖塔的古老建筑，恢弘大气，是难得一见的建筑精品。它由两栋相邻的五层建筑组成，其中的帕帕多波利宫（Palazzo Papadopoli）始建于16世纪，在19世纪时由富豪Ald... 详细信息

威尼斯安缦大运河酒店（AMAN CANAL GRANDE VENJCE）是座拥有两个金色方形尖塔的古老建筑，恢弘大气，是难得一见的建筑精品。它由两栋相邻的五层建筑组成，其中的帕帕多波利宫（Palazzo Papadopoli）始建于16世纪，在19世纪时由富豪Aldobrandini兄弟买下重新装饰，并增建了当时并不常见的私人花园，时至今日，两者皆镀上了岁月的隽永光泽。

关键词：大运河威尼斯酒店静止 GRANDE 古老建筑建筑精品装饰

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"激光组装线"与"兆焦耳激光器"的发展前景与进展

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激光与光电子学进展 2005年第4期42卷 7-9,6页

作者： Claude Carallier No■l Fleurot Lonjaret T jean-michel Di-Nicola 罗山法国原子能委员会军事应用局法国原子能委员会/军事应用局阿基坦科技研究中心

法国原于能委员会渡尔多市阿基坦科技研究中心(CESTA)实验室建造的"兆焦耳激光器"(LMJ)是一个240束的激光装置,它是珐国原子能委员会"模拟计划"(相当于美国的核武器"存贮与管理计划")的基石。

关键词：兆焦耳激光器发展前景法国原子能委员会组装线激光装置研究中心管理计划实验室波尔多核武器

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High-performance waveguide-integrated germanium PIN photodiodes for optical communication applications[Invited]

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Photonics Research 2013年第3期1卷 140-147页

作者： Léopold Virot Laurent Vivien jean-Marc Fédéli Yann Bogumilowicz jean-michel Hartmann Frédéric Bœuf Paul Crozat Delphine Marris-Morini Eric Cassan Institut d’Electronique Fondamentale(IEF) Univ.Paris-SudCNRSBât 220F-91405 OrsayFrance CEA LETIMinatec Campus17 rue des MartyrsF-38054 GrenobleFrance STMicroelectronics Silicon Technology DevelopmentCrollesFrance

This paper reports on high-performance waveguide-integrated germanium photodiodes for optical communications applications.200 mm wafers and production tools were used to fabricate the *** over 97%were obtained for three different compact photodiodes(10×10μm and intrinsic region width of 0.5,0.7,and 1μm)within the same batch of three *** photodiodes exhibit low dark currents under reverse bias with median values of 74,62,and 61 nA for intrinsic widths of 0.5,0.7,and 1μm,respectively,over a full *** up to 0.78 A∕W at 1550 nm and zero bias were *** bias operation is possible for 25 and 40 Gbps with receiver sensitivity estimated to−13.9 and−12.3 dBm,respectively.

关键词： waveguide optical communication

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