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A Web-Based Cardiovascular Risk Assessment via Pharmacists: A Feasibility and Validation Study

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Open Journal of Preventive Medicine 2015年第8期5卷 348-358页

作者： Alexandra de Toledo Pascal Bonnabry jean-michel Gaspoz jean-Philippe de Toledo Idris Guessous Division of Primary Care Medicine Department of Community Medicine Primary Care and Emergency Medicine University Hospitals of Geneva Faculty of Medicine University of Geneva Geneva Switzerland PP Pharmacie Principale SA Geneva Switzerland Pharmacy Geneva University Hospitals Geneva Switzerland School of Pharmaceutical Sciences University of Geneva University of Lausanne Geneva Switzerland Community Prevention Unit University Institute of Social and Preventive Medicine Lausanne University Hospital Lausanne Switzerland Department of Epidemiology Rollins School of Public Health Emory University Atlanta USA

Background: Involving pharmacists in clinical care could improve the identification of subjects at risk for cardiovascular (CV) disease. Data on web-based approach involving pharmacists for CV disease risk assessment are very limited. Methods: We first developed a web-based CV risk assessment tool to be used by pharmacists that includes demographic, lifestyle, biological and anthropometric information. Biological and anthropometric data were collected in independent laboratories. We then assessed the feasibility and validity of this approach by inviting adults who previously (within 6 months) participated in a Swiss standardized population-based study to fill out the web-based platform. Attrition rates and correlations were used to assess the feasibility and validity, respectively. Proportions were expressed as percentages and continuous variables were expressed as means ± standard deviations (SD). Main Outcomes Measure: Proportions of participants who 1) agreed to participate;2) filled out the questionnaire and had their biological and anthropometric measures taken;3) only filled out the questionnaire;and 4) only had their biological and anthropometric measures taken. Correlations were used to compare continuous variables (body mass index [BMI], waist circumference, systolic blood pressure, fasting blood glucose, total plasma cholesterol, HDL plasma cholesterol, LDL plasma cholesterol, triglycerides) collected via both studies. Results: Overall, 218 (53.2% women) adults of the population-based study were eligible and were contacted to participate, from April to November 2013. Of these, 140 (64.2%) agreed to participate. The majority (67/140, 47.8%) both filled out the questionnaire and had their biological/anthropometric measures taken, whereas only 2.8% and 7.1% only filled out the questionnaire or only had their biological measures taken, respectively. Except for systolic blood pressure, fasting glucose, and triglycerides, the correlations between the measures ob

关键词： Pharmacists Web-Based Cardiovascular Disease Risk Feasibility

Physiological and druggable skipping of immunoglobulin variable exons in plasma cells

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Cellular & Molecular Immunology 2019年第10期16卷 810-819页

作者： Mohamad Omar Ashi Nivine Srour jean-Marie Lambert Anne Marchalot Ophelie Martin Sandrine Le Noir Eric Pinaud Maria Victoria Ayala Christophe Sirac Jerome Sauliere Jerome Moreaux michel Cogne Laurent Delpy Unite Mixte de Recherche Centre National de la Recherche Scientifique 7276 INSERM U1262-Controle de la Reponse Immune B et LymphoproliferationsUniversitede LimogesLimogesFrance Institute of Human Genetics CNRS-UM UMR9002Department of Biological HaematologyCHU MontpellierUniversity of MontpellierUFR MedecineMontpellierFrance Institut Universitaire de France Universitede LimogesLimogesFrance Present address:Lady Davis Institute for Medical Research McGill University3755 Cote Ste-Catherine RoadMontrealQC H3T 1E2Canada

The error-prone V(D)J recombination process generates considerable amounts of nonproductive immunoglobulin(Ig)*** recently demonstrated that aberrant Ig chains lacking variable(V)domains can be produced after nonsense-associated altered splicing(NAS)***,the expression of these truncated Ig polypeptides heightens endoplasmic reticulum stress and shortens plasma cell(PC)*** questions remain regarding the molecular mechanisms underlying this new truncated Ig exclusion(TIE-)checkpoint and its restriction to the ultimate stage of B-cell *** address these issues,we evaluated the extent of NAS of Ig pre-mRNAs using an Ig heavy chain(IgH)knock-in model that allows for uncoupling of V exon skipping from TIE-induced *** found high levels of V exon skipping in PCs compared with B cells,and this skipping was correlated with a biallelic boost in IgH transcription during PC *** analysis further revealed that the skipped V exon turned into a ***,we showed that hypertranscription of Ig genes facilitated V exon skipping upon passive administration of splice-switching antisense oligonucleotides(ASOs).Thus,V exon skipping is coupled to transcription and increases as PC differentiation proceeds,likely explaining the late occurrence of the TIE-checkpoint and opening new avenues for ASO-mediated strategies in PC disorders.

关键词： Immunoglobulin Exon skipping Plasma cells Antisense Oligonucleotides Nonsense-associated altered splicing

Role of radionuclide imaging for diagnosis of device and prosthetic valve infections

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World Journal of Cardiology 2016年第9期8卷 534-546页

作者： jean-Fran?ois Sarrazin Francois Philippon Mikael Trottier michel Tessier Department of Cardiology Institut Universitaire de Cardiologie et Pneumologie de QuébecLaval University Department of Nuclear Medicine Institut Universitaire de Cardiologie et Pneumologie de QuébecLaval University

Cardiovascular implantable electronic device(CIED) infection and prosthetic valve endocarditis(PVE) remain a diagnostic *** imaging plays an important role in the diagnosis and management of patients with CIED infection or *** the past few years,cardiac radionuclide imaging has gained a key role in the diagnosis of these patients,and in assessing the need for surgery,mainly in the most difficult *** ^(18)F-fluorodeoxyglucose positron emission tomography/computed tomography(^(18)F-FDG PET/CT) and radiolabelled white blood cell single-photon emission computed tomography/computed tomography(WBC SPECT/CT) have been studied in these *** their 2015 guidelines for the management of infective endocarditis,the European Society of Cardiology incorporated cardiac nuclear imaging as part of their diagnostic algorithm for PVE,but not CIED infection since the data were judged insufficient at the *** article reviews the actual knowledge and recent studies on the use of ^(18)F-FDG PET/CT and WBC SPECT/CT in the context of CIED infection and PVE,and describes the technical aspects of cardiac radionuclide *** also discusses their accepted and potential indications for the diagnosis and management of CIED infection and PVE,the limitations of these tests,and potential areas of future research.

关键词： Device Endocarditis Fluorodeoxyglucose Imaging Infection Leukocytes Positron emission tomography/computed tomography Prosthetic valve Radionuclide Scintigraphy

Donation after cardio-circulatory death liver transplantation

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World Journal of Gastroenterology 2012年第33期18卷 4491-4506页

作者： Hieu Le Dinh Arnaud de Roover Abdour Kaba Séverine Lauwick jean Joris jean Delwaide Pierre Honoré michel Meurisse Olivier Detry Department of Abdominal Surgery and Transplantation University Hospital of Liège University of Liège 4000 Liège Belgium Department of Anesthesia and Intensive Care Medicine University Hospital of Liège University of Liège 4000 Liège Belgium Department of Hepatology and Gastroenterol-ogy University Hospital of Liège University of Liège 4000 Liège Belgium

The renewed interest in donation after cardio-circulatory death (DCD) started in the 1990s following the limited success of the transplant community to expand the donation after brain-death (DBD) organ supply and following the request of potential DCD families. Since then, DCD organ procurement and transplantation activities have rapidly expanded, particularly for nonvital organs, like kidneys. In liver transplantation (LT), DCD donors are a valuable organ source that helps to decrease the mortality rate on the waiting lists and to increase the availability of organs for transplantation despite a higher risk of early graft dysfunction, more frequent vascular and ischemia-type biliary lesions, higher rates of re-listing and re-transplantation and lower graft survival, which are obviously due to theinevitable warm ischemia occurring during the declaration of death and organ retrieval process. Experimental strategies intervening in both donors and recipients at different phases of the transplantation process have focused on the attenuation of ischemia-reperfusion injury and already gained encouraging results, and some of them have found their way from pre-clinical success into clinical reality. The future of DCD-LT is promising. Concerted efforts should concentrate on the identification of suitable donors (probably Maastricht category Ⅲ DCD donors), better donor and recipient matching (high risk donors to low risk recipients), use of advanced organ preservation techniques (oxygenated hypothermic machine perfusion, normothermic machine perfusion, venous systemic oxygen persufflation), and pharmacological modulation (probably a multi-factorial biologic modulation strategy) so that DCD liver allografts could be safely utilized and attain equivalent results as DBD-LT.

关键词： Non-heart-beating donation Complication Bile duct Allocation Ischemia Ischemia-reperfusion injury Liver disease

TRANSCATHETER CLOSURE OF LARGE SECUNDUM ATRIAL SEPTAL DEFECTS WITH AMPLATZER~ SEPTAL OCCLUDER

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Medical Bulletin of Shanghai Jiaotong University 2010年第1期22卷 40-46页

作者：杨震坤 Aubry Pierre Eric Brochet jean-michel Juliard Department of Cardiology Bichat-Claude Bernard HospitalAP-HP46 rue Henri Huchard Department of Cardiology Ruijin HospitalSchool of MedicineShanghai Jiaotong University

Objective To evaluate the safety and feasibility of transcatheter closure of large secundum atrial septal defects(ASDs)with Amplatzer~ septal occluder(ASO).Methods A total of 26 patients(age 16 to 67 years,median 43 years;body weight 52 to 102 kg,median 67 kg)with large ASDs underwent an attempted transcatheter closure using *** ASD was defined as those with a balloon-stretched diameter of ≥30 *** 81 patients with small-to-moderate ASD during same period who underwent closure served as *** In patients with large ASDs,the ASD dimension means were(22.1±3.2)mm(range from 16 to 30 mm)and(23.8±2.6)mm(range from 18 to 31mm)assessed by transesophageal echocardiography(TEE)and transthoracic echocardiography(TTE),*** mean balloon-stretched diameter of the ASD was(31.9±2.1)mm(range from 30 to 37mm).The size of device was(32.0±1.9)mm(range from 30 to 36mm).The transcatheter procedure was successful in all patients(100%).Seventeen deployments were performed using the conventional left atrium approach,and remaining 9 patients required the right upper pulmonary vein *** after deployment,TEE revealed that complete closure rate was 73%.Procedure-related complications were recorded in 3 patients(12%),including device embolization in one patient,pericardial effusion in one patient,and large hematoma at puncture site in one *** follow-up,the complete closure rate increased to 88% at 24h after procedure and 100% at 6 *** procedural success rates,immediate TEE results and TTE results at 24h and 6 months after procedure,were not significantly different between patients with large ASDs and those with small-to-moderate *** Transcatheter closure of large ASDs using ASO is technical feasible and relatively *** care selection and specific technique modification such as the right upper pulmonary vein approach is vital for the implantation success.

关键词： atrial septal defect transcatheter closure Amplatzer septal occluder

Health and sanitary status in 1970 of Tubu nomads dwelling in Northeastern Niger

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Journal of Medical Colleges of PLA(China) 2014年第3期29卷 150-161页

作者： jean-Franois Magnaval Christian Oosterbosch michel Mandl MABN group Department of Medical Parasitology Faculty of Medicine-Purpan Toulouse France CNRS UMR 5288 Paul-Sabatier University Toulouse France Les Nouveaux Généralistes Liège Belgium Lieutenant-General (retired) Belgian Air Force Leefdaal Belgium Mission Anthropologique Belge au Niger

Background: The Tubu are nomadic people who live in remote parts of the central Sahara, primarily in the Tibesti massif(Chad), and in both Northeastern Niger and Southern Libya. All of these areas are close to become conflict zones. However, no data about the Tubu's health and sanitary status are currently available, which would be of major concern if humanitarian interventions would become ***: In 1970, the "Mission Anthropologique Belge au Niger"(MABN) investigated a Tubu tribe named Broaya that lived at Seguedine and Djado on the northeastern rim of the Tenere desert. One hundred fifty-one adult volunteers answered an oral questionnaire and underwent a medical examination, followed by the collection of blood thin films and samples of urine and stool. The environmental fauna of medical importance was also ***: Albeit 43 year-old, these results have not been previously published. The estimated age of death for fathers was approximately 56 years, and that for mothers was 60 years. On average, each married woman had had 4.7 children. The overall perinatal mortality rate was 232 ‰, the overall infant mortality rate was 153 ‰, and the overall child mortality rate was 99 ‰. The mean height was 164.1 cm and 157.4 cm, the mean weight was 50.1 kg and 47.9kg, and the mean blood pressure was 131/78 mm Hg and 127/75 mm Hg for males and females, respectively. The physical examination found 6 cases of blindness(4.0%). Five subjects presented with an elevated blood pressure(3.3%), and 5(3.3%) displayed an abnormal thoracic auscultation evocative of tuberculosis or of an acute lung infection. The abdominal examination and renal palpation found 5 large masses(3.3%), and 2 subjects had a palpable enlarged spleen(1.3%). The blood thin films were fixed in methanol and subsequently examined in Toulouse. The search for blood parasites was negative. The urine samples were centrifuged and then microscopically examined in the field. No blood-fluke eggs were found.

关键词： Saharan nomadic tribes Tubu people Health status Sahara Niger Djado Seguedine Mission anthropologique belge au niger

Dynamics Study of the Deformation of Red Blood Cell by Optical Tweezers

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Open Journal of Biophysics 2017年第2期7卷 59-69页

作者： Konin E. jean michel Yale Pavel Megnassan Eugene michel A. Kouacou Jeremie T. Zoueu Laboratoire d’Instrumentation Image et Spectroscopie UMRI EEA INP-HB Yamoussoukro Cote d’Ivoire Laboratoire de Physique Fondamentale et Appliquée UNA Abidjan Cote d’Ivoire

In recent years, extensive research has been carried out on red blood cells in order to investigate their mechanical properties. The interest in these studies has been possible thanks to the technological innovations made in the field of micro or nano manipulation of biological and non-biological particles without physical contact. In the present project, we have developed a new approach to study the deformation of red blood cells moving against a trapped microbead by applying a sinusoidal voltage (DC offset 3.5 Vpp) to the stage at 0.4 Hz frequencies. The oscillating movement imposed on the stage highlights the indentation test and the tensile test known for the study of mechanical behavior of materials. The mechanical properties found are: the modulus of elasticity (Young Modulus), the shear modulus, the coefficient of hardening and erythrocyte resistance coefficient. The axial shear modulus 25.00 ± 1.5 μN/m and the transversal shear modulus 15.7 ± 4.63 μN/m were compared to those in the literature. These values were respectively determined by Hooke’s law and the Hertz model.

关键词： Optical Tweezers Elasticity Mechanical Properties Tensile Indentation

Acaricidal activity of Derris floribunda essential oil and its main constituent

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Asian Pacific Journal of Tropical Biomedicine 2017年第9期7卷 791-796页

作者： Ana Claudia Fernandes Amaral Aline de SRamos Marcia Reis Pena Jose Luiz Pinto Ferreira jean michel SMenezes Geraldo JNVasconcelos Neliton Marques da Silva Jefferson Rocha de Andrade Silva Lab de Plantas Medicinais e Derivados Depto de Quimica de Produtos NaturaisFarmanguinhosFundacao Oswaldo CruzRio de JaneiroRJBrazil Lab de Entomologia e Acarologia Agricola Faculdade de Ciencias AgrariasUniversidade Federal do AmazonasManausAMBrazil Lab de Cromatografia Depto de QuímicaUniversidade Federal do AmazonasManausAMBrazil 4Instituto de Ciencias Exatas e TecnologiaUniversidade Federal do AmazonasItacoatiaraAMBrazil

Objective: To evaluate the acaricidal activity of the essential oil obtained from roots of Derris floribunda(D. floribunda)(Miq.) Benth, and its main constituent nerolidol against the Mexican mite Tetranychus mexicanus(T. mexicanus)(Mc Gregor).Methods: The essential oil from the roots of D. floribunda collected in the Amazon region(Brazil) was obtained by hydrodistillation. Its chemical composition was determined by GC–MS analysis. The acaricidal activities of this essential oil and nerolidol,were evaluated by recording the number of dead females(mortality) and eggs(fertility).Results: The essential oil showed sesquiterpenes as major volatile components. Nerolidol, the main component, represented 68.5% of the total composition of the essential oil. D. floribunda essential oil and nerolidol showed acaricidal activity, with LC_(50) of9.61 mg/m L air and 9.2 mg/m L air, respectively, over a 72 h period. In addition, both the essential oil and nerolidol significantly reduced the fecundity of T. ***: Due to the economic importance of T. mexicanus and the lack of new pesticides, our data are very promising in the search for efficient and safer acaricidal products. Furthermore, this is the first report about the chemical composition and bioactivity of the essential oil of the Amazon plant species D. floribunda.

关键词： Acaricidal activity Essential oil Nerolidol Organic agriculture Sesquiterpenes Timb

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贝克特与精神分析

外国文学研究 2019年第2期41卷 23-38页

作者：让·米歇尔·瑞贝蒂宾夕法尼亚大学美国艺术和科学院斯洛特基金会

就精神分析而言,贝克特所处的位置与其他现代主义作家相比无疑是独一无二的。这不仅因为他住在伦敦时接受了两年心理治疗,还因为他的著作广泛涉及精神分析,以至于像迪迪埃·安齐厄这样的精神分析学家都认为贝克特的作品以写作来延续拓... 详细信息

就精神分析而言,贝克特所处的位置与其他现代主义作家相比无疑是独一无二的。这不仅因为他住在伦敦时接受了两年心理治疗,还因为他的著作广泛涉及精神分析,以至于像迪迪埃·安齐厄这样的精神分析学家都认为贝克特的作品以写作来延续拓宽了精神分析领域。首先,本文通过回顾贝克特的日记来了解有关他的治疗情况,探讨心理治疗师W. R.贝恩对他的持续影响力。接着,本文着重分析早期(因笛卡尔)与弗洛伊德的接触如何奠定了他与精神分析如此之深的关系,厘清他的治疗对其后期的一些作品所产生的影响。最后,本文试图阐明贝克特整体的哲学证明他一直在与弗洛伊德的无意识理论进行抗争。

关键词：塞缪尔·贝克特精神分析无意识幻想思考真理