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妊娠早期丙泊酚麻醉诱导和苏醒时的预测效应室靶浓度

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麻醉与镇痛 2012年第1期8卷 34-39页

作者： Nicolas Mongardon, md Frederique Servin, md, PhD Mathilde Perrin, md Ennoufous Bedairia, md Sylvie Retout, PhD Chadi Yazbeck, md, PhD Philippe Faucher, md Philippe Montravers, md, PhD jean-marie desmonts, md jean Guglielminotti, md 谢珺田（译） Departement d＇Anesthesie et de Reanimation Chirurgicale Departementd＇Epidemiologie Biostatistique et Recherche Clinique Service de Gynecologie et d＇Obstetrique Assistance Publique-Hopitaux de Paris Hopital Bichat-Claude Bernard Paris France

背景妊娠时孕妇对镇静药的需要量减少，据称与孕酮有关。然而，妊娠和孕酮对丙泊酚的需要量产生怎样的影响，至今没有人彻底的研究过。本研究的目的是确定在妊娠早期，麻醉诱导意识消失期间和麻醉苏醒睁眼时所用丙泊酚的剂量和预测效应... 详细信息

背景妊娠时孕妇对镇静药的需要量减少，据称与孕酮有关。然而，妊娠和孕酮对丙泊酚的需要量产生怎样的影响，至今没有人彻底的研究过。本研究的目的是确定在妊娠早期，麻醉诱导意识消失期间和麻醉苏醒睁眼时所用丙泊酚的剂量和预测效应室靶浓度是否减低。同时观察血孕酮的含量与使意识消失时丙泊酚剂量和效应室靶浓度有无相关性。方法我们研究了57例ASA1-2级拟行终止妊娠的患者和55例行经阴道卵泡穿刺体外受精的对照患者。浓度为1％的丙泊酚以200ml／min的输注速度实施麻醉。记录在诱导时意识丧失过程中所用丙泊酚的剂量和预测效应室靶浓度（Schnider模型）。同时预测在麻醉苏醒睁眼时的效应室靶浓度。血孕酮的量在手术结束时测定。结果在意识消失时，妊娠患者较非妊娠患者所用丙泊酚剂量的平均值（±1个标准差）显著减少（分别为108．57±20．04mg和117．59±17．98mg，P=0．014）。与之相似，意识消失时预计的丙泊酚效应室靶浓度在妊娠患者有显著的降低。在麻醉苏醒睁眼时丙泊酚的预计靶浓度没有差别。没有观察到血孕酮水平与意识消失时丙泊酚的剂量和效应室靶浓度的相关性。结论早期妊娠时使意识消失的丙泊酚的剂量和预计的效应室靶浓度减低。孕酮并不能解释这一结果。

关键词：效应室靶浓度妊娠早期麻醉诱导丙泊酚预测经阴道卵泡穿刺意识消失麻醉苏醒

Spinal cord injury reprograms muscle fibroadipogenic progenitors to form heterotopic bones within muscles

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Bone Research 2022年第2期10卷 310-325页

作者： Hsu-Wen Tseng Dorothée Girard Kylie A.Alexander Susan M.Millard Frédéric Torossian Adrienne Anginot Whitney Fleming Jules Gueguen marie-Emmanuelle Goriot Denis Clay Beulah Jose Bianca Nowlan Allison R.Pettit Marjorie Salga François Genêt marie-Caroline Le Bousse-Kerdilès Sébastien Banzet jean-Pierre Lévesque Mater Research Institute-The University of Queensland WoolloongabbaQLDAustralia Institut de Recherche Biomédicale des Armées(IRBA) INSERM UMRS-MD1197 ClamartFrance INSERM UMRS-md 1197 Universitéde Paris-SaclayHôpital Paul BrousseVillejuifFrance INSERM UMS-44 Universitéde Paris-SaclayHôpital Paul BrousseVillejuifFrance UPOH(UnitéPéri Opératoire du Handicap Perioperative Disability Unit)Physical and Rehabilitation Medicine departmentRaymond-PoincaréHospitalAssistance Publique-Hôpitaux de Paris(AP-HP)GarchesFrance Universitéde Versailles Saint Quentin en Yvelines UFR Simone Veil-SantéEND:ICAP INSERM U1179Montigny le BretonneuxFrance

The cells of origin of neurogenic heterotopic ossifications(NHOs), which develop frequently in the periarticular muscles following spinal cord injuries(SCIs) and traumatic brain injuries, remain unclear because skeletal muscle harbors two progenitor cell populations: satellite cells(SCs), which are myogenic, and fibroadipogenic progenitors(FAPs), which are mesenchymal. Lineage-tracing experiments using the Cre recombinase/Lox P system were performed in two mouse strains with the fluorescent protein Zs Green specifically expressed in either SCs or FAPs in skeletal muscles under the control of the Pax7 or Prrx1 gene promoter, respectively. These experiments demonstrate that following muscle injury, SCI causes the upregulation of PDGFRα expression on FAPs but not SCs and the failure of SCs to regenerate myofibers in the injured muscle, with reduced apoptosis and continued proliferation of muscle resident FAPs enabling their osteogenic differentiation into NHOs. No cells expressing Zs Green under the Prrx1 promoter were detected in the blood after injury, suggesting that the cells of origin of NHOs are locally derived from the injured muscle. We validated these findings using human NHO biopsies. PDGFRα+mesenchymal cells isolated from the muscle surrounding NHO biopsies could develop ectopic human bones when transplanted into immunocompromised mice, whereas CD56+myogenic cells had a much lower potential. Therefore, NHO is a pathology of the injured muscle in which SCI reprograms FAPs to undergo uncontrolled proliferation and differentiation into osteoblasts.

关键词： progenitor injuries muscles

Population Dynamics Approach for the Study of Synergetic Coupling between Antibiotic and Helper Compounds

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Computational Molecular Bioscience 2012年第1期2卷 1-6页

作者： Christian T.Veje Morten Willatzen Oliver Hendricks jean-marie Pagès Jette Kristiansen Mads Clausen Institute University of Southern DenmarkSonderborgDenmark Department of Research King Christian X’s Rheumatism HospitalUniversity of Southern DenmarkOdenseDenmark Aix-Marseille University UMR-MD-1IRBAMarseilleFrance Institute of Physics and Chemistry University of Southern DenmarkDenmark

Non-antibiotics affect bacterial susceptibility towards antibiotics in a multifactorial manner, including perturbation of membrane energetic and a possibly direct interaction with drug efflux transporters themselves. Thus, efflux inhibiting compounds affect susceptibilities to antibiotics that act either intracellular or at the bacterial wall. Therefore they may be applied as helper compounds to conventional antibiotic treatments. A valid definition of the effect of these compounds is crucial. Conventional microbiological quotations such as checkerboard or MIC definition do not discriminate the complexity of a system where several compounds interact with several targets both on the bacterial membrane and soma. We presume the fact, that certain resistance mechanisms, such as efflux, are neither adequately nor precisely monitored, utilizing the established microbiologic screening tools, such as agar- or microdilution techniques. In this context this paper may contribute as an innovative step, utilizing mathematic modeling in order to describe interactions on the surface of microorganisms. Thus, mathematical modeling might be a tool which can be adopted to optimize the description of certain forms of bacterial resistance, as well as the influence of antibacterial drugs on such targets which interact with bacterial outer-membrane transport mechanisms. This paper presents modeling of bacterial population dynamics as an attempt to precise complex compound target interaction. Furthermore, the importance of a synergetic coupling term in the model is exemplified by comparison with experimental data of Kumar et al. [1]. A specific procedure for extraction of model coefficients is devised for further experimental studies of the coupling between an antibiotics and a helper compound. In particular, it is found that the scarce experimental data of Kumar et al. [1] can be fitted to the mathematical model demonstrating synergetic effects of non-antibiotics.

关键词： Reversal of Resistance Non-Antibiotic Mathematical Model

血管性血友病患儿行颅缝早闭成型术的围手术期管理：不同寻常的关注目标

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麻醉与镇痛 2010年第5期6卷 69-73页

作者： Isabelle Maquoi, md Vincent Bonhomme, md, PhD Jacques Daniel Born,md,PhD marie-Frangoise Dresse, md, PhD Elisabeth Ronge-Collard,md jean-Marc Minon, md, PhD Pol Hans, md, PhD 蒋金娣(译) 钱燕宁(校) University Department of Anesthesia and ICM Department of Neurosurgery University Departmentof Pediatrics Liege Hemophilia Treatment Cente~ Department of Laboratory Medicine Hemostasis and Thrombosis Unit CHR Citadelle Liege Belgium 不详

我们报告一例在手术前评估时诊断为重型I型血管性血友病并用VII因子浓缩剂和瑞斯托霉素辅因子治疗的患儿，成功行颅缝早闭成形术的管理经验。麻醉医师、神经外科医师、临床病理医师和小儿血液科医师的合作是成功的关键。

关键词：血管性血友病颅缝早闭围手术期管理患儿成型术神经外科医师麻醉医师瑞斯托霉素

Microscopic enteritis:Bucharest consensus

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World Journal of Gastroenterology 2015年第9期21卷 2593-2604页

作者： Kamran Rostami David Aldulaimi Geoffrey Holmes Matt W Johnson marie Robert Amitabh Srivastava jean-Francois Fléjou David S Sanders Umberto Volta Mohammad H Derakhshan James J Going Gabriel Becheanu Carlo Catassi Mihai Danciu Luke Materacki Kamran Ghafarzadegan Sauid Ishaq Mohammad Rostami-Nejad A Salvador Pe?a Gabrio Bassotti Michael N Marsh Vincenzo Villanacci Department of Gastroenterology Alexandra HospitalWorcestershire B98 7UBUnited Kingdom Department of Gastroenterology Royal Derby HospitalDerby DE22 3NEUnited Kingdom Gastroenterology Unit Luton Dunstable University FT Hospital LU4 0DZUnited Kingdom Department of Pathology and Medicine Yale University School of MedicineNew HavenCT 06520United States Department of Pathology Staff PathologistBrigham and Women’s HospitalHarvard Medical School BostonBostonMA 02115United Sates Department of Pathology Serviced’Anatomie PathologiqueHopital Saint-AntoineAP-HPUniversité Pierre et Marie Curie75005 ParisFrance Department of Gastroenterology University of SheffieldSouth Yorkshire S10 2TNUnited Kingdom Department of Gastroenterology Department of Medical and Surgical SciencesUniversity of Bologna40126 BolognaItaly Section of Gastroenterology Institute of Cardiovascular and Medical SciencesUniversity of GlasgowGlasgow G12 8QQUnited Kingdom Department of Pathology Southern General HospitalLanarkshire G51 4TFUnited Kindom Department of Pathology Carol Davila Univerity of Medicine and PharmacyBucharest 050474Romania Università Politecnica delle Marche AnconaItalyPresidente Società Italiana di GastroenterologiaEpatologia e Nutrizione PediatricaCo-DirectorCenter For Celiac Research University of Maryland School of Medicine BaltimoreMD 21201United States Grigore T Popa" University of Medicine and Pharmacy Iasi 747800Romania Laboratory Department Mashad Razavi HospitalKhorasan Razavi ***Iran Dudley group of Hospitals Birmingham City UniversityBirmingham B42 2SUUnited Kindom Gastroenterology and Liver Diseases Research Institute Shahid Beheshti University of Medical SciencesTehran ***Iran Laboratory of Immunogenetics Department of Medical Microbiology and Infection ControlVrije Universiteit medical centre (VUmc)1081 HZ AmsterdamThe Netherlands Gastroenterology Section Department of MedicineUniversity of Perugia Medical School06100 PerugiaItaly Wolfson College University of OxfordOxford

Microscopic enteritis(ME) is an inflammatory condition of the small bowel that leads to gastrointestinal symptoms,nutrient and micronutrient *** is characterised by microscopic or sub-microscopic abnormalities such as microvillus changes and enterocytic alterations in the absence of definite macroscopic changes using standard modern *** work recognises a need to characterize disorders with microscopic and submicroscopic features,currently regarded as functional or non-specific entities,to obtain further understanding of their clinical *** consensus working party reviewed statements about the aetiology,diagnosis and symptoms associated with ME and proposes an algorithm for its investigation and *** the 5th International Course in Digestive Pathology in Bucharest in November 2012,an international group of 21 interested pathologists and gastroenterologists formed a working party with a view to formulating a consensus statement on ME.A five-step agreement scale(from strong agreement to strong disagreement) was used to score 21 statements,*** was strong agreement on all statements about ME histology(95%-100%).Statements concerning diagnosis achieved 85% to 100% agreement.A statement on the management of ME elicited agreement from the lowest rate(60%) up to 100%.The remaining two categories showed general agreement between experts on clinical presentation(75%-95%) and pathogenesis(80%-90%) of *** was strong agreement on the histological definition of *** agreement on management indicates a need for further investigations,better definitions and clinical trials to produce quality guidelines for *** ME consensus is a step toward greater recognition of a significant entity affecting symptomatic patients previously labelled as non-specific or functional enteropathy.

关键词： Microscopic enteritis Enteropathy Gluten Malabsorption Non-celiac gluten Bucharest consensus