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Very high conservation between Cyp6a2 from Drosophila melanogaster and its ortholog Cyp6a26 from D. simulans

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Insect Science 2007年第1期14卷 15-27页

作者： SOPHIE TARES LAURY ARTHAUD ALEXANDRA BRUN-BARALE DIDIER CROCHARD jean-marc BRIDE marcEL AMICHOT Institut National de la Recherche Agronomique UMR ROSE 1112 Sophia-Antipolis France

Although Drosophila simulans is closely related to D. melanogaster, very few cytochrome P450 genes have been studied in this species until now. As Cyp6a2 from D. melanogaster is a major gene implicated in the detoxification of xenobiotic molecules, we decided to look for its ortholog in D. simulans. The isolated gene, Cyp6a26, presents structural characteristics very similar to those of Cyp6a2： an identical size of 1590-bp comprising two exons separated by a 69-bp intron and a nucleotide sequence homology of 95%. Many putative transcriptionally important motifs were identified in the upstream DNAs of the two genes but only 16 elements are in common positions. Treatment of flies with phenobarbital leads to an increased production of Cyp6a26 mRNAs. The expression of Cyp6a26 mRNAs varies following developmental stages in the same manner as Cyp6a2. Immunohistochemistry experiments of phenobarbital-treated adult drosophila show that the spatial expression pattern of the two proteins is also conserved between the two species. All these data argue in favor of the conservation of the function of these homologous genes between the two Drosophila species.

关键词： cytochrome P450 Drosophila ortholog mRNA expression promotor

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锆基非晶合金的动态弛豫机制和高温流变行为

力学学报 2020年第2期52卷 360-368页

作者：郝奇乔吉超 jean-marc Pelletier 西北工业大学力学与土木建筑学院西安710072 INSA-Lyon MATEIS UMR5510F-69621 VilleurbanneFrance

非晶合金的动态弛豫机制对于理解其塑性变形,玻璃转变行为,扩散机制以及晶化行为都至关重要.非晶合金的力学性能与动态弛豫机制的本征关联是该领域当前重要科学问题之一.本文借助于动态力学分析(DMA),探索了Zr50Cu40Al10块体非晶合金从... 详细信息

非晶合金的动态弛豫机制对于理解其塑性变形,玻璃转变行为,扩散机制以及晶化行为都至关重要.非晶合金的力学性能与动态弛豫机制的本征关联是该领域当前重要科学问题之一.本文借助于动态力学分析(DMA),探索了Zr50Cu40Al10块体非晶合金从室温到过冷液相区宽温度范围内的动态力学行为.通过单轴拉伸实验,研究了玻璃转变温度附近的高温流变行为.基于准点缺陷理论(quasi-point defects theory),对两种力学行为的适用性以及宏观力学行为变化过程中微观结构的演化规律进行描述.研究结果表明,准点缺陷理论可以很好地描述非晶合金损耗模量α弛豫的主曲线.基于非晶合金的内耗行为,玻璃转变温度以下原子运动的激活能Uβ为0.63 eV.与准点缺陷浓度对应的关联因子χ在玻璃转变温度以下约为0.38,而在玻璃转变温度以上则线性增大.Zr50Cu40Al10块体非晶合金在玻璃转变温度附近,随温度和应变速率的不同而在拉伸实验中显示出均匀的或不均匀的流变行为.非晶合金的高温流变行为不仅可以通过扩展指数函数和自由体积理论来描述,还可以通过基于微剪切畴(shear micro-domains,SMDs)的准点缺陷理论来描述.

关键词：非晶合金动态力学分析高温拉伸结构弛豫准点缺陷理论

Compact Z-pinch radiation source dedicated to broadband absorption measurements

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Matter and Radiation at Extremes 2016年第3期1卷 179-186页

作者： Dunpin Hong Herve Rabat Erwan Le Menn Clement Zaepffel jean-marc Bauchire Univ.of Orleans CNRSGREMIUMR 704414 Rue d'IssoudunBP674445067OrleansFrance CNRS LPGUMR 61122 rue de la HoussinereBP 9220844322NantesFrance Onera-The French Aerospace Lab F-91761PalaiseauFrance

In order to acquire a broadband absorption spectrum in a single shot,a compact radiation source was developed by using a Z-pinch type electric *** paper presents the mechanical and electrical construction of the source,as well as its electrical and optical characteristics,including the intense continuum of radiation emitted by the source in the UV and visible spectral *** also shows that the compactness of the source allows direct coupling with the probed medium,enabling broadband absorption measurement in the spectral range of 200e300 nm without use of an optical fiber which strongly attenuates the light in the short wavelength ***,thanks to this source,broadband spectral absorption of NO molecules around 210 nm and that of OH molecules around 310 nm were recorded in this direct coupling *** atom spectral absorption around 325 nm of the peripheral cold zones of an intense transient arc was also recorded.

关键词： Z-pinch Broadband radiation source Broadband absorption spectrum

Assessing School-Based Water, Sanitation and Hygiene (WASH) Facilities in Peri-Urban Settings of Kinshasa, DR Congo

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Open Journal of Epidemiology 2023年第1期13卷 24-45页

作者： jean-Marie Mukiese Nlunda Jöel Nkiama Konde marc Kapenga YambaYamba Guillaume Mbela Kiyombo Department of Environmental Health Kinshasa School of Public Health University of Kinshasa Kinshasa The Democratic Republic of Congo Department of Epidemiology and Biostatistics Kinshasa School of Public Health University of Kinshasa Kinshasa The Democratic Republic of Congo

Background: Kinshasa’s peri-urban settings have a low rate of water access, which has significant consequences for the WASH infrastructures in schools and preventative measures against the spread of waterborne diseases and pathogens. This study aimed to assess the availability, functionality, and gender sensitivity of WASH infrastructures of Kinshasa’s peri-urban schools. Methods: A cross-sectional study was performed in three of the four educational provinces of Kinshasa, targeting 165 peri-urban schools. Data were collected using a questionnaire and an observation grid. Results: An overall proportion of 10.9% of schools possessed a water point, and therefore time-consuming water chores are a necessity in 89.1% of schools. Girl students provided 30% of the labor collecting water during punishments. A total of 98.2% of schools had functional latrines of which 3.6% were found hygienic, associated with water reserve next to the latrines (P = 0.040). Only 2.4% of schools displayed posters raising awareness of latrine hygiene, and 3.6% displayed posters on hand hygiene. The ratios of latrines units for girls were 58:1 for toilets and 115:1 for urinals, justifying open defecation and urination reported in 62.4% of schools. Also, 43% of schools had hand-washing facilities whose functionality was significantly associated with the presence of water points in the school’s inner courtyard (P = 0.032), with water (P P Conclusion: The majority of schools had limited drinking water services, which negatively impact the functionality and gender sensitivity of other WASH provisions. The current evidence as a public health concern would raise government and school authorities’ attention to address these environmental threats.

关键词： Water Access Latrine Hygiene Hand Hygiene Gender Sensitivity Schooled Girl Students

Large endoscopic mucosal resection for colorectal tumors exceeding 4 cm

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World Journal of Gastroenterology 2010年第5期16卷 588-595页

作者： Philippe Ah Soune Charles Ménard Ezzedine Salah Ariadne Desjeux jean-Charles Grimaud marc Barthet Department of Gastroenterology Hpital NordChemin des Bourrely13915 Marseille cedex 20France

AIM:To evaluate the feasibility and the outcome of endoscopic mucosal resection(EMR)for large colorectal tumors exceeding 4 cm(LCRT)undergoing piecemeal resection. METHODS:From January 2005 to April 2008,146 digestive tumors larger than 2 cm were removed with the EMR technique in our *** these,34 tumors were larger than 4 cm and piecemeal resection was carried out on 26 colorectal *** mean age of the patients was 71 *** mean follow-up duration was 12 mo. RESULTS:LCRTs were located in the rectum,left colon,transverse colon and right colon in 58%,15%, 4%and 23%of cases,*** were sessile tumors larger than 4 cm with a mean size of 4.9 cm (4-10 cm).According to the Paris classification,34%of the tumors were typeⅠs,58%typeⅡa,4%typeⅡb and 4%typeⅡ*** examination showed tubulous adenoma in 31%,tubulo-villous adenoma in 27%,villous adenoma in 42%,high-grade dysplasia in38%,in situ carcinoma in 19%of the cases and mucosal carcinoma(m2)in 8%of the *** two cases(7.7%)of procedural bleeding that occurred were managed endoscopically and one small perforation was treated with *** follow-up,recurrence of the tumor occurred in three patients(12%),three of whom received endoscopic treatment. CONCLUSION:EMR for tumors larger than 4 cm is a safe and effective procedure that could compete with endoscopic submucosal dissection,despite providing incomplete histological assessment.

关键词： Endoscopic mucosal resection Perforation Colorectal carcinoma Large polyps

Frey procedure for the treatment of chronic pancreatitis associated with common bile duct stricture

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Hepatobiliary & Pancreatic Diseases International 2013年第6期12卷 637-644页

作者： Lionel Rebibo Thierry Yzet Cyril Cosse Richard Delcenserie Eric Bartoli jean-marc Regimbeau Department of Digestive Surgery Amiens University Medical Center the Jules Verne University of Picardie Department of Radiology Amiens University Medical Center and the Jules Verne University of Picardie Department of Digestive SurgeryAmiens University Medical Center and the Jules Verne University of Picardie Department of Gastroenterology Amiens University Medical Center and the Jules Verne University of Picardie

BACKGROUND:The Frey procedure(FP)is the treatment of choice for symptomatic chronic pancreatitis(CP).In cases of biliary stricture,biliary derivation can be performed by choledochoduodenostomy,Roux-en-Y choledochojejunostomy or,more recently,reinsertion of the common bile duct(CBD)into the resection *** objective of the present study was to evaluate the outcomes associated with each of these three types of biliary ***:We retrospectively analyzed demographic,CPrelated,surgical and follow-up data for patients having undergone FP for CP with biliary derivation between 2004and 2012 in our university medical *** primary efficacy endpoint was the rate of CBD stricture *** secondary endpoints were surgical parameters,postoperative complications,postoperative follow-up and the presence of risk factors for secondary CBD ***:Eighty patients underwent surgery for CP during the study *** these,15 patients received biliary derivation with the *** of the FPs(53.3%)were combined with choledochoduodenostomy,4(26.7%)with choledochojejunostomy and 3(20.0%)with reinsertion of the CBD into the resection *** mean operating time was *** complications(73.3%)were recorded,including one major complication(6.7%)that necessitated radiologicallyguided drainage of an abdominal *** mean(range)length of stay was 17 days(8-28)and the median(range)follow-up time was 35.2 months(7.2-95.4).Two patients presented stricture after CBD reinsertion into the resection cavity;one was treated with radiologically-guided dilatation and the other underwent revisional Roux-en-Y *** patients presented alkaline reflux gastritis(37.5%),one(12.5%)cholangitis and one CBD stricture after FP with *** risk factors for secondary CBD stricture were ***:As part of a biliary derivation,the FP gave good *** did not observe any complications specifically relat

关键词： common bile duct stricture chronic pancreatitis Frey procedure pancreatectomy

Molecular dynamics simulations of initial Pd and PdO nanocluster growth in a magnetron gas aggregation source

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Frontiers of Chemical Science and Engineering 2019年第2期13卷 324-329页

作者： Pascal Brault William Chamorro-Coral Sotheara Chuon Amael Caillard jean-marc Bauchire Stevè Baranton Christophe Coutanceau Erik Neyts GREMI UMR 7344 CNRS Universite d'Orleans45067 Orleans Cedex 2France IC2MP UMR 7285 CNRS Universite de Poitiers86073 Poitiers Cedex 9France Department of Chemistry University of Antwerp2610 AntwerpBelgium

Molecular dynamics simulations are carried out for describing growth of Pd and PdO nanoclusters using the ReaxFF force field. The resulting nanocluster structures are successfully compared to those of nanoclusters experimentally grown in a gas aggregation source. The PdO structure is quasi-crystalline as revealed by high resolution transmission microscope analysis for experimental PdO nanoclusters. The role of the nanocluster temperature in the molecular dynamics simulated growth is highlighted.

关键词： molecular dynamics cluster growth plasma sputtering nanocatalyst

Bartonella species in small mammals and their potential vectors in Asia

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Asian Pacific Journal of Tropical Biomedicine 2014年第10期4卷 757-767页

作者： Tawisa Jiyipong Sathaporn Jittapalapong Serge Morand jean-marc Rolain Research Unit on Infectious and Emerging Tropical Diseases(URMITE).CNRS-IRD-INSERM UMR 7278 IHU Mediterranee InfectionFulty of Medicine and PharmacyAix-Marseille-UniversityMarseilleFrance Center for Agricultural Biotechnology(AG-BIO/PEDRO-CHE) Kasetsart UniversityKamphaeng Saen CampusNakhon Pathom.73140Thailand Center of Excellence ongricultural Biotechnology(AG-BIO/PERDO-CHE) Bangkok 10900Thailand Center of Advanced Studies for Agriculture and Food KU Institute for Advanced Studieskasetsart UniversityBangkok 10900Thailand(CASAFNRU-KUThailand) Department of Parasitology Faculty of Veterinary MedicineKasetsart UniversityBangkokThailand Institut Sciences of Evolution UMR 5554 CNRS-IRD-UM2CC65University de Montpellier 2F-34095MontpellierFrance Walai Rukhavej Btanical Research Institute Mahasarakham UniversityMahasrakhamThailand

In this article,authors review the current knowledge of Bartonella infection in small mammals including rodents,insectivores,bats and exotic small mammal pets and their vectors in *** of Bartonella are Gram-negative intracellular bacteria that infect erythrocytes of various mammalian and non-mammalian animals and mainly transmitted by blood sucking arthropod *** genus Bartonella includes several species of important human diseases with severe clinical *** new Bartonella species were isolated from rodents and other small mammals,and from human patients in *** species are identified using standard polymerase chain reaction amplification and a sequencing targeting two housekeeping genes(glt.A and rpoB) and the internal transcribed spacer *** also discuss the implications in term of potential emerging zoonotic diseases.

关键词： Bartonella Small mammals Rodents Shrews Asia

Biosorption of cadmium(II) and lead(II) ions from aqueous solutions onto dried activated sludge

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Journal of Environmental Sciences 2006年第5期18卷 840-844页

作者： WANG Xue-jiang XIA Si-qing CHEN Ling ZHAO Jian-fu CHOVELON jean-marc NICOLE Jaffrezic-renault State Key Laboratory of Pollution Control and Resources Reuse Yongji University Shanghai 200092 China Application of Chemistry and Environment Laboratory UMR CNRS 5634 University Claude Bernard Lyon I 43 Boulevard du 11 Novemvre 1918Villeurbanne Cedex 69622 France CEGELY UMR/CNRS 5005 Central University of Lyon 69134 Ecully Cedex France

The removal of heavy-metal ions from aqueous solutions by using dried activated sludge has been investigated in batch systems. Effect of solution pH, initial metal ion concentration, and temperature were determined. The results of the kinetic studies showed that the uptake processes of the two metal ions（Cd（Ⅱ） and Pb（Ⅱ）） followed the pseudo-second-order rate expression. The equilibrium data fitted very well to both the Langmuir and Freundlich adsorption models. The FT-IR analysis showed that the main mechanism of Cd（Ⅱ） and Pb（Ⅱ） biosorption onto dried activated sludge was their binding with amide I group.

关键词： biosorption adsorption isotherm cadmium lead activated sludge