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Hepatic complications induced by immunosuppressants and biologics in inflammatory bowel disease

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World Journal of Hepatology 2017年第13期9卷 613-626页

作者： My-Linh Tran-Minh Paula Sousa Marianne Maillet Matthieu Allez jean-marc Gornet Department of Gastroenterology APHPSaint Louis Hospital75010 ParisFrance

The incidence of inflammatory bowel diseases(IBD)is rising *** therapeutic options for IBD are expanding,and the number of drugs with new targets will rapidly increase in coming years.A rapid step-up approach with close monitoring of intestinal inflammation is extensively *** fear of side effects represents one the most limiting factor of their *** a widespread use for years,drug induced liver injury(DILI)management remains a challenging situation with Azathioprine and *** seems less frequent with anti-tumor necrosis factor agents and new biologic *** aim of this review is to report incidence,physiopathology and practical guidelines in case of DILI occurrence with the armamentarium of old and new drugs in the field of IBD.

关键词： Drug induced liver toxicity Inflammatory bowel disease Crohn’s disease Ulcerative colitis

Diagnosis and Management of Patients with Dementia

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国外医学（脑血管疾病分册） 2001年第3期9卷 131-143页

作者： jean－marc Orgogozo From the

Dementia is becoming a major concern worldwide because its prevalence and incidence rise exponentially with increasing age. The prevalence rates double with every 5 years of age, from about 5% (4-12%depending on the studies) in those aged 65 and older to about 40% over 90[1], and up to 58% in those 95 and older[2]. The annual incidence rate of dementia is 2.2% per year over age 65[3]. According to 1996 United Nations projections, the number of individuals ~ed 65 and older in the more developed countries will increase from 169 million (14.2% of the population) to 287 million (24. 7% of the population)[3]. Besides the huge human and social costs, the economic burden of dementia is enormous in countries with a long lifeexpectancy[3], both from direct costs, i.e., those that result in actual monetary expenditures, such as hospital care, physician visits, medications, home health care workers or institutional care and indirect costs, i.e.,those that do not result in actual monetary expenditures, such as time spouses or other caregivers spend helping and caring.

关键词：老年性痴呆病人管理发病率流行病学诊断

High-performance waveguide-integrated germanium PIN photodiodes for optical communication applications[Invited]

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Photonics Research 2013年第3期1卷 140-147页

作者： Léopold Virot Laurent Vivien jean-marc Fédéli Yann Bogumilowicz jean-Michel Hartmann Frédéric Bœuf Paul Crozat Delphine Marris-Morini Eric Cassan Institut d’Electronique Fondamentale(IEF) Univ.Paris-SudCNRSBât 220F-91405 OrsayFrance CEA LETIMinatec Campus17 rue des MartyrsF-38054 GrenobleFrance STMicroelectronics Silicon Technology DevelopmentCrollesFrance

This paper reports on high-performance waveguide-integrated germanium photodiodes for optical communications applications.200 mm wafers and production tools were used to fabricate the *** over 97%were obtained for three different compact photodiodes(10×10μm and intrinsic region width of 0.5,0.7,and 1μm)within the same batch of three *** photodiodes exhibit low dark currents under reverse bias with median values of 74,62,and 61 nA for intrinsic widths of 0.5,0.7,and 1μm,respectively,over a full *** up to 0.78 A∕W at 1550 nm and zero bias were *** bias operation is possible for 25 and 40 Gbps with receiver sensitivity estimated to−13.9 and−12.3 dBm,respectively.

关键词： waveguide optical communication

火花源光发射光谱法分析钢中夹杂物的研究进展——夹杂物成分和尺寸的现象学分析与计算

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冶金分析 2011年第10期31卷 7-13页

作者： Edmund Halász jean-Luc Dorier jean-marc Bhlen 赛默飞世尔科技有限公司

为更好了解与试样电火花烧蚀有关的实验现象,我们设计了一种新算法,并报道了其用于测定夹杂物尺寸的结果。在此算法中,用元素氧化物、硫化物和氮化物测量通道的单火花强度分析技术测定了某一特定类型夹杂物中各元素的浓度,包括铝、钙、... 详细信息

为更好了解与试样电火花烧蚀有关的实验现象,我们设计了一种新算法,并报道了其用于测定夹杂物尺寸的结果。在此算法中,用元素氧化物、硫化物和氮化物测量通道的单火花强度分析技术测定了某一特定类型夹杂物中各元素的浓度,包括铝、钙、镁、锰、钛以及硅等。对每个相关通道,计算了指定类型夹杂物有关的强度峰值对应的强度值之和与所有强度值和之间的比值。在光谱化学分析中,此比值与测试浓度相乘,所得结果为指定类型夹杂物中元素的平均浓度。结合单火花烧蚀质量与夹杂物成分的化学计量学分析,可以估算夹杂物的尺寸。通过进一步的分析可以实现夹杂物尺寸(小、中和大级别)的辨别。本方法的创新性在于,单火花源强度既不需要漂移修正也不需要校正。本算法可以直接用于计算钢中大部分常见夹杂物的平均浓度和尺寸的分析,例如氧化物、硫化物和尖晶石。测定结果显示夹杂物的平均直径在1～10μm之间。

关键词：光发射光谱火花源光发射光谱-脉冲差别分析法非金属夹杂物夹杂物分析夹杂物成分夹杂物尺寸

Effect of serum γ-glutamyltranferase and albumin levels on the response to cardiac resynchronization therapy in the elderly

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Journal of Geriatric Cardiology 2020年第6期17卷 313-320页

作者： Maciej Kubala Alexis Hermida Otilia Buiciuc Pierre-marc Lallemand Geneviève Bertaina Frédéric Anselme Didier Klug Momar Diouf jean-Sylvain Hermida Centre Hospitalier Universitaire AmiensFrance Centre Hospitalier Régional Universitaire RouenFrance Centre Hospitalier Régional Universitaire LilleFrance

Background Several liver function tests have been identified as predictors of hospitalization for heart failure(HF) and death in patients with chronic HF. The relationship between serum γ-glutamyltranferase(GGT) and albumin(SA) levels with the response to cardiac resynchronization therapy(CRT) has not been reliably determined. The aim of the study was to evaluate the impact of liver function tests on the results of CRT in the elderly. Methods Baseline GGT and SA were assessed before CRT device implantation in the elderly(> 70-year-old) patients. The endpoints were:(1) CRT response defined as > 5% left ventricular ejection fraction improvement and no hospitalization for HF or cardiovascular death;(2) hospitalizations;and(3) mortality. Results Eighty of 138(58%) included patients were responders at nine months. Compared to responders, the SA levels were not significantly different(35.1 ± 5.4 vs. 33.6 ± 5.5 g/L, P = 0.103);but the GGT levels, higher(81.6 ± 69.3 vs. 54.7 ± 49.6 U/L, P = 0.013) in non-responders to CRT. GGT level was independently associated with non-response to CRT(P < 0.001, OR = 0.17;95% CI: 0.08–0.38, P < 0.001). GGT cut-off value ≥ 55 U/L was highly predictive of non-response [AUC = 0.65, 64% Sensitivity, 69% Specificity(95% CI: 0.56–0.74)]. GGT ≥ 55 U/L was also associated with higher risk of hospitalization for atrial fibrillation(AF)(95% vs. 83%, P = 0.024). Both SA and GGT had no impact on overall(P = 0.220, P = 0.723) mortality. Conclusions Higher level of GGT is an independent predictor of non-response to CRT in patients over age 70 years and is associated with higher risk of hospitalization for AF. Baseline serum levels of albumin and GGT and have no impact on mortality in elderly patients undergoing CRT.

关键词： Cardiac resynchronization therapy Heart failure Liver enzymes The elderly

Histologically proven hepatic steatosis associates with lower testosterone levels in men with obesity

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Asian Journal of Andrology 2020年第3期22卷 252-257页

作者： Frederique Van de Velde Marlies Bekaert Anne Hoorens Anja Geerts Guy T'Sjoen Tom Fiers jean-marc Kaufman Yves Van Nieuwenhove Bruno Lapauw department of Endocrinology Ghent University Hospital9000 GhentBelgium department of Pathology Ghent University Hospital9000 GhentBelgium Department of Hepathology Ghent University Hospital9000 GhentBelgium Department of Clinical Biology Ghent University Hospital9000 GhentBelgium Department of Gastro-Intestinal Surgery Ghent University Hospital9000 GhentBelgium.

Men with obesity often present with low testosterone(T)and sex hormone-binding globulin(SHBG)*** mechanisms for this have been proposed,but as SHBG is secreted by hepatocytes and sex steroids undergo hepatic metabolization,this study investigates whether severity and histological components of nonalcoholic fatty liver disease(NAFLD)are associated with sex steroid levels in obese *** cross-sectional study included 80 obese men(age:46±11 years;body mass index:42.2±5.5 kg m^-2).Serum levels of total T and estradiol(E.)were measured using liquid chromatography coupled with tandem mass spectroscopy(LC/MS-MS)and SHBG and gonadotropins by *** biopsies were evaluated using ***,and Fibrosis *** with steatohepatitis had similar median(1st quartile-3rd quartile)total T levels(7.6[5.0-11.0]nmol l^-1 vs 8.2[7.2-10.9]nmol l^-1;P=0.147),lower calculated free T(cFT)levels(148.9[122.9-188.8]pmol 1-1 s 199.5[157.3-237.6] pmol l^-1;P=0.006),and higher free E.T ratios(10.0[6.4-13.9]×10^-3 vs 7.1[5.7-10.7]×10^-3;P=0.026)compared to men with only nonalcoholic fatty *** the histological components of *** steatosis was independently associated with total T(r=-0.331.P=0.003)and cFT levels(r=-0.255.P=0.025).Obese men *** have even lower cFT levels compared to those without,an association mainly driven by grade of *** this reflects a subgroup of men with a more severe obesity-related phenotype or results from direct relations between hepatic steatosis and sex steroid metabolism needs further investigation.

关键词： male hypog on adism non alcoholic fatty liver disease obesity sex steroids steatosis testoster one

特质情绪智力与经验丰富的ESL/EFL教师对英语的热爱、对学生和学校的态度、自我报告的课堂实践、课堂愉悦感和创造力之间的关系（英文）

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Chinese Journal of Applied Linguistics 2018年第4期41卷 468-487,552页

作者： jean-marc DEWAELE (英国)伦敦大学伯贝克学院

本文报告了对全局性特质情绪智力及其四要素(幸福感,情绪性,自我情绪管理和社交性)与来自世界各地的513位经验丰富的ESL/EFL老师的定量数据之间的关系,这些定量数据包括他们对英语的热爱、他们对学生和学校的态度、他们自我报告的课堂... 详细信息

本文报告了对全局性特质情绪智力及其四要素(幸福感,情绪性,自我情绪管理和社交性)与来自世界各地的513位经验丰富的ESL/EFL老师的定量数据之间的关系,这些定量数据包括他们对英语的热爱、他们对学生和学校的态度、他们自我报告的课堂实践、他们愉悦感受、不可预测性和创造力。结果显示出显著的正相关。分析显示,全局性特质情绪智力、幸福感和社交性与大多数因变量呈现显著正相关,而情绪性和自我情绪管理与多个因变量显著相关。全局性特质情绪智力和情绪波动与英语作为外语的使用者的英语水平呈现显著正相关,但与英语作为母语的使用者的英语水平没有呈现出显著正相关关系。本研究在教学上的意义在于,拥有足够水平的特质情绪智力可以帮助教师有效地处理自己和学生的情绪。

关键词：教师特质情绪智力享受创造力态度

Software Measurement Methods: An Analysis of Two Designs

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Journal of Software Engineering and Applications 2012年第10期5卷 797-809页

作者： jean-marc Desharnais Alain Abran Department of Software Engineering and IT école de Technologie Supérieure Montreal Canada

In software engineering, software measures are often proposed without precise identification of the measurable concepts they attempt to quantify: consequently, the numbers obtained are challenging to reproduce in different measurement contexts and to interpret, either as base measures or in combination as derived measures. The lack of consistency when using base measures in data collection can affect both data preparation and data analysis. This paper analyzes the similarities and differences across three different views of measurement methods (ISO International Vocabulary on Metrology, ISO 15939, and ISO 25021), and uses a process proposed for the design of software measurement methods to analyze two examples of such methods selected from the literature.

关键词： Software Measures Base Measures Derived Measures Measurement Method Attributes Software Quality Model Metrology Software Metrics

Building Sino-American Strategic Trust： Time to Serve New Fare

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China International Studies 2014年第3期34卷 18-26页

作者： jean-marc F. Blanchard Professor with School of International and Public Affairs Shanghai Jiaotong University

Sino-American relationship is far from perfect. China and the US have tried many techniques to build trust. To date, though, many of these mechanisms have failed to produce a meaningful level of trust. The author reviews briefly some of the trust-building mechanisms that China and the US currently favor, and then proposes some new measures for bolstering trust as well as some modifications to extant mechanisms.

关键词：时间服务收费建筑合作伙伴当代中国大众媒体美国