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Modelling a.d simula.ion of flight control electromecha.ica. a.tua.ors with specia. focus on model a.chitecting, multidisciplina.y effects a.d power flows

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Chinese Journa. of a.rona.tics 2017年第1期30卷 47-65页

作者： Fu Jia. jean-Cha.les mar. Fu Yongling School of Mecha.ica. Engineering a.d a.toma.ion Beihang University Beijing 100083 China Institut Clement a.er (CNRS UMR 5312) INSA-Toulouse Toulouse 31077 France

In the a.rospa.e field, electromecha.ica. a.tua.ors a.e increa.ingly being implemented in pla.e of conventiona. hydra.lic a.tua.ors. For sa.ety-critica. embedded a.tua.ion a.plica.ions like flight controls, the use of electromecha.ica. a.tua.ors introduces specific issues rela.ed to therma. ba.a.ce, reflected inertia. pa.a.itic motion due to complia.ce a.d response to fa.lure. Unfortuna.ely, the physica. effects governing the a.tua.or beha.iour a.e multidisciplina.y, coupled a.d nonlinea.. a.though numerous multi-doma.n a.d system-level simula.ion pa.ka.es a.e now a.a.la.le on the mar.et, these effects a.e ra.ely a.dressed a. a.whole beca.se of a.la.k of scientific a.proa.hes for model a.chitecting, multi-purpose incrementa. modelling a.d judicious model implementa.ion. In this publica.ion, virtua. prototyping of electromecha.ica. a.tua.ors is a.dressed using the Bond-Gra.h forma.ism. New a.proa.hes a.e proposed to ena.le incrementa. modelling,therma. ba.a.ce a.a.ysis, response to free-run or ja.ming fa.lts, impa.t of complia.ce on pa.a.itic motion, a.d influence of tempera.ure. a.specia. focus is pla.ed on friction a.d complia.ce of the mecha.ica. tra.smission with fa.lt injection a.d tempera.ure dependence. a.leron a.tua.ion is used to highlight the proposa.s for control design, energy consumption a.d therma. a.a.ysis, power network pollution a.a.ysis a.d fa.lt response.

关键词： Bond Gra.h Electro-hydrosta.ic a.tua.or Electromecha.ica. a.tua.or More electric a.rcra.t Modelling Power-by-wire Power loss Simula.ion

Investiga.ions on MBSE modelling a.d dyna.ic performa.ce a.sessment of a. electrica. trimma.le horizonta. sta.ilizer a.tua.or

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Chinese Journa. of a.rona.tics 2023年第11期36卷 417-433页

作者： Wensen ZHa.G Jia. FU jean-Cha.les mar. Ha.lin Ma.Tia.xia.g XIa.Yongling FU Jia.ga. ZHa. School of Mecha.ica. Engineering a.d a.toma.ion Beihang UniversityBeijing 100191China INSa.Institut Clément a.er(CNRS UMR 5312) Toulouse 31400France Na.jing Engineer Institute of a.rcra.t System Jincheng AVICNanjing 211100China

With the development of power-by-wire technology for more electric a.rcra.t,the electromecha.ica. a.tua.or(EMa.ha. the a.va.ta.es to repla.e the conventiona. hydra.lic servo a.tua.or in some a.rospa.e flight *** hydra.lica.ly powered trimma.le horizonta. sta.ilizer a.tua.ion(THSa.system is nowa.a.s developed to be electrica.ly *** their sa.ety-critica.ity,no-ba.k mecha.ism a.d redunda.t loa. pa.hs a.e utilized to meet the flight control ***,ra.e litera.ures ha.e introduced these functions a.d a.dressed the virtua. prototyping a.tivities from system-level point of *** pa.er proposed such a.model of a.THSa.system with dua. electric power sources a.d fa.lt-tolera.t mecha.ica. loa. *** nonlinea. effects of components a.e considered with rea.ism,a.d system-level simula.ion test is conducted to support the model-ba.ed system engineering(MBSE)*** models a.e developed with a.power view instea. of a.pure signa. *** on the friction effect a.d complia.ce effect with ba.kla.h or preloa.,some improved a.d novel a.proa.hes a.e a.opted for these crucia. components a.d va.ida.ed via.experimenta. ***,the implemented systemlevel model ena.les injection of crucia. ***,the simula.ion of the proposed model shows tha. it is a. efficient resource to investiga.e the a.tua.or’s dyna.ic performa.ce,to virtua.ly prove tha. the a.tua.or meets the fa.l/sa.e constra.nt,a.d to demonstra.e the soundness of the fa.lt monitoring functions.

关键词： Electro-mecha.ica. a.tua.or Flight control Mecha.ica. loa. pa.h Modelling No-ba.k mecha.ism

a.va.ces in immunothera.y for trea.ment of lung ca.cer

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Ca.cer Biology & Medicine 2015年第3期12卷 209-222页

作者： jean G.Busta.a.te a.va.ez mar.a.González-Ca. Niki Ka.a.ha.iou mar.a.a.mela.Sa.ta.pia.Sa.tia.o Viteri Cristina.Teixidó Ra.a.l Rosell a.bert Einstein Medica. Center Tra.sla.iona. Ca.cer Resea.ch Unit Instituto Oncológico Dr RosellQuirón Dexeus University Hospital Medica. Oncology Unit Human Pathology Department University of Messina Pa.ga.a.Biotech S.L Ca.cer Biology & Precision Medicine Progra. Catalan Institute of Oncology Germans Trias i Pujol Health Sciences Institute and Hospital Campus Can Ruti Funda.ión Molecula. Oncology Resea.ch

Different a.proa.hes for trea.ing lung ca.cer ha.e been developed over time, including chemothera.y, ra.iothera.y a.d ta.geted thera.ies a.a.nst a.tiva.ing muta.ions. La.ely, better understa.ding of the role of the immunologica. system in tumor control ha. opened multiple doors to implement different stra.egies to enha.ce immune response a.a.nst ca.cer cells. It is known tha. tumor cells elude immune response by severa. mecha.isms. The development of monoclona. a.tibodies a.a.nst the checkpoint inhibitor progra.med cell dea.h protein 1 （PD-1） a.d its liga.d （PD-L1）, on T cells, ha. led to high a.tivity in ca.cer pa.ients with long la.ting responses. Nivoluma., a. a.ti PD-1 inhibitor, ha. been recently a.proved for the trea.ment of squa.ous cell lung ca.cer pa.ients, given the surviva. a.va.ta.e demonstra.ed in a.pha.e III tria.. Pembrolizuma.~ a.other a.ti PD-1 a.tibod）5 ha. received FDa.brea.through thera.y designa.ion for trea.ment of non-sma.l cell lung ca.cer （NSCLC）, supported by da.a.from a.pha.e I tria.. Clinica. tria.s with a.ti PD-1/PD-L1 a.tibodies in NSCLC ha.e demonstra.ed very good tolera.ility a.d a.tivity, with response ra.es a.ound 20% a.d a.media. dura.ion of response of 18 months.

关键词： Cytotoxic T-lymphocyte-a.socia.ed protein 4 (CTLa.4) immune checkpoint inhibitors lung ca.cer progra.med celldea.h protein liga.d-1 (PD-L1) progra.med cell dea.h protein i (PD-1)

New horizons in the endoscopic ultra.onogra.hy-ba.ed dia.nosis of pa.crea.ic cystic lesions

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World Journa. of Ga.troenterology 2018年第26期24卷 2853-2866页

作者： mar.a.Victoria.a.va.ez-Sánchez Bertra.d Na.oléon Instituto de Investiga.ión Sa.ita.ia.Ga.icia.Sur Complejo Hospitalario Universitario de Pontevedra Depa.tment of Ga.troenterology Ramsay Générale de Santé Private Hospital Jean Mermoz

Pa.crea.ic cystic lesions(PCLs) a.e increa.ingly being identified beca.se of the widesprea. use of highresolution a.domina. ima.ing. These cysts encompa.s a.spectrum from ma.igna.t disea.e to benign lesions, a.d therefore, a.cura.e dia.nosis is crucia. to determine the best ma.a.ement stra.egy, either surgica. resection or surveilla.ce. However, the current sta.da.d of dia.nosis is not a.cura.e enough due to limita.ions of ima.ing a.d tissue sa.pling techniques, which enta.l the risk of unnecessa.y burdensome surgery for benign lesions or missed opportunities of prophyla.tic surgery for potentia.ly ma.igna.t PCLs. In the la.t deca.e, endoscopic innova.ions ba.ed on endoscopic ultra.onogra.hy(EUS) ima.ing ha.e emerged, a.ming to overcome the present limita.ions. These new EUS-ba.ed technologies a.e contra.t ha.monic EUS, needle-ba.ed confoca. endomicroscopy, through-the-needle cystoscopy a.d through-the needle intra.ystic biopsy. Here, we present a.comprehensive a.d critica. review of these emerging endoscopic tools for the dia.nosis of PCLs, with a.specia. empha.is on fea.ibility, sa.ety a.d dia.nostic performa.ce.

关键词： Intra.ucta. pa.illa.y mucinous neopla.m Pa.crea.ic cystic lesions Endoscopic ultra.onogra.hy Confoca. endomicroscopy Mucinous cysta.enoma Through-the-needle cystoscopy Serous cysta.enoma Through-the-needle forceps biopsy Contra.t ha.monic endoscopic ultra.onogra.hy

Review of endoscopic ra.iofrequency in biliopa.crea.ic tumours with empha.is on clinica. benefits, controversies a.d sa.ety

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World Journa. of Ga.troenterology 2016年第37期22卷 8257-8270页

作者： mar.a.Victoria.a.va.ez-Sánchez Bertra.d Na.oléon Depa.tment of Ga.troenterology Complejo Hospitalario Universitario de Pontevedra Instituto de Investigación Sanitaria Galicia Sur Depa.tment of Ga.troenterology Ramsay Générale de Santé Private Hospital Jean Mermoz

Most pa.crea.ic ca.cers a.d extra.epa.ic chola.gioca.cinoma. a.e unresecta.le a. the time of dia.nosis, a.d even in ca.e of a.resecta.le ca.cer, for elderly or pa.ients with coexistent comorbidities, surgery is not a. option. Current trea.ment a.terna.ives in these scena.ios a.e very limited. Bilia.y stenting with selfexpa.ding meta. stents(SEMS) is the ma.nsta. pa.lia.ive trea.ment of bilia.y obstruction due to unresecta.le pa.crea.ic ca.cer or chola.gioca.cinoma. Nevertheless, more tha. 50% of SEMS become occluded a.ter 6 mo due to tumour over- a.d ingrowth, lea.ing to hospita. rea.missions a.d reinterventions tha. significa.tly impa.r qua.ity of life. Regimes of chemothera.y or chemora.iothera.y a.so provide minima. surviva. benefits. Therefore, novel thera.ies a.e ea.erly a.a.ted. Ra.iofrequency(RF) energy ca.ses coa.ula.ive necrosis lea.ing to loca. destruction of the a.cessed ma.igna.t tissue a.d ha. a. esta.lished role in the trea.ment of ma.igna.cies in severa. solid orga.s, especia.ly liver ca.cers. However, pa.crea.ic a.d extra.epa.ic bilia.y ca.cers a.e not ea.ily a.cessed by a.percuta.eous route, ma.ing the procedure da.gerous. Over the pa.t five yea.s, the development of dedica.ed devices compa.ible with endoscopic instruments ha. offered a.minima.ly inva.ive option for RF energy delivery in biliopa.crea.ic ca.cers. Emerging experience with endoscopic RF a.la.ion(RFa. in this setting ha. been reported in the litera.ure, but little is known a.out its fea.ibility, effica.y a.d sa.ety. a.litera.ure review ma.es it clea. tha. RFa.in biliopa.crea.ic tumours is fea.ible with high ra.es of technica. success a.d a.cepta.le sa.ety profile. a.though a.a.la.le da.a.suggest a.benefit of surviva. with RFa. there is not enough evidence to dra. a.firm conclusion a.out its effica.y. For this rea.on, prospective ra.domized tria.s compa.ing RFa.with sta.da.d pa.lia.ive trea.ments with qua.ity-of-life a.d surviva. endpoints a.e required. a.ecdota. reportsha.e a.so highlig

关键词： Ra.iofrequency a.la.ion Pa.crea.ic tumour Endobilia.y ra.iofrequency Chola.gioca.cinoma Bilia.y stricture

Contra.t-enha.ced ha.monic endoscopic ultra.ound ima.ing: Ba.ic principles, present situa.ion a.d future perspectives

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World Journa. of Ga.troenterology 2014年第42期20卷 15549-15563页

作者： mar.a.Victoria.a.va.ez-Sánchez Bertra.d Na.oléon Depa.tment of Ga.troenterology H?pital Privé Jean Mermoz Depa.tment of Ga.troenterology Complejo Hospitalario de Pontevedra

Over the la.t deca.e, the development of sta.ilised microbubble contra.t a.ents a.d improvements in a.a.la.le ultra.onic equipment, such a. ha.monic ima.ing, ha.e ena.led us to displa. microbubble enha.cements on a.greysca.e with optima. contra.t a.d spa.ia. resolution. Recent technologica. a.va.ces ma.e contra.t ha.monic technology a.a.la.le for endoscopic ultra.ound(EUS) for the first time in 2008. Thus, the eva.ua.ion of microcircula.ion is now fea.ible with EUS, prompting the evolution of contra.t-enha.ced EUS from va.cula. ima.ing to ima.es of the perfused tissue. a.though the releva.t experience is still prelimina.y, severa. reports ha.e highlighted contra.t-enha.ced ha.monic EUS(CHEUS) a. a.promising noninva.ive method to visua.ise a.d cha.a.terise lesions a.d to differentia.e benign from ma.igna.t foca. lesions. Even if histology rema.ns the gold sta.da.d, the combina.ion of CH-EUS a.d EUS fine needle a.pira.ion(EUS-FNa. ca. not only render EUS more a.cura.e but ma. a.so a.sist physicia.s inma.ing decisions when EUS-FNa.is inconclusive,increa.ing the yield of EUS-FNa.by guiding the puncture with simulta.eous ima.ing of the *** development of CH-EUS ha. a.so opened up exciting possibilities in other resea.ch a.ea.,including monitoring responses to a.tica.cer chemothera.y or to etha.olinduced pa.crea.ic tissue a.la.ion,a.tica.cer thera.ies ba.ed on ultra.ound-triggered drug a.d gene delivery,a.d thera.eutic a.juva.ts by contra.t ultra.ound-induced *** ha.monic ima.ing is ga.ning popula.ity beca.se of its effica.y,simplicity a.d noninva.ive na.ure,a.d ma.y expecta.ions a.e currently resting on this *** its potentia. is confirmed in the nea. future,contra.t ha.monic ima.ing will become a.sta.da.d pra.tice in EUS.

关键词： Microbubbles Contra.t a.ents Contra.t-enha.ced ha.monic endoscopic ultra.ound Pa.crea.ic tumour Ga.trointestina. submucosa. tumour

New cha.lenges in periopera.ive ma.a.ement of pa.crea.ic ca.cer

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World Journa. of Ga.troenterology 2015年第8期21卷 2281-2293页

作者： Fra.cesco Puleo Ra.ha.l mar.cha. Pieter Demetter mar.a.a.tonietta.Ba.i a.na.elle Ca.omme jean Closset jean-Ba.tiste Ba.het Ja.ques Deviere jean-Luc Va. La.them Depa.tment of Ga.troenterology a.d Digestive Oncology Erasme Hospital La.ora.ory of Experimenta. Ga.troenterology Free University of Brussels Depa.tment of Pa.hology Erasme Hospital Depa.tment of Ra.iology Erasme Hospital Depa.tment of Hepa.oga.troenterology Pitié Salpêtrière Hospital

Pa.crea.ic ducta. a.enoca.cinoma.PDa.)is the fourth lea.ing ca.se of ca.cer-rela.ed dea.h in the industria.ized *** progress in the understa.ding of the molecula. a.d genetic ba.is of this disea.e,the5-yea. surviva. ra.e ha. rema.ned low a.d usua.ly does not exceed 5%.Only 20%-25%of pa.ients present with potentia.ly resecta.le disea.e a.d surgery represents the only cha.ce for a.*** deca.es of gemcita.ine hegemony a.d limited thera.eutic options,more a.tive chemothera.ies a.e emerging in a.va.ced PDa.,like 5-Fluoroura.il,folinic a.id,irinoteca. a.d oxa.ipla.in a.d na.-pa.lita.el plus gemcita.ine,tha. ha.e profoundly impa.ted thera.eutic *** is considered a.systemic disea.e beca.se of the high ra.e of rela.se a.ter cura.ive surgery in pa.ients with resecta.le disea.e a. *** stra.egies in resecta.le,borderline resecta.le,or loca.ly a.va.ced pa.crea.ic ca.cer ma. improve *** of tissue biomar.er testing a.d ima.ing techniques into preopera.ive stra.egies should a.low clinicia.s to identify pa.ients who ma. ultima.ely a.hieve cura.ive benefit from *** review summar.zes current knowledge of a.juva.t a.d neoa.juva.t trea.ment for PDa. a.d discusses the ra.iona.e for moving from a.juva.t to preopera.ive a.d periopera.ive thera.eutic stra.egies in the current era.of more a.tive chemothera.ies a.d persona.ized *** a.so discuss the integra.ion of good specimen collection,tissue biomar.ers,a.d ima.ing tools into newly designed preopera.ive a.d periopera.ive stra.egies.

关键词： Neoa.juva.t chemothera.y Biomar.ers Preopera.ive s

Epidemiologica., Clinica., Thera.eutic a.d evolutiona.y a.pects of Children Living with HIV in Guédia.a.e, Senega.

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Open Journa. of Pedia.rics 2021年第4期11卷 738-748页

作者： jean Ba.tiste Niokhor Diouf Ndèye mar.me Sougou Cheikh Tidia.e Ta.l mar.a.a.Ka.e Louis Philippe Sa.r Ousma.e Ndia.e Pedia.ric Depa.tment Roi Baudouin Hospital Guédiawaye Senegal Sa.nt Christopher Iba.mar.Diop School of Medicine-Pha.ma.y-Denta. Dakar Senegal Depa.tment of Public Hea.th Institute of Health and Development (ISED) Cheikh Anta Diop University Dakar Senegal a.bert Royer Na.iona. Children’s Hospita. Dakar Senegal

Introduction: HIV infection in children is a.ma.or public hea.th problem. The objective of this study ca.ried out in the pa.dia.ric depa.tment of the Centre Hospita.ier Roi Ba.douin de Guédia.a.e, wa. to eva.ua.e the... 详细信息

Introduction: HIV infection in children is a major public health problem. The objective of this study carried out in the paediatric department of the Centre Hospitalier Roi Baudouin de Guédiawaye, was to evaluate the epidemiological, clinical, therapeutic and evolutionary aspects of a cohort of children with HIV over a 15-year period and to determine the factors associated with discontinuation of treatment and transition to second-line treatment. Patients and Methods: a. style="font-fa.ily:Verda.a.">This wa. a.descriptive a.d a.a.ytica. cross-sectiona. study from a.gust 2004 to December 2019 a. the Centre Hospita.ier Roi Ba.douin de Guédia.a.e. Through this study, a.e a. dia.nosis, current a.e, gender, orpha. sta.us, thera.eutic a.pects, sta.us a.nouncement a.d evolution were eva.ua.ed. a.tota. of 129 pa.ient records were studied over a.15-yea. period (2004-2019). HIV-positive children with profile I represented 93.8% a.d there wa. a.ma.e predomina.ce with a.sex ra.io of 1.43. The current mea. a.e of the children wa. 12.2 ± 4.5 a.d the media. wa. 14 yea.s. Fa.herless a.d motherless children represented 24.0% a.d 20.2%, respectively, while both fa.herless a.d motherless children represented 11.6%. The mea. a.e a. the sta.t of a.V trea.ment wa. 7.6 ± 4.3 yea.s a.d the media. wa. 7.5 yea.s. The mea. a.e a. the sta.t of second-line trea.ment wa. 13.7 yea.s with a.sta.da.d devia.ion of 2.6 while the media. wa. 13 yea.s. a.T + 3TC + NVP wa. the most commonly used combina.ion (29.5%) followed by TDF + FTC + NVP (26.2%). The mea. a.e a. trea.ment discontinua.ion wa. 13.3 ± 4.3 yea.s while the media. wa. 15 yea.s. More tha. ha.f of the children (57.0%) (N = 69) were a.a.e of their sta.us. Fa.tors a.socia.ed with discontinua.ion were gender (p va.ue = 0.025 a.d OR = 3.2), orpha. sta.us (p va.ue = 0.027 a.d OR = 3.0) a.d follow-up time grea

关键词： Children HIV Guédia.a.e Senega.

a.a.ysis of La.d Use a.d La.d Cover Cha.ges a.d Eva.ua.ion of Na.ura. Genera.ion a.d Potentia. Restora.ion a.ea. in the Mexica. Hua.teca.Region

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Open Journa. of Forestry 2014年第2期4卷 124-135页

作者： Ca.melo Pera.ta.Rivero Ca.los Contrera.-Servín mar.a.G.Ga.indo-Mendoza.jean-Fra.cois Ma. Ca.ssel mar.os a.ga.a.Siller Multidisciplina.y Gra.ua.e Progra.me in Environmenta. Sciences Autonomous University of San Luis/Coordination for Innovation and the Application of Science and TechnologySan Luis PotosiMexico Institute of Geogra.hy National Autonomous University of MexicoMoreliaMexico Multidisciplina.y Gra.ua.e Progra.me in Environmenta. Sciences Faculty of EngineeringEnvironmental EngineeringAutonomous University of San LuisSan Luis PotosiMexico

This study a.ms to a.a.yze tempora. cha.ges in la.d use a.d la.d cover cha.ge (LUCC) a. well a. identify a.ea. for na.ura. regenera.ion a.d potentia. a.ea. for forest restora.ion in the Hua.teca.region for the period from 1976 to 2007. Cha.ges were qua.tified in numbers a.d, a.ditiona.ly, ca.togra.hy wa. used to identify a.d ma. the ma.n a.fected a.ea.. Different models ba.ed on Geogra.hic Informa.ion Systems (GIS) demonstra.ed tha. LUCC ha.e occurred on a. a.ea.of 11718.82 km2, representing 17.84% of the region’s surfa.e. a.riculture a.d the growth of pa.ture could be identified a. the ma.n huma.-induced a.tivities tha. ha.e led to la.dsca.e modifica.ion. In a.dition, forest cover is a.fected by a.deforesta.ion ra.e which is higher tha. the na.iona. a.era.e. Further importa.t cha.ges include a.cha.ge from na.ura. la.d cover to non-origina. la.d cover, a.fecting a. a.ea.of 4911.88 km2 in the period from 1976-1993, a.d a. a.ea.of 1892.5 km2 in the period from 1993-2002. Sma.ler cha.ges could be observed for the period from 1993-2002 with a. a.fected a.ea.of 1029.78 km2. a. the sa.e time, a.na.ura. regenera.ion from nonorigina. to origina. la.d cover took pla.e from 1976-1993 on a. a.ea.of 1318.68 km2, a.d a.so on a. a.ea.of 974.18 km2 between 1993 a. 2002. The surfa.e tha. underwent a.na.ura. regenera.ion of forest cover ma.e up 1932.07 km2. a. the sa.e time, a. a.ea.of 5739.29 km2 for potentia. forest restora.ion wa. identified. Dra.ing on GIS methods a.d techniques, the development of thema.ic ma.s for la.d use, la.d use a.d la.d cover cha.ges for the yea.s of a.a.ysis (1976-1993-2002-2007) proved to be very a.equa.e for the eva.ua.ion a.d a.a.ysis of the la.d cover a.d la.d use cha.ge, in pa.ticula. with rega.d to the decrea.e of na.ura. vegeta.ion cover.

关键词： La.d User La.d Cover Na.ura. Regenera.ion Forest Restora.ion LUCC GIS Tempora. a.a.ysis Hua.teca