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Epididymis-specific lipocalin promoters

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Asian Journal of Andrology 2007年第4期9卷 515-521页

作者： Kichiya Suzuki Xiuping Yu Pierre Chaurand Yoshihiko Araki jean-jacques Lareyre Richard M. Caprioli Marie-Claire Orgebin-Crist Robert J. Matusik Department of Obstetrics and Gynecology Tohoku University Graduate School of Medicine Sendai 980-8574 Japan Departments of Urologic Surgery Vanderbilt University School of Medicine Nashville Tennessee 37232 USA Departments of Biochemistry Vanderbilt University School of Medicine Nashville Tennessee 37232 USA Departments of Obstetrics and Gynecology Vanderbilt University School of Medicine Nashville Tennessee 37232 USA Departments of Cell and Developmental Biology Vanderbilt University School of Medicine Nashville Tennessee 37232 USA Departments of Mass Spectrometry Research Center and Vanderbilt University School of Medicine Nashville Tennessee 37232 USA Departments of Center for Reproductive Biology Research Vanderbilt University School of Medicine Nashville Tennessee 37232 USA

Our goal is to decipher which DNA sequences are required for tissue-specific expression of epididymal genes. At least 6 epididymis-specific lipocalin genes are known. These are differently regulated and regionalized in the epididymis. Lipocalin 5 （Lcn5 or mE-RABP） and Lipocalin 8 （Lcn8 or mEP17） are homologous genes belonging to the epididymis-specific lipocalin gene cluster. Both the 5 kb promoter fragment of the Lcn5 gene and the 5.3 kb promoter fragment of the Lcn8 gene can direct transgene expression in the epididymis （Lcn5 to the distal caput and Lcn8 to the initial segment）, indicating that these promoter fragments contain important cis-regulatory element（s） for epididymisspecific gene expression. To define further the fragments regulating gene expression, the Lcn5 promoter was examined in transgenic mice and immortalized epididymal cell lines. After serial deletion, the 1.8 kb promoter fragment of the Lcn5 gene was sufficient for tissue-specific and region-specific gene expression in transgenic mice. Transient transfection analysis revealed that a transcription factor forkhead box A2 （Foxa2） interacts with androgen receptor and binds to the 100 bp fragment of the Lcn5 promoter between 1.2 kb and 1.3 kb and that Foxa2 expression inhibits androgen-dependent induction of the Lcn5 promoter activity. Immunohistochemistry indicated a restricted expression of Foxa2 in the epididymis where endogenous Lcn5 gene expression is suppressed and that the Foxa2 inhibition of the Lcn5 promoter is consistent with the lack of expression of Lcn5 in the corpus and cauda. Our approach provides a basic strategy for further analysis of the epididymal lipocalin gene regulation and flexible control of epididymal function. （Asian J Androl 2007 July; 9： 515-521）

关键词： androgen epididymis gene cluster gene evolution gene regulation lipocalin transcription factor

Effect of sustained virological response on long-term clinical outcome in 113 patients with compensated hepatitis C-related cirrhosis treated by interferon alpha and ribavirin

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World Journal of Gastroenterology 2007年第42期13卷 5648-5653页

作者： Roland El Braks Nathalie Ganne-Carrié Hélène Fontaine jacques Paries Véronique Grando-Lemaire Michel Beaugrand Stanislas Pol jean-Claude Trinchet Department of Hepatology Hopital Jean Verdier (AP-HP) and UPRES EA 3409 (University Paris 13) Bondy 93140 France Department of Hepatology Hopital Cochin (AP-HP) and University Paris 5 Paris 75014 France Department of Public Health Jean Verdier Hospital (AP-HP) and UPRES EA 3409 (University Paris 13) Bondy 93140 France

AIM： To assess the long-term clinical benefit of sustained virological response （SVR） in patients with hepatitis C virus （HCV） cirrhosis treated by antiviral therapy using mostly ribavirin plus interferon either standard or ***： One hundred and thirteen patients with uncomplicated HCV biopsy-proven cirrhosis, treated by at least one course of antiviral treatment ≥ 3 mo and followed ≥ 30 mo were included. The occurrence of clinical events [hepatocellular carcinoma （HCC）, decompensation and death] was compared in SVR and non SVR ***： Seventy eight patients received bitherapy and 63 had repeat treatments. SVR was achieved in 37 patients （33%）. During a mean follow-up of 7.7 years, clinical events occurred more frequently in non SVR than in SVR patients, with a significant difference for HCC （24/76 vs 1/37, P = 0.01）. No SVR patient died while 20/76 non-SVR did （P = 0.002）, mainly in relation to HCC （45%）.CONCLUSION： In patients with HCV-related cirrhosis, $VR is associated with a significant decrease in the incidence of HCC and mortality during a follow-up period of 7.7 years. This result is a strong argument to perform and repeat antiviral treatments in patients with compensated cirrhosis.

关键词： Hepatitis C Cirrhosis Interferon alpha

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Changes in smoking patterns after HIV diagnosis or antiretroviral treatment initiation: a global systematic review and meta-analysis

作者： (法)让·卢梭(jean-jacques Rousseau)

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Infectious Diseases of Poverty 2020年第2期9卷 14-22页

作者： Jobert Richie Nansseu Dalhia Noelle Tounouga jean jacques Noubiap jean Joel Bigna Department of Public Health Faculty of Medicine and Biomedical Sciences of the University of YaoundéIYaoundéCameroon Department for the Control of Disease Epidemics and PandemicsMinistry of Public HealthYaoundéCameroon Centre for Heart Rhythm Disorders University of Adelaide and Royal Adelaide HospitalAdelaideAustralia Department of Epidemiology and Public Health Centre Pasteur of CameroonPO Box 1274YaoundéCameroon School of Public Health Faculty of MedicineUniversity of Paris Sud XILe Kremlin BicêtreFrance

Background:Tobacco consumption is more life-threatening in people living with human immunodeficiency virus(HIV)than within the general population;therefore,people living with HIV(PLWH)should be highly motivated to take action towards quitting smoking at or after HIV *** aim of this systematic review with meta-analysis was to investigate changes in smoking habits among PLWH over *** text:We considered prospective and retrospective cohort studies including PLWH aged 15 years and above,which have measured the prevalence of tobacco smoking(current,former or never)at study initiation and completion,and published between January 1,2000 and April 15,2018 without language or geographical *** searched PubMed,EMBASE,Web of Science,Africa Journal Online,and Global Index *** used a random-effects model to pool *** studies were *** proportion of current and former smokers decreased slightly over time,around 2.5 and 3.8%,***,the proportion of never smokers decreased sharply by 22.5%,and there were 2.1 and 1.5%PLWH who shifted from never and former smoking to current smoking,*** the other hand,10.5%PLWH shifted from current to former smoking,7.1%tried to quit tobacco consumption but failed,and 10.1%stayed in the"never smoking"category over ***:PLWH seem not to change positively their smoking habits towards quitting tobacco *** is urgent need to increase actions aimed at helping this vulnerable population to quit tobacco consumption,including individually tailored therapeutic education,psychosocial and pharmacologic supports.

关键词： Smoking HIV AIDS Tobacco Global health

Exercise-induced albuminuria vs circadian variations in blood pressure in type 1 diabetes

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World Journal of Diabetes 2017年第2期8卷 74-79页

作者： Isabelle Hota Tadida Meli Aurel T Tankeu Mesmin Y Dehayem David Chelo jean jacques N Noubiap Eugene Sobngwi Institut Supérieur des Sciences de la Santé Université des Montagnes Department of Internal Medicine and Specialties Faculty of Medicine and Biomedical Sciences National Obesity Center Yaoundé Central Hospital Mother and Child Center of the Chantal Biya Foundation Department of Medicine Groote Schuur Hospital and University of Cape Town

AIM To investigated the relationship between exerciseinduced ambulatory blood pressure measurement(ABPM) abnormalities in type 1 diabetes mellitus(T1DM) adolescents. METHODS We conducted a case-control at the National Obesity Center of the Yaoundé Central Hospital, Cameroon. We compared 24 h ABPM and urinary albumin-to-creatinine ratio(ACR) at rest and after a standardized treadmill exercise between 20 Cameroonian T1 DM patients and 20 matched controls. T1 DM adolescents were aged 12-18 years, with diabetes for at least one year, without proteinuria, with normal office blood pressure(BP) and renal function according to the general referencepopulation. Non-diabetic controls were adolescents of general population matched for sex, age and *** Mean duration of diabetes was 4.2 ± 2.8 years. The mean 24 h systolic blood pressure(SBP) and diastolic blood pressure(DBP) were respectively 116 ± 9 mm Hg in the diabetic group vs 111 ± 8 mm Hg in the nondiabetic(P = 0.06), and 69 ± 7 mm Hg vs 66 ± 5 mm Hg(P = 0.19). There was no difference in the diurnal pattern of BP in diabetes patients and non-diabetic controls(SBP: 118 ± 10 mm Hg vs 114 ± 10 mm Hg, P = 0.11; DBP: 71 ± 7 mm Hg vs 68 ± 6 mm Hg, P = 0.22). Nighttime BP was higher in the diabetic group with respect to SBP(112 ± 11 mm Hg vs 106 ± 7 mm Hg, P = 0.06) and to the mean arterial pressure(MAP)(89 ± 9 mm Hg vs 81 ± 6 mm Hg, P = 0.06). ACR at rest was similar in both groups(5.5 mg/g vs 5.5 mg/g, P = 0.74), but significantly higher in diabetes patients after exercise(10.5 mg/g vs 5.5 mg/g, P = 0.03). SBP was higher in patients having exercise-induced albuminuria(116 ± 10 mm Hg vs 108 ± 10 mm Hg, P = 0.09). CONCLUSION Exercise-induced albuminuria could be useful for early diagnosis of kidney damage in adolescents with T1 DM.

关键词： Albuminuria Blood pressure Ambulatory blood pressure measurement Exercise Type 1 diabetes

A new hemostatic agent composed of Zn^(2+)-enriched Ca^(2+)alginate activates vascular endothelial cells in vitro and promotes tissue repair in vivo

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Bioactive Materials 2022年第12期7卷 368-382页

作者： Anne-Charlotte Ponsen Richard Proust Sabrina Soave Françoise Mercier-Nom´e Isabelle Garcin Laurent Combettes jean-jacques Lataillade Georges Uzan INSERM UMRS-MD 1197 Universit´e Paris-SaclayInstitut Andr´e LwoffHˆopital Paul BrousseVillejuifFrance Plateforme d’Histologie Immunopathologie de Clamart(PHIC) Universit´e Paris-SaclayINSERMCNRSInstitut Paris Saclay d’Innovation Th´erapeutiqueChˆatenay-MalabryFrance Universit´e Paris-Saclay INSERMInflammationMicrobiome and ImmunosurveillanceClamartFrance INSERM UMRS 1174 Universit´e Paris-SaclayOrsayFrance Centre de Transfusion Sanguine des Arm´ees ClamartFrance

To control capillary bleeding, surgeons may use absorbable hemostatic agents, such as Surgicel® and TachoSil®. Due to their slow resorption, their persistence in situ can have a negative impact on tissue repair in the resected organ. To avoid complications and obtain a hemostatic agent that promotes tissue repair, a zinc-supplemented calcium alginate compress was developed: HEMO-IONIC®. This compress is non-absorbable and is therefore removed once hemostasis has been achieved. After demonstrating the hemostatic efficacy and stability of the blood clot obtained with HEMO-IONIC, the impact of Surgicel, TachoSil, and HEMO-IONIC on cell activation and tissue repair were compared (i) in vitro on endothelial cells, which are essential to tissue repair, and (ii) in vivo in a mouse skin excision model. In vitro, only HEMO-IONIC maintained the phenotypic and functional properties of endothelial cells and induced their migration. In comparison, Surgicel was found to be highly cytotoxic, and TachoSil inhibited endothelial cell migration. In vivo, only HEMO-IONIC increased angiogenesis, the recruitment of cells essential to tissue repair (macrophages, fibroblasts, and epithelial cells), and accelerated maturation of the extracellular matrix. These results demonstrate that a zinc-supplemented calcium alginate, HEMO-IONIC, applied for 10 min at the end of surgery and then removed has a long-term positive effect on all phases of tissue repair.

关键词： Hemostatic agent Alginate Surgery Hemostasis Endothelial cells Tissue repair

The Importance of Spatiotemporal Heterogeneity for Biodiversity in Forest—Heathland Mosaics and Implications for Heathland Conservation

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Journal of Environmental Protection 2016年第10期7卷 1317-1332页

作者： Samira Mobaied jean-jacques Geoffroy Nathalie Machon Centre d’Ecologie et des Sciences de la Conservation (CESCO UMR7204) Sorbonne University MNHN CNRS UPMC CP51 Paris France Museum National d’Histoire Naturelle CNRS UMR MNHN UPMC 7204 Conservation of Species Restoration and Monitoring of Populations Brunoy France

In biodiversity management, spatio-temporal heterogeneity is important to consider conserving high levels of habitat diversity and ecosystems. In this study, we investigated the relationship between landscape spatio-temporal heterogeneity and biodiversity in a mosaic-landscape, located in the Fontainebleau forest (France). The diversity of successional stages along a gradient from heathland to forest as well as the persistence of Calluna vulgaris (L.) Hull in different forest stands was examined in order to find how the numerous patches of European Heathland habitat embedded in this area should be maintained. The results indicated that in the areas of high spatio-temporal heterogeneity, a general increase is observed in species richness, in particular for vascular plants, bryophytes and carabids. C. vulgaris persisted in coniferous stands and young mixed stand but decreased under deciduous trees and old mixed stands. The Ellenberg’s values for light, nutrients and acidity, show the persistence of favorable enviromental conditions for heathland vegetation under coniferous stands and young mixed stands. These results enable us to offer recommendations to better manage mosaic-landscape biodiversity, and in particular, the heathland semi-natural habitats in the Fontainebleau forest and elsewhere in Europe.

关键词： Spatiotemporal Heterogeneity Conservation Management Calluna vulgaris Biodiversity

Front-of-pack labeling:a health literacy intervention to improve cardiovascular health in Sub-Saharan Africa

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Global Health Journal 2022年第4期6卷 227-230页

作者： Boni Maxime Ale jean jacques Noubiap Holo Healthcare Limited NairobiKenya Centre for Heart Rhythm Disorders the University of AdelaideAdelaideAustralia

There is a surge in the burden of cardiovascular disease(CVD)in Sub-Saharan African(SSA)*** the last 50 years there has been a rapid growth in the consumption of ultra-processed food products high in salt,fat,and glycemic load in *** is overwhelming evidence linking UPFP consumption to an increased risk of coronary artery disease,cerebrovascular disease,overall CVD,and all-cause ***-of-pack labeling(FOPL)represents an important intervention to guide consumers towards healthier diets and ultimately contribute to the prevention of diet-related adverse health outcomes including *** paper discusses the challenges in the development and implementation of FOPL systems in SSA,and proposes some key elements that would be critical for developing an effective FOPL system in SSA countries.

关键词： Front-of-pack labeling Diet Cardiovascular Sub-Saharan Africa

Liver insulin-like growth factor 2 methylation in hepatitis C virus cirrhosis and further occurrence of hepatocellular carcinoma

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World Journal of Gastroenterology 2008年第35期14卷 5419-5427页

作者： Philippe Couvert Alain Carrié jacques Pariès Jenny Vaysse Audrey Miroglio Antoine Kerjean Pierre Nahon Jamel Chelly jean-Claude Trinchet Michel Beaugrand Nathalie Ganne-Carrié INSERM U551 Dyslipopro-teinemia and Atherosclerosis Research UnitParis F-75013France Université Paris6 UMR S551Paris F-75013France AP-HP Groupe hospitalier Pitié SalpétrièreService de Biochimie endocrinienne et OncologiqueParis F-75013France Department of Public health Jean Verdier HospitalAP-HPBondy 93140France Department of Biochemistry Jean Verdier HospitalAP-HPBondy 93140France Cochin Institut-INSERM-CNRS-University Paris 5-CHU Cochin Paris 75014France Department of Hepato-Gastroenterology Jean Verdier HospitalAP-HPBondy 93140France UPRES EA3409 University Paris 13Paris F-75651France

AIM: To assess the predictive value of the insulinlike growth factor 2 (Igf2) methylation profile for the occurrence of Hepatocellular Carcinoma (HCC) in hepatitis C (HCV) cirrhosis. METHODS: Patients with: (1) biopsy-proven compensated HCV cirrhosis; (2) available baseline frozen liver sample; (3) absence of detectable HCC; (4) regular screening for HCC; (5) informed consent for genetic analysis were studied. After DNA extraction from liver samples and bisulfite treatment, unbiased PCR and DHPLC analysis were performed for methylation analysis at the Igf2 locus. The predictive value of the Igf2 methylation profile for HCC wasassessed by Kaplan-Meier and Cox methods. RESULTS: Among 94 included patients, 20 developed an HCC during follow-up (6.9 ± 3.2 years). The methylation profile was hypomethylated, intermediate and hypermethylated in 13, 64 and 17 cases, respectively. In univariate analysis, two baseline parameters were associated with the occurrence of HCC: age (P = 0.01) and prothrombin (P = 0.04). The test of linear tendency between the three ordered levels of Igf2 methylation and probability of HCC occurrence was significant (Log Rank, P = 0.043; Breslow, P = 0.037; Tarone-Ware, P = 0.039). CONCLUSION: These results suggest that hypomethylation at the Igf2 locus in the liver could be predictive for HCC occurrence in HCV cirrhosis.

关键词： Liver cancer Cirrhosis Insulin-growth factor 2, DNA methylation