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Nano Research 2014年第1期7卷 154-162页

作者： Nicolas Reckinger Eloise Van Hooijdonk Frederic Joucken Anastasia V. Tyurnina Stephane Lucas jean-francois Colome~ Research Center in Physics of Matter and Radiation (PMR) University of Namur Rue de Bruxelles 6 1 B-5000 Namur Belgium

The growth of graphene on oriented （111） copper films has been achieved by atmospheric pressure chemical vapor deposition. The structural properties of as-produced graphene have been investigated by scanning tunneling microscopy. Anomalous moir6 superstructures composed of well-defined linear periodic modulations have been observed. We report here on comprehensive and detailed studies of these particular moir6 patterns present in the graphene topography revealing that, in certain conditions, the growth can occur on the oxygen-induced reconstructed copper surface and not directly on the oriented （111） copper film as expected.

关键词： graphene scanning tunnelingmicroscopy Cu(111) copper oxidation atmospheric pressurechemical vapor deposition

Esophageal metastasis of stem cell-subtype hepatocholangio carcinoma:Rare presentation of a rare tumor

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World Journal of Gastroenterology 2018年第7期24卷 870-875页

作者： Maeva Salimon Nicolas Chapelle Tamara Matysiak-Budnik jean-francois Mosnier Eric Frampas Yann Touchefeu Institut des Maladies de l’Appareil Digestif Nantes University HospitalNantes 44000France Department of Pathology Nantes University HospitalNantes 44000France Department of Radiology Nantes University HospitalNantes 44000France

Hepatocholangiocarcinoma(c HCC-ICC) is a rare primary hepatic tumor defined by the presence of histological features of both hepatocellular carcinoma(HCC) and intrahepatic cholangiocarcinoma(ICC). Its prevalence ranges from 1%-5% of all primary liver cancers. We report the case of a 55-year-old cirrhotic male patient admitted to our university hospital for dysphagia, revealing a 10 cm lower-third esophageal metastasis of an unresectable c HCC-ICC with stemcell features. Computed tomography and abdominal magnetic resonance imaging scans revealed multiple hepatic lesions combining features of both HCC and ICC, associated with synchronous bone metastasis. Histological and immunohistochemical analyses of biopsies from the esophageal lesion and the hepatic tumor confirmed the diagnosis of c HCC-ICC with a stem cell-subtype, according to the World HealthOrganization classification. After a multidisciplinary meeting, the patient was treated with chemotherapy. He received two cycles of a gemcitabine plus cisplatin regimen before bone progression, and he died 3 mo after the initial diagnosis.

关键词： Hepatocholangiocarcinoma Stem cellsubtype Esophageal metastasis Chemotherapy Gemcitabine plus platinum-based chemotherapy

Safety and efficacy of a docetaxel-5FU-oxaliplatin regimen with or without trastuzumab in neoadjuvant treatment of localized gastric or gastroesophageal junction cancer: A retrospective study

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World Journal of Gastrointestinal Oncology 2019年第8期11卷 634-641页

作者： Valeria Basso David Orry jean Fraisse Julie Vincent Audrey Hennequin Leila Bengrine francois Ghiringhelli Department of Surgery Centre Georges Francois LeclercDijon 21000France Department of Medical Oncology Centre Georges Francois LeclercDijon 21000France

BACKGROUND Triplet chemotherapy,with docetaxel-5FU-oxaliplatin FLOT regimen recently became the standard perioperative treatment for localized gastric cancer(GC).An adapted regimen called TeFOX was recently tested in metastatic setting and gave promising *** To determine safety and efficacy of TeFOX perioperative *** This monocentric retrospective study aims to test efficacy and safety of the perioperative TeFOX regimen given alone or in combination with trastuzumab in patients with localized *** consist in docetaxel(50 mg/m^2)with oxaliplatin 85 mg/m^2 and and leucovorin(400mg/m^2^)5 FU bolus(400mg/m^2)on day 1,followed by continuous infusion of 5FU for 46h(2400mg/m^2)every 2 *** Thirty-three consecutive patients were included in this retrospective *** patients have a gastroesophageal junction cancer and 11 have a *** follow-up of surviving patients was 32 mo.R0 resection was obtained in 30(91)*** patients(36)had a pathological complete response and 8(24)patients a nearly complete pathological *** OS and PFS were not reached at data base *** have observed 6 metastatic relapses and 1 localized *** relapse was observed in patients with pathological complete *** most common grade 3-4 adverse events were peripheral neuropathy(21)and asthenia(20).CONCLUSION TeFOX regimen could be safely administrated in perioperative treatment of localized *** and the FLOT regimen have comparable efficacy and safety profiles.

关键词： Gastric cancer Neoadjuvant chemotherapy TeFOX Retrospective study

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Lamb波压差式微流量传感器

光学精密工程 2009年第5期17卷 1033-1038页

作者：贾宏光光玲玲 MANCEAU jean-francois BASTIEN francois 刘波中国科学院长春光学精密机械与物理研究所吉林长春130033 中国科学院研究生院北京100039 法国科学院FEMTO-ST研究所MN2S实验室法国贝桑松25044

为提高微流体系统中的流量检测灵敏度,增大动态检测范围,实现温度补偿,提出了一种基于Lamb波的压差式微流量传感系统。该传感系统主要由两个Lamb波压力传感器和微通道组成,它利用Lamb波薄膜内应力的敏感特性,以频率计量的方式间接测量... 详细信息

为提高微流体系统中的流量检测灵敏度,增大动态检测范围,实现温度补偿,提出了一种基于Lamb波的压差式微流量传感系统。该传感系统主要由两个Lamb波压力传感器和微通道组成,它利用Lamb波薄膜内应力的敏感特性,以频率计量的方式间接测量微通道两端的压力差;并采用双Lamb波压力传感器构成差动式测量结构进行温度补偿。对长20 mm,宽1 mm,高50μm的微通道进行了流量测试实验,结果表明:在流量测试范围内,微通道两端的频率差与流量基本呈线性变化,其线性相关系数为0.999 9;在微流量传感器未进行优化的前提下,最小检测量为0.627μL/s。

关键词：微流体系统微流量传感器 Lamb波

Fluorination of suspended graphene

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Nano Research 2017年第9期10卷 3151-3163页

作者： Claudia Struzzi Mattia Scardamaglia Nicolas Reckinger jean-francois Colomer Hikmet Sezen Matteo Amati Luca Gregoratti Rony Snyders Carla Bittencourt Chimie des Interactions Plasma-Surface CIRMAP University of Mons 7000 Mons Belgium Research Group on Carbon Nanostructures (CARBONNAGe) University of Namur 5000 Namur Belgium Elettra - Sincrotrone Trieste S.C.p.A. di interesse nazionale Strada Statale 14 km 163.5 34149 Trieste Italy Materia Nova Research Center B-7000 Mons Belgium

Suspended graphene is exposed to different fluorine-containing species produced by a plasma source fed with CF4 precursor gas. We investigate the fluorination process by selecting two different kinetic energies for the ions striking the graphene surface. The chemical-bonding environment is discussed, and the control of the graphene-fluorination homogeneity is investigated at the individual graphene sheets. The modifications of the electronic and structural properties are examined by scanning photoelectron microscopy, micro-Raman analysis, and scanning electron microscopy. The results are compared with those obtained for supported graphene on copper. Suspended graphene provides a quasi-ideal model for investigating the intrinsic properties of irradiated carbon nano-systems while avoiding damage due to backscattered atoms and recoil due to a supporting substrate.

关键词： graphene fluorination spectromicroscopy X-ray photoelectron spectroscopy (XPS) Raman scanning electron microscopy (SEM)

Onto Orthogonal Projections in the Space of Polynomials P_n[x]

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Journal of Applied Mathematics and Physics 2023年第1期11卷 22-45页

作者： jean-francois Niglio Department of Mathematics Kingston University London UK

In this article, I consider projection groups on function spaces, more specifically the space of polynomials Pn[x]. I will show that a very similar construct of projection operators allows us to project into the subspaces of Pn[x] where the function h ∈Pn[x] represents the closets function to f ∈Pn[x] in the least square sense. I also demonstrate that we can generalise projections by constructing operators i.e. in Rn+1 using the metric tensor on Pn[x]. This allows one to project a polynomial function onto another by mapping it to its coefficient vector in Rn+1. This can be also achieved with the Kronecker Product as detailed in this paper.

关键词： Polynomials and Projections Projections The Kronecker Product Idempotent Operators

From Control Theory to Gravitational Waves

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Advances in Pure Mathematics 2024年第2期14卷 49-100页

作者： jean-francois Pommaret CERMICS Ecole des Ponts Paris Tech Paris France

When D:ξ→η is a linear ordinary differential (OD) or partial differential (PD) operator, a “direct problem” is to find the generating compatibility conditions (CC) in the form of an operator D1:η→ξ such that Dξ = η implies D1η = 0. When D is involutive, the procedure provides successive first-order involutive operators D1,...,Dn when the ground manifold has dimension n. Conversely, when D1 is given, a much more difficult “inverse problem” is to look for an operator D:ξ→η having the generating CC D1η = 0. If this is possible, that is when the differential module defined by D1 is “torsion-free”, that is when there does not exist any observable quantity which is a sum of derivatives of η that could be a solution of an autonomous OD or PD equation for itself, one shall say that the operator D1 is parametrized by D. The parametrization is said to be “minimum” if the differential module defined by D does not contain a free differential submodule. The systematic use of the adjoint of a differential operator provides a constructive test with five steps using double differential duality. We prove and illustrate through many explicit examples the fact that a control system is controllable if and only if it can be parametrized. Accordingly, the controllability of any OD or PD control system is a “built in” property not depending on the choice of the input and output variables among the system variables. In the OD case and when D1 is formally surjective, controllability just amounts to the formal injectivity of ad(D1), even in the variable coefficients case, a result still not acknowledged by the control community. Among other applications, the parametrization of the Cauchy stress operator in arbitrary dimension n has attracted many famous scientists (G. B. Airy in 1863 for n = 2, J. C. Maxwell in 1870, E. Beltrami in 1892 for n = 3, and A. Einstein in 1915 for n = 4).

关键词： Differential Operator Differential Sequence Killing Operator Riemann Operator Bianchi Operator Cauchy Operator Control Theory Controllability Elasticity General Relativity

Inverse Scattering for a Schr■dinger Operator with a Repulsive Potential

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Acta Mathematica Sinica,English Series 2006年第5期22卷 1485-1492页

作者： francois NICOLEAU Laboratoire de Mathéatiques jean Leray UMR CNRS-UN 6629 Département de Mathématiques2 rue de la Houssinière BP 92208 F-44322 Nantes cedex 03 France

We consider a pair of Hamiltonians （H, H0） on L2（R^n）, where H0=p^2 -x^2 is a SchrSdinger operator with a repulsive potential, and H = H0＋V（x）. We show that, under suitable assumptions on the decay of the elect... 详细信息

关键词： Inverse scattering Repulsive potential

Homological Solution of the Lanczos Problems in Arbitrary Dimension

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Journal of Modern Physics 2021年第6期12卷 829-858页

作者： jean-francois Pommaret CERMICS Ecole des Ponts ParisTech France

When D is a linear partial differential operator of any order, a direct problem is to look for an operator D1 generating the compatibility conditions (CC) D1η = 0 of Dξ = η. Conversely, when D1 is given, an inverse problem is to look for an operator D such that its CC are generated by D1 and we shall say that D1 is parametrized by D = D0. We may thus construct a differential sequence with successive operators D, D1, D2, ..., each operator parametrizing the next one. Introducing the formal adjoint ad() of an operator, we have but ad (Di-1) may not generate all the CC of ad (Di). When D = K [d1, ..., dn] = K [d] is the (non-c

关键词： Differential Sequence Variational Calculus Lanczos Potential Lanczos Operator Vessiot Structure Equations

3D bioprinted breast cancer model reveals stroma-mediated modulation of extracellular matrix and radiosensitivity

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Bioactive Materials 2024年第12期42卷 316-327页

作者： Theo Desigaux Leo Comperat Nathalie Dusserre Marie-Laure Stachowicz Malou Lea jean-William Dupuy Anthony Vial Michael Molinari jean-Christophe Fricain francois Paris Hugo Oliveira Univ.Bordeaux Tissue Bioengineering INSERM U1026F-33000BordeauxFrance INSERM U1026 ART BioPrintF-33000BordeauxFrance Univ.Bordeaux Bordeaux ProteomeF-33000BordeauxFrance Univ.Bordeaux CNRSINSERMTBM-CoreUS5UAR 3427OncoProtF-33000BordeauxFrance Univ.Bordeaux CNRSBordeaux INPCBMNUMR 5248F-33600PessacFrance Services d’Odontologie et de Sante Buccale CHU BordeauxF-33000BordeauxFrance CRCINA INSERMCNRSUniv.NantesF-44000NantesFrance Institut de Cancerologie de l’Ouest F-44800Saint HerblainFrance

Deciphering breast cancer treatment resistance remains hindered by the lack of models that can successfully capture the four-dimensional dynamics of the tumor ***,we show that microextrusion bioprinting can reproducibly generate distinct cancer and stromal compartments integrating cells relevant to human *** findings unveil the functional maturation of this millimeter-sized model,showcasing the development of a hypoxic cancer core and an increased surface *** was also driven by the presence of cancer-associated fibroblasts(CAF)that induced elevated microvascular-like structures *** modulation was concomitant to extracellular matrix remodeling,with high levels of collagen and matricellular proteins deposition by CAF,simultaneously increasing tumor stiffness and recapitulating breast cancer fibrotic ***,our bioprinted model faithfully reproduced response to treatment,further modulated by ***,CAF played a protective role for cancer cells against radiotherapy,facilitating increased paracrine *** model holds promise as a platform to decipher interactions within the microenvironment and evaluate stroma-targeted drugs in a context relevant to human pathology.

关键词： Bioprinting Cancer microenvironment Extracellular matrix