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Safety and efficacy of a docetaxel-5FU-oxaliplatin regimen with or without trastuzumab in neoadjuvant treatment of localized gastric or gastroesophageal junction cancer: A retrospective study

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World Journal of Gastrointestinal Oncology 2019年第8期11卷 634-641页

作者： Valeria Basso David Orry jean Fraisse Julie Vincent Audrey Hennequin Leila Bengrine francois Ghiringhelli Department of Surgery Centre Georges Francois LeclercDijon 21000France Department of Medical Oncology Centre Georges Francois LeclercDijon 21000France

BACKGROUND Triplet chemotherapy,with docetaxel-5FU-oxaliplatin FLOT regimen recently became the standard perioperative treatment for localized gastric cancer(GC).An adapted regimen called TeFOX was recently tested in metastatic setting and gave promising *** To determine safety and efficacy of TeFOX perioperative *** This monocentric retrospective study aims to test efficacy and safety of the perioperative TeFOX regimen given alone or in combination with trastuzumab in patients with localized *** consist in docetaxel(50 mg/m^2)with oxaliplatin 85 mg/m^2 and and leucovorin(400mg/m^2^)5 FU bolus(400mg/m^2)on day 1,followed by continuous infusion of 5FU for 46h(2400mg/m^2)every 2 *** Thirty-three consecutive patients were included in this retrospective *** patients have a gastroesophageal junction cancer and 11 have a *** follow-up of surviving patients was 32 mo.R0 resection was obtained in 30(91)*** patients(36)had a pathological complete response and 8(24)patients a nearly complete pathological *** OS and PFS were not reached at data base *** have observed 6 metastatic relapses and 1 localized *** relapse was observed in patients with pathological complete *** most common grade 3-4 adverse events were peripheral neuropathy(21)and asthenia(20).CONCLUSION TeFOX regimen could be safely administrated in perioperative treatment of localized *** and the FLOT regimen have comparable efficacy and safety profiles.

关键词： Gastric cancer Neoadjuvant chemotherapy TeFOX Retrospective study

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Fluorination of suspended graphene

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Nano Research 2017年第9期10卷 3151-3163页

作者： Claudia Struzzi Mattia Scardamaglia Nicolas Reckinger jean-francois Colomer Hikmet Sezen Matteo Amati Luca Gregoratti Rony Snyders Carla Bittencourt Chimie des Interactions Plasma-Surface CIRMAP University of Mons 7000 Mons Belgium Research Group on Carbon Nanostructures (CARBONNAGe) University of Namur 5000 Namur Belgium Elettra - Sincrotrone Trieste S.C.p.A. di interesse nazionale Strada Statale 14 km 163.5 34149 Trieste Italy Materia Nova Research Center B-7000 Mons Belgium

Suspended graphene is exposed to different fluorine-containing species produced by a plasma source fed with CF4 precursor gas. We investigate the fluorination process by selecting two different kinetic energies for the ions striking the graphene surface. The chemical-bonding environment is discussed, and the control of the graphene-fluorination homogeneity is investigated at the individual graphene sheets. The modifications of the electronic and structural properties are examined by scanning photoelectron microscopy, micro-Raman analysis, and scanning electron microscopy. The results are compared with those obtained for supported graphene on copper. Suspended graphene provides a quasi-ideal model for investigating the intrinsic properties of irradiated carbon nano-systems while avoiding damage due to backscattered atoms and recoil due to a supporting substrate.

关键词： graphene fluorination spectromicroscopy X-ray photoelectron spectroscopy (XPS) Raman scanning electron microscopy (SEM)

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Lamb波压差式微流量传感器

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光学精密工程 2009年第5期17卷 1033-1038页

作者：贾宏光光玲玲 MANCEAU jean-francois BASTIEN francois 刘波中国科学院长春光学精密机械与物理研究所吉林长春130033 中国科学院研究生院北京100039 法国科学院FEMTO-ST研究所MN2S实验室法国贝桑松25044

为提高微流体系统中的流量检测灵敏度,增大动态检测范围,实现温度补偿,提出了一种基于Lamb波的压差式微流量传感系统。该传感系统主要由两个Lamb波压力传感器和微通道组成,它利用Lamb波薄膜内应力的敏感特性,以频率计量的方式间接测量... 详细信息

为提高微流体系统中的流量检测灵敏度,增大动态检测范围,实现温度补偿,提出了一种基于Lamb波的压差式微流量传感系统。该传感系统主要由两个Lamb波压力传感器和微通道组成,它利用Lamb波薄膜内应力的敏感特性,以频率计量的方式间接测量微通道两端的压力差;并采用双Lamb波压力传感器构成差动式测量结构进行温度补偿。对长20 mm,宽1 mm,高50μm的微通道进行了流量测试实验,结果表明:在流量测试范围内,微通道两端的频率差与流量基本呈线性变化,其线性相关系数为0.999 9;在微流量传感器未进行优化的前提下,最小检测量为0.627μL/s。

关键词：微流体系统微流量传感器 Lamb波

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Onto Orthogonal Projections in the Space of Polynomials P_n[x]

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Journal of Applied Mathematics and Physics 2023年第1期11卷 22-45页

作者： jean-francois Niglio Department of Mathematics Kingston University London UK

In this article, I consider projection groups on function spaces, more specifically the space of polynomials Pn[x]. I will show that a very similar construct of projection operators allows us to project into the subspaces of Pn[x] where the function h ∈Pn[x] represents the closets function to f ∈Pn[x] in the least square sense. I also demonstrate that we can generalise projections by constructing operators i.e. in Rn+1 using the metric tensor on Pn[x]. This allows one to project a polynomial function onto another by mapping it to its coefficient vector in Rn+1. This can be also achieved with the Kronecker Product as detailed in this paper.

关键词： Polynomials and Projections Projections The Kronecker Product Idempotent Operators

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Homological Solution of the Lanczos Problems in Arbitrary Dimension

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Journal of Modern Physics 2021年第6期12卷 829-858页

作者： jean-francois Pommaret CERMICS Ecole des Ponts ParisTech France

When D is a linear partial differential operator of any order, a direct problem is to look for an operator D1 generating the compatibility conditions (CC) D1η = 0 of Dξ = η. Conversely, when D1 is given, an inverse problem is to look for an operator D such that its CC are generated by D1 and we shall say that D1 is parametrized by D = D0. We may thus construct a differential sequence with successive operators D, D1, D2, ..., each operator parametrizing the next one. Introducing the formal adjoint ad() of an operator, we have but ad (Di-1) may not generate all the CC of ad (Di). When D = K [d1, ..., dn] = K [d] is the (non-c

关键词： Differential Sequence Variational Calculus Lanczos Potential Lanczos Operator Vessiot Structure Equations

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Inverse Scattering for a Schr■dinger Operator with a Repulsive Potential

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Acta Mathematica Sinica,English Series 2006年第5期22卷 1485-1492页

作者： francois NICOLEAU Laboratoire de Mathéatiques jean Leray UMR CNRS-UN 6629 Département de Mathématiques2 rue de la Houssinière BP 92208 F-44322 Nantes cedex 03 France

We consider a pair of Hamiltonians （H, H0） on L2（R^n）, where H0=p^2 -x^2 is a SchrSdinger operator with a repulsive potential, and H = H0＋V（x）. We show that, under suitable assumptions on the decay of the elect... 详细信息

关键词： Inverse scattering Repulsive potential

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Vapor and Pressure Sensors Based on Cellulose Nanofibers and Carbon Nanotubes Aerogel with Thermoelectric Properties

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Journal of Renewable Materials 2018年第3期6卷 277-287页

作者： Rajendran Muthuraj Abhishek Sachan Mickael Castro jean-francois Feller Bastien Seantier Yves Grohens Dupuy de Lôme Research Institute(IRDL) FRE CNRS 3744University of Southern BrittanyRue de Saint Maudé56321 Lorient CedexFrance

In this work,thermally insulating and electrically conductive aerogels were prepared from cellulose nanofibers(CNF)and carbon nanotubes(CNTs)by environmentally friendly freeze-drying *** thermal conductivity of neat CNF aerogel is 24 mW/(m・K)with a density of 0.025 g/*** the addition of CNTs into CNF aerogel,the electrical conductivity was significantly increased while the thermal conductivity was increased to 38 mW/(m・K).Due to these interesting properties,the Seebeck coefficient and the figure of merit(ZT)of the CNF/CNTs aerogels were measured and showed that CNF/CNTs aerogel thermoelectric properties can be *** compressibility and electrical resistance of the CNF/CNTs aerogel highlighted its pressure-responsive property.A set of volatile organic compounds(VOCs)were exposed to aerogels to monitor the resistance *** CNF/CNTs aerogel showed high sensitivity and good response to both nonpolar and polar vapors due to the absorption by both CNF and CNTs *** prepared CNF/CNTs aerogel is therefore a good candidate for thermal insulation,thermoelectric material,VOCs sensing,and pressure-sensing applications.

关键词： CNF/CNTs aerogel thermal conductivity pressure sensing thermoelectric materials VOCs sensing

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Synergistic control of sex hormones by 17β-HSD type 7: a novel target for estrogen-dependent breast cancer

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分子细胞生物学报:英文版 2015年第6期7卷 568-579页

作者： Xiaoqiang Wang Catherine Gérard jean-francois Thériault Donald Poirier Charles J.Doillon Sheng-Xiang Lin Laboratory of Molecular Endocrinology and Oncology Centre Hospitalier Universitaire de Québec Research Center(CHULCHU)and Laval UniversityQuébec CityQuebecG1V4G2Canada

17β-hydroxysteroid dehydrogenase(17β-HSD)type 1 is known as a critical target to block the final step of estrogen production in estrogen-dependent breast *** confirmation of the role of dyhydroxytestosterone(DHT)in counteracting estrogeninduced cell growth prompted us to study the reductive 17β-HSD type 7(17β-HSD7),which activates estrone while markedly *** role ofDHTin breast cancer cell proliferation isdemonstratedby its independent suppression of cell growthin the presence of a physiological concentration of estradiol(E2).Moreover,an integral analysis of a large number of clinical samples in Oncomine datasets demonstrated the overexpression of 17β-HSD7 in breast *** of 17β-HSD7 in breast cancer cells resulted in a lower level of E2 and a higher level of DHT,successively induced regulation of cyclinD1,p21,Bcl-2,and Bik,consequently arrested cell cycle in the G0/G1 phase,and triggered apoptosis and auto-downregulation feedback of the *** inhibition led to significant shrinkage of xenograft tumors with decreased cancer cell density and reduced 17β-HSD7 *** plasma E2 and elevated plasma DHT levels were also ***,the dual functional 17β-HSD7 is proposed as a novel target for estrogen-dependent breast cancer by regulating the balance of E2 *** aconceptual advance on the general belief that the major role of this enzyme is in cholesterol metabolism.

关键词： 17β-hydroxysteroid dehydrogenase type 7 breast cancer xenograft tumor steroid enzyme inhibition

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A new friedelane triterpenoid and saponin with moderate antimicrobial activity from the stems of Drypetes laciniata

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Chinese Chemical Letters 2011年第2期22卷 171-174页

作者： Simone Veronique Fannang Victor Kuete Celine Mbazoa Djama Marlise Diane J.Dongfack jean Duplex Wansi francois Tillequin Elisabeth Seguin Elizabeth Chosson jean Wandji Laboratoire de Synthese et de Produits Naturels Departement de Chimie Organique de l'Universite de Yaounde-1Faculte des SciencesP.O.Box 812 YaoundeCameroon Department of Biochemistry University of DschangFaculty of ScienceP.O.Box 67 DschangCameroon Laboratoire de Pharmacognosie de l'Universite Paris Descartes UMR/CNRS No.8638Faculte des Sciences Biologiques et Pharmaceutiques4-Avenue de l'Observatoire75006 ParisFrance Department of Chemistry University of DoualaFaculty of ScienceP.O.Box 24157 DoualaCameroon Laboratoire de Pharmacognosie UFR de Medecine Pharmacie Rouen22-Bld Gambetta76183 Rouen Cedex 1France

A new friedelane-type triterpene named 3β-hydroxyfriedelane-7,12,22-trione,as well as nine known compounds were isolated from the whole stems of Drypetes laciniata Hutch.（Euphorbiaceae）.Their structures were established on the basis of spectroscopic *** new triterpene derivative and a known saponin were tested for antimicrobial and antifungal activities and they appeared to be moderate active.

关键词： Drypetes laciniata Euphorbiaceae Stem Friedelane-type triterpenoid Antimicrobial activity

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Impact of time to diagnosis on the occurrence of cardiogenic shock in MIS‑C post‑COVID-19 infection

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World Journal of Pediatrics 2023年第6期19卷 595-604页

作者： Said Bichali Mathilde Bonnet Marie‑Emilie Lampin jean‑Benoit Baudelet Heloise Reumaux Olivia Domanski Thameur Rakza Alexandre Delarue Morgan Recher Jerome Soquet francois Dubos Stephane Leteurtre Ali Houeijeh francois Godart Pediatric Cardiology Univ.LilleCHU Lille2 Avenue Oscar Lambret59000 LilleFrance Pediatric Intensive Care Univ.LilleCHU Lille59000 LilleFrance ULR 2694‑Metrics:Evaluation des Technologies de Sante et des Pratiques Medicales Univ.Lille59000 LilleFrance Pediatric Rhumatology Univ.LilleCHU Lille59000 LilleFrance Cardiac Surgery Univ.LilleCHU Lille59000 LilleFrance Pediatric Emergency Univ.LilleCHU Lille59000 LilleFrance

Background In multisystem inflammatory syndrome in children(MIS-C),diagnostic delay could be associated with *** study aims to measure the time to diagnosis in MIS-C,assess its impact on the occurrence of cardiogenic shock,and specify its *** A single-center prospective cohort observational study was conducted between May 2020 and July 2022 at a tertiary care *** meeting the World Health Organization MIS-C criteria were included.A long time to diagnosis was defined as six days or *** on time to diagnosis were collected by two independent *** primary outcome was the occurrence of cardiogenic *** regression and receiver operating characteristic curve analysis were used for outcomes,and a Cox proportional hazards model was used for *** Totally 60 children were assessed for inclusion,and 31 were finally analyzed[52%males,median age 8.8(5.7-10.7)years].The median time to diagnosis was 5.3(4.2-6.2)*** univariable analysis,age above the median,time to diagnosis,high C-reactive protein,and high N-terminal pro-B-type natriuretic peptide(NT-proBNP)were associated with cardiogenic shock[odds ratio(OR)6.13(1.02-36.9),2.79(1.15-6.74),2.08(1.05-4.12),and 1.70(1.04-2.78),respectively].In multivariable analysis,time to diagnosis≥6 days was associated with cardiogenic shock[adjusted OR(aOR)21.2(1.98-227)].Time to diagnosis≥6 days had a sensitivity of 89% and a specificity of 77% in predicting cardiogenic shock;the addition of age>8 years and NT-proBNP at diagnosis≥11,254 ng/L increased the specificity to 91%.Independent determinants of short time to diagnosis were age<8.8 years[aHR 0.34(0.13-0.88)],short distance to tertiary care hospital[aHR 0.27(0.08-0.92)],and the late period of the COVID-19 pandemic[aHR 2.48(1.05-5.85)].Conclusions Time to diagnosis≥6 days was independently associated with cardiogenic shock in *** diagnosis and treatment are crucial to avoid the use of inotropes and

关键词： COVID-19 Delay in diagnosis Heart failure MIS-C SARS-CoV-2

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