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Antiplasmodial activity of traditional polyherbal remedy from Odisha, India:Their potential for prophylactic use

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Asian Pacific Journal of Tropical Biomedicine 2015年第12期5卷 982-986页

作者： Prakash Bangalore Nagendrappa jean-francois Franetich Frederick Gay Audrey Lorthiois Padma Venkatasubramanian Dominique Mazier Institute of Trans-Disciplinary Health Sciences and Technology Foundation for Revitalisation of Local Health Traditions Manipal University Cimi-Paris (UPMC UMRS CR7 Inserm U1135 CNRS ERL 8255) AP-HP Pitié-Salpêtrière Hospital Group

Objective:To evaluate the potential prophylactic activity of traditional polyherbal remedy against ***:A traditional polyherbal remedy against malaria from Odisha,India was evaluated for its potential prophylactic activity using in vitro hepatic cell lines assay and the murine malaria system Plasmodium yoelii yoelii/Anopheles ***:The polyherbal extract inhibited the Plasmodium yoelii hepatic stages in vitro(IC500.74 mg/m L),a therapeutic index of *** mice treated with the aqueous extract(2 000 mg/kg/day),peak parasitaemia values were 81%lower in the experimental2.35%±0.14%as compared to controls 12.62%±0.52%(P<0.001),suggesting significant prophylactic ***:The observations provide a proof of concept for a traditional malaria prophylactic remedy used by tribal populations in India.

关键词： Polyherbal remedy Plasmodium Malaria prophylaxis Antiplasmodial activity

Molecular investigation of Tuscan sweet cherries sampled over three years: gene expression analysis coupled to metabolomics and proteomics

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Horticulture Research 2021年第1期8卷 1-24页

作者： Roberto Berni Sophie Charton Sebastien Planchon Sylvain Legay Marco Romi Claudio Cantini Giampiero Cai jean-francois Hausman Jenny Renaut Gea Guerriero Department of Life Sciences University of Sienavia P.A.Mattioli 4I-53100 SienaItaly TERRA Teaching and Research Center Gembloux Agro-Bio TechUniversity of Liège5030 GemblouxBelgium Environmental Research and Innovation Department Luxembourg Institute of Science and Technology41Rue du BrillL-4422 BelvauxLuxembourg Environmental Research and Innovation Department Luxembourg Institute of Science and Technology5rue BommelL-4940 HautcharageLuxembourg Istituto per la BioEconomia(IBE CNR) Dipartimento di Scienze BioAgroAlimentarivia Aurelia 4958022 FollonicaItaly

Sweet cherry(Prunus avium L.)is a stone fruit widely consumed and appreciated for its organoleptic properties,as well as its nutraceutical *** here investigated the characteristics of six non-commercial Tuscan varieties of sweet cherry maintained at the Regional Germplasm Bank of the CNR-IBE in Follonica(Italy)and sampled ca.60 days post-anthesis over three consecutive years(2016-2017-2018).We adopted an approach merging genotyping and targeted gene expression profiling with *** complement the data,a study of the soluble proteomes was also performed on two varieties showing the highest content of *** identified the presence of flavanols and proanthocyanidins in highest abundance in the varieties Morellona and Crognola,while gene expression revealed that some differences were present in genes involved in the phenylpropanoid pathway during the 3 years and among the ***,proteomics on Morellona and Crognola showed variations in proteins involved in stress response,primary metabolism and cell wall *** the best of our knowledge,this is the first multi-pronged study focused on Tuscan sweet cherry varieties providing insights into the differential abundance of genes,proteins and metabolites.

关键词： metabolism maintained sweet

Predictors of long-term clinical outcome of patients with acute massive pulmonary embolism after thrombolytic therapy

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Chinese Medical Journal 2003年第4期116卷 503-509页

作者：刘品明 Nicolas Meneveau francois Schiele jean Pierre Bassand Department of Cardiology Second Affiliated HospitalZhongshan University Service de Cardiologie Centre Hospitalier Universitare

To assess the in-hospital clinical course and the long-term evolution of acute massive pulmonary embolism after thrombolytic therapy and to identify predictors of adverse clinical outcome Methods A total of 260 patients hospitalized from January 1989 to October 1998 were retrospectively reviewed and followed up for 3 9 to 8 4 years Baseline characteristics and variables pre- and post-thrombolysis were identified Particular attention was paid to the clinical events, including death, recurrent thromboembolism, chronic thromboembolic pulmonary hypertension, and major bleeding attributable to the use of anticoagulants Kaplan-Meier event-free survival curves were generated Univariate analysis by means of the log-rank test was used to test each candidate variable for association with clinical outcome Multivariate analysis with the Cox proportional hazard model was used to determine independent predictors of the long-term outcome Results The in-hospital mortality rate was 8 5%, with 68 2% due to pulmonary embolism itself, and the follow-up mortality rate was 31 7%, with 29 2% due to recurrent embolism Factors associated with an adverse outcome in univariate analysis were: (1) prior thromboembolic diseases; (2) duration of anticoagulant therapy 50 mmHg after thrombolysis; and (6) greater than 30% obstruction of pulmonary vasculature identified by pulmonary ventilation/perfusion scintigraphy before hospital discharge Multivariate analysis identified three independent predictors of poor long-term outcome for patients with acute massive pulmonary embolism after thrombolysis; which were: (1) Doppler recording of pulmonary artery systolic pressure >50 mm Hg, with relative risk of 3 78 and a 95% confidence interval of 2 70 to 4 86; (2)

关键词： pulmonary embolism · deep venous thrombosis · thrombolytic therapy

ACTIF,A Design Assistance for Interoperable Transportation Systems in France

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ACTIF,A Design Assistance for Interoperable Transportation S...

Urinary metabolic insights into host-gut microbial interactions in healthy and IBD children

第一届中国智能交通年会

作者： jean-francois JANIN

The ACTIF project was launched in 2001 by the French Ministry of Transport to build a national frame for the deployment of ITS around the coun- *** a first phase of modelisation inspired by the foreign architectures (USA,Japan,European) it appeared that a specific method was needed to as- sist the authorities in charge of the deployment of real systems to precise their needs and their organisation.A tool has been develop to create architectures ap- propriate to these *** is now a combination of a conceptual model describing the whole domain of ITS,at a high level but including all modes of transport,a method to use it and a set of tools available without charge from the web site ***-actif,*** method is illustrated by case studies in vari- ous domains.

关键词： Architecture Interoperability Intermodality multimodal transport functional modelling ACTIF road information advanced traveller information system enforcement dissemination

来源： cnki会议评论

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World Journal of Gastroenterology 2017年第20期23卷 3643-3654页

作者： francois-Pierre Martin Ming-Ming Su Guo-Xiang Xie Seu Ping Guiraud Martin Kussmann jean-Philippe Godin Wei Jia Andreas Nydegger NestléInstitute of Health Sciences University of Hawaii Cancer Center Metabo-Profile Biotechnology(Shanghai)Co. Ltd. The Liggins Institute The University of Auckland NestléResearch Center Division of Pediatric Gastroenterology University of Lausanne

AIMTo identify metabolic signatures in urine samples from healthy and inflammatory bowel disease(IBD)*** applied liquid chromatography and gas chromatography coupled to targeted mass spectrometry(MS)-based metabolite profiling to identify and quantify bile acids and host-gut microbial metabolites in urine samples collected from 21 pediatric IBD patients monitored three times over one year(baseline,6 and 12 mo),and 27age-and gender-matched healthy *** metabolic profiles of IBD children differ significantly from healthy *** metabolic differences encompass central energy metabolism,amino acids,bile acids and gut microbial *** particular,levels of pyroglutamic acid,glutamic acid,glycine and cysteine,were significantly higher in IBD children in the course of the *** suggests that glutathione cannot be optimally synthesized and *** alterations of the enterohepatic circulation of bile acids in pediatric IBD patients is known,we show here that non-invasive urinary bile acid profiling can assess those altered hepatic and intestinal barrier *** present study shows how non-invasive sampling of urine followed by targeted MS-based metabonomic analysis can elucidate and monitor the metabolic status of children with different GI health/disease status.

关键词： Pediatric Metabolism Phenotype Growth Inflammatory bowel disease Crohn's disease Ulcerative colitis

是是非非是是非——欧盟对华反倾销新政策的灵活性和消极性

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国际贸易 2000年第11期 18-21页

作者： jean-francois Bellis 傅东辉比利时VBB律师事务所

中国从20世纪80年代末开始成为欧盟反倾销的主要对象。欧盟反倾销则随之逐渐成为中国对欧出口的主要贸易障碍。 1998年4月30日,欧盟理事会通过一个对反倾销法的重要修正案,总体上承认中国和俄罗斯为“市场经济国家”,这是欧盟对华反倾... 详细信息

中国从20世纪80年代末开始成为欧盟反倾销的主要对象。欧盟反倾销则随之逐渐成为中国对欧出口的主要贸易障碍。 1998年4月30日,欧盟理事会通过一个对反倾销法的重要修正案,总体上承认中国和俄罗斯为“市场经济国家”,这是欧盟对华反倾销政策上一个极为重要的变化。

关键词：欧盟对华反倾销政策灵活性消极性中国应诉

番茄形态结构模型参数的多目标拟合估算方法研究

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农业工程学报 2006年第2期22卷 1-5页

作者：董乔雪王一鸣 jean francois Barczi 贺超兴中国农业大学(东校区)信息与电气工程学院北京100083 中国科学院自动化研究所中法联合实验室LIAMA 北京100080 中国农业科学院蔬菜花卉研究所北京100081

对番茄生长模型参数进行准确估算是模型得以验证和面向应用的前提条件。基于番茄拓扑结构,采用非线性最小二乘优化方法,通过对植株形态数据的多目标拟合,实现模型参数的最优估计和校准。非线性最小二乘法的权值根据目标数据自动调整,使... 详细信息

对番茄生长模型参数进行准确估算是模型得以验证和面向应用的前提条件。基于番茄拓扑结构,采用非线性最小二乘优化方法,通过对植株形态数据的多目标拟合,实现模型参数的最优估计和校准。非线性最小二乘法的权值根据目标数据自动调整,使得不同量纲和不同数值范围的观测数据可以在同一水平上进行,提高了计算的精度和稳定性;另一方面用差商近似代替导数加快了算法的收敛速度。通过应用拟合优度检验,得出模型输出对观测值的拟合程度较好,说明模型合理,参数可靠。实践表明该估算方法是对模型进行验证的一个行之有效的方法。

关键词：番茄模型参数估算多目标拟合非线性最小二乘方法

Another Example of Devastating Complication of Heparin-Induced Thrombocytopenia Post-Cardiac Surgery

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International Journal of Clinical Medicine 2010年第2期1卷 75-77页

作者： Karine Toledano francois Beique Donald Hickey jean-francois Morin Department of Anesthesia and Cardiac Surgery SMBD Jewish General HospitalMcGill UniversityMontrealCanada

We describe a patient who developed catastrophic consequences of heparin-induced thrombocytopenia (HIT) post car?diac surgery, for which she required reoperation using CPB. We also illustrate the impact of intraoperat... 详细信息

关键词： Danaparoid Heparin-Induced Thrombocytopenia Stroke Emboli

Are multidisciplinary consultation meetings for prenatal diagnosis achievable in a low-income country? A descriptive cross-sectional survey in Benin

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World Journal of Pediatric Surgery 2023年第4期6卷 270-275页

作者： Monsoia Gildas Yassegoungbe Beaudelaire Romulus Assan Amoussou Sedjro Clotaire Romeo Houegban Codjo Serge Metchihoungbe jean-francois Lecompte Christine Tschabu Aguemon Sidoine Bitho Gbetey jean Breaud Antoine Seraphin Gbenou Pediatric Surgery Department Mother and Child Teaching Hospital LaguneUniversity of Abomey-CalaviCotonouBenin Pediatric Surgery Department National Teaching Hospital Hubert Koutoukou MagaUniversity of Abomey-CalaviCotonouBenin Pediatric Surgery Department CHU-LENVAL Paediatric Hospitals of NiceNiceFrance University Clinic of Gynecological Obstetrics National Teaching Hospital Hubert Koutoukou MagaUniversity of Abomey-CalaviCotonouBenin Intellectual Production Department Center of Expertise in Applied Social SciencesCotonouBenin

Objective The multidisciplinary antenatal diagnosis staff bring together practitioners who are involved in the management of the antenatal period at *** project was designed following the French experience to institute multidisciplinary consultation meetings for prenatal diagnosis(MCMPD)in *** This is a descriptive cross-sectional study examining the knowledge,attitudes,and practices of Beninese practitioners in the field of MCMPD to develop the pilot phase of the *** We collected 108 participants from different *** and pediatric surgeons were in the majority at 23.9% and 16.5%,***-seven percent of participants were from the public sector(n=75).One practitioner felt that it was not a good idea to implement these *** all staff(96.2%)agreed that this meeting would have a positive impact on reducing neonatal ***(58.5%),spina bifida aperta(43.6%),and gastroschisis(34%)were the most commonly diagnosed antenatal conditions in *** neonatal pathology required medical termination of the pregnancy according to 35.6% of the *** The objective of reducing infant mortality due to medical and surgical pathologies is a noble one and deserves to be *** innovative project,developed through this study,the first of its kind in the subregion,will contribute inexorably to the achievement of the third Goal Sustainable Development.

关键词： diagnosis sectional income