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3D bioprinted breast cancer model reveals stroma-mediated modulation of extracellular matrix and radiosensitivity

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Bioactive Materials 2024年第12期42卷 316-327页

作者： Theo Desigaux Leo Comperat Nathalie Dusserre Marie-Laure Stachowicz Malou Lea jean-William Dupuy Anthony Vial Michael Molinari jean-Christophe Fricain francois Paris Hugo Oliveira Univ.Bordeaux Tissue Bioengineering INSERM U1026F-33000BordeauxFrance INSERM U1026 ART BioPrintF-33000BordeauxFrance Univ.Bordeaux Bordeaux ProteomeF-33000BordeauxFrance Univ.Bordeaux CNRSINSERMTBM-CoreUS5UAR 3427OncoProtF-33000BordeauxFrance Univ.Bordeaux CNRSBordeaux INPCBMNUMR 5248F-33600PessacFrance Services d’Odontologie et de Sante Buccale CHU BordeauxF-33000BordeauxFrance CRCINA INSERMCNRSUniv.NantesF-44000NantesFrance Institut de Cancerologie de l’Ouest F-44800Saint HerblainFrance

Deciphering breast cancer treatment resistance remains hindered by the lack of models that can successfully capture the four-dimensional dynamics of the tumor ***,we show that microextrusion bioprinting can reproducibly generate distinct cancer and stromal compartments integrating cells relevant to human *** findings unveil the functional maturation of this millimeter-sized model,showcasing the development of a hypoxic cancer core and an increased surface *** was also driven by the presence of cancer-associated fibroblasts(CAF)that induced elevated microvascular-like structures *** modulation was concomitant to extracellular matrix remodeling,with high levels of collagen and matricellular proteins deposition by CAF,simultaneously increasing tumor stiffness and recapitulating breast cancer fibrotic ***,our bioprinted model faithfully reproduced response to treatment,further modulated by ***,CAF played a protective role for cancer cells against radiotherapy,facilitating increased paracrine *** model holds promise as a platform to decipher interactions within the microenvironment and evaluate stroma-targeted drugs in a context relevant to human pathology.

关键词： Bioprinting Cancer microenvironment Extracellular matrix

The Restoration of Kidane Mehret Church in Sen＇afe

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Sociology Study 2016年第11期6卷 713-720页

作者： jean-francois Breton The French National Center for Scientific Research CCNRS) France

The Church of Kidane Mehret stands at 2,450 m above sea level, close to the village of Sen＇afe, on the border between Ethiopia and Eritrea. Probably built in the fifteenth or sixteenth century, the church gradually became a ruin in the middle of the last century. Following the intervention of the monks of this church, a restoration program was set up in 2006. With the agreement of the National Museum in Asmara and the World Monuments Fund, funding was collected together by the German Embassy, the French Embassy, and the Alliance Fran^aise of Asmara, which made it possible to restore the church, between 2006 and 2008. Teams of workmen and women were created to this end. Only traditional techniques were employed for the masonry of the walls, the wooden roofing the plastering, and the interior paintwork. This project, which conforms to the Charter of Venice, could serve as an example for similar restorations in the region and as a model for professional training. Finally, a trilingual article （English, German, and Tigrinya） was published in the Collection ＂Cultures et Patrimoines d＇ErythrGe＂, 2009.

关键词： Eritrea church wooden architecture restoration Orthodox Church

Synergistic control of sex hormones by 17β-HSD type 7: a novel target for estrogen-dependent breast cancer

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Journal of Molecular Cell Biology 2015年第6期7卷 568-579页

作者： Xiaoqiang Wang Catherine Gérard jean-francois Thériault Donald Poirier Charles J.Doillon Sheng-Xiang Lin Laboratory of Molecular Endocrinology and Oncology Centre Hospitalier Universitaire de Québec Research Center(CHULCHU)and Laval UniversityQuébec CityQuebecG1V4G2Canada

17β-hydroxysteroid dehydrogenase(17β-HSD)type 1 is known as a critical target to block the final step of estrogen production in estrogen-dependent breast *** confirmation of the role of dyhydroxytestosterone(DHT)in counteracting estrogeninduced cell growth prompted us to study the reductive 17β-HSD type 7(17β-HSD7),which activates estrone while markedly *** role ofDHTin breast cancer cell proliferation isdemonstratedby its independent suppression of cell growthin the presence of a physiological concentration of estradiol(E2).Moreover,an integral analysis of a large number of clinical samples in Oncomine datasets demonstrated the overexpression of 17β-HSD7 in breast *** of 17β-HSD7 in breast cancer cells resulted in a lower level of E2 and a higher level of DHT,successively induced regulation of cyclinD1,p21,Bcl-2,and Bik,consequently arrested cell cycle in the G0/G1 phase,and triggered apoptosis and auto-downregulation feedback of the *** inhibition led to significant shrinkage of xenograft tumors with decreased cancer cell density and reduced 17β-HSD7 *** plasma E2 and elevated plasma DHT levels were also ***,the dual functional 17β-HSD7 is proposed as a novel target for estrogen-dependent breast cancer by regulating the balance of E2 *** aconceptual advance on the general belief that the major role of this enzyme is in cholesterol metabolism.

关键词： 17β-hydroxysteroid dehydrogenase type 7 breast cancer xenograft tumor steroid enzyme inhibition

A new friedelane triterpenoid and saponin with moderate antimicrobial activity from the stems of Drypetes laciniata

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Chinese Chemical Letters 2011年第2期22卷 171-174页

作者： Simone Veronique Fannang Victor Kuete Celine Mbazoa Djama Marlise Diane J.Dongfack jean Duplex Wansi francois Tillequin Elisabeth Seguin Elizabeth Chosson jean Wandji Laboratoire de Synthese et de Produits Naturels Departement de Chimie Organique de l'Universite de Yaounde-1Faculte des SciencesP.O.Box 812 YaoundeCameroon Department of Biochemistry University of DschangFaculty of ScienceP.O.Box 67 DschangCameroon Laboratoire de Pharmacognosie de l'Universite Paris Descartes UMR/CNRS No.8638Faculte des Sciences Biologiques et Pharmaceutiques4-Avenue de l'Observatoire75006 ParisFrance Department of Chemistry University of DoualaFaculty of ScienceP.O.Box 24157 DoualaCameroon Laboratoire de Pharmacognosie UFR de Medecine Pharmacie Rouen22-Bld Gambetta76183 Rouen Cedex 1France

A new friedelane-type triterpene named 3β-hydroxyfriedelane-7,12,22-trione,as well as nine known compounds were isolated from the whole stems of Drypetes laciniata Hutch.（Euphorbiaceae）.Their structures were established on the basis of spectroscopic *** new triterpene derivative and a known saponin were tested for antimicrobial and antifungal activities and they appeared to be moderate active.

关键词： Drypetes laciniata Euphorbiaceae Stem Friedelane-type triterpenoid Antimicrobial activity

Differential Homological Algebra and General Relativity

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Journal of Modern Physics 2019年第12期10卷 1454-1486页

作者： jean-francois Pommaret CERMICS Ecole des Ponts Paris Tech Paris France

In 1916, F.S. Macaulay developed specific localization techniques for dealing with “unmixed polynomial ideals” in commutative algebra, transforming them into what he called “inverse systems” of partial differential equations. In 1970, D.C. Spencer and coworkers studied the formal theory of such systems, using methods of homological algebra that were giving rise to “differential homological algebra”, replacing unmixed polynomial ideals by “pure differential modules”. The use of “differential extension modules” and “differential double duality” is essential for such a purpose. In particular, 0-pure differential modules are torsion-free and admit an “absolute parametrization” by means of arbitrary potential like functions. In 2012, we have been able to extend this result to arbitrary pure differential modules, introducing a “relative parametrization” where the potentials should satisfy compatible “differential constraints”. We recently noticed that General Relativity is just a way to parametrize the Cauchy stress equations by means of the formal adjoint of the Ricci operator in order to obtain a “minimum parametrization” by adding sufficiently many compatible differential constraints, exactly like the Lorenz condition in electromagnetism. In order to make this difficult paper rather self-contained, these unusual purely mathematical results are illustrated by many explicit examples, two of them dealing with contact transformations, and even strengthening the comments we recently provided on the mathematical foundations of General Relativity and Gauge Theory. They also bring additional doubts on the origin and existence of gravitational waves.

关键词： Homological Algebra Extension Module Torsion-Free Module Pure Module Purity Filtration Involution Electromagnetism General Relativity

Peace, Peace to the Far and the Near： Who Comes First？

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Journal of Philosophy Study 2017年第5期7卷 261-268页

作者： jean-francois REY

Peace＇s gift when you meet the other is not a polite phrase. This is courtesy or politeness which institutes a priority order： first the far, then the near. In Levinas＇ thought, there is a peace of pure rest, ＂at home＂ and a peace which questions my own identity. A fair peace is a peace where the foreigner goes before me. ＂Close peace is my responsibility for the other man,＂ says Levinas. It is an ＂ethical＂ peace, different from political peace. Peace comes from my own responsibility for the other, until it could die for him. Maybe this welcome will seem crazy, but it is moderated, i.e., involved and estimated in politics. Levinas knows the political moment. But he puts it to its place： to welcome the strangers is an objective fact. Proximity of social link and perspective of far cannot be separated. It＇s a matter of politics and right.

关键词： peace proximity against Hobbes the other the stranger history

The Projective Group as a Topological Manifold

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Advances in Linear Algebra & Matrix Theory 2018年第4期8卷 134-142页

作者： jean-francois Niglio Department of Mathematics Kingston University London UK

In this article, we start by a review of the circle group? [1] and its topology induced [1] by the quotient metric, which we later use to define a topological structure on the unit circle . Using points on? under the complex exponential map, we can construct orthogonal projection operators. We will show that under this construction, we arrive at a topological group, denoted? of projection matrices. Together with the induced topology, it will be demonstrated that? is Hausdorff and Second Countable forming a topological manifold. Moreover, I will use an example of a group action on? to generate subgroups of?.

关键词： Projection Orthogonal Projections Projective Operators Projective Manifolds

A Follow-Up on Projection Theory: Theorems and Group Action

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Advances in Linear Algebra & Matrix Theory 2019年第1期9卷 1-19页

作者： jean-francois Niglio Department of Mathematics Kingston University London UK

In this article, we wish to expand on some of the results obtained from the first article entitled Projection Theory. We have already established that one-parameter projection operators can be constructed from the unit circle . As discussed in the previous article these operators form a Lie group known as the Projection Group. In the first section, we will show that the concepts from my first article are consistent with existing theory [1] [2]. In the second section, it will be demonstrated that not only such operators are mutually congruent but also we can define a group action on ?by using the rotation group [3] [4]. It will be proved that the group acts on elements of ?in a non-faithful but ∞-transitive way consistent with both group operations. Finally, in the last section we define the group operation ?in terms of matrix operations using the operator and the Hadamard Product;this construction is consistent with the group operation defined in the first article.

关键词： Projection Theory Projection Manifolds Projectors Congruent Projection Matrices

The Mathematical Foundations of Gauge Theory Revisited

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Journal of Modern Physics 2014年第5期5卷 157-170页

作者： jean-francois Pommaret CERMICS Ecole des Ponts ParisTech 77455 Marne-la-Vallée Cedex 02 France

We start recalling with critical eyes the mathematical methods used in gauge theory and prove that they are not coherent with continuum mechanics, in particular the analytical mechanics of rigid bodies (despite using the same group theoretical methods) and the well known couplings existing between elasticity and electromagnetism (piezzo electricity, photo elasticity, streaming birefringence). The purpose of this paper is to avoid such contradictions by using new mathematical methods coming from the formal theory of systems of partial differential equations and Lie pseudo groups. These results finally allow unifying the previous independent tentatives done by the brothers E. and F. Cosserat in 1909 for elasticity or H. Weyl in 1918 for electromagnetism by using respectively the group of rigid motions of space or the conformal group of space-time. Meanwhile we explain why the Poincaré duality scheme existing between geometry and physics has to do with homological algebra and algebraic analysis. We insist on the fact that these results could not have been obtained before 1975 as the corresponding tools were not known before.

关键词： Gauge Theory Curvature Torsion Maurer-Cartan Forms Maurer-Cartan Equations Lie Groups Lie Pseudo Groups Differential Sequence Janet Sequence Spencer Sequence Differential Module Homological Algebra Extension Modules