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Genome-wide association studies in apple reveal loci of large effect controlling apple polyphenols

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Horticulture Research 2019年第1期6卷 444-455页

作者： Kendra AMcClure YuiHui Gong Jun Song Melinda Vinqvist-Tymchuk Leslie Campbell Palmer Lihua Fan Karen Burgher-MacLellan ZhaoQi Zhang jean-Marc Celton Charles FForney ZoëMigicovsky Sean Myles Department of Plant and Animal Sciences Faculty of AgricultureDalhousie UniversityTruroNS B2N 5E3Canada Agriculture and Agri-Food Canada Kentville Research and Development CentreKentvilleNS B4N 1J5Canada College of Horticulture South China Agriculture UniversityGuangzhou 510642China IRHS Agrocampus-OuestINRAUniversitéd’AngersSFR 4207 QuaSaVBeaucouzéFrance

Apples are a nutritious food source with significant amounts of polyphenols that contribute to human health and wellbeing,primarily as dietary *** numerous pre-and post-harvest factors can affect the composition of polyphenols in apples,genetics is presumed to play a major role because polyphenol concentration varies dramatically among apple *** we investigated the genetic architecture of apple polyphenols by combining high performance liquid chromatography(HPLC)data with~100,000 single nucleotide polymorphisms(SNPs)from two diverse apple *** found that polyphenols can vary in concentration by up to two orders of magnitude across cultivars,and that this dramatic variation was often predictable using genetic markers and frequently controlled by a small number of large effect genetic *** GWAS,we identified candidate genes for the production of quercitrin,epicatechin,catechin,chlorogenic acid,4-O-caffeoylquinic acid and procyanidins B1,B2,and *** observation that a relatively simple genetic architecture underlies the dramatic variation of key polyphenols in apples suggests that breeders may be able to improve the nutritional value of apples through markerassisted breeding or gene editing.

关键词： effect apple cultivar

Hele-Shaw装置中单一气泡近竖直壁面上升过程实验研究

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Hele-Shaw装置中单一气泡近竖直壁面上升过程实验研究

Erratum to:Effect of the synthesis route on the structural and dielectric properties of SrBi1.8Y0.2Nb2O9 ceramics

第十二届全国流体力学学术会议

作者：菅振向诗评 Abderrahmane Kherbeche Marie-jean Thoraval 西安交通大学航天航空学院工程力学系机械结构强度与振动国家重点实验室国际应用力学中心 Université Paris-Est Laboratoire Géomatériaux et Environnement(EA4508)UPEM

本文利用高速摄像实验技术研究了二维Hele-Shaw装置中单一气泡近竖直壁面上升过程,建立了考虑附加质量效应的力平衡方程,查清了气泡几何及动力学特征量的时间演化规律,揭示了壁面对气泡上升动力学过程的影响机制。利用流变液,观察到了... 详细信息

本文利用高速摄像实验技术研究了二维Hele-Shaw装置中单一气泡近竖直壁面上升过程,建立了考虑附加质量效应的力平衡方程,查清了气泡几何及动力学特征量的时间演化规律,揭示了壁面对气泡上升动力学过程的影响机制。利用流变液,观察到了气泡上升过程清晰尾迹结构。实验中发现,气泡被释放后首先竖直上升,然后开始之字形摆动,并逐渐远离壁面。从尾迹结构的时空演化角度来看,气泡释放后首先形成直线尾迹,随后在气泡后部形成附着对称涡对,然后漩涡脱落触发之字形摆动,并最终形成卡门涡街,竖直壁面导致近壁区复杂尾迹结构的产生。

关键词：气泡 Hele-Shaw 壁面尾迹卡门涡街

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International Journal of Minerals,Metallurgy and Materials 2020年第11期27卷 1568-1568页

作者： Mohamed Afqir Amina Tachafine Didier Fasquelle Mohamed Elaatmani jean-Claude Carru Abdelouahad Zegzouti Mustapha El Hammioui Laboratoire des Sciences des Matériaux Inorganiques et leurs Applications Facultédes Sciences SemlaliaUniversitéCadi AyyadMarrakech40000Maroc Unitéde Dynamique et Structure des Matériaux Moléculaires Universitédu Littoral-Côte d’OpaleCalais62100France Laboratoire de recherche sur la réactivitédes matériaux et l’optimisation des procédés Facultédes Sciences SemlaliaUniversitéCadi AyyadMarrakech40000Maroc

The original version of this article unfortunately contained a mistake. In the Table 1, the values of volume are not correct.

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老年人的蛋白质摄入量和骨病

老年人的蛋白质摄入量和骨病

作者： Ren Rizzoli Patrick Ammann Thierry Chevalley jean-Philippe Bonjour 王劲 Bony diseases division centre collaborateur de I’ OMS pou l’ ost oporose et lesmaladies osseuses d partement dem decine internehopital cantonal universitaireCH 1211 Geneva 14Switzerland

营养不良、大多数显著的蛋白质缺乏,不仅通过减少骨量,而且通过改变肌肉功能来导致骨质疏松性骨折的发生。此外,营养不良与骨质疏松性骨折发病率增加有关。生长调节素系统(IGF-1)可能直接涉及老年人髋部骨质疏松性骨折及其并发症的发病... 详细信息

营养不良、大多数显著的蛋白质缺乏,不仅通过减少骨量,而且通过改变肌肉功能来导致骨质疏松性骨折的发生。此外,营养不良与骨质疏松性骨折发病率增加有关。生长调节素系统(IGF-1)可能直接涉及老年人髋部骨质疏松性骨折及其并发症的发病机制。低IGF-1水平是髋骨骨折的危险因素。维生素D和钙摄入量合适的研究对象,给予纠正自然蛋白质摄入量不足的蛋白质补充量可增加循环血中IGF-1,改善髋骨骨折后的临床结局,和预防股骨近端骨矿物质密度的丢失。补充蛋白质也可明显减少住院患者康复治疗的时间。这些资料强调了适量营养素摄入量在骨质疏松性骨折防治方面的重要性。

关键词：骨折 IGF-1 营养骨质疏松症

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移植肾动脉狭窄:血管成形术径路和方法

放射学实践 1998年第3期13卷 93-97页

作者：刘鹏程 Otal Philippe Colombier Daniel Rousseau Herve Cisterne jean-Marc francisJoffre 同济医科大学附属同济医院放射科 Service de Radiologie H■pital de Rangueil CHRU de ToulouseFrance Service de Nephrologie H■pital de RangueilCHRU de ToulouseFrance

目的用于评价两种径路的血管成形术的方法对移植肾动脉狭窄的治疗作用。材料与方法 18例移植肾动脉狭窄并高血压患者成功进行了血管成形术。18例中,15例患者血管狭窄位于外科手术血管吻合处或吻合处远侧端移植肾动脉主干,3例位于移植肾... 详细信息

目的用于评价两种径路的血管成形术的方法对移植肾动脉狭窄的治疗作用。材料与方法 18例移植肾动脉狭窄并高血压患者成功进行了血管成形术。18例中,15例患者血管狭窄位于外科手术血管吻合处或吻合处远侧端移植肾动脉主干,3例位于移植肾的肾内分支动脉。同侧股动脉径路用于治疗端-侧血管吻合的患者(n=10),对侧股动脉径路,用于治疗端-端血管吻合的患者(n=6)。16例采用股动脉径路,2例经肱动脉径路。疗效以临床随访、血管造影和超声追踪为评价。结果 18例移植肾动脉狭窄患者成功地施行了血管成形术。成形术后,所有病人均治愈。1例患者因为复发动脉狭窄,而再次作血管扩张,同时放置1个支撑器。第二次血管成形术后6个月,考虑病人已治愈。结论血管成形术是移植肾动脉狭窄所致长期高血压和肾功能减退的有效的、首选治疗方法。

关键词：肾移植动脉狭窄血管成形术移植肾

Cooperation Partnership Promotes Launching of Infrastructural Projects

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China's Foreign Trade 2016年第5期 13-页

作者： jean-Sébastien JACQUE b20 infrastructure taskforce rio tinto

The global infrastructural investment gap will reach several trillion USD in the next 10 to 15 *** is undeniable that the private sector should and is willing to play a part in this *** the same time,all parties shall... 详细信息

关键词： Bank

X-ray Spectroscopy at Ultra-High Pressure: Present and Future

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X-ray Spectroscopy at Ultra-High Pressure: Present and Futur...

18th International Conference on High Pressure Science and Technology

作者： James Badro Guilla Fiquet francois Guyot Michael Krisch Alain Mermet Herwig Requardt Abhay Shukla jean-Pascal Kueff Florent Occelli Viktor Struzhkin Ho-kwang Mao Laboratoire de Mineralogie-Cristallographie CNRS4 place Jussieu75252 Paris cedex 05France Laboratoire de Mineralogie-Cristallographie CNRS4 place Jussieu75252 Paris cedex 05France Laboratoire de Mineralogie-Cristallographie CNRS4 place Jussieu75252 Paris cedex 05France ESRF BP 220 GrenobleFrance ESRF BP 220 GrenobleFrance ESRF BP 220 GrenobleFrance ESRF BP 220 GrenobleFrance ESRF BP 220 GrenobleFrance CEA-DAM Bruyeres-le-Chatel France arnegie Institution Washington DCUSA arnegie Institution Washington DCUSA

＜正＞High pressure research has entered the era of high-end state of the art measurements, especially in the field of synchrotron x-ray research. Nowadays, a large number of techniques are readily available and applicable in conjunction with the most widely used high pressure apparatus, namely the diamond anvil cell. In the past years, diffraction constituted the largest part of high-pressure synchrotron-based x-ray research, along with limited efforts in the field of x-ray absorption spectroscopy. The appearance of high-energy third generation x-ray sources （ESRF, APS, SPring-8） allowed extremely brilliant x-ray beams to be focused down to very small sizes, due to the conjunction of high flux, small source size and divergence, and high coherence. With the help of an x-ray spectrometer set up in the Rowland geometry （figure 1） and low-Z （x-ray transparent） gaskets, a wide variety of high-resolution spectroscopic techniques can be accessed. We will briefly present techniques such as high resolution x-ray emission as local probe for magnetism and electronic modifications, as well as resonant x-ray scattering （x-ray Raman）. Inelastic x-ray scattering with ultra-high resolution allows us to access the vibrational properties （acoustic and optical phonons） of materials. These new techniques allowed us to investigate the electronic and magnetic properties of wiistite （FeO）, hematite （Fe2O3） and iron （Fe） well into the megabar pressure range. FeO is shown to become a paramagnetic compound at high pressure, and a closed-loop anti-ferromagnetic stability domain is depicted [1]. The vibrational properties （longitudinal and transverse sound wave velocities, and optical phonons in some cases） of iron （Fe） [2] and iron-bearing compounds （FeSi, FeS, FeS2, and FeO） [3-4] were measured to megabar pressures by ultra-high resolution （4 meV） inelastic x-ray scattering, along with the acoustic phonon dispersion curves. This set of data provides the first d

关键词： High Pressure X-ray Spectroscopy Phonons Electronic Structure Magnetism

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提高猪场中锌的平衡

饲料工业 2015年第12期36卷 64-64页

作者： jean-Yves Dourmad 张永刚法国农业科学研究院

尽管锌是猪体内的微小组分（2.2 g锌100 kg体重）,但是锌参与了动物体内大量的代谢活动。给猪提供足够量的锌是为了确保猪的生产性能和健康。然而在实际生产中,猪日粮中锌的添加量通常是超标的,过量的锌会对环境造成危害,尤其是在密集... 详细信息

尽管锌是猪体内的微小组分（2.2 g锌100 kg体重）,但是锌参与了动物体内大量的代谢活动。给猪提供足够量的锌是为了确保猪的生产性能和健康。然而在实际生产中,猪日粮中锌的添加量通常是超标的,过量的锌会对环境造成危害,尤其是在密集化养猪区域。在泥浆状的排泄物中锌会浓缩在固态物质中,从而使锌的含量超过有机肥所规定的浓度。土壤中的微生物对土壤中锌浓度的敏感程度要高于植物。

关键词：固态物质密集化浆状生产性能排泄量仔猪日粮促生长因子供给情况猪粪下降程度

New targeted therapies for breast cancer: A focus on tumor microenvironmental signals and chemoresistant breast cancers

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World Journal of Clinical Cases 2014年第12期2卷 769-786页

作者： Armel Hervé Nwabo Kamdje Paul Faustin Seke Etet Lorella Vecchio Richard Simo Tagne Jeremie Mbo Amvene jean-Marc Muller Mauro Krampera Kiven Erique Lukong Department of Biomedical Sciences Faculty of Sciences University of NgaoundéréPO Box 454 NgaoundéréCameroon Department of Basic Health Sciences College of Applied Medical Sciences Qassim UniversityBuraydah 52571 Saudi Arabia Université de Poitiers Faculté des Sciences P?le Biologie-Santé Bat B36 1 rue Georges Bonnet-BP633 86022 Poitiers cedex France Department of Medicine Section of Hematology Stem Cell Research Laboratory University of Verona 37129 Verona Italy Department of Biochemistry College of Medicine University of Saskatchewan Saskatoon S7N 5E5 Canada

Breast cancer is the most frequent female malignancy worldwide. Current strategies in breast cancer therapy,including classical chemotherapy, hormone therapy, and targeted therapies, are usually associated with chemoresistance and serious adverse effects. Advances in our understanding of changes affecting the interactome in advanced and chemoresistant breast tumors have provided novel therapeutic targets, including, cyclin dependent kinases, mammalian target of rapamycin,Notch, Wnt and Shh. Inhibitors of these molecules recently entered clinical trials in mono- and combination therapy in metastatic and chemo-resistant breast cancers. Anticancer epigenetic drugs, mainly histone deacetylase inhibitors and DNA methyltransferase inhibitors, also entered clinical trials. Because of the complexity and heterogeneity of breast cancer, the future in therapy lies in the application of individualized tailored regimens. Emerging therapeutic targets and the implications for personalized-based therapy development in breast cancer are herein discussed.

关键词： Breast cancer Microenvironment Signaling molecule Targeted therapy Chemoresistance