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Humus: dark side of life or intractable “aether”?

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Pedosphere 2022年第4期32卷 660-664页

作者： jean-françois PONGE Muséum National d'Histoire Naturelle CNRS UMR 7179Brunoy 91800France

dear Editor,Johannes Lehmann and Markus Kleber,in a controversial paper entitled"The contentious nature of soil organic matter"(Lehmann and Kleber,2015),suggested the abandonment of the term"humus"and other associated terms such as"humic","humir","humified","humification".The first reason they cited was that these labels are only instrumental in outdated soil analytical methods,which are based on alkaline extraction of soil organic matter(SOM).

关键词： soil humic life

Hepatocyte nuclear factor 4-alpha involvement in liver and intestinal inflammatory networks

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World Journal of Gastroenterology 2014年第1期20卷 22-30页

作者： jean-Philippe Babeu franois Boudreau département d’ Anatomie et de Biologie Cellulaire Faculté de Médecine et des Sciences de la SantéUniversité de SherbrookeSherbrooke J1E 4K8QuébecCanada

Hepatocyte nuclear factor 4-alpha (HNF4-α) is a nuclear receptor regulating metabolism, cell junctions, differentiation and proliferation in liver and intestinal epithelial cells. Mutations within the HNF4A gene are associated with human diseases such as maturity-onset diabetes of the young. Recently, HNF4A has also been described as a susceptibility gene for ulcerative colitis in genome-wide association studies. In addition, specific HNF4A genetic variants have been identified in pediatric cohorts of Crohn’s disease. Results obtained from knockout mice supported that HNF4-α can protect the intestinal mucosae against inflammation. However, the exact molecular links behind HNF4-α and inflammatory bowel diseases remains elusive. In this review, we will summarize the current knowledge about the role of HNF4-α and its isoforms in inflammation. Specific nature of HNF4-α P1 and P2 classes of isoforms will be summarized. HNF4-α role as a hepatocyte mediator for cytokines relays during liver inflammation will be integrated based on documented examples of the literature. Conclusions that can be made from these earlier liver studies will serve as a basis to extrapolate correlations and divergences applicable to intestinal inflammation. Finally, potential functional roles for HNF4-α isoforms in protecting the intestinal mucosae from chronic and pathological inflammation will be presented.

关键词： Hepatocyte nuclear factor 4-alpha Inflammatory bowel diseases Colitis-associated cancer Gastrointestinal tract Intestinal epithelium barrier Inflammation

Interendoscopist variability in proximal colon polyp detection is twice higher for serrated polyps than adenomas

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World Journal of Gastroenterology 2016年第38期22卷 8549-8557页

作者： jean-françois Bretagne Stéphanie Hamonic Christine Piette jean-françois Viel Guillaume Bouguen Service des maladies de l'appareil digestif hopital PontchaillouCentre hospitalo-universitaire de Rennes35033 RennesFrance Service d'épidémiologie et de santé publique Centre hospitalo-universitaire de Rennes35033 Rennes France Association pour le dépistage des cancers en Ille et Vilaine 35033 RennesFrance

AIM To assess the interendoscopist variability in the detection of colorectal polyps according to their location and histological *** This study was a retrospective analysis of prospectively collected data from a regional colorectal cancer(CRC) screening program; 2979 complete colonoscopies from 18 endoscopists were included. Variability in performance between endoscopists for detection of at least one adenoma(A), one proximal adenoma(PA), one distal adenoma(dA), and one proximal serrated polyp(PSP) was assessed by using multilevel logistic regression *** The observed detection rates among the 18 endoscopists ranged from 24.6% to 47.6%(mean = 35.7%) for A, from 19.1% to 39.0%(mean = 29.4%) for dA, from 6.0% to 22.9%(mean = 12.4%) for PA, and from 1.3% to 19.3%(mean = 6.9%) for *** adjusting for patient-level variables(sex, age), the interendoscopist detection rates variability achieved a significant level for A, PA, and PSP but not for dA(P = 0.03, P = 0.02, P = 0.02 and P = 0.08, respectively). This heterogeneity, as measured by the variance partition coefficient, was approximately threefold higher for PA(6.6%) compared with A(2.1%), and twofold higher for PSP(12.3%) compared with *** These results demonstrate significant interendoscopist variability for proximal polyp particularly for serrated p o l y p s, b u t n o t f o r d i s t a l a d e n o m a d e t e c t i o n. These findings contribute to explain the decreased effectiveness of complete colonoscopies at preventing proximal CRCs and the need to carefully assess the proximal colon during scope procedure.

关键词： Colonoscopy Colorectal cancer Adenoma Serrated polyp Proximal polyp detection rate Quality performance

Hepatocellular carcinoma in a non-cirrhotic patient with Wilson's disease

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World Journal of Gastroenterology 2013年第13期19卷 2110-2113页

作者： Raphael Thattil jean-franois dufour department of Hepatology University Clinic of Visceral Surgery and MedicineInselspital University Hospital Bern division of Hepatology Department of Clinical ResearchUniversity of Bern

We report the exceptional case of hepatocellular carcinoma in a non-cirrhotic patient, whose Wilson's disease was diagnosed at the unusual age of 58 years. The liver histology revealed macrovesicular steatosis with fibrosis, but no cirrhosis. The disease was treated with d-penicillamine for 3 years until acute discomfort in the right upper quadrant led to detection of multifocal hepatocellular carcinoma, which was successfully resected. The histological examination confirmed the malignant nature of the 4 lesions, which were classified according to Edmondson and Steiner as poorly differentiated hepatocellular carcinoma grade 3. The non-tumoral parenchyma showed 80% steatosis with ballooned cells, lobular inflammation, septal fibrosis but no cirrhosis. Hepatocellular carcinoma is rare in Wilson's disease, especially in the absence of cirrhosis. The literature's 28 published cases are reviewed and the contributory role of copper in the hepatocarcinogenic process is discussed.

关键词： Wilson’s disease Hepatocellular carcinoma Hepatocarcinogenesis Copper Liver Fibrosis Cirrhosis

Soil Macrofaunal Communities are Heterogeneous in Heathlands with different Grazing Intensity

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Pedosphere 2015年第4期25卷 524-533页

作者： jean-franois PONGE Sandrine SALMON Amélie BENoisT jean-Jacques GEOFFROY Muséum National d’Histoire Naturelle CNRS UMR 7179 4 avenue du Petit Chteau 91800 Brunoy (France) Muséum National d’Histoire Naturelle CNRS UMR 7204 4 avenue du Petit Chteau 91800 Brunoy (France)

Moderate grazing by cattle increases the heterogeneity of soil and vegetation. This has been suggested as an ecologically sustainable mean of managing natural environments endangered by tree encroachment, such as heathlands. Our study was performed to test the impact of grazing intensity on soil macroinvertebrate communities in heterogeneous landscapes in a private property eligible to the Natura 2000 European Network of Special Protection Areas within the Brenne Natural Regional Park （Indre, ~rance）. We sampled macroinvertebrates along a broken line crossing 5 different land-use types, from pasture to pine forest, passing through a besom heath （Erica scoparia） heathland at 3 levels of cattle pressure. We hypothesized that： i） litter-dwelling （mostly arthropods and mollusks） and soil-dwelling macroinvertebrates （mostly earthworms） would respond in an opposite manner to various grazing intensities, and ii） intermediate cattle pressure （pastured heath） would increase soil and community heterogeneity. The results supported the first hypothesis, which was explained by land-use impacts mediated by soil properties. However, our results supported only partly the second hypothesis since maximum dissimilarity （whether in the composition of soil macroinvertebrate communities or in soil features） was observed in only one out of the two pastured heaths where cattle pressure was intermediate.

关键词： besom heath cattle grazing heterogeneity land-use types soil macroinvertebrates

Characterizing historical(1992–2010) transitions between grassland and cropland in mainland france through mining land-cover survey data

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Journal of Integrative Agriculture 2015年第8期14卷 1511-1523页

作者： Ying Xiao Catherine Mignolet jean-fran?ois Mari Marc Beno?t INRA SAd UPR 055 ASTER 662 Avenue Louis BuffetMirecourt 88500 France Université de Lorraine LORIA UMR 7503Vandoeuvre-lès-Nancy 54506 France

Grassland, as one of the largest ecosystems on the earth, supports various goods and services to ***, humans have increased agricultural output primarily by cropland expansion and agricultural *** cropland area was primarily gained at the expense of grassland and *** from grassland conversion, increasing consumption of calorie- and meat-intensive diets drives the intensification of livestock systems, which is shifting steadily from grazing to feeding with *** cope with the environmental degradation due to agriculture, various forms of ‘green payment＇ were implemented to promote the adoption of sustainable farming practices over the last two decades in the European *** aim of this study is to monitor the recent transitions（1992–2010） between grassland and cropland during two Common Agricultural Policy（CAP） reforms at the French mainland *** proposed an innovative approach to link grassland conversion to agricultural commodities and farming systems *** first assessed the grassland-to-cropland conversion and further investigated the crop sequence patterns that were observed to be dominant after the conversion through mining land-cover survey data Teruti and *** found the trends of the transitions between grassland and cropland over the two time intervals： The loss of grassland（1992–2003） and restoration or re-expansion of grassland（2006–2010） in mainland *** finding on the crop sequence patterns after the grassland conversion reveals two notable evolutions of agricultural production *** evolutions were related to the increase in the proportion of cropland in the total agricultural land *** evolution was most likely influenced by the demand for fodder： The conversion from grazing livestock to feeding *** evolution was the conversion from livestock production to field crop *** results indicate that the intensification of livestock farming systems

关键词： conversion crop sequence patterns land-cover survey agricultural land-use change

Immune precision medicine for cancer:a novel insight based on the efficiency of immune effector cells

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Cancer Communications 2019年第1期39卷 318-333页

作者： jean-françois Rossi Patrice Céballos Zhao-Yang Lu Institut Sainte Catherine 84918 AvignonFrance UniversitéMontpellier 1 UFR Médecine34396 MontpellierFrance département d’Hématologie CHU de Montpellier34295 MontpellierFrance Unitéde Thérapie Cellulaire CHU Saint-Eloi34295 MontpellierFrance

Cancer cell growth is associated with immune surveillance ***,restoring the desired immune response against cancer cells remains a major therapeutic *** to the recent advances in biological knowledge,efficient therapeutic tools have been developed to support the best bio-clinical approaches for immune precision *** of the most important successes in immune therapy is represented by the applicational use of monoclonal antibodies,particularly the use of rituximab for B-cell lymphoproliferative *** recently,other monoclonal antibodies have been developed,to inhibit immune checkpoints within the tumor microenvironment that limit immune suppression,or to enhance some immune functions with immune adjuvants through different targets such as Toll-receptor *** aim is to inhibit cancer proliferation by the diminishing/elimination of cancer residual cells and clinically improving the response duration with no or few adverse *** effect is supported by enhancing the number,functions,and activity of the immune effector cells,including the natural killer(NK)lymphocytes,NKT-lymphocytes,γδT-lymphocytes,cytotoxic T-lymphocytes,directly or indirectly through vaccines particularly with neoantigens,and by lowering the functions of the immune suppressive *** these new therapeutics and their personalized usage,new considerations have to be taken into account,such as epigenetic regulation particularly from microbiota,evaluation of transversal functions,particularly cellular metabolism,and consideration to the clinical consequences at the body *** aim of this review is to discuss some practical aspects of immune therapy,giving to clinicians the concept of immune effector cells balancing between control and *** precision medicine is a combination of modern biological knowledge and clinical therapeutic decisions in a global vision of the patient.

关键词： Precision therapy Immunotherapy NK lymphocytes T-lymphocytes dendritic cells Vaccination Cancer

Adhesive wear mechanisms uncovered by atomistic simulations

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Friction 2018年第3期6卷 245-259页

作者： jean-fran?ois MOLINARI Ramin AGHABABAEI Tobias BRINK Lucas FRéROT Enrico MILANESE Civil Engineering department Materials Science Department école Polytechnique Fédérale de Lausanne department of Engineering-Mechanical Engineering Aarhus Universitet

In this review, we discuss our recent advances in modeling adhesive wear mechanisms using coarse-grained atomistic simulations. In particular, we present how a model pair potential reveals the transition from ductile shearing of an asperity to the formation of a debris particle. This transition occurs at a critical junction size, which determines the particle size at its birth. Atomistic simulations also reveal that for nearby asperities, crack shielding mechanisms result in a wear volume proportional to an effective area larger than the real contact area. As the density of microcontacts increases with load, we propose this crack shielding mechanism as a key to understand the transition from mild to severe wear. We conclude with open questions and a road map to incorporate these findings in mesoscale continuum models. Because these mesoscale models allow an accurate statistical representation of rough surfaces, they provide a simple means to interpret classical phenomenological wear models and wear coefficients from physics-based principles.

关键词： adhesive wear molecular dynamics continuum mechanics

Guest editorial: Special Issue on Science of Wear

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Friction 2018年第3期6卷 243-244页

作者： Yonggang MENG Valentin L.POPOV jean-fran?ois MOLINARI State Key Laboratory of Tribology Tsinghua University Institute of Mechanics Technische Universit?t Berlin Civil Engineering department Materials Science Department école Polytechnique Fédérale de Lausanne

Among the basic tribological phenomena of contact,adhesion, friction, lubrication and wear, wear remains the least scientifically understood. At the same time,wear remains one of the most important tribological phenom... 详细信息

关键词：摩擦学工艺优化可持续发展摩擦理论