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生物医学工程学杂志 2005年第S1期22卷 15-16页

作者： Nguyen TRAN Pierre-Yves MARIE Philippe franKEN jean-fran·ois stoltz jean-Pierre VILLEMOT Laboratory of Surgery School Faculty of Medicine-NancyFrance Department of Cell therapy and Tissue Engineering UMR-CNRS7563 Department of Nuclear Medicine-EA344 CHU-NancyFrance Department of Nuclear Medicine AZ-VUB-BrusselsBelgium

Potential Use of Polyelectrolyte Multilayer thin Films in Vascular Tissue Engineering:Evaluation of the Viability and Adhesion of Endothelial Cells

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生物医学工程学杂志 2005年第S1期22卷 117-118页

作者： Cédric BOURA Halima KERDJOUDJ Vanessa MOBY Pierre SCHAAJ jean Claude VOEGEL jean-fran·ois stoltz Patrick MENU Mécanique et Ingénierie Cellulaire et Tissulaire LEMTA-UMR CNRS 7563Facultéde Médecine54505 Vandoeuvre-lès-NancyFrance Institut Charles Sadron(CNRS-ULP) UPR 22 CNRS67083 StrasbourgFrance INSERM U 595 Facultéde Médecine67085 StrasbourgFrance

1 Introduction A method in vascular tissue engineering to obtain hemocompatible synthetic prosthesis consist s to cover the luminal surface by a monolayer of endothelial cell s(ECs).Nevertheless,the surface of current prosthesi s does not favour the development of an ECs ***,a new versatile method of self2assembled archi2 tectures based on the alternate adsorption of polycations and polyanions has been developed to lead to the build2up of multilayered polyelectrolyte films(MPF).This new type of surface modification offers also large possibilities for varying the physico2chemical properties such as rough2 ness or surface charges,film thickness and viscoelastic properties.

关键词： Tissue Engineering thin Films viscoelastic properties surface modification tissue engineering endothelial cells method of type of

Mechanobiology and Cartilage Tissue Engineering

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生物医学工程学杂志 2005年第S1期22卷 33-34页

作者： Céline HUSELSTEIN Natalia de ISLA Jing-Wei YANG Yun WANG Sylvaine MULLER jean-fran·ois stoltz Research Group of Cell and Tissue Engineering LEMTA-CNRS UMR 7563 et IFR 111 BioingénierieFacultéde Médecine54505 Vandoeuvre-lès-Nancy CedexFrance Unitéde Thérapie Cellulaire et Tissulaire(UTCT)-CHRU-54500 Vandoeuvre-lès-Nancy Cedex France

1 Introduction The cartilage i s a hydrated connective tissue in joint s that withstands and distributes mechanical *** utilize mechanical signals to maintain tissue *** regulate their metabolic activity through complex biological and biophysical interactions with the extracellular matrix(ECM).Although some of the mechanisms of mechanotransduction are known today,there are certainly many others left *** topics of chondrocytes mechanobiology have led to the development of tissue *** is the concept of substitute tissue developed in vitro,from bioresorbable or non2bioresorbable scaffolds and from cells harvested in a physiologic mechanical environment.

关键词： Ca MSCs Mechanobiology and Cartilage Tissue Engineering

Interest of Polyelectrolyte Multilayer thin Films in Tissue Engineering:Application to Vascular Allograft

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生物医学工程学杂志 2005年第S1期22卷 116-116页

作者： Halima KERDJOUDJ Cedric BOURA Vanessa MOBY Dominique DUMAS Luc MARCHAL jean-Claude VOEGEL jean-fran·ois stoltz Patrick MENU Mécanique et Ingénierie Cellulaire et Tissulaire LEMTA-UMR CNRS 7563Facultéde Médecine54505 Vandoeuvre-lès-NancyFrance INSERMU 595 Facultéde Médecine67085 StrasbourgFrance)

1 Introduction Obstructive atherosclerosis vascular disease remains one of the greatest public health threats in the ***2 gical treatment to replace diseased blood vessels is usually done using major human allografts(veins or arteries)or synthetic prosthesis(PTFE,Dacron).However,these substitutes have not a good patency,because of the lack of endothelial cell s(ECs)layer,which prevent s thrombus *** challenge of tissue engineering vessel s i s to build2up blood/substitute interface near native *** order to improve ECs adhesion,it is necessary to pre2 coat the intra2luminal ***,a new surface modification technique arose,based on the alternate ad2 sorption of oppositely charged *** objec2 tive was to favour the endothelialization of the cryo2pre2 served allografts,treated with a thin polyelectrolyte multi2 layered film,made of PSS(poly(sodium242styrenesul2 fonate))or PAH(poly(allylamine hydrochloride)).

关键词： Tissue Engineering surface modification tissue engineering endothelial cells vascular disease public health blood vessels the world

Improving the utility of locally differentially private protocols for longitudinal and multidimensional frequency estimates

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Digital Communications and Networks 2024年第2期10卷 369-379页

作者： Héber H.Arcolezi jean-fran.ois Couchot Bechara Al Bouna Xiaokui Xiao Inria andÉcole Polytechnique(IPP) PalaiseauFrance Femto-ST Institute Univ.Bourg.Franche-ComtéUBFCCNRSBelfortFrance TICKET Lab. Antonine University Hadat-BaabdaBaabdaLebanon School of Computing National University of SingaporeSingaporeSingapore

This paper investigates the problem of collecting multidimensional data throughout time(i.e.,longitudinal studies)for the fundamental task of frequency estimation under Local Differential Privacy(LDP)*** to frequency estimation of a single attribute,the multidimensional aspect demands particular attention to the privacy ***,when collecting user statistics longitudinally,privacy progressively ***,the“multiple”settings in combination(i.e.,many attributes and several collections throughout time)impose several challenges,for which this paper proposes the first solution for frequency estimates under *** tackle these issues,we extend the analysis of three state-of-the-art LDP protocols(Generalized Randomized Response–GRR,Optimized Unary Encoding–OUE,and Symmetric Unary Encoding–SUE)for both longitudinal and multidimensional data *** the known literature uses OUE and SUE for two rounds of sanitization(***),i.e.,L-OUE and L-SUE,respectively,we analytically and experimentally show that starting with OUE and then with SUE provides higher data utility(i.e.,L-OSUE).Also,for attributes with small domain sizes,we propose Longitudinal GRR(L-GRR),which provides higher utility than the other protocols based on unary ***,we also propose a new solution named Adaptive LDP for LOngitudinal and Multidimensional FREquency Estimates(ALLOMFREE),which randomly samples a single attribute to be sent with the whole privacy budget and adaptively selects the optimal protocol,i.e.,either L-GRR or *** shown in the results,ALLOMFREE consistently and considerably outperforms the state-of-the-art L-SUE and L-OUE protocols in the quality of the frequency estimates.

关键词： Local differential privacy Discrete distribution estimation Frequency estimation Multidimensional data Longitudinal studies

Template-free nanostructured particle growth via a one-pot continuous gradient nanoprecipitation

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Aggregate

Aggregate 2024年第1期5卷 409-418页

作者： Xie Cheng Shuai Wang Julien Bernard fran.ois Ganachaud Xibo Yan School of Chemical Engineering and Technology Tianjin UniversityTianjinChina College of Food Science and Engineering Tianjin University of Science and TechnologyTianjinChina Universitéde Lyon CNRSUniversitéClaude Bernard Lyon 1INSA-LyonUniversitéJean MonnetUMR5223Ingénierie des Matériaux PolymèresVilleurbanne CedexFrance

Engineered nanoparticles have emerged as new types of materials for a wide range of applications from therapeutics to ***,fabricating nanomaterials presenting complex inner morphologies and shapes in a simple manner remains a great ***,we report the template-free one-pot continuous gradient nanoprecipitation of different types of non-compatible polymers to spontaneously form nanostructured *** continuous addition of antisolvent induces precipitation and(re)organization of polymer chains at the forming particle interface,ultimately and naturally developing complex inner morphologies and shapes while particle *** low-energy-cost bottom-up assembly approach applies to various functional polymers,possibly embedded with metal nanoparticles,for continuous growth into well-organized *** crosslinking of the particles and core removal allows both confirming the building process and leading to hollow or multivoid nanomaterials.

关键词： aggregation nanoprecipitation phase diagrams polymeric nanoparticles self-assembly

Irrigated Agriculture Facing the Challenge of Climate Change: Adaptation Strategies for Farmers in the Irrigated Perimeters of Môle Saint-Nicolas, Haiti

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American Journal of Climate Change 2024年第3期13卷 477-498页

作者： frantz Mial jean-fran.ois Bissonnette Marc-André Bourgault Meryem Qacami Department of Geography Laval University Quebec Canada

Môle Saint-Nicolas, like all other communes in the Republic of Haiti, faces increasing climate variability, impacting agricultural production and water resources. Consequently, there is a pressing need for adaptation to these climatic changes. This research aims to showcase the adaptation strategies deployed by farmers to cope with the increasing climate variability. Surveys were conducted through group and individual discussions with a randomly selected cohort of 150 farmers. Two types of analysis were performed: quantitative and qualitative. The quantitative data analysis was conducted using Statistical Package for the Social Sciences (SPSS) software. The findings reveal that farmers have perceived changes in rainfall patterns, temperature, wind, and their environment. These changes manifest as irregular rainfall, higher temperatures, prolonged drought periods, violent winds accompanied by rain, premature cessation of rains, and reduced flow from water sources. In response, the most common adaptation strategies adopted include selecting new cultivars, early-maturing varieties, crop rotation and diversification, canal dredging, new soil preparation methods, upstream water source protection, and micro-watershed management. The significance of this research lies in its contribution to enhancing farmers’ adaptive capacities by alerting stakeholders in the irrigated perimeters about the consequences of climate change, thereby incorporating the real needs of farmers in future projects.

关键词： Climate Change Perception Adaptation Agriculture Irrigated Perimeter

An ethically guided preclinical device for phenotyping H_(2)production in laboratory rodents

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Animal Models and Experimental Medicine 2024年第4期7卷 553-561页

作者： Victor Pascal-Moussellard Emilie Boucher Stéphane Tanguy Philippe Cinquin Pierre-Alain Barraud ChloéDavin Cordélia Salomez-Ihl Dalil Hannani fran.ois Boucher jean-Pierre Alcaraz University Grenoble Alpes CNRSUMR 5525VetAgro SupGrenoble INPTIMCGrenobleFrance

Background:Dihydrogen(H_(2))is produced endogenously by the intestinal microbiota through the fermentation of diet *** the past few years,numer-ous studies have demonstrated the significant therapeutic potential of H_(2)in various pathophysiological contexts,making the characterization of its production in labora-tory species of major preclinical ***:This study proposes an innovative solution to accurately monitor H_(2)pro-duction in free-moving rodents while respecting animal welfare *** devel-oped device consisted of a wire rodent cage placed inside an airtight chamber in which the air quality was maintained,and the H_(2)concentration was continuously *** the airtightness and efficiency of the systems used to control and maintain air quality in the chamber were checked,tests were carried out on rats and mice with different metabolic phenotypes,over 12 min to 1-h experiments and repeatedly.H_(2)production rates(HPR)were obtained using an easy calculation algorithm based on a first-order moving ***:HPR in hyperphagic Zucker rats was found to be twice as high as in control Wistar rats,respectively,2.64 and 1.27 nmol.s^(−1)per *** addition,the ingestion of inulin,a dietary fiber,stimulated H_(2)production in *** were 0.46 nmol.s^(−1)for animals under control diet and 1.99 nmol.s^(−1)for animals under inulin ***:The proposed device coupled with our algorithm enables fine analysis of the metabolic phenotype of laboratory rats or mice with regard to their endogenous H_(2)production.

关键词： hydrogen therapy laboratory rodents microbiota molecular hydrogen noninvasive monitoring device

Nutritional and Sensory Properties of Penne-Type Pasta Based on Cereals (Oryza sativa (L.), Digitaria exilis, Pennicetum glaucum), Tubers (Ipomoea batata, Manihot esculenta Crantz), and a Legume (Vigna unguiculata (L.))

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Food and Nutrition Sciences 2024年第5期15卷 351-360页

作者： Maurice jean fran.ois Sylvestre Lopy Ndèye Fatou Ndiaye Malick Mbengue Mamadou Salif Sow Abdou Diouf Department of Cereals and Legumes Institute of Food Technology (ITA) Dakar Senegal Polytechnic School Cheikh Anta Diop University Dakar Senegal

This study aimed to evaluate the nutritional and sensory characteristics of penne-type pasta produced from locally sourced cereals, tubers, and legumes. To achieve this, we formulated four different types of pasta with varying levels of incorporation ranging from 10 to 50% cereals such as millet, fonio, and rice, tubers such as manioc and sweet potato, and legumes such as cowpea. The results showed that the incorporation of local products considerably improved the nutrient content of penne without being rejected by consumers. Sensory analysis showed that the best results were obtained with mixtures of sweet potato, cowpea, and wheat, as well as with rice, manioc, cowpea, and sample wheat. These results are of great importance to manufacturers in a world where developing nutritious and attractive food products is a crucial challenge.

关键词： Pasta Tubers Cereals Legumes

The Evolutionary Profile of Patients Operated for Peptic Ulcer Perforation in Bujumbura

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Surgical Science 2024年第1期15卷 7-18页

作者： jean Claude Mbonicura Prudence Bukuru Stanislas Harakandi frank Ijeneza Révérien Ndayirorere fran.ois Nduwimana Astère Mbonicura Department of General and Gastro-Intestinal Surgery Centre Universitaire de Recherche en Santé Faculty of Medicine University of Burundi Bujumbura Burundi Department of Anesthesia-Resuscitations Faculty of Health Sciences Hope Africa University Bujumbura Burundi Department of Anesthesia-Resuscitation Centre Universitaire de Recherche en Santé Faculty of Medicine University of Burundi Bujumbura Burundi Department of Andro-Urology Centre Universitaire de Recherche en Santé Faculty of Medicine University of Burundi Bujumbura Burundi Department of Multi-Purpose Medicine Easter Grand Hospital Francilien Meaux France

Background: The evolutionary profile of patients operated for peptic ulcer perforation in Bujumbura. Perforated peptic ulcer is a serious complication of peptic ulcer with potential risk of grave complications. Aim: To study the early morbidity and mortality of surgery for peptic ulcer perforation in Bujumbura City Hall hospitals: Kamenge University Hospital Center (CHUK), Kamenge Military Hospital (HMK) and Prince Louis Rwagasore Clinic (CPLR). Patients and methods: This is a retrospective, descriptive and analytical study carried out in the three hospitals of Bujumbura over a period of three years from January 1, 2020 to December 31, 2022. It involved 57 cases (n = 57) of peptic ulcer perforation. Results: The frequency of surgery for peptic ulcer perforation was 2.7% with a mean age of 43.6 years +/- 15.3 years and a male predominance with a sex ratio of 3.7. Eight percent of patients presented with shock, 24.5% were smokers, and 67.9% had taken non steroidal anti-inflammatory drugs. The mean hospital stay was 15.2 days with a standard deviation of 12.1. The morbidity rate was 30.2%, 32% were classified in grade IIIb of the Clavien-Dindo Surgical Complications Scale. There were 9 deaths (17%). Seven patients who underwent surgery and received late consultations died. Conclusion: Surgery for peptic ulcer perforation remains an intervention associated with a high rate of morbidity and mortality in Bujumbura. Surgery for peptic ulcer perforation remains a procedure associated with a high morbidity and mortality rate in Bujumbura. The time before consultation was the only factor associated with early morbidity and mortality of Surgery for peptic ulcer’s perforations.

关键词： Peritonitis Peptic Ulcer Perforation Complications